Injuries
| 2025-11-08 |
 | Bryce Huff Status: Active San Francisco 49ers | Huff (hamstring) does not carry an injury designation into Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
 | Keion White Status: Questionable San Francisco 49ers | White (groin) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
 | Kalia Davis Status: Questionable San Francisco 49ers | Davis (ankle) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
 | Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (thigh) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
 | Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
 | Alfred Collins Status: Questionable San Francisco 49ers | Collins (hip) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
| 2025-11-07 |
| Keion White Status: Questionable San Francisco 49ers | questionable |
| Kalia Davis Status: Questionable San Francisco 49ers | questionable |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
| Keion White Status: Questionable San Francisco 49ers | White was a limited participant in practice Thursday due to a groin injury, Matt Barrows of The Athletic reports. |
| Kalia Davis Status: Questionable San Francisco 49ers | Davis (ankle) was a limited participant in practice Thursday, Matt Barrows of The Athletic reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins has a hip injury and did not participate in Thursday's practice, Matt Barrows of The Athletic reports. |
| Bryce Huff Status: Questionable San Francisco 49ers | Huff (hamstring) was a limited participant in practice for the second day in a row Thursday, Matt Barrows of The Athletic reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) was a limited participant in Thursday's practice, Matt Barrows of The Athletic reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (thigh) was a limited participant in practice for the second day in a row Thursday, Matt Barrows of The Athletic reports. |
 | Jake Brendel Status: Active San Francisco 49ers | NA |
 | Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) has been ruled out for Sunday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
 | Mac Jones Status: Active San Francisco 49ers | Jones will start Sunday's game against the Rams even if Brock Purdy (toe) is active, Nick Wagoner of ESPN.com reports. |
 | Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) is listed as questionable for Sunday's game against the Rams, but Mac Jones will start even if Purdy is active, Nick Wagoner of ESPN.com reports. |
| 2025-11-06 |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Tatum Bethune Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) didn't practice Thursday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) remained limited at Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Bryce Huff Status: Questionable San Francisco 49ers | Huff (hamstring) was a limited participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) was limited in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune was limited in Wednesday's practice due to a thigh injury, Cam Inman of The San Jose Mercury News reports. |
| 2025-11-05 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) isn't practicing Wednesday, Matt Barrows of The Athletic reports. |
 | Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan said Wednesday that he's "pretty confident" Aiyuk (knee) will play at some point this season, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) will be limited at Wednesday's practice, Matt Barrows of The Athletic reports. |
| 2025-11-04 |
 | Mykel Williams Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Monday that Williams tore his ACL during the fourth quarter of Sunday's 34-24 win over the Giants, Matt Barrows and Dianna Russini of The Athletic report. |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Bryce Huff Status: Questionable San Francisco 49ers | questionable |
| Jake Brendel Status: Questionable San Francisco 49ers | questionable |
| 2025-11-03 |
 | Eddy Pineiro Status: Active San Francisco 49ers | Pineiro made both of his field-goal attempts and connected on all four of his point-after tries during the 49ers' 34-24 win over the Giants on Sunday. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune recorded 16 total tackles (eight solo) and a pass defensed in Sunday's 34-24 win over the Giants. |
 | Jordan Watkins Status: Active San Francisco 49ers | Watkins hauled in his only target for 19 yards in Sunday's 34-24 win over the Giants. |
 | Skyy Moore Status: Active San Francisco 49ers | Moore had one reception for 21 yards while returning five combined kicks for 85 yards in Sunday's 34-24 win over the Giants. |
 | Demarcus Robinson Status: Active San Francisco 49ers | Robinson finished with no receptions on one target in Sunday's 34-24 win over the Giants. |
 | Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson took five carries for 53 yards and a touchdown in Sunday's 34-24 win over the Giants. He also returned a kickoff for 41 yards. |
| Ricky Pearsall Status: Out San Francisco 49ers | Coach Kyle Shanahan noted Monday that Pearsall (knee) has a chance to play Sunday against the Rams, but will be evaluated mid-week, Matt Barrows of The Athletic reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Aiyuk (knee) won't have his 21-day practice window opened this week, David Lombardi of SFStandard.com reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Bryce Huff Status: Out San Francisco 49ers | out |
| Jake Brendel Status: Out San Francisco 49ers | out |
 | CJ West Status: Active San Francisco 49ers | NA |
 | Jordan James Status: Active San Francisco 49ers | NA |
| 2025-11-02 |
 | Kendrick Bourne Status: Active San Francisco 49ers | Bourne caught both of his targets for 34 yards in Sunday's 34-24 win over the Giants. |
 | Jauan Jennings Status: Active San Francisco 49ers | Jennings caught four of five targets for 41 yards and a touchdown in Sunday's 34-24 win over the Giants. |
 | George Kittle Status: Active San Francisco 49ers | Kittle caught all four of his targets for 32 yards in Sunday's 34-24 win over the Giants. |
 | Marques Sigle Status: Out San Francisco 49ers | Sigle (coach's decision) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports. |
 | Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu (ankle) is active for Sunday's matchup with the Giants, Briana Jeannel of the 49ers' official site reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters (knee) is active for Sunday's contest against the Giants, Briana Jeannel of the 49ers' official site reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports. |
| CJ West Status: Out San Francisco 49ers | inactive |
| Ricky Pearsall Status: Out San Francisco 49ers | inactive |
| Jordan James Status: Out San Francisco 49ers | inactive |
| Bryce Huff Status: Out San Francisco 49ers | inactive |
| Jake Brendel Status: Out San Francisco 49ers | inactive |
 | Jordan Elliott Status: Active San Francisco 49ers | Elliott (ankle) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports. |
 | Spencer Burford Status: Active San Francisco 49ers | Burford (knee) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports. |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliott (ankle) is expected to play in Sunday's game against the Giants, Eric Branch of the San Francisco Chronicle reports. |
 | Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Gross-Matos (knee) was placed on injured reserve Saturday. |
 | Ben Bartch Status: Injured Reserve San Francisco 49ers | Bartch (ankle) was ruled out ahead of Sunday's game against the Giants. |
| Spencer Burford Status: Questionable San Francisco 49ers | Burford (knee) was activated from injured reserve Saturday. |
 | Upton Stout Status: Active San Francisco 49ers | NA |
| Mykel Williams Status: Questionable San Francisco 49ers | questionable |
| Mac Jones Status: Active San Francisco 49ers | Jones completed 19 of 24 passes for 235 yards and two touchdowns in Sunday's 34-24 win over the Giants. He added four rushing attempts for four yards. |
 | Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 28 times for 106 yards and a touchdown while catching five of six targets for 67 yards and a touchdown in Sunday's 34-24 win over the Giants. |
| Mykel Williams Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said Mykel Williams might have injured his ACL in Sunday's win over the Giants, Vic Tafur of The Athletic reports. |
| 2025-11-01 |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliott (ankle), who is questionable for Sunday's matchup against the Giants, is not traveling with the 49ers to New York on Friday due to personal reasons, Vic Tafur of The Athletic reports. |
| Jake Brendel Status: Out San Francisco 49ers | Brendel (hamstring) was ruled out ahead of Sunday's matchup against the Giants,Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2025-10-31 |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (ankle) was a limited participant in Thursday's practice, Eric Branch of the San Francisco Chronicle reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) was a limited participant in Thursday's practice, Eric Branch of the San Francisco Chronicle reports. |
 | Renardo Green Status: Active San Francisco 49ers | Green registered eight tackles (four solo) during the 49ers' 26-15 loss to the Texans on Sunday. |
 | Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir registered three tackles (two solo) and one interception during the 49ers' 26-15 loss to the Texans on Sunday. |
| Bryce Huff Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Jake Brendel Status: Out San Francisco 49ers | out |
| Upton Stout Status: Active San Francisco 49ers | NA |
| Alfred Collins Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) won't play Sunday against the Giants, Cam Inman of The San Jose Mercury News reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones will start Sunday's game at the Giants, Matt Maiocco of NBC Sports Bay Area reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) won't start Sunday's game against the Giants but is listed as questionable to be available in a backup capacity, Matt Maiocco of NBC Sports Bay Area reports. |
| Bryce Huff Status: Out San Francisco 49ers | Huff (hamstring) has been ruled out for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliott (ankle) is questionable for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) is listed as questionable for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | Gross-Matos (knee/hamstring) has been ruled out for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (shoulder) has no injury designation ahead of Sunday's game against the Giants. |
| 2025-10-30 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) didn't take part in Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) was limited at Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (ankle) did not participate at practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Bryce Huff Status: Questionable San Francisco 49ers | Huff (hamstring) did not participate at practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (shoulder) was a limited participant at practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) did not participate at practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Ben Bartch Status: Injured Reserve San Francisco 49ers | Bartch (ankle) was a limited participant in San Francisco's practice Wednesday, David Lombardi of SFStandard.com reports. |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliott (ankle) was a limited participant in San Francisco's practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | Burford (knee) was a full participant in San Francisco's practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Jake Brendel Status: Questionable San Francisco 49ers | Brendel (hamstring) didn't participate in San Francisco's practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| 2025-10-29 |
 | Malik Mustapha Status: Active San Francisco 49ers | Mustapha made 12 tackles (six solo) during Sunday's loss to the Texans. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune made 14 tackles (four solo) during Sunday's loss to the Texans. |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee/knee) practiced in full Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) officially was limited at Wednesday's practice, Eric Branch of the San Francisco Chronicle reports. |
 | Jake Tonges Status: Active San Francisco 49ers | Tonges recorded a two-yard touchdown reception on his lone target while playing five of the 49ers' 48 snaps on offense in Sunday's 26-15 loss to the Texans. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins recorded a seven-yard reception on two targets in Sunday's 26-15 loss to the Texans. |
 | Isaac Guerendo Status: Active San Francisco 49ers | Guerendo played all 10 of his snaps on special teams in Sunday's 26-15 loss to the Texans. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) is expected to be limited at Wednesday's practice, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) isn't practicing Wednesday, Vic Tafur of The Athletic reports. |
| Keion White Status: Active San Francisco 49ers | The 49ers acquired White and a 2026 seventh-round pick from the Patriots on Tuesday in exchange for a 2026 sixth-round pick, Tom Pelissero of NFL Network reports. |
| 2025-10-28 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Bryce Huff Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Jake Brendel Status: Questionable San Francisco 49ers | questionable |
| 2025-10-27 |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Bryce Huff Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Jake Brendel Status: Out San Francisco 49ers | out |
| CJ West Status: Active San Francisco 49ers | NA |
| Jordan James Status: Active San Francisco 49ers | NA |
| Mac Jones Status: Active San Francisco 49ers | Jones completed 19 of 32 passes for 193 yards with two touchdowns and one interception while adding two rushes for 23 yards in the 49ers' 26-15 loss to the Texans on Sunday. He also threw a two-point conversion pass. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson pulled in two of three targets for five yards while catching a successful two-point attempt in Sunday's 26-15 loss to Houston. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson did not record a touch on offense while returning three kicks for 99 yards in Sunday's 26-15 loss to the Texans. |
| George Kittle Status: Active San Francisco 49ers | Kittle brought in four of five targets for 43 yards and a touchdown in the 49ers' 26-15 loss to the Texans on Sunday. |
| Skyy Moore Status: Active San Francisco 49ers | Moore failed to collect his only target on offense while returning two kicks for 52 yards in Sunday's 26-15 loss to the Texans. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne brought in three of four targets for 44 yards in the 49ers' 26-15 loss to the Texans on Sunday. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings brought in four of seven targets for 45 yards in the 49ers' 26-15 loss to the Texans on Sunday. |
| Dee Winters Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said Monday that Winters is considered day-to-day due to a knee injury he sustained during Sunday's 26-15 loss to the Texans, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
| Brandon Aiyuk Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that the 49ers don't intend to designate Aiyuk (knee) to return from the reserve/PUP list Wednesday, Matt Barrows of The Athletic reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Monday that Jones suffered a bruised knee during Sunday's 26-15 loss at Houston and is "day-to-day," David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has a chance to return to action Sunday at the Giants, Nick Wagoner of ESPN.com reports. "It's too early to say," coach Kyle Shanahan said Monday. "I don't think it's a long shot. We'll see how he's doing on Wednesday." |
| 2025-10-26 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed eight times for 25 yards and brought in three of six targets for 43 yards in the 49ers' 26-15 loss to the Texans on Sunday. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro made his lone extra-point try during the 49ers' 26-15 loss to the Texans on Sunday. |
 | Luke Gifford Status: Active San Francisco 49ers | Gifford is active for Sunday's game against the Texans. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (quadriceps) is active for Sunday's game against the Texans. |
| CJ West Status: Out San Francisco 49ers | inactive |
| Brock Purdy Status: Out San Francisco 49ers | inactive |
| Ricky Pearsall Status: Out San Francisco 49ers | inactive |
| Jordan James Status: Out San Francisco 49ers | inactive |
| Bryce Huff Status: Out San Francisco 49ers | inactive |
| Yetur Gross-Matos Status: Out San Francisco 49ers | inactive |
| Jake Brendel Status: Out San Francisco 49ers | inactive |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliot (ankle) is questionable to return to Sunday's game against Houston, |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | Burford (knee) has been ruled out for Sunday's game against Houston. |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu is questionable to return to Sunday's matchup against Houston due to an ankle injury, Nick Wagoner of ESPN.com reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) has been ruled out for the rest of Sunday's game against the Texans. |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliott (ankle) has been ruled out for the rest of Sunday's game against the Texans, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-10-24 |
| Brandon Aiyuk Status: Out San Francisco 49ers | Coach Kyle Shanahan said Friday that the 49ers may designate Aiyuk (knee) to return from the reserve/PUP list next week, David Lombardi of SFStandard.com reports. |
| Bryce Huff Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Jake Brendel Status: Out San Francisco 49ers | out |
| Mac Jones Status: Active San Francisco 49ers | Jones will start Sunday's game at Houston after coach Kyle Shanahan ruled out Brock Purdy (toe), Adam Schefter of ESPN reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) has been ruled out for Sunday's game at Houston, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has been ruled out for Sunday's game at Houston, Nick Wagoner of ESPN.com reports. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (quadriceps) is listed as questionable for Sunday's game against the Texans, Nick Wagoner of ESPN.com reports. |
| Bryce Huff Status: Out San Francisco 49ers | Huff (hamstring) has been ruled out for Sunday's game against the Texans, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | Gross-Matos (knee/hamstring) has been ruled out for Sunday's game against the Texans, Nick Wagoner of ESPN.com reports. |
| Mac Jones Status: Active San Francisco 49ers | With Brock Purdy (toe) unlikely to be ready to play Sunday against the Texans, Jones is expected to make another start at quarterback, Ian Rapoport of NFL Network reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) is not expected to start Sunday against the Texans, Ian Rapoport of NFL Network reports. |
| Jake Brendel Status: Out San Francisco 49ers | Brendel (hamstring) is listed as out for Sunday's game at Houston, Nick Wagoner of ESPN.com reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (hamstring) is listed as questionable for Sunday's game at Houston, Nick Wagoner of ESPN.com reports. |
| 2025-10-23 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) didn't take part in Thursday's practice, Matt Barrows of The Athletic reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) was a limited practice participant Thursday, Matt Barrows of The Athletic reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (ankle) was a full practice participant Thursday, Matt Barrows of The Athletic reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (toe) was a full participant in Thursday's practice, Matt Barrows of The Athletic reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (toe) was a limited participant at practice Wednesday, Vic Tafur of The Athletic reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (ankle) was a limited participant at practice Wednesday, Vic Tafur of The Athletic reports. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (quadricep) did not participate at practice Wednesday, Vic Tafur of The Athletic reports. |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | The 49ers designated Burford (knee) to return to practice on Wednesday. |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco general manager John Lynch said Thursday that he has both hope and "evidence" that Aiyuk (knee) will soon be ready to make his 2025 debut, David Lombardi of SFStandard.com reports. |
| 2025-10-22 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) will not participate in Wednesday's practice, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) will be limited in practice Wednesday, Vic Tafur of The Athletic reports. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha tallied six tackles (three solo) Sunday in a 20-10 win over the Falcons. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle recorded two tackles (one solo) while playing just 31 percent of San Francisco's defensive snaps in Sunday's 20-10 win over Atlanta. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | questionable |
| Luke Gifford Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Active San Francisco 49ers | Winters totaled three tackles (all solo) in Sunday's 20-10 win against Atlanta. |
| 2025-10-21 |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune recorded 10 tackles (four solo), including one tackle forloss, in Sunday's 20-10 win over the Falcons. |
| 2025-10-20 |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne pulled in both of his targets for 14 yards in Sunday's 20-10 win over the Falcons. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (ankle/ribs/shoulder) had four receptions on seven targets for 31 yards in Sunday's 20-10 win over Atlanta. |
| George Kittle Status: Active San Francisco 49ers | Kittle (hamstring) failed to bring in either of his targets in Sunday's 20-10 win over the Falcons. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee/oblique) completed 17 of 26 pass attempts for 152 yards and an interception while recording five rush attempts for 11 yards in Sunday's 20-10 win over the Falcons. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 24 times for 129 yards and two touchdowns while bringing in seven of eight targets for 72 yards in Sunday's 20-10 win over the Falcons. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges logged eight snaps on offense (12 percent) and was not targeted in Sunday's 20-10 win over the Falcons. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson carried the ball nine times for 36 yards and was not targeted as a receiver in Sunday's 20-10 win over Atlanta. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson failed to catch his only target in Sunday's 20-10 win over the Falcons. |
| Ricky Pearsall Status: Out San Francisco 49ers | Coach Kyle Shanahan noted Monday that the 49ers will continue monitoring Pearsall (knee) ahead of Sunday's game against the Texans, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Coach Kyle Shanahan noted Monday that the 49ers will continue monitoring Purdy (toe) ahead of this coming Sunday's game against the Texans, per Nick Wagoner of ESPN.com, while acknowledging at this stage that the QB playing this weekend is viewed as a stretch, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan relayed Monday that Green (toe) will be considered day-to-day heading into the 49ers' Week 8 clash against the Texans on Sunday, Nick Wagoner of ESPN.com reports. |
| Bryce Huff Status: Doubtful San Francisco 49ers | Huff is expected to miss a couple weeks due to a hamstring injury, Matt Maiocco of NBC Sports Bay Area reports. |
| Jake Brendel Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said Monday that Brendel is expected to be sidelined for a couple of weeks due to a hamstring injury, Matt Maiocco of NBC Sports Bay Area reports. |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
 | Drew Moss Status: Active San Francisco 49ers | NA |
| Jake Brendel Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | Green (toe) is questionable to return to Sunday night's contest against Atlanta, Matt Barrows of The Athletic reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (toe) has been ruled out for the rest of Sunday night's game against the Falcons, Nick Wagoner of ESPN.com reports. |
| Jake Brendel Status: Questionable San Francisco 49ers | Brendel has a hamstring injury and has been ruled out for the rest of Sunday night's matchup with the Falcons, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-10-19 |
 | Malik Turner Status: Active San Francisco 49ers | The 49ers elevated Turner from the practice squad to the active roster Saturday. |
 | Marquez Valdes-Scantling Status: Questionable San Francisco 49ers | questionable |
 | Fred Warner Status: Injured Reserve San Francisco 49ers | The 49ers placed Warner (ankle) on injured reserve Saturday. |
 | Kevin Givens Status: Questionable San Francisco 49ers | The 49ers reinstated Givens (pectoral) from injured reserve Saturday. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) will be out for Sunday's game against the Falcons, but the 49ers are hopeful that the quarterback will return to the lineup for a Week 8 contest in Houston, Tom Pelissero of NFL Network reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (neck) is active for Sunday night's matchup with the Falcons. |
| Upton Stout Status: Out San Francisco 49ers | Stout (ankle) is inactive for Sunday night's clash with the Falcons. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday Night Football against the Falcons. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Sunday night's matchup with the Falcons. |
| Brock Purdy Status: Out San Francisco 49ers | inactive |
| Ricky Pearsall Status: Out San Francisco 49ers | inactive |
| Drew Moss Status: Out San Francisco 49ers | inactive |
| Yetur Gross-Matos Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Active San Francisco 49ers | NA |
| Kevin Givens Status: Active San Francisco 49ers | Givens (pectoral) is active for Sunday night's game against the Falcons. |
| 2025-10-18 |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins does not have an injury designation ahead of Sunday's game against the Falcons, Briana Jeannel of the 49ers' official site reports. |
| Skyy Moore Status: Active San Francisco 49ers | Moore does not have an injury designation ahead of Sunday's game against the Falcons, Briana Jeannael of the 49ers' official site reports. |
| George Kittle Status: Active San Francisco 49ers | The 49ers activated Kittle (hamstring) from injured reserve Saturday, and he has no designation for Sunday's game against the Falcons. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | ir |
| 2025-10-17 |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Mac Jones Status: Active San Francisco 49ers | Coach Kyle Shanahan said Friday that Jones (knee/oblique) will start Sunday's game against the Falcons with Brock Purdy (toe) ruled out, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | San Francisco coach Kyle Shanahan confirmed Friday that the team plans to activate Kittle (hamstring) from injured reserve ahead of Sunday's game against Atlanta, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) has been ruled out for Sunday's game against the Falcons, Matt Barrows of The Athletic reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (ankle/rib/shoulder) doesn't have an injury designation for Sunday's game against the Falcons, Matt Barrows of The Athletic reports. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
 | Dominick Puni Status: Active San Francisco 49ers | NA |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has been ruled out for Sunday's game against Atlanta, Matt Barrows of The Athletic reports. |
| Marquez Valdes-Scantling Status: Injured Reserve San Francisco 49ers | Valdes-Scantling (calf) was placed on injured reserve Friday. |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Friday that the 49ers will likely activate Givens (pectoral) from injured reserve ahead of Sunday's game against the Falcons, Matt Barrows of The Athletic reports. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | Gross-Matos (hamstring) is listed as out for Sunday's game versus Atlanta, Nick Wagoner of ESPN.com reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout injured his ankle during Thursday's practice and is questionable to play against the Falcons on Sunday, Noah Furtado of the San Francisco Chronicle reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) is listed as questionable for Sunday's game versus the Falcons, Nick Wagoner of ESPN.com reports. |
 | Jacob Cowing Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Friday that Cowing (hamstring) is "getting close" to returning from injured reserve, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) isn't practicing Friday, Nick Wagoner of ESPN.com reports. |
| 2025-10-16 |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) was a limited participant in practice for the second day in a row Thursday, Cam Inman of The San Jose Mercury News reports. |
| Skyy Moore Status: Questionable San Francisco 49ers | Moore (ankle) was a limited participant in practice Thursday after missing Wednesday's session, Cam Inman of The San Jose Mercury News reports. |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | Givens (pectoral) was a full participant at practice Thursday, Cam Inman of The San Jose Mercury News reports. |
| Marquez Valdes-Scantling Status: Questionable San Francisco 49ers | Valdes-Scantling missed Thursday's practice due to a calf injury, Cam Inman of The San Jose Mercury News reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) was a non-participant at Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/rib/shoulder) was a limited practice participant Thursday, Cam Inman of The San Jose Mercury News reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee/oblique) practiced in full Thursday, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | Kittle (hamstring) practiced in a limited capacity Thursday, Cam Inman of The San Jose Mercury News reports. |
| CJ West Status: Questionable San Francisco 49ers | questionable |
| Dominick Puni Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| Kalia Davis Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) was a limited participant at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) was a limited participant at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Fred Warner Status: Out San Francisco 49ers | 49ers coach Kyle Shanahan said Tuesday that Warner (ankle) has undergone successful surgery to address the right dislocated and fractured ankle he suffered Week 6, Matt Barrows of The Athletic reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) was a limited practice participant Thursday, Cam Inman of The San Jose Mercury News reports. |
| Marquez Valdes-Scantling Status: Questionable San Francisco 49ers | questionable |
| Kalia Davis Status: Active San Francisco 49ers | NA |
| CJ West Status: Active San Francisco 49ers | NA |
| Mac Jones Status: Active San Francisco 49ers | NA |
| 2025-10-15 |
| Marques Sigle Status: Active San Francisco 49ers | Sigle registered four tackles (all solo) Sunday in a loss to the Buccaneers. |
| Mac Jones Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jones (knee/oblique) will be limited at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Skyy Moore Status: Questionable San Francisco 49ers | San Francisco coach Kyle Shanahan said Wednesday that Moore (ankle) is not practicing, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | Coach Kyle Shanahan said Kittle (hamstring) will be limited at Wednesday's practice, thereby designating the tight end to return from injured reserve, Cam Inman of The San Jose Mercury News reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco coach Kyle Shanahan said Pearsall (knee) will not practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) will be limited at Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Jennings (ribs) will be limited in practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| 2025-10-14 |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
 | Jason Pinnock Status: Active San Francisco 49ers | Pinnock played two snaps on special teams and none on defense in Sunday's 30-19 loss to the Buccaneers. |
| 2025-10-13 |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee/oblique) completed 27 of 39 pass attempts for 347 yards and two interceptions while rushing five times for 13 yards in Sunday's 30-19 loss to the Buccaneers. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro made all four of his field-goal attempts and his lone extra-point try during the 49ers' 30-19 loss to the Buccaneers on Sunday. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges corralled six of seven targets for 57 yards in Sunday's 30-19 loss to Tampa Bay. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne finished with five receptions on nine targets for 142 yards in Sunday's 30-19 loss to the Buccaneers. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson had two receptions on three targets for 44 yards in Sunday's 30-19 loss to the Buccaneers. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune recorded 10 total tackles (five solo) during Sunday's 30-19 loss to the Buccaneers. |
| Skyy Moore Status: Active San Francisco 49ers | Moore logged three snaps (four percent) on offense and did not record a touch while generating 134 return yards on six combined attempts in Sunday's 30-19 loss to Tampa Bay. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson did not record a carry and caught all three of his targets for eight yards in Sunday's 30-19 loss to the Buccaneers. |
| Marquez Valdes-Scantling Status: Active San Francisco 49ers | Valdes-Scantling had two receptions on three targets for 22 yards in Sunday's 30-19 loss to the Buccaneers. |
| Ricky Pearsall Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Pearsall (knee) will be evaluated Wednesday to see if he'll be able to practice this week, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Purdy (toe) will be evaluated Wednesday to see if the quarterback will be able to practice this week, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | Coach Kyle Shanahan said Monday that the 49ers expect Kittle (hamstring) to practice this week, Nick Wagoner of ESPN.com reports. |
| Fred Warner Status: Out San Francisco 49ers | Warner (ankle) will undergo season-ending surgery Tuesday, Nick Wagoner of ESPN.com reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Aiyuk (knee) is getting "closer and closer" to being able to practice, but the 49ers don't have a specific timeline for the wide receiver to do so, Nick Wagoner of ESPN.com reports. |
| Jordan Watkins Status: Out San Francisco 49ers | out |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
 | Nick Martin Status: Active San Francisco 49ers | NA |
| 2025-10-12 |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey took 17 carries for 54 yards and a touchdown while hauling in seven of eight targets for 57 yards in Sunday's 30-19 loss to the Buccaneers. |
| Fred Warner Status: Out San Francisco 49ers | Head coach Kyle Shanahan told reporters after Sunday's 30-19 loss to the Buccaneers that Warner will undergo season-ending surgery on his right ankle, Nick Wagoner of ESPN.com reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings said after Sunday's loss to the Bucs that he played with five broken ribs against Tampa Bay, David Lombardi of SFStandard.com reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (ankle) is active for Sunday's game against the Buccaneers, Briana Jeannel of the 49ers' official site reports. |
| Alfred Collins Status: Active San Francisco 49ers | Collins (knee) will play in the 49ers' matchup versus the Buccaneers on Sunday, Briana Jeannel of the team's official site reports. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha (knee) is active for Sunday's game against the Buccaneers, Briana Jeannel of the 49ers' official site reports. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Buccaneers, Briana Jeannel of the 49ers' official site reports. |
| Kalia Davis Status: Active San Francisco 49ers | Davis (hand) is active for San Francisco's matchup versus Tampa Bay on Sunday, Briana Jeannel of the team's official site reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (ankle/rib) is listed as active Sunday at Tampa Bay, Briana Jeannel of the 49ers' official site reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee/oblique) is active for Sunday's game in Tampa Bay, Briana Jeannel of the 49ers' official site reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) may be able to return to action in Week 7 against Atlanta, Adam Schefter of ESPN reports. |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings, who is questionable to play against Tampa Bay on Sunday due to an ankle injury, is expected to suit up, Adam Schefter of ESPN reports. |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Yetur Gross-Matos Status: Out San Francisco 49ers | inactive |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has "a chance" to play in next Sunday's Week 7 game against the Falcons, Adam Schefter of ESPN reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (oblique/knee), who is officially questionable to suit up Sunday against the Buccaneers, is expected to play and start, Adam Schefter of ESPN reports. |
| Fred Warner Status: Questionable San Francisco 49ers | Warner (ankle) will miss the remainder of San Francisco's matchup versus the Buccaneers on Sunday, Jennifer Lee Chan of NBC Sports reports. |
| 2025-10-11 |
 | Robert Beal Jr. Status: Active San Francisco 49ers | Beal (groin) doesn't carry an injury designation into Sunday's game against Tampa Bay, Greg Auman of Fox Sports reports. |
| Malik Mustapha Status: Questionable San Francisco 49ers | The 49ers activated Mustapha (knee) off injured reserve Saturday. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (calf) has been ruled out for Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | Gross-Matos (hamstring) will not play in Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports. |
| Malik Mustapha Status: Out San Francisco 49ers | Mustapha (knee) is listed as questionable for Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports. |
| Kalia Davis Status: Questionable San Francisco 49ers | Davis (hand) is questionable to face the Buccaneers on Sunday, Greg Auman of Fox Sports reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins (knee) is questionable for Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle) is listed as questionable and may be a game-time decision Sunday at Tampa Bay, ESPN.com's Nick Wagoner reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee) is expected to start Sunday's game at Tampa Bay, ESPN.com's Nick Wagoner reports. |
| 2025-10-10 |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee/oblique) is practicing Friday and doing more throwing than the day before, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/rib) is practicing Friday, Cam Inman of The San Jose Mercury News reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) isn't practicing Friday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) is doing side work Friday but still isn't practicing, Cam Inman of The San Jose Mercury News reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins (knee) was a limited participant at practice Thursday, Vic Tafur of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) did not participate at practice Thursday, Vic Tafur of The Athletic reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/rib) is listed as questionable for Sunday's game at Tampa Bay, Matt Maiocco of NBC Sports Bay Area reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee/oblique) is listed as questionable for Sunday's game at Tampa Bay, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) has been ruled out for Sunday's game at Tampa Bay, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Kalia Davis Status: Questionable San Francisco 49ers | questionable |
| CJ West Status: Active San Francisco 49ers | NA |
| Robert Beal Jr. Status: Active San Francisco 49ers | NA |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | Givens (pectoral) is out for Sunday's game against Tampa Bay, Greg Auman of Fox Sports reports. |
| 2025-10-09 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/rib) returned to practice Thursday, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) didn't practice Thursday but was seen doing some conditioning work while wearing cleats, Cam Inman of The San Jose Mercury News reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee) was in uniform for Thursday's practice but didn't attempt many throws, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) was working on the side with a sleeve on his right leg during Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/rib) practiced in a limited fashion Thursday, Vic Tafur of The Athletic reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee/oblique) officially was limited at Thursday's practice, Vic Tafur of The Athletic reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins (knee) did not practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (ankle) was a limited practice participant Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Malik Mustapha Status: Out San Francisco 49ers | Mustapha (knee) practiced fully Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) did not practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | The 49ers designated Givens (pectoral) to return from injured reserve Wednesday. |
| 2025-10-08 |
| Mac Jones Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jones (knee) will be limited in practice Wednesday, Matt Barrows of The Athletic reports. |
| CJ West Status: Questionable San Francisco 49ers | questionable |
| Mac Jones Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jennings (ankle/ribs) won't participate in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | San Francisco head coach Kyle Shanahan said Wednesday that there's a chance Kittle (hamstring) could return from IR in time to play Week 7 against the Falcons, David Lombardi of SFStandard.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Pearsall (knee) won't take part in practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) won't practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| 2025-10-07 |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
| 2025-10-06 |
| Jordan Watkins Status: Out San Francisco 49ers | out |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Jauan Jennings Status: Out San Francisco 49ers | out |
| Robert Beal Jr. Status: Out San Francisco 49ers | out |
| Nick Martin Status: Active San Francisco 49ers | NA |
| Jordan James Status: Active San Francisco 49ers | NA |
| Malik Mustapha Status: Out San Francisco 49ers | The 49ers opened Mustapha's (knee) 21-day practice window to return from the reserve/PUP list. |
| 2025-10-04 |
| Yetur Gross-Matos Status: Doubtful San Francisco 49ers | Coach Kyle Shanahan said Friday that Gross-Matos will miss some time with a strained hamstring, Nick Wagoner of ESPN.com reports. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir registered six tackles (two solo) and one pass defense during the 49ers' 26-23 overtime win over the Rams. |
| Dee Winters Status: Active San Francisco 49ers | Winters registered four tackles (three solo) during Thursday's 26-23 overtime win over the Rams. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle registered 13 tackles (seven solo) and one pass defense during Thursday's 26-23 overtime win over the Rams. |
| Fred Warner Status: Active San Francisco 49ers | Warner logged 12 tackles (seven solo) during the 49ers' 26-23 overtime win over the Rams on Thursday. |
| 2025-10-03 |
| Kalia Davis Status: Questionable San Francisco 49ers | Davis (hand) is questionable to return to Thursday's game against the Rams, Eric Branch of the San Francisco Chronicle reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Kalia Davis Status: Questionable San Francisco 49ers | Davis (hand) has been ruled out for the rest of Thursday night's game against the Rams, Ian Rapoport of NFL Network reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters is back in the game Thursday night after briefly leaving with a shoulder issue, Matt Maiocco of NBC Sports Bay Area reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos has a hamstring injury and has been ruled out for the rest of Thursday's game against the Rams, Eric Branch of the San Francisco Chronicle reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones completed 33 of 49 passes for 342 yards with two touchdowns and no interceptions while adding four rushes for five yards in the 49ers' 26-23 overtime win over the Rams on Thursday night. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 22 times for 57 yards and brought in eight of nine targets for 82 yards and a touchdown in the 49ers' 26-23 overtime win over the Rams on Thursday night. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro went 4-for-4 on field-goal tries and made both of his extra-point attempts in Thursday's 26-23 overtime win over the Rams. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson brought in three of seven targets for 39 yards in the 49ers' 26-23 overtime win over the Rams on Thursday night. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges secured seven of 11 targets for 41 yards and a touchdown in the 49ers' 26-23 overtime win over the Rams on Thursday night. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne brought in 10 of 11 targets for 142 yards in the 49ers' 26-23 overtime win over the Rams on Thursday night. |
| Brock Purdy Status: Out San Francisco 49ers | Head coach Kyle Shanahan confirmed after Thursday's 26-23 overtime victory over the Rams that Purdy is without a timeline for a return after a recent MRI revealed that he aggravated a turf toe injury in the Week 4 loss to the Jaguars, Ian Rapoport of NFL Network reports. "He's week-to-week," Shanahan said of Purdy. "Don't know how [the toe] will heal." |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed five times for 12 yards and was not targeted as a receiver in Thursday's 26-23 overtime win against the Rams. |
| Kalia Davis Status: Doubtful San Francisco 49ers | Davis (hand) is set to undergo surgery after breaking his hand in Thursday's 26-23 win over the Rams, Ian Rapoport of NFL Network reports. |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Doubtful San Francisco 49ers | doubtful |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Injured Reserve San Francisco 49ers | San Francisco head coach Kyle Shanahan said Friday that Kittle (hamstring) is considered a "long shot" to be available for the team's Week 6 game against the Buccaneers, but the tight end could be more likely to return from injured reserve for a Week 7 matchup with the Falcons on Oct. 19, Adam Schefter of ESPN reports. |
 | Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk had one carry for a loss of one yard and three receptions on four targets for 21 yards in Thursday's 26-23 overtime win over the Rams. |
| Skyy Moore Status: Active San Francisco 49ers | Moore had one carry for one yard without being targeted as a receiver in Thursday's 26-23 win over the Rams. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo ran back one kickoff for 18 yards while receiving no carries or targets in Thursday's 26-23 overtime win over the Rams. |
| Upton Stout Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan relayed Friday that Stout is considered day-to-day due to an ankle sprain that he suffered during the 49ers' 23-20 overtime win over the Rams on Thursday, Nick Wagoner of ESPN.com reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins sprained his knee during the 49ers' 23-20 overtime win over the Rams on Thursday, Nick Wagoner of ESPN.com reports. |
| Malik Mustapha Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Friday that the 49ers will aim to open Mustapha's (knee) 21-day practice window Monday, Matt Barrows of The Athletic reports. |
| 2025-10-02 |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| George Kittle Status: Injured Reserve San Francisco 49ers | Kittle has had no setbacks while on injured reserve due to a hamstring injury and has a chance to return Week 6 at Tampa Bay, Ian Rapoport of NFL Network reports. |
| Robert Beal Jr. Status: Out San Francisco 49ers | Beal (groin) has been ruled out for Thursday night's contest against the Rams, Matt Barrows of The Athletic reports. |
| Malik Turner Status: Active San Francisco 49ers | The 49ers elevated Turner from the practice squad to the active roster ahead of Thursday night's game against the Rams. |
 | Adrian Martinez Status: Active San Francisco 49ers | The 49ers signed Martinez from the practice squad to the active roster ahead of Thursday's game against the Rams. |
| CJ West Status: Active San Francisco 49ers | West (thumb) is active for Thursday's game against the Rams, Briana Jeannel of the 49ers' official site reports. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Thursday night's game against the Rams, Briana Jeannel of the 49ers' official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Brock Purdy Status: Out San Francisco 49ers | inactive |
| Ricky Pearsall Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Jauan Jennings Status: Out San Francisco 49ers | inactive |
| 2025-10-01 |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee) was listed as a full participant at the 49ers' walkthrough Tuesday, Vic Tafur of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) was a non-participant in Tuesday's walk-through practice. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee) will start Thursday at the Rams after Brock Purdy (toe) was ruled out for that contest, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) is ruled out for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Renardo Green Status: Active San Francisco 49ers | NA |
| Dee Winters Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Mykel Williams Status: Active San Francisco 49ers | NA |
| Robert Beal Jr. Status: Out San Francisco 49ers | out |
| Jauan Jennings Status: Out San Francisco 49ers | Jennings (ankle, ribs) is ruled out for Thursday's matchup against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has been ruled out for Thursday's game at the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (neck) doesn't carry an injury designation into Thursday night's game against the Rams, Matt Barrows of The Athletic reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters (knee) doesn't carry an injury designation into Thursday night's game against the Rams, Matt Barrows of The Athletic reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (calf) has been ruled out for Thursday night's game against the Rams, Matt Barrows of The Athletic reports. |
| 2025-09-30 |
| CJ West Status: Questionable San Francisco 49ers | questionable |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Tuesday that he expects Pearsall (knee) to be listed as questionable for Thursday's game against the Rams, The Athletic reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Tuesday that he expects Purdy (toe) to be listed as questionable for Thursday's game against the Rams, The Athletic reports. "We will take every precaution to make sure Brock's all right, Lynch said. "I think he is. Now it's just a matter of, can he turn it around on a short week?" |
| Jauan Jennings Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said that Jennings (ankle/ribs) won't participate in Tuesday's walk-through practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said that Pearsall (knee) won't participate in Tuesday's walk-through practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) will be a non-participant in Tuesday's walk-through practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle logged eight tackles (six solo) and one pass defense during the 49ers' 26-21 loss to the Jaguars on Sunday. |
| 2025-09-29 |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 22 of 38 pass attempts for 309 yards, two touchdowns, two interceptions and one lost fumble while rushing twice for 13 yards in Sunday's 26-21 loss to the Jaguars. |
| CJ West Status: Out San Francisco 49ers | out |
| Jordan Watkins Status: Out San Francisco 49ers | out |
| Nick Martin Status: Active San Francisco 49ers | NA |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (ankle/shoulder) brought in two of four targets for 24 yards in Sunday's 26-21 loss to Jacksonville. |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that the team's initial belief is that Pearsall (knee) is dealing with a "minor PCL" injury, Nick Wagoner of ESPN.com reports. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson caught one of two targets for 20 yards in Sunday's 26-21 loss to Jacksonville. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne was held to one reception on four targets for 17 yards in Sunday's 26-21 loss to the Jaguars. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges had three receptions on five targets for 58 yards and a touchdown in Sunday's 26-21 loss to the Jaguars. |
| Malik Mustapha Status: Out San Francisco 49ers | Head coach Kyle Shanahan told reporters Monday that the 49ers are hopeful Mustapha (knee) can practice following the team's Week 6 matchup against the Buccaneers, David Lombardi of SFStandard.com reports. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo logged 14 snaps on special teams and was not used on offense in Sunday's 26-21 loss to the Jaguars. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed five times for 21 yards and was not targeted as a receiver in Sunday's 26-21 loss to Jacksonville. |
| Skyy Moore Status: Active San Francisco 49ers | Moore failed to bring in his only target on offense while returning four combined kicks for 96 yards in Sunday's 26-21 loss to the Jaguars. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) was listed as a non-participant on Monday's estimated practice report, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/ribs) was listed as a non-participant on Monday's practice estimate, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) was listed as a non-participant on Monday's estimated injury report, Cam Inman of The San Jose Mercury News reports. |
| Renardo Green Status: Out San Francisco 49ers | Green (neck) was listed as a limited participant on Monday's estimated practice report. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters was listed as a limited participant in Monday's estimated practice report due to a knee injury. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee) was listed as full on Monday's practice estimate. |
| Mykel Williams Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
| Fred Warner Status: Active San Francisco 49ers | Warner recorded eight tackles (six solo) with a forced fumble in Sunday's 26-21 loss to the Jaguars. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey took 17 carries for 49 yards while adding six receptions on 11 targets for 92 yards and a touchdown in Sunday's 26-21 loss to Jacksonville. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall said he felt some pain and instability after he fell hard on his knee in Sunday's loss to the Jaguars, David Lombardi of SFStandard.com reports. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro connected on both field-goal attempts and his only extra-point try in Sunday's 26-21 loss to the Jaguars. |
| 2025-09-28 |
| Renardo Green Status: Out San Francisco 49ers | Green (neck) is inactive for Sunday's game against Jacksonville, Briana Jeannel of the 49ers' official site reports. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Jaguars, Briana Jeannel of the 49ers' official site reports. |
| Marquez Valdes-Scantling Status: Out San Francisco 49ers | Valdes-Scantling (coach's decision) is inactive for Sunday's game against the Jaguars. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee) is active for Sunday's contest against the Jaguars, Briana Jeannel of the 49ers' official site reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (knee) is listed as active Sunday against the Jaguars, Briana Jeannel of the 49ers' official site reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (ankle/shoulder) is active for Sunday's game versus the Jaguars, Briana Jeannel of the 49ers' official site reports. |
| CJ West Status: Out San Francisco 49ers | inactive |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
 | Connor Colby Status: Active San Francisco 49ers | NA |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) is expected to suit up for Sunday's game versus the Jaguars, Adam Schefter of ESPN reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) is slated to play Sunday versus the Jaguars, Adam Schefter of ESPN reports. |
| Jake Tonges Status: Questionable San Francisco 49ers | Tonges suffered a shoulder injury during Sunday's contest against the Jaguars, Matt Maiocco of NBC Sports Bay Area reports. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges (shoulder) has returned for Sunday's game against the Jaguars, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall sustained a right knee injury during Sunday's contest against the Jaguars, Eric Branch of the San Francisco Chronicle reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (knee) returned to Sunday's game against the Jaguars, Eric Branch of the San Francisco Chronicle reports. |
| 2025-09-26 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) is in uniform for practice Friday, Matt Barrows of The Athletic reports. |
| Deommodore Lenoir Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee) is listed as questionable for Sunday's contest versus the Jaguars, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) is listed as questionable for Sunday's contest against the Jaguars, Nick Wagoner of ESPN.com reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder/ankle) is listed as questionable for Sunday's game versus the Jaguars, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy (left shoulder/knee) doesn't have a designation for and will start Sunday's game against the Jaguars, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) is questionable to play Sunday against the Jaguars. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (calf) has been ruled out for Sunday's contest against the Jaguars. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (illness) was a full participant at practice Friday. |
 | Nick Bosa Status: Injured Reserve San Francisco 49ers | Bosa (knee) underwent surgery to address his torn ACL on Friday, Cam Inman of The San Jose Mercury News reports. |
| CJ West Status: Out San Francisco 49ers | out |
| CJ West Status: Out San Francisco 49ers | West (thumb) has been ruled out for Sunday's contest against Jacksonville. |
| 2025-09-25 |
| Nick Bosa Status: Injured Reserve San Francisco 49ers | The 49ers placed Bosa (knee) on injured reserve Thursday. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) isn't practicing Thursday, David Lombardi of SFStandard.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) participated in Thursday's practice, David Lombardi of SFStandard.com reports. |
| Kalia Davis Status: Active San Francisco 49ers | NA |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan told KNBR on Thursday that Purdy (left shoulder/knee) is progressing toward a return to action Sunday against the Jaguars, per Ian Rapoport of NFL Network. "I think (the toe) is feeling better each day, and if that continues he should be good on Sunday," Shanahan said. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) was limited at practice Thursday, Nick Wagoner of ESPN.com reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee) practiced in a limited capacity Thursday, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) logged a limited practice Wednesday, Matt Barrows of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) did not practice Wednesday, Matt Barrows of The Athletic reports. |
| Mykel Williams Status: Active San Francisco 49ers | Williams logged a full practice session Wednesday, Matt Barrows of The Athletic reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (left shoulder/toe) was a limited practice participant Thursday, Nick Wagoner of ESPN.com reports. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (illness) logged a limited practice Wednesday, Matt Barrows of The Athletic reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | 49ers GM John Lynch said Thursday that Aiyuk (knee, PUP) is "not close" to returning, David Lombardi of SFStandard.com reports. |
| 2025-09-24 |
| Mac Jones Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jones (knee) will be a limited practice participant Wednesday, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall will miss Wednesday's practice due to a knee injury, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (left shoulder/toe) will be limited at Wednesday's practice, Matt Barrows of The Athletic reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) is not participating in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Mykel Williams Status: Active San Francisco 49ers | NA |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Kalia Davis Status: Questionable San Francisco 49ers | questionable |
| Connor Colby Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Active San Francisco 49ers | Winters logged eight tackles (four solo) and a pass defense during the 49ers' 16-15 win over the Cardinals on Sunday. |
| 2025-09-23 |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| 2025-09-22 |
| Jordan Watkins Status: Out San Francisco 49ers | out |
 | Jordan Jefferson Status: Active San Francisco 49ers | NA |
| Nick Martin Status: Active San Francisco 49ers | NA |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne had four receptions on six targets for 38 yards in Sunday's 16-15 win over Arizona. |
| Fred Warner Status: Active San Francisco 49ers | Warner tallied 11 total tackles (five solo) and two passes defended during Sunday's 16-15 win over the Cardinals. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo did not receive a carry while gaining 19 yards on a kickoff return in Sunday's 16-15 win over the Cardinals. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson had two carries for 22 yards and was not targeted as a receiver in Sunday's 16-15 win over Arizona. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges brought in two of three targets for 21 yards in Sunday's 16-15 win over the Cardinals. |
| Skyy Moore Status: Active San Francisco 49ers | Moore brought in his only target for 10 yards in Sunday's 16-15 win over the Cardinals. |
| Marquez Valdes-Scantling Status: Active San Francisco 49ers | Valdes-Scantling had one reception for nine yards in Sunday's 16-15 win over Arizona. |
| Nick Bosa Status: Doubtful San Francisco 49ers | Bosa (knee) is feared to have suffered a season-ending ACL tear during Sunday's win over the Cardinals, Adam Schefter of ESPN reports. |
| CJ West Status: Questionable San Francisco 49ers | questionable |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson's suspension has been lifted by the NFL, which sets the stage for the wideout to be available for Sunday's game against the Jaguars, Aaron Wilson of KPRC 2 Houston reports. |
| CJ West Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan relayed Monday that West will need to undergo surgery to repair a broken thumb, Eric Branch of the San Francisco Chronicle reports. |
| Mykel Williams Status: Questionable San Francisco 49ers | Williams is considered day-to-day due to a wrist injury, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green is managing a neck injury and is considered day-to-day, Nick Wagoner of ESPN.com reports. |
| Jauan Jennings Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Jennings (shoulder/ankle) is considered "day-to-day," Nick Wagoner of ESPN.com reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Monday that Jones is day-to-day after aggravating a PCL sprain in his left knee during Sunday's 18-16 win against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Out San Francisco 49ers | Coach Kyle Shanahan confirmed Monday that Bosa is out for the season with an ACL injury, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Purdy (left shoulder/toe) will resume practicing Wednesday, at which point the 49ers will evaluate him to see if he'll be ready to return Sunday against the Jaguars, Nick Wagoner of ESPN.com reports. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro hit all three field-goal tries, including a 35-yarder as time expired, and his only extra-point attempt in Sunday's 16-15 win over the Cardinals. |
| Mac Jones Status: Questionable San Francisco 49ers | questionable |
| Mac Jones Status: Questionable San Francisco 49ers | Jones said he aggravated a previous knee injury in Sunday's win over the Cardinals, Ian Rapoport of NFL Network reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall racked up eight receptions on 11 targets for 117 yards in Sunday's 16-15 victory over the Cardinals. |
| 2025-09-21 |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Jordan Jefferson Status: Out San Francisco 49ers | inactive |
| Connor Colby Status: Active San Francisco 49ers | NA |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | Burford (knee) was placed on injured reserve Saturday. |
| Malik Turner Status: Active San Francisco 49ers | The 49ers elevated Turner from the practice squad to the active roster Saturday. |
| Adrian Martinez Status: Active San Francisco 49ers | The 49ers elevated Martinez from the practice squad to the active roster Saturday. |
| Brock Purdy Status: Questionable San Francisco 49ers | The 49ers are optimistic that Purdy (toe/shoulder) -- who is listed as questionable but not expected to play Sunday against the Cardinals -- could be ready to start the team's Week 4 game versus the Jaguars, aIan Rapoport of NFL Network reports. |
| Connor Colby Status: Active San Francisco 49ers | Colby (groin) is active for Sunday's Week 3 clash against the Cardinals, Briana Jeannel of the 49ers' official site reports. |
| Mykel Williams Status: Questionable San Francisco 49ers | Williams is questionable to return to Sunday's game against the Cardinals due to a wrist injury, Matt Barrows of The Athletic reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa is questionable to return to Sunday's game against the Cardinals due to a knee injury, Nick Wagoner of ESPN.com reports. |
| Mykel Williams Status: Active San Francisco 49ers | Williams (wrist) has returned to Sunday's contest against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) has been ruled out for the rest of Sunday's game against the Cardinals, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) did not tear his ACL when he got injured during Sunday's 16-15 win over the Cardinals, Matt Barrows of The Athletic reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 17 times for 52 yards while corralling 10 of 15 targets for 88 yards in Sunday's 16-15 victory over the Cardinals. |
| Kendrick Bourne Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Bourne is "probably" going to be a starting receiver for the team in Sunday's game against the Cardinals with Jauan Jennings (ankle) listed as questionable but set to be inactive for the Week 3 contest, Matt Maiocco of NBC Sports Bay Area reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) is not in line to play Sunday against the Cardinals, according to Adam Schefter of ESPN. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (left shoulder/toe) isn't in line to play Sunday against the Cardinals, Adam Schefter of ESPN reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones will start Sunday's game against the Cardinals after the 49ers ruled out Brock Purdy (left shoulder/toe). |
| Brock Purdy Status: Out San Francisco 49ers | The 49ers downgraded Purdy (toe/shoulder) from questionable to out for Sunday's game against the Cardinals. |
| Jauan Jennings Status: Out San Francisco 49ers | The 49ers downgraded Jennings (ankle/shoulder) from questionable to out for Sunday's game against the Cardinals. |
| 2025-09-20 |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (calf) has been ruled out ahead of Sunday's game against the Jaguars, Matt Barrows of The Athleticreports. |
| Connor Colby Status: Questionable San Francisco 49ers | Colby (groin) is listed as questionable for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk does not have an injury designation ahead of Sunday's matchup against the Cardinals, Tyler Drake of ArizonaSports.com reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos does not have an injury designation ahead of Sunday's game against the Cardinals, Tyler Drake of ArizonaSports.com reports. |
 | Siran Neal Status: Active San Francisco 49ers | Neal does not have an injury designation for Sunday's game against the Cardinals, Tyler Drake of ArizonaSports.com reports. |
| Spencer Burford Status: Out San Francisco 49ers | Burford (knee) has been ruled out ahead of Sunday's game against the Cardinals, Matt Barrows of The Athletic reports. |
| 2025-09-19 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/calf) doesn't appear to be practicing Friday, Matt Barrows of The Athletic reports. |
| Spencer Burford Status: Out San Francisco 49ers | out |
| Mac Jones Status: Active San Francisco 49ers | Jones is on track for another start, with 49ers coach Kyle Shanhan saying Friday that Brock Purdy (toe/shoulder) is "highly unlikely" to start Sunday's game against Arizona, Adam Schefter of ESPN reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) is listed as questionable for Sunday's game against the Cardinals, Matt Barrows of The Athletic reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (shoulder/toe) is listed as questionable for Sunday's game against the Cardinals, even though 49ers coach Kyle Shanahan considers the quarterback "highly unlikely" to play, Adam Schefter of ESPN reports. |
| Connor Colby Status: Questionable San Francisco 49ers | questionable |
 | Trent Williams Status: Active San Francisco 49ers | NA |
| Siran Neal Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| 2025-09-18 |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe/left shoulder) participated in the media-access portion of Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) didn't take part in Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) officially was limited at Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) was a limited participant at the 49ers' practice Thursday, Matt Barrows of The Athletic reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (concussion) was a limited participant at practice Thursday, Matt Barrows of The Athletic reports. |
| 2025-09-17 |
 | Brayden Willis Status: Active San Francisco 49ers | The 49ers signed Willis to the active roster from the practice squad Wednesday. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder/ankle) will be limited at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe/shoulder) will be limited at Wednesday's practice, Eric Branch of the San Francisco Chronicle reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | Aiyuk (knee) did some running while his teammates were practicing Wednesday, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Ben Bartch Status: Injured Reserve San Francisco 49ers | ir |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (left shoulder/toe) officially was a limited practice participant Wednesday, Matt Barrows of The Athletic reports. |
| Ben Bartch Status: Injured Reserve San Francisco 49ers | Bartch (ankle) was placed on injured reserve Wednesday, Noah Furtado of the San Francisco Chronicle reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) officially didn't practice Wednesday, Matt Barrows of The Athletic reports. |
| 2025-09-16 |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ben Bartch Status: Out San Francisco 49ers | Bartch will be sidelined for a few weeks after suffering a high-ankle sprain in Sunday's win over the Saints, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Siran Neal Status: Questionable San Francisco 49ers | Neal has entered the league's concussion protocol following the 49ers' Week 2 win over the Saints, Nick Wagoner of ESPN.com reports. |
| Ben Bartch Status: Doubtful San Francisco 49ers | Bartch suffered a high ankle sprain during the 49ers' win over New Orleans on Sunday, Nick Wagoner of ESPN reports. |
| Spencer Burford Status: Questionable San Francisco 49ers | Burford suffered a knee injury in Sunday's 26-21 win over the Saints, David Lombardi of SFStandard.com reports. |
| 2025-09-15 |
| Nick Bosa Status: Active San Francisco 49ers | Bosa recorded nine total tackles (three solo), including 1.0 sacks, during Sunday's 26-21 win over the Saints. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed six times for 20 yards and caught his only target for a loss of one yard in Sunday's 26-21 win over New Orleans. |
| Marquez Valdes-Scantling Status: Active San Francisco 49ers | Valdes-Scantling failed to bring in his only target in Sunday's 26-21 win over the Saints. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges finished with four receptions on five targets for 31 yards in Sunday's 26-21 win over the Saints. |
 | Luke Farrell Status: Active San Francisco 49ers | Farrell brought in two of three targets for 15 yards and a touchdown in Sunday's 26-21 win over the Saints. |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan noted Monday that Jennings came out of Week 2 action with an ankle injury, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Ben Bartch Status: Doubtful San Francisco 49ers | doubtful |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro went 2-for-3 on extra-point attempts and made both of his field-goal tries during the 49ers' 26-21 win over the Saints on Sunday. |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Jordan Jefferson Status: Active San Francisco 49ers | NA |
| Nick Martin Status: Active San Francisco 49ers | NA |
 | Austen Pleasants Status: Active San Francisco 49ers | NA |
| Drew Moss Status: Active San Francisco 49ers | NA |
| Fred Warner Status: Active San Francisco 49ers | Warner recorded 11 total tackles (seven solo), one pass defended, one forced fumble and one fumble recovery in Sunday's 26-21 win over the Saints. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints. |
| 2025-09-14 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings, who is questionable to play Sunday against New Orleans due to a shoulder injury, is considered a game-time decision, though there is "optimism he goes," Ian Rapoport of NFL Network reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings caught five of 10 targets for 89 yards and a touchdown in Sunday's 26-21 win over New Orleans. |
| Mac Jones Status: Active San Francisco 49ers | Jones completed 26 of 39 passes for 279 yards and three touchdowns in Sunday's 26-21 win over the Saints. He added six rushing yards on six carries. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe/shoulder), who has been ruled out for Sunday's game in New Orleans, is considered unlikely to be available for the 49ers' Week 3 game versus the Cardinals, though his condition his improved over the past week, Adam Schefter of ESPN reports. "We'll see for next week," one source told Schefter, regarding Purdy's status. "Next week will be tight, but he progressed a lot this week." |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey carried the ball 13 times for 55 yards and caught six of seven targets for 52 yards and a touchdown in Sunday's 26-21 win over the Saints. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) remains listed as questionable but is expected to play Sunday in New Orleans, Adam Schefter of ESPN reports. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne caught all three of his targets for 32 yards in Sunday's 26-21 win over the Saints. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall caught four of six targets for 56 yards in Sunday's 26-21 win over the Saints. He also had minus-four yards on his only carry. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Saints, Briana Jeannel of the 49ers' official site reports. |
| Trent Williams Status: Active San Francisco 49ers | Williams (knee) is active for Sunday's matchup with the Saints, Briana Jeannel of the 49ers' official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Sunday's game at New Orleans, Briana Jeannel of the 49ers' official site reports. |
| Austen Pleasants Status: Out San Francisco 49ers | inactive |
| Drew Moss Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Jordan Jefferson Status: Out San Francisco 49ers | inactive |
| Siran Neal Status: Questionable San Francisco 49ers | Neal is being evaluated for a concussion and is questionable to return to Sunday's game against the Saints, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk has been ruled out for the rest of Sunday's game against the Saints due to a concussion, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch has an ankle injury and is questionable to return to Sunday's matchup with the Saints. |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch (ankle) has been downgraded to out for the rest of Sunday's game against the Saints, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-09-13 |
| Jordan James Status: Active San Francisco 49ers | James (finger) doesn't have an injury designation heading into Sunday's Week 2 contest against the Saints, Noah Furtado of the San Francisco Chronicle reports. |
| Brayden Willis Status: Active San Francisco 49ers | Willis was elevated from the 49ers' practice squad to the active roster Saturday. |
| Adrian Martinez Status: Active San Francisco 49ers | Martinez was elevated from the 49ers' practice squad to the active roster Saturday. |
| 2025-09-12 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) returned to practice Friday, Noah Furtado of the San Francisco Chronicle reports. |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has been ruled out for Sunday's game at New Orleans, Matt Maiocco of NBC Sports Bay Area reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) is listed as questionable for Sunday's game at New Orleans, Matt Maiocco of NBC Sports Bay Area reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones will start Sunday's game at New Orleans in place of Brock Purdy (toe), Adam Schefter of ESPN reports. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins (ankle) doesn't have a designation for Sunday's game in New Orleans, Noah Furtado of the San Francisco Chronicle reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) was a limited participant in Thursday's practice, Vic Tafur of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (ankle) was a limited participant in Thursday's practice, Vic Tafur of The Athletic reports. |
| Jordan James Status: Questionable San Francisco 49ers | James (finger) was a limited participant in Thursday's practice, Vic Tafur of The Athletic reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (knee) is questionable for Sunday's Week 2 game against New Orleans, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-09-11 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) was spotted working off to the side with a trainer during Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) officially didn't practice Thursday, Nick Wagoner of ESPN.com reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (ankle) was a limited participant at practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Jordan James Status: Questionable San Francisco 49ers | James (finger) was a limited participant at practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) did not participate at practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Brock Purdy Status: Doubtful San Francisco 49ers | Purdy, who coach Kyle Shanahan has called a "long shot" to play Sunday against the Saints, per Briana Jeannel of the 49ers' official site, could miss two-to-five weeks with a turf toe variant, according to Ian Rapoport of NFL Network. |
| 2025-09-10 |
| Mac Jones Status: Active San Francisco 49ers | San Francisco coach Kyle Shanahan suggested Jones is likely to start Sunday's game at New Orleans in place of Brock Purdy (toe, shoulder), Nick Wagoner of ESPN.com reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) won't take part in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe/left shoulder) won't practice Wednesday, Vic Tafur of The Athletic. Shanahan added that Purdy is "a long shot" to play Sunday at New Orleans, per David Lombardi of SFStandard.com. |
| Ben Bartch Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Luke Farrell Status: Active San Francisco 49ers | Farrell and Jake Tonges are in line for increased snaps, beginning Sunday versus the Saints, with starting tight end George Kittle (hamstring) having been placed on IR and out a minimum of four games, Dianna Russini, Vic Tafur and Matt Barrows of The Athletic report. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges and Luke Farrell are in line for more snaps at tight end, beginning Sunday versus the Saints, with George Kittle (hamstring) on IR and set to miss at least four games, Dianna Russini, Vic Tafur and Matt Barrows of The Athletic report. |
| 2025-09-09 |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Jordan James Status: Questionable San Francisco 49ers | questionable |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro agreed to a one-year contract with the 49ers on Tuesday, Adam Schefter of ESPN reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings appears to have avoided a serious injury to his left shoulder after he underwent an MRI on Monday, Ian Rapoport of NFL Network reports. |
| George Kittle Status: Out San Francisco 49ers | The 49ers are expected to place Kittle (hamstring) on injured reserve within the next few days, Adam Schefter of ESPN reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | The 49ers placed Kittle (hamstring) on injured reserve Tuesday. |
 | Russell Gage Jr. Status: Active San Francisco 49ers | Gage reverted to San Francisco's practice squad Monday, per the NFL's transaction log. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa recorded six solo tackles, including 1.0 sacks, while also adding a forced fumble and a fumble recovery in Sunday's 17-13 win over the Seahawks. |
| 2025-09-08 |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne has agreed to terms Monday on a one-year contract worth up to $5 million with San Francisco, Adam Schefter of ESPN reports. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges hauled in all three of his targets for 15 yards and a touchdown in Sunday's 17-13 win over Seattle. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo played 15 snaps on special teams and did not receive a carry in Sunday's 17-13 win over the Seahawks. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed nine times for 33 yards with one reception for four yards on two targets in Sunday's 17-13 win over Seattle. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk had two receptions on as many targets for 32 yards in Sunday's 17-13 win over Seattle. |
| Luke Farrell Status: Active San Francisco 49ers | Farrell brought in his only target for four yards in Sunday's 17-13 win over the Seahawks. |
| Marquez Valdes-Scantling Status: Active San Francisco 49ers | Valdes-Scantling logged 27 snaps on offense and did not receive a target in Sunday's 17-13 win over the Seahawks. |
| Skyy Moore Status: Active San Francisco 49ers | Moore did not receive a target and returned five combined kicks for 63 yards in Sunday's 17-13 win over Seattle. |
| Jordan Jefferson Status: Active San Francisco 49ers | NA |
| Nick Martin Status: Active San Francisco 49ers | NA |
| Robert Beal Jr. Status: Active San Francisco 49ers | NA |
| Austen Pleasants Status: Active San Francisco 49ers | NA |
| Drew Moss Status: Active San Francisco 49ers | NA |
| Brock Purdy Status: Questionable San Francisco 49ers | The 49ers are expected to give Purdy (toe/shoulder) the entire week ahead of this coming Sunday's game at New Orleans to see if he'll be healthy enough to play, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| George Kittle Status: Out San Francisco 49ers | Kittle likely will miss 3-to-5 weeks due to the hamstring injury he sustained during Sunday's victory at Seattle, Ian Rapoport of NFL Network reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | The 49ers are awaiting the results of imaging done on Jennings' shoulder, Nick Wagoner of ESPN.com reports. |
 | Jake Moody Status: Active San Francisco 49ers | Moody went 1-for-3 on field-goal tries and 2-for-2 on PATs in Sunday's 17-13 win over the Seahawks. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 26 of 35 pass attempts for 277 yards, two touchdowns and two interceptions while taking five carries for 17 yards in Sunday's 17-13 win over the Seahawks. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall brought in four of seven targets for 108 yards in Sunday's 17-13 win over Seattle. |
| Fred Warner Status: Active San Francisco 49ers | Warner tallied eight total tackles (four solo), including one tackle for loss, in Sunday's 17-13 win over the Seahawks. |
 | Colton McKivitz Status: Active San Francisco 49ers | McKivitz signed a three-year, $45 million extension with the 49ers on Monday, Adam Schefter of ESPN reports. |
| 2025-09-07 |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (calf) remains listed as questionable for Sunday's game in Seattle, though he's still "trending" toward playing after he was a "big participant" in the 49ers' team walk-through Saturday, Ian Rapoport of NFL Network reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (calf) remains listed as questionable but is expected to play in Sunday's season opener against the Seahawks, Adam Schefter of ESPN reports. "He's good to go," one source told Schefter. |
| George Kittle Status: Out San Francisco 49ers | Kittle won't return to Sunday's game at Seattle due to a hamstring injury, Adam Schefter of ESPN reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings exited Sunday's game in Seattle due to a left shoulder injury, Adam Schefter of ESPN reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) will have an MRI within the next 24 hours to determine the severity of his injury, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (hamstring) will have an MRI within the next 24 hours to determine the severity of his injury, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (calf) handled 22 carries for 69 yards and nine receptions for 73 yards on 10 targets in Sunday's 17-13 win over the Seahawks. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle will be the 49ers' starting safety against the Seahawks on Sunday, Matt Maiocco of NBC Sports Bay Area reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (ankle) has been ruled out for Sunday's game against the Seahawks. |
| Jordan James Status: Out San Francisco 49ers | James (finger) is inactive for Sunday's game against the Seahawks. |
| Austen Pleasants Status: Out San Francisco 49ers | inactive |
| Drew Moss Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Jordan Jefferson Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (calf) is active for Sunday's game against the Seahawks. |
| 2025-09-06 |
| Russell Gage Jr. Status: Active San Francisco 49ers | The 49ers elevated Gage (knee) from the practice squad to the active roster ahead of Sunday's game at Seattle. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (calf), who is officially listed as questionable for Sunday's road game against the Seahawks, is expected to suit up unless he suffers any setbacks, Ian Rapoport of NFL Network reports. |
| 2025-09-05 |
| Dominick Puni Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Jordan James Status: Doubtful San Francisco 49ers | James (finger) is listed as doubtful for Sunday's contest in Seattle, Matt Maiocco of NBC Sports Bay Area reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Coach Kyle Shanahan said Friday that Jennings (calf) is "good to go" for Sunday's contest at Seattle, Cam Inman of The San Jose Mercury News reports. "He's had a real good week," Shanahan added. "[He's] gotten better and better throughout the week, and I'm excited to see him out there Sunday." |
| Christian McCaffrey Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Friday that McCaffrey (calf) is listed as questionable for Sunday's game in Seattle, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (calf), who is listed as questionable for Sunday's game at Seattle, said Friday that he "feels great" and is preparing to suit up Week 1, David Lombardi of SFStandard.com reports. |
| Jordan Watkins Status: Doubtful San Francisco 49ers | Watkins (ankle) is listed as doubtful for Sunday's game at Seattle, Matt Maiocco of NBC Sports Bay Area reports. |
| Dominick Puni Status: Active San Francisco 49ers | Puni (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athletic reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (calf) practiced on a limited basis Thursday, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athleticreports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) was a limited participant in Thursday's practice. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (ankle) was a limited participant in Thursday's practice. |
| Jordan James Status: Questionable San Francisco 49ers | James (finger) was a limited participant in Thursday's practice. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (calf) is warming up in uniform at the start of Friday's practice, Nick Wagoner of ESPN.com reports. |
| 2025-09-04 |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey was limited at Thursday's practice due to a calf injury, Cam Inman of The San Jose Mercury News reports. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu (shoulder) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) did not participate in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| CJ West Status: Active San Francisco 49ers | West (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (calf) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Mykel Williams Status: Active San Francisco 49ers | Williams (knee) practiced in full Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Jason Pinnock Status: Active San Francisco 49ers | Pinnock (heel) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (hip) was not listed on the 49er's injury report Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (neck) was not listed on Wednesday's injury report, Cam Inman of The San Jose Mercury News reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | The 49ers and Jennings (calf) agreed to add $3 million in play-time incentives to his contract for the 2025 season, Adam Schefter of ESPN reports. |
| Dominick Puni Status: Questionable San Francisco 49ers | Puni (knee) was a limited participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Ben Bartch Status: Active San Francisco 49ers | Bartch (elbow) was a full participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| 2025-09-03 |
 | Tanner Mordecai Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Deommodore Lenoir Status: Active San Francisco 49ers | NA |
| Nick Bosa Status: Active San Francisco 49ers | NA |
| CJ West Status: Active San Francisco 49ers | NA |
| Jason Pinnock Status: Active San Francisco 49ers | NA |
| Mykel Williams Status: Active San Francisco 49ers | NA |
| Upton Stout Status: Active San Francisco 49ers | NA |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| Mac Jones Status: Active San Francisco 49ers | NA |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (ankle) was a non-participant at Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jennings (calf) will be a limited participant at Wednesday's practice, Nick Wagoner of ESPN.com reports. |
| 2025-09-02 |
| Marquez Valdes-Scantling Status: Active San Francisco 49ers | The 49ers signed Valdes-Scantling to the active roster from the practice squad Tuesday, Aaron Wilson of KPRC 2 Houston reports. |
 | Evan Anderson Status: Active San Francisco 49ers | The 49ers signed Anderson to their practice squad on Friday. |
| 2025-09-01 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (calf) is participating in practice Monday, Nick Wagoner of ESPN.com reports. |
 | Isaiah Prince Status: Questionable San Francisco 49ers | questionable |
| 2025-08-28 |
| Russell Gage Jr. Status: Questionable San Francisco 49ers | Gage (knee) is re-signing with the 49ers on Thursday, Adam Schefter of ESPN reports. |
| Russell Gage Jr. Status: Questionable San Francisco 49ers | Gage (knee) didn't practice Thursday, Matt Barrows of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (ankle) didn't practice Thursday, Matt Barrows of The Athletic reports. |
| Tanner Mordecai Status: Injured Reserve San Francisco 49ers | Modecai (undisclosed) cleared waivers and reverted to injured reserve Wednesday. |
 | Carter Bradley Status: Injured Reserve San Francisco 49ers | Bradley (undisclosed) cleared waivers and reverted to injured reserve Wednesday. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (calf) returned to practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
 | Jakob Robinson Status: Injured Reserve San Francisco 49ers | Robinson (forearm) was placed on injured reserve Tuesday. |
| 2025-08-27 |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | ir |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | The 49ers placed Cowing (hamstring) on injured reserve Wednesday. |
| Jauan Jennings Status: Questionable San Francisco 49ers | The 49ers are unsure if Jennings (calf/contract) will play Week 1 at Seattle, but GM John Lynch said Wednesday that he won't trade the wide receiver, ESPN.com's Nick Wagoner reports. |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | Givens (pectoral) was placed on injured reserve Tuesday. |
| Jordan James Status: Questionable San Francisco 49ers | James (finger) returned to practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (undisclosed) was activated from the active/PUP list Tuesday. |
| Tanner Mordecai Status: Injured Reserve San Francisco 49ers | ir |
| Malik Mustapha Status: Out San Francisco 49ers | Mustapha (knee) was placed on the reserve/PUP list Tuesday. |
| Carter Bradley Status: Injured Reserve San Francisco 49ers | ir |
 | Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) was placed on the reserve/non-football injury list Tuesday. |
| 2025-08-26 |
| Brandon Aiyuk Status: Out San Francisco 49ers | The 49ers moved Aiyuk (knee) to the reserve/PUP list Tuesday. |
| Jakob Robinson Status: Injured Reserve San Francisco 49ers | ir |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | ir |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Isaiah Prince Status: Injured Reserve San Francisco 49ers | San Francisco placed Prince (knee) on its injured reserve list Monday. |
| 2025-08-25 |
| Isaiah Prince Status: Injured Reserve San Francisco 49ers | ir |
 | Stone Blanton Status: Active San Francisco 49ers | NA |
| 2025-08-24 |
 | Robbie Chosen Status: Active San Francisco 49ers | Chosen brought in all three of his targets for 24 receiving yards in Saturday's 30-23 preseason win over the Chargers. |
| George Kittle Status: Active San Francisco 49ers | Kittle isn't involved in warmups ahead of Saturday's preseason game against the Chargers, Matt Barrows of The Athletic reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey isn't warming up ahead of Saturday's preseason contest versus the Chargers, Matt Barrows of The Athletic reports. |
| Jacob Cowing Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Cowing (hamstring) could be sidelined for six weeks, Matt Maiocco of NBC Sports Bay Area reports. |
| Jakob Robinson Status: Questionable San Francisco 49ers | questionable |
| Isaiah Prince Status: Questionable San Francisco 49ers | Prince exited Saturday's preseason game against the Chargers with an apparent left knee injury and will not return, Matt Barrows of The Athletic reports. |
| Jakob Robinson Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Robinson is believed to have suffered a broken forearm in Saturday's preseason game against the Chargers, Matt Maiocco of NBC Sports Bay Area reports. |
| Skyy Moore Status: Active San Francisco 49ers | Moore recorded three receptions on six targets for 19 yards in Saturday's 30-23 preseason win over the Chargers. |
| Demarcus Robinson Status: Suspension San Francisco 49ers | Robinson recorded two receptions on two targets for 30 yards and a touchdown in Saturday's 30-23 preseason win over the Chargers. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo (shoulder) rushed the ball eight times for 13 yards in Saturday's 30-23 preseason win over the Chargers. He added one reception on one target for one yard. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan relayed after Saturday's preseason contest against the Chargers that Jennings (calf) has a chance to be available for a Week 1 road matchup with the Seahawks, Matt Barrows of The Athletic reports. "I expect him to be back, he should be back from it," Shanahan said. "But you never know with a calf." |
| 2025-08-22 |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo may open the season as San Francisco's No. 2 running back even though the team is trading for Brian Robinson, Cam Inman of The San Jose Mercury News reports. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | The Commanders are trading Robinson to the 49ers, Tom Pelissero of NFL Network reports. |
 | Tre Brown Status: Injured Reserve San Francisco 49ers | Brown (heel) was placed on injured reserve Thursday. |
 | Corey Kiner Status: Injured Reserve San Francisco 49ers | Kiner (ankle) reverted to injured reserve with the 49ers on Thursday, Nick Wagoner of ESPN.com reports. |
| 2025-08-21 |
| Russell Gage Jr. Status: Questionable San Francisco 49ers | Gage (knee) is expected to miss 7-to-10 days due to a sprained MCL, Adam Schefter of ESPN reports. |
| Skyy Moore Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said Thursday that Moore is expected to suit up for Saturday's preseason finale against the Chargers, David Lombardi of SFStandard.com reports. |
| Robert Beal Jr. Status: Active San Francisco 49ers | NA |
| Robert Beal Jr. Status: Active San Francisco 49ers | Beal (groin) returned to practice Thursday, Nick Wagoner of ESPN.com reports. |
| Corey Kiner Status: Injured Reserve San Francisco 49ers | ir |
| Tre Brown Status: Injured Reserve San Francisco 49ers | ir |
| Tanner Mordecai Status: Active San Francisco 49ers | Mordecai signed with the 49ers on Thursday. |
 | Malik Knowles Status: Active San Francisco 49ers | The 49ers signed Knowles on Wednesday. |
| Skyy Moore Status: Active San Francisco 49ers | Moore was traded from the Chiefs to the 49ers on Wednesday for a swap of late-round picks, NFL reporter Jordan Schultz reports. |
| Russell Gage Jr. Status: Questionable San Francisco 49ers | questionable |
| 2025-08-20 |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing isn't practicing Wednesday after suffering a lower-body injury Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Demarcus Robinson Status: Suspension San Francisco 49ers | San Francisco head coach Kyle Shanahan said Wednesday that Robinson has been suspended the first three games of the regular season for violating the NFL's substance abuse policy, Adam Schefter of ESPN reports. |
 | Patrick Taylor Jr. Status: Injured Reserve San Francisco 49ers | Taylor will undergo season-ending surgery to repair a fracture in his shoulder, Nick Wagoner of ESPN.com reports. |
| 2025-08-19 |
| Patrick Taylor Jr. Status: Injured Reserve San Francisco 49ers | ir |
| Mac Jones Status: Questionable San Francisco 49ers | Jones is not practicing Tuesday due to an apparent knee injury suffered during Saturday's 22-19 preseason win over the Raiders, Matt Maiocco of NBC Sports Bay Area reports. |
 | Equanimeous St. Brown Status: Questionable San Francisco 49ers | questionable |
 | Ameer Abdullah Status: Questionable San Francisco 49ers | questionable |
| Corey Kiner Status: Doubtful San Francisco 49ers | doubtful |
| Mac Jones Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Tuesday that Jones will miss Saturday's preseason finale against the Chargers due to a knee sprain, Adam Schefter of ESPN reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Tuesday that the 49ers aren't worried about Stout's (calf) availability for Week 1 against the Seahawks on Sept. 7, David Lombardi of SFStandard.com reports. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo (shoulder) participated in Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| Patrick Taylor Jr. Status: Injured Reserve San Francisco 49ers | The 49ers placed Taylor (shoulder) on injured reserve Tuesday, Adam Schefter of ESPN reports. |
 | Nate Sudfeld Status: Active San Francisco 49ers | The 49ers signed Sudfeld on Tuesday, Adam Schefter of ESPN reports. |
| Corey Kiner Status: Questionable San Francisco 49ers | questionable |
| Stone Blanton Status: Questionable San Francisco 49ers | questionable |
| Jordan Elliott Status: Active San Francisco 49ers | NA |
| Renardo Green Status: Active San Francisco 49ers | NA |
| Sam Okuayinonu Status: Active San Francisco 49ers | NA |
| Jordan Elliott Status: Active San Francisco 49ers | Elliott (back) participated during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu (groin) participated during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (neck) was limited to individual drills during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| Jason Pinnock Status: Questionable San Francisco 49ers | Pinnock (heel) was limited to individual drills during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (hamstring) participated during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| 2025-08-18 |
 | Bradlee Anae Status: Questionable San Francisco 49ers | questionable |
| 2025-08-17 |
 | Chazz Surratt Status: Active San Francisco 49ers | NA |
| Kyle Juszczyk Status: Active San Francisco 49ers | NA |
| Marques Sigle Status: Active San Francisco 49ers | NA |
 | Ji'Ayir Brown Status: Active San Francisco 49ers | NA |
| Evan Anderson Status: Active San Francisco 49ers | NA |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune (ankle) logged two tackles (one solo) during Saturday's 22-19 preseason win over the Raiders. |
| Evan Anderson Status: Active San Francisco 49ers | Anderson (knee) played 27 snaps (25 on offense, two on special teams) but did not otherwise appear in the box score in the 49ers' 22-19 preseason win over the Raiders on Saturday. |
| Chazz Surratt Status: Active San Francisco 49ers | Surratt (undisclosed) tallied six tackles (six solo) during San Francisco's preseason win over the Raiders on Saturday. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle (knee) logged three tackles (three solo) in San Francisco's preseason win over the Raiders on Saturday. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (Achilles) played six snaps on offense without otherwise showing up on the box score during the 49ers' 22-19 preseason win over the Raiders on Saturday. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (ankle) logged four tackles (three solo) during the 49ers' 22-19 preseason win over the Raiders on Saturday. |
| Dominick Puni Status: Questionable San Francisco 49ers | Puni suffered a possible PCL injury in Saturday's preseason game against the Raiders and is expected to miss a few weeks, Eric Branch of the San Francisco Chronicle reports. |
| Jake Moody Status: Active San Francisco 49ers | Moody went 5-for-6 on field-goal attempts and 1-for-1 in extra-point tries during a 22-19 preseason win against the Raiders on Saturday. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall caught three of four targets for 42 yards in a 22-19 exhibition win against Las Vegas on Saturday. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed five of seven pass attempts for 66 yards with no touchdowns or interceptions in a 22-19 exhibition win over the Raiders on Saturday. |
| 2025-08-16 |
| George Kittle Status: Active San Francisco 49ers | Kittle will suit up alongside Brock Purdy and the majority of the 49ers' starters during Saturday's preseason game against the Raiders, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey will not join Brock Purdy and the majority of San Francisco's starters in suiting up for Saturday's preseason game against the Raiders, David Lombardi of SFStandard.com reports. |
| CJ West Status: Questionable San Francisco 49ers | West (knee) has been ruled out for Saturday's preseason game against the Raiders, Eric Branch of the San Francisco Chronicle reports. |
| Mykel Williams Status: Questionable San Francisco 49ers | Williams (knee) has been ruled out for Saturday's preseason game against Las Vegas, Eric Branch of the San Francisco Chronicle reports. |
 | Richie Grant Status: Questionable San Francisco 49ers | Grant (knee) will not play in Saturday's preseason game against the Raiders, Cam Inman of The San Jose Mercury News reports. |
| Jason Pinnock Status: Questionable San Francisco 49ers | Pinnock (heel) will not play against Las Vegas on Saturday, Cam Inman of The San Jose Mercury News reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (calf) will not play in Saturday's preseason game against the Raiders on Saturday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy is scheduled to play a series or two during Saturday's preseason matchup against the Raiders, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Dominick Puni Status: Questionable San Francisco 49ers | Puni has been ruled out for the rest of Saturday's preseason game against the Raiders due to a knee injury, Cam Inman of The San Jose Mercury News reports. |
| Corey Kiner Status: Questionable San Francisco 49ers | Kiner was carted off the field during the second quarter of Saturday's preseason game against the Raiders due to a left leg injury, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Patrick Taylor Jr. Status: Questionable San Francisco 49ers | Taylor is questionable to return to Saturday's preseason game against the Raiders due to a shoulder injury, Cam Inman of The San Jose Mercury News reports. |
| Patrick Taylor Jr. Status: Questionable San Francisco 49ers | Taylor (shoulder) has been ruled out for the rest of Saturday's preseason game against the Raiders, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Patrick Taylor Jr. Status: Questionable San Francisco 49ers | Taylor suffered a dislocated shoulder in Saturday's preseason game against the Raiders, Nick Wagoner of ESPN.com reports. |
| Corey Kiner Status: Questionable San Francisco 49ers | Kiner suffered a left high-ankle sprain in Saturday's preseason game versus Las Vegas, Eric Branch of the San Francisco Chronicle reports. |
| 2025-08-14 |
| Tre Brown Status: Questionable San Francisco 49ers | questionable |
| Jason Pinnock Status: Questionable San Francisco 49ers | questionable |
| Nick Bosa Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said Thursday that Bosa is dealing with neck soreness and could be back at practice next week, Nick Wagoner of ESPN.com reports. |
 | Andre Dillard Status: Injured Reserve San Francisco 49ers | Dillard (ankle) was placed on injured reserve Thursday. |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch (elbow) won't be available for Saturday's preseason game against Las Vegas, Nick Wagoner of ESPN.com reports. |
 | Demone Harris Status: Active San Francisco 49ers | Harris (head) signed with the 49ers on Thursday. |
| Tre Brown Status: Questionable San Francisco 49ers | Brown is dealing with a heel injury that puts him in jeopardy of missing Saturday's preseason game against the Raiders, Nick Wagoner of ESPN.com reports. |
| Jason Pinnock Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan told reporters Thursday that Pinnock is working through a heel injury, Nick Wagoner of ESPN.com reports. |
| Bradlee Anae Status: Injured Reserve San Francisco 49ers | Anae (undisclosed) was placed on injured reserve by the 49ers on Wednesday. |
| Andre Dillard Status: Injured Reserve San Francisco 49ers | ir |
| Demone Harris Status: Active San Francisco 49ers | NA |
| CJ West Status: Questionable San Francisco 49ers | questionable |
| CJ West Status: Questionable San Francisco 49ers | West has a hyperextended knee, David Lombardi of the San Francisco Standard reports. |
| Brock Purdy Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said Thursday that Purdy and "some" starters will suit up for Saturday's preseason game against the Raiders, Vic Tafur of The Athletic reports. |
| 2025-08-13 |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch suffered an undisclosed injury during San Francisco's practice Tuesday, Nick Wagoner of ESPN.com reports. |
| Bradlee Anae Status: Injured Reserve San Francisco 49ers | ir |
| Malik Turner Status: Active San Francisco 49ers | The 49ers signed Turner to a contract Wednesday. |
| 2025-08-12 |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (calf) did not participate at Monday's training camp practice, David Lombardi of SFStandard.com reports. |
| Andre Dillard Status: Active San Francisco 49ers | The 49ers activated Dillard (undisclosed) off the active/PUP list Monday. |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing (hamstring) returned to a limited practice Tuesday, Nick Wagoner of ESPN.com reports. |
| Ben Bartch Status: Questionable San Francisco 49ers | questionable |
| 2025-08-11 |
| Andre Dillard Status: Active San Francisco 49ers | NA |
| Ameer Abdullah Status: Injured Reserve San Francisco 49ers | ir |
| Jordan Watkins Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that Watkins is nursing a high-ankle sprain and will be out roughly one month, Vic Tafur of The Athletic reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that Week 6 could be a realistic target for Aiyuk (ACL) to take the field, Vic Tafur of The Athletic reports. |
| Ameer Abdullah Status: Injured Reserve San Francisco 49ers | The 49ers placed Abdullah (ribs) on the injured reserve list Monday. |
 | Fabian Moreau Status: Questionable San Francisco 49ers | Moreau (undisclosed) did not play in Saturday's 30-9 loss to Denver, Matt Barrows of The Athletic reports. |
| Chazz Surratt Status: Questionable San Francisco 49ers | Surratt (undisclosed) did not play in Saturday's 30-9 loss to the Broncos, Matt Barrows of The Athletic reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune suffered an ankle injury in Saturday's 30-9 loss to the Broncos, Matt Barrows of The Athletic reports. |
| 2025-08-10 |
| Chazz Surratt Status: Questionable San Francisco 49ers | questionable |
| Fabian Moreau Status: Questionable San Francisco 49ers | questionable |
| Jordan Elliott Status: Questionable San Francisco 49ers | questionable |
 | Jeff Wilson Jr. Status: Active San Francisco 49ers | The 49ers signed Wilson to a contract Sunday, Adam Schefter of ESPN reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle isn't warming up ahead of Saturday's preseason game against the Broncos and isn't slated to play, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy didn't warm up and isn't likely to play in Saturday's preseason game against Denver, Nick Wagoner of ESPN.com reports. |
| Jordan Elliott Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Sunday that Elliott (back) is dealing with injury, Matt Barrows of The Athletic reports. |
| Jake Moody Status: Active San Francisco 49ers | Moody did not attempt a field goal while converting his lone extra-point attempt in Saturday's 30-9 preseason loss to Denver. |
| Mac Jones Status: Active San Francisco 49ers | Jones completed four of seven pass attempts for 74 yards and an interception while rushing once for two yards in Saturday's 30-9 preseason loss the Broncos. |
| Ameer Abdullah Status: Questionable San Francisco 49ers | questionable |
| Marques Sigle Status: Questionable San Francisco 49ers | questionable |
| Richie Grant Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Saturday that Grant (knee) did not suit up for the team's 30-9 preseason loss to Denver due to an injury and is expected to miss roughly one week, Nick Wagoner of ESPN.com reports. |
| Upton Stout Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Stout (calf) did not suit up for Saturday's 30-9 preseason loss to the Broncos due to calf tightness, Rich Cimini of ESPN.com reports. |
| Ameer Abdullah Status: Questionable San Francisco 49ers | Abdullah was forced out of Saturday's 30-9 preseason loss to the Broncos due to a ribs injury. |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Saturday that Beal (groin) suffered an injury late during the team's 30-9 preseason loss to Denver, David Lombardi of SFStandard.com reports. |
| Marques Sigle Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Saturday that Sigle (knee) will still undergo testing but that initial indications are that he's avoided a serious knee injury, Nick Wagoner of ESPN.com reports. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson brought in all two targets for 20 yards in the 49ers' 30-9 preseason loss to the Broncos on Saturday night. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins brought in three of six targets for 56 yards in the 49ers' 30-9 preseason loss to the Broncos on Saturday night. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor rushed five times for seven yards and a touchdown and secured his only target for four yards in the 49ers' 30-9 preseason loss to the Broncos on Saturday night. |
| 2025-08-09 |
 | Ke'Shawn Vaughn Status: Active San Francisco 49ers | The 49ers signed Vaughn to a contract Saturday. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. |
| 2025-08-08 |
| Equanimeous St. Brown Status: Injured Reserve San Francisco 49ers | The 49ers placed St. Brown on injured reserve Friday due to a foot injury, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy is a candidate to sit out Saturday's preseason opener against the Broncos, Cam Inman of The San Jose Mercury News reports. |
| Tanner Mordecai Status: Active San Francisco 49ers | The 49ers signed Mordecai to a contract Friday, Cam Inman of The San Jose Mercury News reports. |
| 2025-08-07 |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco GM John Lynch said Thursday he "doesn't think" Aiyuk (ACL), who remains on the active/PUP list, will be cleared to play Week 1, Cam Inman of The San Jose Mercury News reports. |
| Mykel Williams Status: Questionable San Francisco 49ers | Williams is unlikely to suit up for Saturday's preseason game against Denver after exiting Thursday's practice due to a knee injury, Matt Barrows of The Athletic reports. |
| Jordan James Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Thursday that James will miss a couple weeks due to a broken finger, Cam Inman of The San Jose Mercury News reports. |
| 2025-08-06 |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall has impressed in recent practices and was a clear standout on offense Tuesday, with quarterback Brock Purdy on five targets, Nick Wagoner of ESPN reports. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor should get an extended look this preseason after primary backup Isaac Guerendo (shoulder) suffered a multi-week injury in training camp. |
| 2025-08-05 |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (groin) sat out of practice Monday, Eric Branch of The San Francisco Chronicle reports. |
| Evan Anderson Status: Questionable San Francisco 49ers | questionable |
 | Andy Isabella Status: Questionable San Francisco 49ers | Isabella had to leave practice Monday with an undisclosed injury, Nick Wagoner of ESPN.com reports. |
| Evan Anderson Status: Questionable San Francisco 49ers | Anderson (knee) did not practice Monday, Nick Wagoner of ESPN.com reports. |
| Equanimeous St. Brown Status: Active San Francisco 49ers | The 49ers signed St. Brown on Tuesday, Matt Barrows of The Athletic reports. |
| 2025-08-04 |
| Ben Bartch Status: Active San Francisco 49ers | Offensive line coach Chris Foerster declared Sunday that the starting left guard spot is "Bartch's job to lose," Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Jordan James Status: Active San Francisco 49ers | James (knee) returned to practice Monday, Matt Barrows of The Athletic reports. |
| Jake Moody Status: Active San Francisco 49ers | Moody is the only kicker on San Francisco's roster after the team released Greg Joseph on Monday, Matt Maiocco of NBC Sports Bay Area reports. |
 | Mason Pline Status: Active San Francisco 49ers | Pline was waived by the 49ers on Monday, Matt Barrows of The Athletic reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | 49ers coach Kyle Shanahan said Monday that Guerendo (shoulder) is expected to miss a couple weeks, Matt Maiocco of NBC Sports Bay Area reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (calf) isn't practicing Monday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Andy Isabella Status: Questionable San Francisco 49ers | questionable |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | questionable |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | questionable |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) did not participate in practice Monday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (Achilles) did not participate in practice Monday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Kevin Givens Status: Questionable San Francisco 49ers | Givens is expected to miss the start of the 2025 regular season due to a pectoral injury, David Lombardi of SFStandard.com reports. |
| 2025-08-03 |
| Robbie Chosen Status: Active San Francisco 49ers | Chosen and the 49ers agreed on a one-year contract Sunday. |
| 2025-08-02 |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (undisclosed) is expected to return to practice Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| Jordan Watkins Status: Active San Francisco 49ers | NA |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo had an early departure from practice Saturday due to an apparent shoulder injury, Jennifer Lee Chan of NBC Sports Bay Area reports. |
 | Curtis Robinson Status: Active San Francisco 49ers | The 49ers activated Robinson (undisclosed) off the active/PUP list Saturday, Vic Tafur of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| 2025-08-01 |
| Ben Bartch Status: Active San Francisco 49ers | Bartch (quadriceps) was activated from the active/non-football injury list by the 49ers on Thursday. |
| Curtis Robinson Status: Active San Francisco 49ers | NA |
| Jordan James Status: Questionable San Francisco 49ers | questionable |
| 2025-07-31 |
 | Darrell Luter Jr. Status: Active San Francisco 49ers | Luter (pelvis) was cleared to start practicing Wednesday, Grant Cohn of Sports Illustrated reports. |
| Robert Beal Jr. Status: Active San Francisco 49ers | Beal (ankle) was a full participant in practice Tuesday, Grant Cohn reports. |
| Colton McKivitz Status: Active San Francisco 49ers | McKivitz (undisclosed) is fully healthy and participated in training camp Wednesday, Mike Maynard reports. |
| Jordan James Status: Active San Francisco 49ers | 49ers coach Kyle Shanahan said Thursday that James (knee) is not practicing due to "knee issues," Eric Branch of the San Francisco Chronicle reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | 49ers coach Kyle Shanahan said Thursday that Jennings (calf) is dealing with a reaggravation of the injury he dealt with during spring activities, Clayton Holloway of NFL Network reports. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (shoulder) was spotted taking reps during this week's training camp practice sessions, Matt Barrows of The Athletic reports. |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir is expected to miss the next few practices with a hip injury, David Lombardi of SFStandard.com reports. |
| Andy Isabella Status: Active San Francisco 49ers | The 49ers signed Isabella to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
 | Marquez Callaway Status: Active San Francisco 49ers | The 49ers signed Callaway to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Carter Bradley Status: Active San Francisco 49ers | The 49ers signed Bradley to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Ameer Abdullah Status: Active San Francisco 49ers | The 49ers signed Abdullah to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Alfred Collins Status: Active San Francisco 49ers | Collins (calf) has fully participated in practices during the 49ers' first week of training camp, Mike Maynard of The Sporting News reports. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (ankle) has participated in practices during the 49ers' first week of training camp, Jerry McDonald of The Mercury News reports. |
| 2025-07-30 |
| Russell Gage Status: Active San Francisco 49ers | Gage put his improved health on display when he made an athletic grab during Tuesday's padded practice session, Matt Barrows of The Athletic reports. |
| Jordan James Status: Active San Francisco 49ers | James made a strong first impression on the 49ers' coaching staff during team practices this training camp, according to Matt Barrows of The Athletic. |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco offensive coordinator Klay Kubiak said Tuesday that Aiyuk (knee), who remains on the active/PUP, has been "kind of a coach on the side" throughout the early stages of training camp, Nick Wagoner of ESPN reports. |
| Colton McKivitz Status: Active San Francisco 49ers | NA |
| Darrell Luter Jr. Status: Active San Francisco 49ers | NA |
| Ji'Ayir Brown Status: Active San Francisco 49ers | NA |
| Alfred Collins Status: Active San Francisco 49ers | NA |
| Robert Beal Jr. Status: Active San Francisco 49ers | NA |
| 2025-07-29 |
| Mykel Williams Status: Questionable San Francisco 49ers | questionable |
| Mykel Williams Status: Questionable San Francisco 49ers | Williams (ankle) did not participate in Tuesday's practice, Nick Wagoner of ESPN.com reports. |
 | Tarron Jackson Status: Injured Reserve San Francisco 49ers | The 49ers placed Jackson (undisclosed) on injured reserve Tuesday. |
| Tarron Jackson Status: Questionable San Francisco 49ers | Jackson (undisclosed) was discharged from the hospital and returned to the 49ers on Monday, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-07-28 |
| Dee Winters Status: Active San Francisco 49ers | Winters drew praise from a star teammate at the start of training camp as the linebacker prepares to compete for a starting role in 2025, Vic Tafur of The Athletic reports. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins is in the mix to be third or fourth on San Francisco's WR depth chart to start the season, according to Matt Barrows of The Athletic. |
 | Eli Apple Status: Active San Francisco 49ers | Apple and the 49ers agreed on a one-year contract Sunday, Adam Schefter of ESPN reports. |
| 2025-07-27 |
| Ricky Pearsall Status: Active San Francisco 49ers | The 49ers activated Pearsall (hamstring) from the active/PUP list Sunday. |
| Tarron Jackson Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings left practice Sunday due to a calf injury, Nick Wagoner of ESPN.com reports. |
| Jacob Cowing Status: Questionable San Francisco 49ers | San Francisco coach Kyle Shanahan said Sunday that he's hopeful Cowing (hamstring) will be back by the week of Aug. 11 for joint practices with the Raiders, David Lombardi of SFStandard.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (hamstring) is expected to be sidelined for the next several weeks, David Lombardi of SFStandard.com reports. |
| Tarron Jackson Status: Questionable San Francisco 49ers | Jackson (undisclosed) was taken to the hospital after suffering an injury during San Francisco's practice Sunday, Eric Branch of the San Francisco Chronicle reports. |
| 2025-07-26 |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | Green left Friday's practice due to a hamstring injury, Eric Branch of the San Francisco Chronicle reports. |
| 2025-07-25 |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (hamstring) is considered healthy and just needs to build endurance before getting clearance for training camp, Ralph Vacchiano of Fox Sports reports. |
| 2025-07-24 |
 | Quintez Cephus Status: Active San Francisco 49ers | The 49ers signed Cephus to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2025-07-23 |
| Ben Bartch Status: Out San Francisco 49ers | Bartch is dealing with a quadriceps injury, Eric Branch of the San Francisco Chronicle reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings participated in individual drills at the start of Wednesday's practice, David Lombardi of SFStandard.com reports. |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing pulled his hamstring Wednesday, Nick Wagoner of ESPN.com reports. |
| Jake Moody Status: Active San Francisco 49ers | Moody is competing with Greg Joseph for San Francisco's placekicker job, David Lombardi of SFStandard.com reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (hamstring) trained on a side field Wednesday and is expected to practice Sunday, Matt Barrows of The Athletic reports. |
| 2025-07-22 |
| Jauan Jennings Status: Active San Francisco 49ers | GM John Lynch said Tuesday that Jennings (calf) reported to 49ers training camp and passed a physical Monday, Eric Branch of the San Francisco Chronicle reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (hamstring) is expected to be cleared early in training camp after the 49ers placed him on the active/PUP list last Friday, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | Coach Kyle Shanahan said Tuesday that McCaffrey is "here and healthy" for the start of 49ers training camp, but the running back's workload will be managed in advance of the regular season, Nick Wagoner of ESPN.com reports. |
| Equanimeous St. Brown Status: Active San Francisco 49ers | The 49ers signed St. Brown on Tuesday, Eric Branch of the San Francisco Chronicle reports. |
| 2025-07-19 |
| Malik Mustapha Status: Out San Francisco 49ers | Mustapha (knee) was placed on the active/PUP list by the 49ers on Friday. |
| Ben Bartch Status: Out San Francisco 49ers | Bartch (undisclosed) was placed on the active/non-football injury list Friday. |
| Curtis Robinson Status: Out San Francisco 49ers | Robinson (undisclosed) was placed on the active/PUP list Friday. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | Gross-Matos (undisclosed) was placed on the active/PUP list Friday. |
| Andre Dillard Status: Out San Francisco 49ers | Dillard (undisclosed) was placed on the active/PUP list Friday. |
 | George Odum Status: Out San Francisco 49ers | Odum (knee) was placed on the active/non-football injury list Friday. |
| 2025-07-18 |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (hamstring) was placed on the active/PUP list by the 49ers on Friday. |
| George Odum Status: Out San Francisco 49ers | nfi-a |
| Ben Bartch Status: Out San Francisco 49ers | nfi-a |
| Brandon Aiyuk Status: Out San Francisco 49ers | Aiyuk (knee) was placed on the active/PUP list by the 49ers on Friday. |
| Curtis Robinson Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Andre Dillard Status: Out San Francisco 49ers | out |
| Malik Mustapha Status: Out San Francisco 49ers | out |
| 2025-07-16 |
| Kurtis Rourke Status: Out San Francisco 49ers | The 49ers placed Rourke (knee) on the active/non-football injury list Wednesday, Matt Barrows of The Athletic reports. |
| 2025-07-14 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (calf) is unhappy with his contract and wants a new deal or a trade, Adam Schefter of ESPN reports. |
| 2025-07-10 |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson, who pleaded no contest to a misdemeanor DUI charge stemming from his arrest last November, has been sentenced to three years' probation, the Orange County Register reports. |
| 2025-06-14 |
| Brandon Aiyuk Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Thursday that Aiyuk (knee) has been "doing a tremendous job coming back," Kevin Patra of NFL.com reports. |
| 2025-06-13 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey was one of a few 49ers veterans to participate in 11-on-11 work during mandatory minicamp, Matt Barrows of The Athletic reports. |
| 2025-06-12 |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings dealt with a minor calf injury during the offseason program, Matt Barrows of The Athletic reports. |
| 2025-06-11 |
| Alfred Collins Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Collins (calf) will be back on the practice field during training camp, Vic Tafur of The Athletic reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) isn't participating in San Francisco's minicamp, Matt Maiocco of NBC Sports Bay Area reports. |
| Brandon Aiyuk Status: Questionable San Francisco 49ers | Aiyuk (knee) is present at San Francisco's mandatory minicamp but is not practicing, though he contributed Tuesday by coaching up the team's younger receivers, Matt Barrows of The Athletic reports. |
| 2025-06-10 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | 49ers coach Kyle Shanahan said Tuesday that Pearsall (hamstring) is healthy enough to participate in mandatory minicamp but that the team plans to be careful, and to prioritize having the second-year wideout ready for training camp, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
| 2025-06-06 |
| Isaac Guerendo Status: Active San Francisco 49ers | NA |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo (knee/ankle) was an active participant at voluntary OTAs, per the 49ers' official site. |
| 2025-06-03 |
| Trent Williams Status: Active San Francisco 49ers | NA |
 | Trent Taylor Status: Injured Reserve San Francisco 49ers | ir |
| Trent Williams Status: Active San Francisco 49ers | Williams (ankle) has been an active participant at the 49ers' OTAs, Vic Tafur of The Athletic reports. |
| Malik Knowles Status: Active San Francisco 49ers | Knowles signed a one-year contract with the 49ers on Tuesday. |
| Trent Taylor Status: Injured Reserve San Francisco 49ers | The 49ers placed Taylor (undisclosed) on injured reserve Tuesday. |
| 2025-06-02 |
| Bryce Huff Status: Active San Francisco 49ers | Huff was traded from the Eagles to the 49ers on Monday in exchange for a mid-round pick in 2026, Adam Schefter of ESPN reports. |
| 2025-05-30 |
| Spencer Burford Status: Active San Francisco 49ers | NA |
| Spencer Burford Status: Active San Francisco 49ers | Burford (calf) participated in Thursday's organized team activities, Matt Barrows of The Athletic reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (groin) participated in Thursday's organized team activities, Grant Cohn of Spots Illustrated reports. |
| Tre Brown Status: Active San Francisco 49ers | NA |
| Tre Brown Status: Active San Francisco 49ers | Brown (knee) participated in Thursday's organized team activities, Matt Barrows of The Athletic reports. |
| 2025-05-29 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall is dealing with a hamstring injury, according to head coach Kyle Shanahan, Nick Wagoner of ESPN.com reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | questionable |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown will be out until training camp after undergoing a procedure on his ankle, Cam Inman of The San Jose Mercury News reports. |
| 2025-05-28 |
 | Mitch Wishnowsky Status: Active San Francisco 49ers | NA |
 | Thomas Morstead Status: Active San Francisco 49ers | Morstead signed with the 49ers on Wednesday. |
| 2025-05-19 |
| Fred Warner Status: Active San Francisco 49ers | Warner signed a three-year, $63 million contract extension with the 49ers on Monday, Adam Schefter of ESPN reports. |
| 2025-05-16 |
| Brock Purdy Status: Active San Francisco 49ers | Purdy and the 49ers agreed to terms Friday on a five-year, $265 million contract extension, Tom Pelissero of NFL Network reports. |
 | Greg Joseph Status: Active San Francisco 49ers | The 49ers are slated to sign Joseph, Matt Barrows of The Athletic reports. |
| 2025-05-13 |
 | Tre Tomlinson Status: Injured Reserve San Francisco 49ers | Tomlinson (undisclosed) reverted to the 49ers' injured reserve Tuesday, per the NFL's transaction log. |
| 2025-05-09 |
| Kurtis Rourke Status: Questionable San Francisco 49ers | Rourke (knee) won't participate in the 49ers' rookie camp, Matt Maiocco of NBC Sports Bay Area reports. |
| Andre Dillard Status: Active San Francisco 49ers | The 49ers signed Dillard (concussion) on Friday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2025-05-02 |
 | Ross Dwelley Status: Active San Francisco 49ers | Dwelley signed a one-year contract with the 49ers on Friday. |
| 2025-04-29 |
| George Kittle Status: Active San Francisco 49ers | Kittle is signing a four-year, $76.4 million extension with the 49ers, ESPN's Nick Wagoner reports. |
| 2025-04-27 |