Team Schedule
| Wk | Date | Opponent | Time | TV | Streaming |
|---|---|---|---|---|---|
| 1 | 09/09 | vs.  NYJ | 8:15 EST | ESPN | ABC |
| 2 | 09/15 | @  MIN | 1:00 EST | CBS | Sun Ticket |
| 3 | 09/22 | @  LAR | 4:25 EST | FOX | Sun Ticket |
| 4 | 09/29 | vs.  NE | 4:05 EST | FOX | Sun Ticket |
| 5 | 10/06 | vs.  ARI | 4:05 EST | FOX | Sun Ticket |
| 6 | 10/10 | @  SEA | 8:15 EST | Prime | - |
| 7 | 10/20 | vs.  KC | 4:25 EST | FOX | Sun Ticket |
| 8 | 10/27 | vs.  DAL | 8:20 EST | NBC | Peacock |
| 9 | 11/10 | @  TB | 1:00 EST | FOX | Sun Ticket |
| 10 | 11/17 | vs. SEA | 4:05 EST | FOX | Sun Ticket |
| 11 | 11/24 | @  GB | 4:25 EST | FOX | Sun Ticket |
| 12 | 12/01 | @  BUF | 8:20 EST | NBC | Peacock |
| 13 | 12/08 | vs.  CHI | 4:25 EST | FOX | Sun Ticket |
| 14 | 12/12 | vs. LAR | 8:15 EST | Prime | - |
| 15 | 12/22 | @  MIA | 4:25 EST | CBS | Sun Ticket |
| 16 | 12/30 | vs.  DET | 8:15 EST | ESPN | ABC |
| 17 | 01/05 | @ ARI | 4:25 EST | FOX | Sun Ticket |
49ers
| 12/31/69 | 7:00 PM EST | |
| | ||
Injuries
| Date | Player | Status |
|---|---|---|
| 2025-11-08 | Tatum Bethune | Questionable |
| 2025-11-07 | Ricky Pearsall | Out |
| 2025-11-07 | Brock Purdy | Questionable |
| 2025-11-05 | Brandon Aiyuk | Out |
| 2025-11-05 | Ricky Pearsall | Questionable |
| 2025-11-04 | Mykel Williams | Out |
| 2025-11-02 | Ben Bartch | Injured Reserve |
| 2025-11-02 | Jake Brendel | Out |
| 2025-11-02 | Spencer Burford | Questionable |
| 2025-11-02 | Yetur Gross-Matos | Injured Reserve |
| 2025-11-02 | Bryce Huff | Out |
| 2025-11-02 | Mykel Williams | Questionable |
| 2025-11-01 | Jake Brendel | Out |
| 2025-11-01 | Spencer Burford | Questionable |
Transactions
| Date | Transaction |
|---|---|
| 2025-11-01 | Placed DL Yetur Gross-Matos on injured reserve. Activated G Spencer Burford from the injured reserve list. Elevated DE Clelin Ferrell and G Nick |
