Team Schedule
| Wk | Date | Opponent | Time | TV | Streaming |
|---|---|---|---|---|---|
| 1 | 09/09 | vs.  NYJ | 8:15 EST | ESPN | ABC |
| 2 | 09/15 | @  MIN | 1:00 EST | CBS | Sun Ticket |
| 3 | 09/22 | @  LAR | 4:25 EST | FOX | Sun Ticket |
| 4 | 09/29 | vs.  NE | 4:05 EST | FOX | Sun Ticket |
| 5 | 10/06 | vs.  ARI | 4:05 EST | FOX | Sun Ticket |
| 6 | 10/10 | @  SEA | 8:15 EST | Prime | - |
| 7 | 10/20 | vs.  KC | 4:25 EST | FOX | Sun Ticket |
| 8 | 10/27 | vs.  DAL | 8:20 EST | NBC | Peacock |
| 9 | 11/10 | @  TB | 1:00 EST | FOX | Sun Ticket |
| 10 | 11/17 | vs. SEA | 4:05 EST | FOX | Sun Ticket |
| 11 | 11/24 | @  GB | 4:25 EST | FOX | Sun Ticket |
| 12 | 12/01 | @  BUF | 8:20 EST | NBC | Peacock |
| 13 | 12/08 | vs.  CHI | 4:25 EST | FOX | Sun Ticket |
| 14 | 12/12 | vs. LAR | 8:15 EST | Prime | - |
| 15 | 12/22 | @  MIA | 4:25 EST | CBS | Sun Ticket |
| 16 | 12/30 | vs.  DET | 8:15 EST | ESPN | ABC |
| 17 | 01/05 | @ ARI | 4:25 EST | FOX | Sun Ticket |
49ers
| 12/31/69 | 7:00 PM EST | |
| | ||
Injuries
| Date | Player | Status |
|---|---|---|
| 2025-09-16 | Ben Bartch | Doubtful |
| 2025-09-16 | Spencer Burford | Questionable |
| 2025-09-15 | Ben Bartch | Doubtful |
| 2025-09-15 | Spencer Burford | Questionable |
| 2025-09-15 | Brock Purdy | Out |
| 2025-09-14 | Ben Bartch | Questionable |
| 2025-09-14 | Jordan James | Out |
| 2025-09-14 | Jauan Jennings | Questionable |
| 2025-09-14 | Nick Martin | Out |
| 2025-09-14 | Siran Neal | Questionable |
| 2025-09-14 | Austen Pleasants | Out |
| 2025-09-12 | Yetur Gross-Matos | Questionable |
| 2025-09-12 | Brock Purdy | Out |
| 2025-09-12 | Jordan Watkins | Questionable |
| 2025-09-11 | Brock Purdy | Doubtful |
| 2025-09-11 | Jordan Watkins | Questionable |
Transactions
| Date | Transaction |
|---|---|
| 2025-09-11 | Signed TE Messiah Swinson to the practice squad. |
| 2025-09-10 | Signed K Eddy Pineiro to the active roster. |
