Injuries
| 2026-09-02 |
 | Nick Martin Status: Injured Reserve San Francisco 49ers | The 49ers placed Martin (hamstring) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports. |
| 2026-09-01 |
 | George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) participated in practice Monday and plans to do so again Tuesday, David Lombardi of the San Francisco Standard reports. |
 | Mike Evans Status: Questionable San Francisco 49ers | 49ers general manager John Lynch said Tuesday the team hopes to have Evans (groin) back at practice next week, David Lombardi of the San Francisco Standard reports. |
 | Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) worked to the side on the practice field Monday and is expected to do the same Tuesday, with a return to practice planned for Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
 | Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (finger) is not practicing Tuesday, Matt Barrows of The Athletic reports. |
 | Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) suited up and went through drills at Tuesday's practice, according to Matt Lively of CBS Sports Bay Area. |
| Nick Martin Status: Injured Reserve San Francisco 49ers | ir |
 | Nate Hobbs Status: Injured Reserve San Francisco 49ers | ir |
 | Brayden Willis Status: Questionable San Francisco 49ers | Willis (concussion) participated in Tuesday's practice, Nick Wagoner of ESPN.com reports. |
| Nate Hobbs Status: Injured Reserve San Francisco 49ers | The 49ers placed Hobbs (groin) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports. |
 | Nick Zakelj Status: Injured Reserve San Francisco 49ers | Zakelj (undisclosed) was placed on the 49ers' injured reserve Sunday. |
 | Brett Toth Status: Injured Reserve San Francisco 49ers | The 49ers placed Toth (concussion) on injured reserve Sunday. |
 | Austen Pleasants Status: Injured Reserve San Francisco 49ers | The 49ers placed Pleasants (knee) on injured reserve with a designation to return Sunday. |
| 2026-08-31 |
 | Christian Kirk Status: Injured Reserve San Francisco 49ers | ir |
| Christian Kirk Status: Injured Reserve San Francisco 49ers | Kirk (calf) was placed on injured reserve by the 49ers on Sunday with a designation to return. |
| Nick Zakelj Status: Injured Reserve San Francisco 49ers | ir |
| Brett Toth Status: Injured Reserve San Francisco 49ers | ir |
| Austen Pleasants Status: Injured Reserve San Francisco 49ers | ir |
 | Mykel Williams Status: Out San Francisco 49ers | Williams (knee) was moved to the reserve/PUP list by the 49ers on Sunday. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) will be eased back into practice this week, Matt Barrows of The Athletic reports. |
| 2026-08-30 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) is expected to practice this week as he continues his push to play in the 49ers' season opener against the Rams in Australia, Adam Schefter of ESPN reports. |
 | Isaac Guerendo Status: Out San Francisco 49ers | Guerendo (pectoral) was placed on the reserve/PUP list, Jeremy Fowler of ESPN reports. |
 | Jarrett Patterson Status: Active San Francisco 49ers | Patterson was traded to the 49ers on Sunday, Tom Pelissero of Netflix reports. |
| 2026-08-29 |
 | Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel didn't play in Thursday's preseason victory against Las Vegas. |
 | Brock Purdy Status: Active San Francisco 49ers | Purdy sat out Thursday's exhibition win over the Raiders. |
| 2026-08-28 |
 | Ephesians Prysock Status: Questionable San Francisco 49ers | Prysock suffered a shoulder injury and will not return to Thursday's preseason matchup with the Raiders, Noah Furtado of the San Francisco Chronicle reports. |
 | Victor Dimukeje Status: Injured Reserve San Francisco 49ers | Dimukeje (undisclosed) was placed on injured reserve by the 49ers on Thursday. |
 | Jah Joyner Status: Active San Francisco 49ers | Joyner signed with the 49ers on Thursday. |
| Brayden Willis Status: Questionable San Francisco 49ers | Willis (concussion) has been ruled out for the remainder of Thursday's preseason matchup with the Raiders, Noah Furtado of the San Francisco Chronicle reports. |
 | Jordan James Status: Active San Francisco 49ers | NA |
| Jordan James Status: Active San Francisco 49ers | James (ribs) rushed eight times for 35 yards and brought in one of two targets for 20 yards in the 49ers' 18-12 preseason win over the Raiders on Thursday. |
 | Kaelon Black Status: Active San Francisco 49ers | Black rushed four times for 28 yards and failed to bring in his only target in the 49ers' 18-12 preseason win over the Raiders on Thursday. |
 | Patrick Taylor Jr. Status: Questionable San Francisco 49ers | questionable |
 | Eddy Pineiro Status: Active San Francisco 49ers | Pineiro made all six of his field-goal attempts in Thursday night's 18-12 preseason win over the Raiders. |
 | Jordan Watkins Status: Active San Francisco 49ers | Watkins caught four of eight targets for 64 yards in Thursday night's 18-12 preseason win over the Raiders. |
 | Mac Jones Status: Active San Francisco 49ers | Jones completed one of his five pass attempts for seven yards in Thursday night's preseason finale against the Raiders. |
| 2026-08-27 |
| Victor Dimukeje Status: Injured Reserve San Francisco 49ers | ir |
 | De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (shoulder) won't suit up for Thursday's preseason contest at Las Vegas, David Lombardi of SFStandard.com reports. |
| 2026-08-26 |
 | Upton Stout Status: Questionable San Francisco 49ers | Stout (hip) did not participate at the 49ers' training camp practice Tuesday, Nick Wagoner of ESPN.com reports. |
 | Robert Jones Status: Questionable San Francisco 49ers | Jones (calf) did not participate at the 49ers' training camp practice Tuesday, Nick Wagoner of ESPN.com reports. |
 | Kurtis Rourke Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Rourke (ribs) has a chance to return to the field next week, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans' groin injury is considered minor, and he plans to be ready for the 49ers' Week 1 regular-season opener against the Rams on Thursday, Sept. 10, Jeremy Fowler of ESPN reports. |
| 2026-08-25 |
 | Josiah Deguara Status: Active San Francisco 49ers | Deguara was released by the 49ers on Monday. |
 | Xavier Thomas Status: Injured Reserve San Francisco 49ers | Thomas (undisclosed) reverted to injured reserve with the 49ers on Monday, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans is not practicing Tuesday due to a groin injury, Matt Maiocco of NBC Sports Bay Area reports. |
| Kurtis Rourke Status: Questionable San Francisco 49ers | questionable |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Robert Jones Status: Questionable San Francisco 49ers | questionable |
 | Jacob Cowing Status: Questionable San Francisco 49ers | questionable |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing (groin) did not participate at the 49ers' training camp practice Tuesday, Nick Wagoner of ESPN.com reports. |
| 2026-08-24 |
| Xavier Thomas Status: Injured Reserve San Francisco 49ers | ir |
 | Tanner McLachlan Status: Questionable San Francisco 49ers | questionable |
 | Titus Leo Status: Questionable San Francisco 49ers | questionable |
 | Deion Jones Status: Active San Francisco 49ers | Jones was traded from the Saints to the 49ers in exchange for running back Zamir White on Sunday, Adam Schefter of ESPN reports. |
| 2026-08-23 |
| Xavier Thomas Status: Questionable San Francisco 49ers | questionable |
| Khalil Dinkins Status: Active San Francisco 49ers | The 49ers signed Dinkins to a three-year contract Saturday. | |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) was activated from the active/PUP list Sunday. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) is in uniform for Sunday's training camp practice, Matt Barrows of The Athletic reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (shoulder) returned to practice Sunday, Nick Wagoner of ESPN.com reports. |
 | Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (shoulder) participated in Sunday's training camp practice, Noah Furtado of the San Francisco Chronicle reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) was in uniform for Sunday's practice but did not participate in team drills, Vic Tafur of The Athletic reports. |
 | Romello Height Status: Questionable San Francisco 49ers | Height (undisclosed) did not participate in Sunday's practice, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) said Sunday that he always planned to take a break during training camp and then "ramp back up," Vic Tafur of The Athletic reports. |
| 2026-08-22 |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir is day-to-day with a shoulder injury, Nick Wagoner of ESPN.com reports. |
| Nick Martin Status: Questionable San Francisco 49ers | questionable |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) is suited up for Saturday's practice, Nick Wagoner of ESPN.com reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling is considered day-to-day due to a shoulder injury, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Martin Status: Questionable San Francisco 49ers | Martin (hamstring) didn't participate in San Francisco's practice Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| Jordan James Status: Questionable San Francisco 49ers | James (ribs) returned to practice Saturday, Nick Wagoner of ESPN.com reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk (calf) continued to work on a side field at Saturday's practice, Vic Tafur of The Athletic reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) took part in 11-on-11 work at Saturday's practice, Noah Furtado of the San Francisco Chronicle reports. |
| Romello Height Status: Active San Francisco 49ers | Height (elbow) recorded one tackle for a loss in Thursday's 41-17 preseason win over the Chargers. |
 | Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu recorded two solo tackles in Thursday night's 41-17 preseason win over the Chargers. |
 | Jake Tonges Status: Active San Francisco 49ers | Tonges did not record any stats in Thursday's 41-17 preseason win against the Chargers. |
| 2026-08-21 |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) will not play in Thursday night's preseason game against the Chargers, David Lombardi of SFStandard.com reports. |
 | Khalil Herbert Status: Active San Francisco 49ers | The 49ers signed Herbert on Thursday. |
| Patrick Taylor Jr. Status: Injured Reserve San Francisco 49ers | The 49ers placed Taylor (undisclosed) on injured reserve Thursday, David Lombardi of SFStandard.com reports. |
| George Kittle Status: Out San Francisco 49ers | Kittle (Achilles) visited with Dr. Neal ElAttrache on Wednesday and remains ahead of schedule in his recovery with a chance to play Week 1 against the Rams, Adam Schefter of ESPN reports. |
 | Renardo Green Status: Questionable San Francisco 49ers | Green has a hamstring injury and is questionable to return to Thursday's matchup with the Chargers. |
| Austen Pleasants Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed four of six passes for 29 yards with no touchdowns or interceptions and rushed once for three yards in the 49ers' 41-17 preseason win over the Chargers on Thursday night. |
| Austen Pleasants Status: Questionable San Francisco 49ers | Pleasants won't return to Thursday's preseason game at the Chargers due to a knee injury, Jennifer Lee Chan of NBC Sports Bay Area reports |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel brought in one of two targets for four yards in the 49ers' 41-17 preseason win over the Chargers on Thursday night. |
| Kaelon Black Status: Active San Francisco 49ers | Black rushed eight times for 33 yards and wasn't targeted in the 49ers' 41-17 preseason win over the Chargers on Thursday night. |
| De'Zhaun Stribling Status: Active San Francisco 49ers | Stribling secured four of five targets for 46 yards in the 49ers' 41-17 preseason win over the Chargers on Thursday. |
| Sam Okuayinonu Status: Active San Francisco 49ers | NA |
| Romello Height Status: Active San Francisco 49ers | NA |
 | Demarcus Robinson Status: Active San Francisco 49ers | Robinson did not receive any targets in Thursday night's 41-17 preseason win over the Chargers. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro converted five PAT's and two field goal attempts in Thursday night's 41-17 preseason win over the Chargers. |
 | Sincere McCormick Status: Active San Francisco 49ers | McCormick rushed six times for 53 yards and a touchdown in Thursday night's 41-17 preseason win over the Chargers. |
| 2026-08-20 |
| Titus Leo Status: Injured Reserve San Francisco 49ers | Leo (undisclosed) reverted from waivers to San Francisco's injured reserve list Wednesday, Nick Wagoner of ESPN.com reports. |
| Patrick Taylor Jr. Status: Injured Reserve San Francisco 49ers | ir |
| 2026-08-19 |
| Brett Toth Status: Questionable San Francisco 49ers | questionable |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | questionable |
 | Dominick Puni Status: Questionable San Francisco 49ers | questionable |
 | Gracen Halton Status: Questionable San Francisco 49ers | questionable |
 | KJ Henry Status: Questionable San Francisco 49ers | questionable |
| Nate Hobbs Status: Questionable San Francisco 49ers | questionable |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | questionable |
| Titus Leo Status: Questionable San Francisco 49ers | questionable |
| Christian McCaffrey Status: Questionable San Francisco 49ers | questionable |
| Mike Evans Status: Questionable San Francisco 49ers | questionable |
| Mykel Williams Status: Out San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Williams (knee) is considered a "long shot" to play in Week 1 against the Rams, Dylan Grausz of NBC Sports reports. |
 | Luke Gifford Status: Questionable San Francisco 49ers | questionable |
| Kaelon Black Status: Active San Francisco 49ers | NA |
 | Jakob Robinson Status: Active San Francisco 49ers | NA |
| De'Zhaun Stribling Status: Active San Francisco 49ers | NA |
| 2026-08-18 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey is dealing with "tightness," but it doesn't seem to be an issue to worry about, Ian Rapoport of NFL Network reports. |
| Victor Dimukeje Status: Active San Francisco 49ers | Dimukeje signed with the 49ers on Monday. |
| Kaelon Black Status: Questionable San Francisco 49ers | Black (thigh) is back in uniform for Tuesday's practice session, Matt Barrows of The Athletic |
| Christian McCaffrey Status: Active San Francisco 49ers | Coach Kyle Shanahan said McCaffrey (undisclosed) would've practiced Tuesday if the 49ers hadn't been in a joint session with the Chargers, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Active San Francisco 49ers | Coach Kyle Shanahan said after Tuesday's joint practice with the Chargers that Evans (quadriceps) experienced some tightness and doesn't believe the issue to be a serious one, Matt Maiocco of NBC Sports Bay Area reports. |
| Kaelon Black Status: Questionable San Francisco 49ers | Black (thigh) looked like himself at Tuesday's practice, Grant Cohn of SI.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | San Francisco coach Kyle Shanahan said Tuesday that Purdy has a "good chance" to play in Thursday's preseason matchup with the Chargers, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa's (knee) tendinitis symptoms have been subsiding recently, David Lombardi of SFStandard.com reports. |
| 2026-08-17 |
| Gracen Halton Status: Active San Francisco 49ers | Halton (ankle) was unavailable for practice Sunday, Matt Maiocco of NBC Sports Bay Area reports. |
| Dominick Puni Status: Active San Francisco 49ers | Puni (concussion) was unavailable for the 49ers' preseason practice Sunday, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-08-16 |
| George Kittle Status: Out San Francisco 49ers | Kittle (Achilles) said Sunday that he's "very confident" he won't start the season on PUP and that he's still got a chance to play Week 1 versus the Rams, Nick Wagoner of ESPN.com reports. |
| 2026-08-15 |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing (hip) was a full participant in Saturday's practice, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Mike Evans Status: Active San Francisco 49ers | Evans (quadriceps) participated in team drills during Saturday's training camp practice, Noah Furtado of the San Francisco Chronicle reports. |
 | Marques Sigle Status: Active San Francisco 49ers | Sigle (oblique) was a full participant in Saturday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Martin Status: Active San Francisco 49ers | Martin (stinger) was a full participant in Saturday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (ribs) was a full participant in Saturday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (undisclosed) remained sidelined during practice Saturday, Nick Wagoner of ESPN.com reports. |
 | Tatum Bethune Status: Active San Francisco 49ers | Bethune logged six tackles (two solo), including 1.0 sacks, during Thursday night's preseason opener against the Titans. |
| Jakob Robinson Status: Questionable San Francisco 49ers | Robinson logged two solo tackles in Thursday night's preseason opener against the Titans. |
| 2026-08-14 |
| Kaelon Black Status: Questionable San Francisco 49ers | Black (thigh) will not play in Thursday's preseason opener against the Titans, Nick Wagoner of ESPN.com reports. |
| Jordan James Status: Questionable San Francisco 49ers | James (ribs) will not play in Thursday's preseason opener against the Titans, Nick Wagoner of ESPN.com reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk (calf) is not suited up for Thursday's preseason opener against the Titans, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) is not dressed in uniform for Thursday night's preseason opener against the Titans, Nick Wagoner of ESPN.com reports. |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (ribs) is questionable to return to Thursday night's contest against the Titans, Nick Wagoner of ESPN.com reports. |
 | Jack Jones Status: Active San Francisco 49ers | Jones (hand) is questionable to return to Thursday's preseason opener against the Titans, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (ribs) will not return to Thursday night's preseason opener against the Titans, Matt Maiocco of NBC Sports Bay Area reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling brought in seven of eight targets for 63 yards in the 49ers' 19-13 preseason loss to the Titans on Thursday. |
| Tatum Bethune Status: Active San Francisco 49ers | NA |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel did not play in Thursday night's preseason opener against the Titans. |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (ribs) was discharged from the hospital Thursday night, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Nate Hobbs Status: Active San Francisco 49ers | Hobbs (groin) is projected to miss a few weeks due to injury, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-08-13 |
 | Ricky Pearsall Status: Injured Reserve San Francisco 49ers | Pearsall announced Thursday in a post on his personal Instagram account that he underwent season-ending surgery to repair the PCL in his right knee, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy isn't in line to play in Thursday's preseason opener against the Titans, Vic Tafur and Matt Barrows report. |
| KJ Henry Status: Active San Francisco 49ers | Henry (undisclosed) reverted to the 49ers' injured reserve list Thursday, per the NFL's transaction log. |
| 2026-08-12 |
 | Zamir White Status: Active San Francisco 49ers | The 49ers signed White on Wednesday. |
| 2026-08-11 |
| Brock Purdy Status: Active San Francisco 49ers | Purdy and rookie wide receiver De'Zhaun Stribling have been starting to connect more frequently at training camp, Marc Adams of 49ers Webzone reports. |
 | Carver Willis Status: Active San Francisco 49ers | Willis has cleared concussion protocol and was a full participant in Monday's practice, David Lombardi of SFStandard.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) is in pads and taking part in warmups ahead of Tuesday's joint practice with the Titans, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (undisclosed) isn't participating in Tuesday's joint practice with the Titans, Cam Inman of The San Jose Mercury News reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Bosa has missed recent practices due to soreness/tendinitis in his right knee, and the pass rusher is considered week-to-week, Noah Furtado of the San Francisco Chronicle reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) took part primarily in individual drills at Tuesday's joint practice with the Titans, Nick Wagoner of ESPN.com reports. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson has been working with the first-team offense in training camp due to multiple injuries to the 49ers' wide receiver corps, Dan Graziano of ESPN.com reports. |
| 2026-08-10 |
| Christian McCaffrey Status: Active San Francisco 49ers | Offensive coordinator Klay Kubiak said the 49ers are "just managing" McCaffrey (undisclosed), who missed Monday's practice due to "tightness," Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Out San Francisco 49ers | Kittle (Achilles) was seen running routes, catching passes and doing conditioning work prior to Monday's practice, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (ACL) did not participate during the 49ers' training camp practice Monday, Eric Branch of the San Francisco Chronicle reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey won't practice Monday due to "tightness," Nick Wagoner of ESPN.com reports. |
| 2026-08-08 |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (hamstring) participated in 11-on-11 team drills during Saturday's training camp practice, Noah Furtado of the San Francisco Chronicle reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said the 49ers continue to "be smart with" Evans (quadriceps), who didn't practice Saturday, Nick Wagoner of ESPN.com reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk (calf) remained sidelined at Saturday's practice, Nick Wagoner of ESPN.com reports. |
| Luke Gifford Status: Active San Francisco 49ers | Gifford did not practice Saturday due to a hamstring injury, Matt Barrows of The Athletic reports. |
| 2026-08-07 |
| Gracen Halton Status: Active San Francisco 49ers | Halton (knee) participated during the 49ers' training camp practice Thursday, Chris Biderman of The Sacramento Bee reports. |
| Brett Toth Status: Active San Francisco 49ers | Toth (concussion) was absent from Thursday's training camp session, Cam Inman of The San Jose Mercury News reports. |
 | Kion Smith Status: Active San Francisco 49ers | Smith and the 49ers agreed on a one-year contract Thursday. |
| 2026-08-06 |
| Nick Zakelj Status: Active San Francisco 49ers | Zakelj (upper body) exited San Francisco's practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Carver Willis Status: Active San Francisco 49ers | Willis (concussion) didn't participate in San Francisco's training camp Wednesday, Cam Inman of The San Jose Mercury News reports. |
 | Ogbo Okoronkwo Status: Active San Francisco 49ers | The 49ers signed Okoronko on Wednesday, Jeremy Fowler of ESPN reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (hamstring) is in uniform for Thursday's practice, Matt Barrows of The Athletic reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | In his return to practice Thursday, Stribling (hamstring) didn't take part in team drills, Matt Barrows of The Athletic reports. |
| Gracen Halton Status: Active San Francisco 49ers | NA |
 | Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw (undisclosed) was a participant in Thursday's training camp session, Cam Inman of The San Jose Mercury News reports. |
 | Osa Odighizuwa Status: Questionable San Francisco 49ers | Odighizuwa (undisclosed) was a participant in Thursday's training camp session, Cam Inman of The San Jose Mercury News reports. |
| 2026-08-05 |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) didn't practice Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing (hip) did not participate in Wednesday's training camp session, Cam Inman of The San Jose Mercury News reports. |
| Osa Odighizuwa Status: Questionable San Francisco 49ers | Odighizuwa (undisclosed) did not participate at the 49ers' training camp practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (finger) did not participate in Wednesday's training camp session, Cam Inman of The San Jose Mercury News reports. |
| Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw (undisclosed) did not participate in Wednesday's training camp session, Cam Inman of The San Jose Mercury News reports. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu suffered an apparent ankle injury during the 49ers' training camp practice Wednesday, Matt Barrows of The Athletic reports. |
 | KhaDarel Hodge Status: Active San Francisco 49ers | The 49ers signed Hodge to a contract Wednesday, Jeremy Fowler of ESPN.com reports. |
| 2026-08-04 |
| Ricky Pearsall Status: Injured Reserve San Francisco 49ers | Pearsall (knee) is one of the few prominent athletes to have surgery on an isolated PCL injury, making it difficult to set expectations for rehab length or a potential return to pre-injury form, Eric Branch of the San Francisco Chronicle reports. |
| 2026-08-03 |
| Mikail Kamara Status: Injured Reserve San Francisco 49ers | Kamara (knee) reverted to the 49ers' injured reserve Monday, per the NFL's transaction log. | |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (hamstring) remains day-to-day and won't practice Monday, Nick Wagoner of ESPN.com reports. |
| Kaelon Black Status: Questionable San Francisco 49ers | Black is missing Monday's practice due to an adductor injury, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Active San Francisco 49ers | Evans (quad) won't practice Monday, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) didn't don a uniform at Monday's practice, but he did make some stationary over-the-shoulder catches during special-teams drills, Matt Barrows of The Athletic reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk (calf) worked out on the side at Monday's practice, Matt Barrows of The Athletic reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans, who didn't practice Monday, is tending to a minor quad strain, Ian Rapoport of NFL Network reports. |
| 2026-08-02 |
| Khalil Herbert Status: Active San Francisco 49ers | The 49ers signed Herbert to a one-year deal Sunday. |
| 2026-08-01 |
 | Trenton Irwin Status: Active San Francisco 49ers | The 49ers signed Irwin to a one-year contract Friday. |
| Josiah Deguara Status: Active San Francisco 49ers | Deguara signed a one-year contract with the 49ers on Friday. |
 | Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (hamstring) is participating at the 49ers' training camp, Ines Diaz of the team's official site reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (ACL) is doing individual work on the side at the 49ers' training camp, Nick Wagoner of ESPN reports. |
 | Alfred Collins Status: Active San Francisco 49ers | The 49ers activated Collins (shoulder) from the active/PUP list Friday after passing a physical, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| De'Zhaun Stribling Status: Active San Francisco 49ers | Stribling will have the opportunity to earn an expanded role in the 49ers' offense after Ricky Pearsall (knee) was placed on injured reserve Saturday. |
| Ricky Pearsall Status: Injured Reserve San Francisco 49ers | Pearsall was placed on injured reserve Saturday and will undergo season-ending PCL surgery on his right knee, Cam Inman of The San Jose Mercury News reports. |
| Mikail Kamara Status: Questionable San Francisco 49ers | questionable | |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling will not participate in Saturday's training camp practice due to hamstring tightness, David Lombardi of SFStandard.com reports. |
 | Cameron Sample Status: Questionable San Francisco 49ers | questionable |
 | Keion White Status: Questionable San Francisco 49ers | White (groin) left Saturday's practice early, Nick Wagoner of ESPN.com reports. |
| Romello Height Status: Questionable San Francisco 49ers | Height (elbow) did not participate in Saturday's practice session, Nick Wagoner of ESPN.com reports. |
| Cameron Sample Status: Questionable San Francisco 49ers | Sample (knee) missed Saturday's practice session, David Lombardi of SFStandard.com reports. |
| Mikail Kamara Status: Questionable San Francisco 49ers | Kamara (knee) was unable to finish Saturday's practice due to injury, Nick Wagoner of ESPN.com reports. | |
| Deebo Samuel Status: Active San Francisco 49ers | Samuel was a full participant in Saturday's training camp practice, his first since signing with the 49ers on Thursday, Matt Barrows of The Athletic reports. |
| Tanner McLachlan Status: Questionable San Francisco 49ers | McLachlan (undisclosed) reverted to the 49ers' injured reserve Saturday, per the NFL's transaction log. |
| 2026-07-31 |
| Tanner McLachlan Status: Questionable San Francisco 49ers | questionable |
| Alfred Collins Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco assistant head coach Chris Foerster said Friday that the team is "continuing to evaluate" Pearsall (knee) after the wide receiver aggravated the PCL issue in his right knee during early training camp practices, Matt Barrows of The Athletic reports. |
 | Andrew Farmer II Status: Injured Reserve San Francisco 49ers | San Francisco placed Farmer (back) on its injured reserve list Thursday, Aaron Wilson of KPRC 2 Houston reports. |
 | William Bradley-King Status: Injured Reserve San Francisco 49ers | San Francisco placed Bradley-King (undisclosed) on its injured reserve list Thursday, Aaron Wilson of KPRC 2 Houston reports. |
| Deebo Samuel Status: Active San Francisco 49ers | Samuel and the 49ers agreed on a one-year, $7 million contract Thursday, Ian Rapoport of NFL Network reports. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | NA |
| 2026-07-30 |
| Mac Jones Status: Active San Francisco 49ers | NA |
| Mac Jones Status: Active San Francisco 49ers | Jones (undisclosed) passed his conditioning test and is good to go for training camp, Vic Tafur and Matt Barrows of The Athletic report. |
| 2026-07-29 |
| Jordan James Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
 | Malik Mustapha Status: Questionable San Francisco 49ers | questionable |
| William Bradley-King Status: Questionable San Francisco 49ers | questionable |
| Kaelon Black Status: Active San Francisco 49ers | Black faces an opportunity to handle the bulk of No. 2 running back role behind Christian McCaffrey early in training camp after Jordan James suffered a fractured rib on Tuesday, David Lombardi of SFStandard.com reports. |
| Jordan James Status: Questionable San Francisco 49ers | James fractured a rib during Tuesday's practice, Vic Tafur of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) is dealing with knee swelling in the early stages of training camp, Vic Tafur of The Athletic reports. |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha (hamstring) was ruled out of Wednesday's practice, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | The 49ers have some "concern" about Pearsall's latest knee issue and are "exploring all options" when it comes to what the next step will be in addressing it, Nick Wagoner of ESPN reports. |
| 2026-07-28 |
| Andrew Farmer II Status: Questionable San Francisco 49ers | Farmer (back) did not participate during the 49ers' training camp practice Monday, Nick Wagoner of ESPN.com reports. |
 | Vederian Lowe Status: Questionable San Francisco 49ers | Lowe suffered a high ankle sprain during the 49ers' practice Sunday, Nick Wagoner of ESPN.com reports. |
| Gracen Halton Status: Questionable San Francisco 49ers | Halton is missing practice during the 49ers' training camp due to a bone bruise on his knee, Nick Wagoner of ESPN.com reports. |
| 2026-07-27 |
| Jordan James Status: Active San Francisco 49ers | James appears to be operating as the No. 2 running back behind Christian McCaffrey to begin training camp, Nick Wagoner of ESPN.com reports. |
| Jake Tonges Status: Active San Francisco 49ers | NA |
| Jake Tonges Status: Active San Francisco 49ers | Tonges (foot) is participating in practice to begin training camp, Brooke Evans of the 49ers' official site reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk sustained a calf injury during Sunday's practice and is not practicing Monday, Nick Wagoner of ESPN.com reports. |
| Gracen Halton Status: Questionable San Francisco 49ers | questionable |
| Andrew Farmer II Status: Questionable San Francisco 49ers | questionable |
| Nate Hobbs Status: Active San Francisco 49ers | NA |
| Romello Height Status: Active San Francisco 49ers | Height (lower body) was carted off the field at Monday's practice due to cramps, rather than any sort of severe injury, Nick Wagoner of ESPN.com reports. |
| Nate Hobbs Status: Active San Francisco 49ers | Hobbs (knee) is participating at the 49ers' training camp, Vic Tafur of The Athletic reports. |
| Romello Height Status: Active San Francisco 49ers | Height (lower body) was carted off the field at Monday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-07-26 |
 | Kevin Givens Status: Active San Francisco 49ers | The 49ers signed Givens to a one-year deal Sunday. |
| Vederian Lowe Status: Questionable San Francisco 49ers | Lowe exited San Francisco's practice Sunday with an ankle injury, David Lombardi of SFStandard.com reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk walked off with an apparent injury during the 49ers' practice Sunday, Matt Barrows of The Athletic reports. |
| Vederian Lowe Status: Questionable San Francisco 49ers | questionable |
| 2026-07-25 |
| Mykel Williams Status: Out San Francisco 49ers | out |
| Isaac Guerendo Status: Out San Francisco 49ers | out |
| George Kittle Status: Out San Francisco 49ers | out |
| Khalil Dinkins Status: Questionable San Francisco 49ers | questionable | |
 | Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco general manager John Lynch told reporters Saturday that Aiyuk (knee) will remain on the 49ers' reserve/left squad list, Adam Schefter of ESPN reports. |
| Alfred Collins Status: Out San Francisco 49ers | out |
| George Kittle Status: Out San Francisco 49ers | The 49ers placed Kittle (Achilles) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| Alfred Collins Status: Out San Francisco 49ers | The 49ers Matt Maiocco of NBC Sports Bay Area Collins (shoulder) on the active/PUP list Saturday, Matt reports. |
| Isaac Guerendo Status: Out San Francisco 49ers | The 49ers placed Guerendo (pectoral) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| Mykel Williams Status: Out San Francisco 49ers | The 49ers placed Williams (knee) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) wasn't placed on the PUP list ahead of the start of San Francisco's training camp, Matt Barrows of The Athletic reports. |
| Tanner McLachlan Status: Active San Francisco 49ers | The 49ers signed McLachlan on Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-07-18 |
| Khalil Dinkins Status: Out San Francisco 49ers | The 49ers placed Dinkins (undisclosed) on the active/non-football injury list Saturday. |
| 2026-07-16 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey has been named the Best Comeback Athlete the 2026 ESPYS, Briana Jeannel of the 49ers' official site reports. |
| 2026-06-27 |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall is expected to enter training camp as San Francisco's starting wide receiver opposite Mike Evans, Kyle Madson of USA Today reports. |
| 2026-06-25 |
| Mac Jones Status: Questionable San Francisco 49ers | Jones, who dealt with a sore shoulder during the 49ers' spring program, threw passes this week at Tight End University, an event hosted by teammate George Kittle (Achilles), David Lombardi of the San Francisco Standard reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy, who has been participating in this week's Tight End University, an event hosted by teammate George Kittle (Achilles), said that he plans to gather with other 49ers for throwing sessions over the next month prior to training camp, David Lombardi of the San Francisco Standard reports. |
| 2026-06-24 |
| Brandon Aiyuk Status: Out San Francisco 49ers | In a video posted to Instagram Wednesday, Aiyuk (knee) said that if the 49ers released him, he'd sign with the Commanders "tomorrow," ESPN.com reports. |
| 2026-06-23 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) said Tuesday that he feels "definitely on track" for Week 1 though "nothing is 100 percent certain," David Lombardi of SFStandard.com reports. |
| 2026-06-10 |
| Sincere McCormick Status: Active San Francisco 49ers | McCormick signed a one-year deal with the 49ers on Wednesday. |
| 2026-06-04 |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (undisclosed) did not throw during practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) said Wednesday that he's "doing great" and is "ahead of schedule" in his rehab, ESPN.com's Nick Wagoner reports. |
| Mike Evans Status: Active San Francisco 49ers | Evans is making a strong impression at voluntary OTAs and feels rejuvenated after an injury-plagued 2025, Matt Barrows of The Athletic reports. |
| 2026-06-03 |
 | Ashtyn Davis Status: Active San Francisco 49ers | The Lions signed Davis on Tuesday. |
| Brandon Aiyuk Status: Out San Francisco 49ers | Aiyuk (knee) has been issued an arrest warrant on a misdemeanor charge of exhibition of speed by the Santa Clara County District Attorney's Office, David Lombardi of SFStandard.com reports. |
| Mac Jones Status: Questionable San Francisco 49ers | questionable |
| 2026-05-29 |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) told reporters Thursday that he expects to be ready for training camp and the regular season, Matt Maiocco of NBC Sports Bay Area reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo is not participating in OTAs due to a torn pectoral, Cam Inman of The San Jose Mercury News reports. |
 | Darrick Forrest Status: Injured Reserve San Francisco 49ers | San Francisco placed Forrest (undisclosed) on its injured reserve list Thursday. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey said after Thursday's OTAs that he's looking forward to sustaining another heavy workload in 2026 and that any reductions in touches should come in practice rather than games, Nick Wagoner of ESPN.com reports. |
| 2026-05-28 |
| Jacob Cowing Status: Active San Francisco 49ers | NA |
| Darrick Forrest Status: Injured Reserve San Francisco 49ers | ir |
| Isaac Guerendo Status: Questionable San Francisco 49ers | questionable |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing (hamstring) is participating in OTAs, Matt Maiocco of NBC Sports Bay Area reports. |
 | Jermar Jefferson Status: Active San Francisco 49ers | Jefferson signed with the 49ers on Thursday. |
 | Jordan Mims Status: Active San Francisco 49ers | San Francisco signed Mims to a one-year contract Thursday. |
| 2026-05-27 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) said Wednesday that he is still targeting the 49ers' regular-season opener against the Rams in Week 1 as his return date, Cameron DaSilva of USA Today reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones agreed to terms Wednesday on a contract restructure with the 49ers that adds a $300,000 roster bonus for 2026, Tom Pelissero of NFL Network reports. |
| 2026-05-22 |
| Jordan James Status: Active San Francisco 49ers | James "seems the most likely" of San Francisco's running backs behind Christian McCaffrey to earn the No. 2 running-back role for the upcoming campaign, Nick Wagoner of ESPN.com reports. |
| 2026-05-07 |
| De'Zhaun Stribling Status: Active San Francisco 49ers | The 49ers' selection of Stribling at No. 33 overall in the 2026 NFL Draft was partially motivated by the organization's strong belief in his personality, leadership and work ethic, according to Matt Barrow of The Athletic. |
| Kurtis Rourke Status: Active San Francisco 49ers | NA |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (knee) will participate in rookie minicamp starting Friday, David Lombardi of SFStandard.com reports. |
| 2026-05-04 |
| Kaelon Black Status: Active San Francisco 49ers | Black is set to compete with recent draft picks Jordan James and Isaac Guerendo for backup touches behind Christian McCaffrey, Grant Gordon of NFL.com reports. |
| 2026-04-30 |
| George Kittle Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Thursday that Kittle (Achilles) is aiming to be ready for the 49ers' Week 1 game against the Rams, David Lombardi of SFStandard.com reports. |
 | Tre Tomlinson Status: Active San Francisco 49ers | NA |
| 2026-04-29 |
 | Patrick McMorris Status: Active San Francisco 49ers | The 49ers signed McMorris to a one-year deal Tuesday, Adam Schefter of ESPN reports. |
| 2026-04-27 |
| Sincere McCormick Status: Active San Francisco 49ers | McCormick signed with the 49ers on Monday, David Lombardi of SFStandard.com reports. |
| 2026-04-26 |
| Khalil Dinkins Status: Active San Francisco 49ers | The 49ers signed Dinkins as an undrafted free agent Sunday. | |
| Will Pauling Status: Active San Francisco 49ers | The 49ers signed Pauling as an undrafted free agent Sunday. | |
| Wesley Grimes Status: Active San Francisco 49ers | The 49ers signed Grimes as an undrafted free agent Sunday. |
| 2026-04-25 |
| Gracen Halton Status: Active San Francisco 49ers | The 49ers selected Halton in the fourth round of the 2026 NFL Draft, 107th overall. | |
| Ephesians Prysock Status: Active San Francisco 49ers | The 49ers selected Prysock in the fourth round of the 2026 NFL Draft, 139th overall. | |
| Carver Willis Status: Active San Francisco 49ers | The 49ers selected Willis in the fourth round of the 2026 NFL Draft, 127th overall. | |
| Jaden Dugger Status: Active San Francisco 49ers | The 49ers selected Dugger in the fifth round of the 2026 NFL Draft, 154th overall. | |
| Enrique Cruz Jr. Status: Active San Francisco 49ers | The 49ers selected Cruz in the fifth round of the 2026 NFL Draft, 179th overall. | |
| Romello Height Status: Active San Francisco 49ers | The 49ers selected Height in the third round of the 2026 NFL Draft, 70th overall. | |
| Kaelon Black Status: Active San Francisco 49ers | The 49ers selected Black in the third round of the 2026 NFL Draft, 90th overall. |
| 2026-04-24 |
| De'Zhaun Stribling Status: Active San Francisco 49ers | The 49ers selected Stribling in the second round of the 2026 NFL Draft, 33rd overall. |
| 2026-04-20 |
 | Trent Williams Status: Active San Francisco 49ers | Williams and San Francisco agreed to terms Monday on a two-year, $50 million contract extension, Adam Schefter of ESPN reports. |
 | Fred Warner Status: Active San Francisco 49ers | NA |
| Fred Warner Status: Active San Francisco 49ers | Warner (ankle) said at the start of San Francisco's voluntary workout program Monday that he no longer has any limitations relating to the ankle injury he suffered Week 6 of the 2025 season, Noah Furtado of the San Francisco Chronicle reports. |
| 2026-04-10 |
| Jack Jones Status: Active San Francisco 49ers | Jones signed a one-year contract with San Francisco on Friday, Ian Rapoport of NFL Network reports. |
| 2026-04-09 |
| Cam Sample Status: Active San Francisco 49ers | Sample has agreed to a one-year deal with the 49ers, Tom Pelissero of NFL Network reports. |
| 2026-03-30 |
| Christian McCaffrey Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that "in order to have [McCaffrey] be as good as he can be throughout the whole year, we've got to get someone to help him," Matt Barrows of The Athletic reports. |
| 2026-03-29 |
| George Kittle Status: Questionable San Francisco 49ers | 49ers general manager John Lynch told reporters Sunday that he is "hopeful" that Kittle (Achilles) will be available for Week 1 of the 2026 season, Nick Wagoner of ESPN.com reports. |
| Mykel Williams Status: Questionable San Francisco 49ers | 49ers GM John Lynch said Sunday that Williams (knee) is expected to be back for training camp, David Lombardi of SFStandard.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | 49ers GM said Sunday at the NFL's league meetings that he expects Bosa (knee) to be ready for training camp, David Lombardi of SFStandard.com reports |
| Nick Martin Status: Active San Francisco 49ers | San Francisco GM John Lynch said Sunday that Martin has been cleared from the concussion that ended his 2026 season, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Active San Francisco 49ers | 49ers GM John Lynch said Sunday that talks with Williams regarding a reworked contract have "intensified" over the last week, Eric Branch of the San Francisco Chronicle reports. |
| 2026-03-25 |
 | Ben Bartch Status: Active San Francisco 49ers | NA |
| 2026-03-24 |
| Rob Jones Status: Active San Francisco 49ers | The 49ers are set to sign Jones to a contract, Tom Pelissero of NFL Network reports. |
| 2026-03-21 |
| Trent Williams Status: Active San Francisco 49ers | The 49ers declined Williams' $10 million option bonus Friday, instead adding it to his base salary for the 2026 season, David Lombardi of SFStandard.com reports. |
| 2026-03-19 |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu signed his restricted free-agent tender with the 49ers on Wednesday. |
| 2026-03-16 |
| Christian Kirk Status: Active San Francisco 49ers | Kirk is slated to sign a one-year, $6 million contract with San Francisco, NFL reporter Jordan Schultz reports. |
| 2026-03-15 |
 | Corliss Waitman Status: Active San Francisco 49ers | The 49ers are set to sign Waitman, Tom Pelissero of NFL Network reports. |
| 2026-03-13 |
| Nate Hobbs Status: Questionable San Francisco 49ers | The 49ers agreed to terms with Hobbs (knee) on a one-year, $4 million contract Thursday, Aaron Wilson of KPRC 2 Houston reports. |
| Luke Gifford Status: Active San Francisco 49ers | The 49ers and Gifford agreed to terms on a two-year, $5.3 million extension Friday, Tom Pelissero of NFL Network reports. |
| 2026-03-12 |
| Dre Greenlaw Status: Active San Francisco 49ers | The 49ers signed Greenlaw to a one-year, $7.5 million contract Thursday, Ian Rapoport of NFL Network reports. |
| 2026-03-11 |
 | Garret Wallow Status: Active San Francisco 49ers | Wallow is in line to sign a one-year contract with the 49ers on Tuesday, Matt Barrows of The Athletic reports. |
| Brett Toth Status: Active San Francisco 49ers | Toth (concussion) agreed to terms Tuesday on a one-year contract with the 49ers, Dave Zangaro of NBC Sports Philadelphia reports. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor (shoulder) is slated to re-sign with the 49ers, per his representation at Equity Sports. |
| Jake Tonges Status: Questionable San Francisco 49ers | Tonges (foot) is signing a two-year, $8 million contract to stay with the 49ers, Ian Rapoport of NFL Network reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | The 49ers are still expected to move on from Aiyuk (knee) but won't necessarily release him Wednesday, Nick Wagoner of ESPN.com reports. |
| Osa Odighizuwa Status: Questionable San Francisco 49ers | The 49ers acquired Odighizuwa (elbow) from the Cowboys in exchange for a 2026 third-round pick Wednesday, Adam Schefter of ESPN reports. |
| 2026-03-09 |
| Vederian Lowe Status: Active San Francisco 49ers | Lowe and the 49ers agreed to a two-year, $12 million contract Monday that includes $5.75 million guaranteed, Ian Rapoport of NFL Network reports. |
| 2026-03-07 |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro and the 49ers agreed to a four-year, $17 million contract Saturday, Adam Schefter of ESPN reports. |
| 2026-02-25 |
| Trent Williams Status: Active San Francisco 49ers | San Francisco general manager John Lynch said Tuesday at the NFL Scouting Combine that Williams and the team have "had really good, productive and substantive meetings" regarding a contract restructure, Nick Wagoner of ESPN reports. |
| 2026-02-19 |
 | Curtis Robinson Status: Active San Francisco 49ers | Robinson recorded 42 tackles (19 solo) with one pass defended across 14 active games with the 49ers in 2025. |
 | Clelin Ferrell Status: Active San Francisco 49ers | Ferrell finished the 2025 regular season with 24 tackles (13 solo) and 4.0 sacks in eight games played for the 49ers. |
 | Kalia Davis Status: Active San Francisco 49ers | Davis finished the regular season with 28 tackles (10 solo), three passes defended and 0.5 sacks across 17 games played. |
 | Jordan Elliott Status: Active San Francisco 49ers | Elliott appeared in 16 games for the 49ers in 2025, finishing the regular season with 31 tackles (eight solo) and one pass batted down. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu finished the 2025 regular season with 39 tackles (23 solo), 3.0 sacks and a forced fumble across 15 active games. |
| Alfred Collins Status: Active San Francisco 49ers | Collins recorded 17 tackles (four solo), two forced fumbles and one sack across 16 regular season games in 2025. |
 | C.J. West Status: Active San Francisco 49ers | West appeared in 14 games for the 49ers in 2025, finishing the regular season with 21 tackles (12 solo) and one sack. |
| 2026-02-17 |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (hamstring) had 76 tackles (44 solo), two interceptions and one forced fumble in 17 regular-season starts with the 49ers in 2025. |
 | Dee Winters Status: Active San Francisco 49ers | Winters recorded 101 tackles (67 solo) and an interception in 17 regular-season games with the 49ers in 2025. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle finished the 2025 regular season with 52 tackles (28 solo) and two passes defended across 15 active games with the 49ers. |
| Renardo Green Status: Active San Francisco 49ers | Green finished the regular season with 60 tackles (36 solo) made and 10 passes defended across 14 starts with the 49ers. |
| 2026-02-13 |
| Mykel Williams Status: Questionable San Francisco 49ers | questionable |
| Fred Warner Status: Questionable San Francisco 49ers | questionable |
| Tre Tomlinson Status: Questionable San Francisco 49ers | questionable |
 | Trent Taylor Status: Questionable San Francisco 49ers | questionable |
| Patrick Taylor Jr. Status: Questionable San Francisco 49ers | questionable |
| Jakob Robinson Status: Questionable San Francisco 49ers | questionable |
| Kurtis Rourke Status: Questionable San Francisco 49ers | questionable |
| Nick Martin Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Questionable San Francisco 49ers | questionable |
 | Tarron Jackson Status: Questionable San Francisco 49ers | questionable |
| 2026-02-12 |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | Cowing was unable to take the field during the 2025 season due to a hamstring injury. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk caught 24 of 28 targets for 213 yards and two touchdowns while rushing twice for minus-3 yards across 17 regular-season games in 2025. |
| 2026-02-10 |
| Keion White Status: Questionable San Francisco 49ers | White was shot in the ankle early Monday morning and is expected to be OK after undergoing surgery, Matt Barrows of The Athletic reports. |
| 2026-02-06 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey was named the 2025 Comeback Player of the Year on Thursday, Matt Barrows of The Athletic reports. |
| 2026-01-23 |
 | Hayden Rucci Status: Active San Francisco 49ers | The 49ers signed Rucci to a reserve/future contract Thursday. |
| 2026-01-22 |
 | Adrian Martinez Status: Active San Francisco 49ers | San Francisco signed Martinez to a reserve/future contract Tuesday. |
| 2026-01-21 |
 | Malik Turner Status: Active San Francisco 49ers | The 49ers signed Turner to a reserve/future contract Tuesday. |
 | Junior Bergen Status: Active San Francisco 49ers | Bergen signed a reserve/future contract with the 49ers on Tuesday. |
 | Eli Apple Status: Active San Francisco 49ers | The 49ers signed Apple to a reserve/future contract Tuesday. |
| Mac Jones Status: Active San Francisco 49ers | San Francisco coach Kyle Shanahan said Wednesday that he expects Jones to be with the 49ers for 2026, Cam Inman of The San Jose Mercury News reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco GM John Lynch said Wednesday that Aiyuk (knee) won't play for the 49ers again, Nick Wagoner of ESPN.com reports. |
| Jake Tonges Status: Questionable San Francisco 49ers | Tonges suffered a plantar fascia injury in his foot during this past Saturday's divisional-round loss at Seattle, Cam Inman of The San Jose Mercury News reports. |
| Nick Bosa Status: Injured Reserve San Francisco 49ers | The 49ers are hopeful that Bosa (ACL) will be back in time for training camp ahead of the 2026 season, Cam Inman of The San Jose Mercury News reports. |
| 2026-01-20 |
| George Kittle Status: Injured Reserve San Francisco 49ers | Kittle said Monday that the right Achilles surgery he underwent last week went as well as possible, and the tight end said he expects to return to action "well before November" during the 2026 season, Eric Branch of the San Francisco Chronicle reports. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) said Tuesday that he's confident he would have been able to play in the NFC Championship Game this weekend had the 49ers beaten the Seahawks in the divisional round, Matt Barrows of The Athletic reports. |
| Mykel Williams Status: Injured Reserve San Francisco 49ers | Williams (knee) told reporters Tuesday that he "should" be ready to return for the beginning of training camp, Matt Barrows of The Athletic reports. |
| 2026-01-19 |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | questionable |
 | Brandon Parker Status: Active San Francisco 49ers | NA |
 | Sebastian Valdez Status: Active San Francisco 49ers | NA |
 | Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson had three carries for four yards and one reception for three yards in Saturday's 41-6 playoff loss to the Seahawks. |
 | Kendrick Bourne Status: Active San Francisco 49ers | Bourne finished the regular season with 37 receptions for 551 yards across 16 games played with the 49ers. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson brought in his only target for one yard in Saturday's 41-6 divisional round loss to the Seahawks. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy said Monday that he will not require any offseason procedures to address the turf toe injury that hampered him early during the 2025 campaign, Nick Wagoner of ESPN.com reports. |
| 2026-01-18 |
| Luke Gifford Status: Active San Francisco 49ers | Gifford (quadriceps) will play in Saturday's NFC divisional-round game versus the Seahawks. |
| Jake Tonges Status: Questionable San Francisco 49ers | Tonges is questionable to return to Saturday's divisional-round game against the 49ers due to a foot injury, Eric Williams of NFL on FOX reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey is sidelined to begin the second half of Saturday's divisional-round matchup against the Seahawks, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (shoulder) returned to Saturday's divisional-round game against the Seahawks, Eric Branch of the San Francisco Chronicle reports. |
 | Jauan Jennings Status: Active San Francisco 49ers | Jennings recorded two receptions on five targets for 39 yards in Saturday's divisional-round loss to the Seahawks. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 15 of 27 passes for 140 yards, no touchdowns and one interception in Saturday's 41-6 divisional-round loss to the Seahawks. He added five rushes for 37 yards but lost a fumble. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed the ball 11 times for 35 yards in Saturday's 41-6 divisional-round loss to the Seahawks. He added five receptions on six targets for 39 yards. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall did not record a catch on two targets in Saturday's 41-6 divisional-round loss to the Seahawks. |
| 2026-01-17 |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | Cowing (hamstring) has been ruled out for San Francisco's divisional-round matchup versus the Seahawks on Saturday. |
| Luke Gifford Status: Questionable San Francisco 49ers | The 49ers expect Gifford (quadriceps) to play in Saturday's divisional-round matchup versus the Seahawks, Matt Barrows of The Athletic reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters (ankle) is active for Saturday's divisional-round matchup versus the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (knee) is listed as active Saturday in Seattle, Briana Jeannel of the 49ers' official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Sebastian Valdez Status: Out San Francisco 49ers | inactive |
| Brandon Parker Status: Out San Francisco 49ers | inactive |
| Isaac Guerendo Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Ji'Ayir Brown Status: Out San Francisco 49ers | inactive |
 | Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| 2026-01-16 |
| Ji'Ayir Brown Status: Out San Francisco 49ers | Brown (hamstring) has been ruled out for Saturday's NFC divisional-round clash against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) has been ruled out for Saturday's NFC divisional-round clash against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (quadriceps) is listed as questionable for Saturday's NFC divisional-round tilt against Seattle, John Boyle of the Seahawks' official site reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (ankle) is listed as questionable for Saturday's NFC divisional-round game against the Seahawks, John Boyle of the Seahawks' official site reports. |
 | Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (knee) does not carry an injury designation into Saturday's NFC divisional-round clash against Seattle. |
| Dominick Puni Status: Active San Francisco 49ers | Puni (ankle) does not carry an injury designation into Saturday's NFC divisional-round game against the Seahawks. |
| 2026-01-15 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) will be listed as questionable for Saturday's divisional-round game against the Seahawks, Matt Barrows of The Athletic reports. |
| Ji'Ayir Brown Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) was a limited participant at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (hamstring) did not participate at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (ankle) was a limited participant at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) was a limited participant at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Dominick Puni Status: Questionable San Francisco 49ers | Puni (ankle) was a limited participant in San Francisco's practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Trent Williams Status: Active San Francisco 49ers | Williams (hamstring) was a full participant in San Francisco's practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| 2026-01-14 |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (quadriceps) did not participate in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (hamstring) did not participate in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (ankle) was a limited participant in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) was a limited participant in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) was a limited participant in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | The 49ers placed Kittle (Achilles) on injured reserve Wednesday. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) practiced in a limited capacity Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Brayden Willis Status: Active San Francisco 49ers | The 49ers elevated Willis from the practice squad to the active roster. |
| 2026-01-13 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) was officially estimated as limited in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Keion White Status: Questionable San Francisco 49ers | questionable |
| Dominick Puni Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Luke Gifford Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan announced that Kittle (Achilles) will undergo season-ending surgery Wednesday. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Pearsall (knee/ankle) will be listed as a limited participant in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | San Francisco head coach Kyle Shanahan said Warner (ankle) will be designated to return to practice Tuesday in order to participate in walk-throughs, with the hope that he could return for the NFC Championship Game if the 49ers advance that far in the postseason, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-01-12 |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson corralled six of seven targets for 111 yards and a touchdown in Sunday's 23-19 wild-card round win over Philadelphia. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) is not expected to return to practice this week, Mike Garafolo of NFL Network reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings had one reception on three targets for 45 yards and completed his only pass attempt for a 29-yard touchdown in Sunday's 23-19 wild-card game win over the Eagles. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 18 of 31 pass attempts for 262 yards, two touchdowns and two interceptions while rushing nine times for 24 yards in Sunday's 23-19 wild-card round win over Philadelphia. |
| George Kittle Status: Out San Francisco 49ers | out |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 15 times for 48 yards and caught six of eight targets for 66 yards and two touchdowns in Sunday's 23-19 playoff win over the Eagles. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges caught one of three targets for 14 yards in Sunday's 23-19 wild-card round win over the Eagles. |
| George Kittle Status: Out San Francisco 49ers | Head coach Kyle Shanahan confirmed after Sunday's 23-19 wild-card win over the Eagles that Kittle tore his Achilles during the game, Mike Garafolo of NFL Network reports. |
| Dee Winters Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Luke Gifford Status: Out San Francisco 49ers | out |
| 2026-01-11 |
| Dee Winters Status: Out San Francisco 49ers | inactive |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
 | Chase Lucas Status: Out San Francisco 49ers | inactive |
| Isaac Guerendo Status: Out San Francisco 49ers | inactive |
| Luke Gifford Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Trent Williams Status: Active San Francisco 49ers | Williams (hamstring) is active for Sunday's wild-card game versus the Eagles. |
| Keion White Status: Active San Francisco 49ers | White (groin/hamstring) is active for Sunday's wild-card game versus Philadelphia. |
| Renardo Green Status: Active San Francisco 49ers | Green (ankle) is active for Sunday's wild-card matchup versus the Eagles. |
| Dee Winters Status: Out San Francisco 49ers | Winters (ankle) is inactive for Sunday's wild-card contest versus the Eagles. |
| Luke Gifford Status: Out San Francisco 49ers | Gifford (quadriceps) is inactive for Sunday's wild-card game versus the Eagles. |
| George Kittle Status: Out San Francisco 49ers | Kittle won't return to Sunday's playoff game against the Eagles after sustaining an Achilles' injury. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (hamstring) is questionable to return to Sunday's contest against the Eagles, Eric Branch of the San Francisco Chronicle reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (hamstring) has been ruled out for the remainder of Sunday's contest against Philadelphia, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee/ankle) is inactive for Sunday's playoff game against the Eagles. |
| 2026-01-10 |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) is trending toward returning for Sunday's wild-card matchup against the Eagles, Jeremy Fowler of ESPN.com reports. |
 | Bryce Huff Status: Active San Francisco 49ers | Huff appeared in 15 games for the 49ers in 2025 and finished the regular season with 30 tackles (14 solo), 4.0 sacks and two forced fumbles. |
| Malik Turner Status: Active San Francisco 49ers | The 49ers elevated Turner to the active roster from their practice squad Saturday ahead of Sunday's wild-card matchup versus the Eagles. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | Cowing (hamstring) has been ruled out for San Francisco's wild-card matchup versus the Eagles on Sunday. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir finished the 2025 regular season with 61 tackles (39 solo) and two interceptions across 17 starts. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha wrapped up 76 combined tackles (44 solo) and defended three passes (one interception) across 12 regular-season starts in 2025. |
| 2026-01-09 |
| Keion White Status: Questionable San Francisco 49ers | White (groin/hamstring) is listed as questionable ahead of Sunday's wild-card round matchup with the Eagles, Noah Furtado of the San Francisco Chronicle reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (foot) is listed as questionable for Sunday's wild-card round road game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (quadriceps) is listed as questionable for Sunday's wild-card round game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (ankle) is listed as questionable for Sunday's wild-card round road game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | Cowing (hamstring) is listed as questionable for Sunday's wild-card round game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports, but the wide receiver remains on injured reserve. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) is listed as questionable for Sunday's wild-card round road game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) is listed as questionable for Sunday's game at Philadelphia despite not practicing at all this week, Noah Furtado of the San Francisco Chronicle reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle (ankle) doesn't have an injury designation for Sunday's wild-card game at Philadelphia, Cam Inman of The San Jose Mercury News reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (ankle) is listed as questionable for Sunday's wild-card round matchup with the Eagles. |
 | Skyy Moore Status: Active San Francisco 49ers | Moore finished the 2025 regular season with five receptions for 87 yards, two carries for 11 yards and 1,198 combined return yards in 17 appearances. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown had 76 tackles (44 solo), two interceptions and one forced fumble in 17 regular-season starts with the 49ers in 2025. |
| Upton Stout Status: Active San Francisco 49ers | Stout finished with 82 tackles (43 solo), one sack and one forced fumble across 16 regular-season games in 2025. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins was active for four games in 2025 and finished the regular season with two receptions on three targets for 26 yards. |
| 2026-01-08 |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) was seen sprinting on the side during Thursday's practice, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) isn't participating in Thursday's practice, Matt Barrows of The Athletic reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) was a limited participant in Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) was a limited practice participant Thursday, Cam Inman of The San Jose Mercury News reports. |
| Jordan James Status: Active San Francisco 49ers | James did not record a touch while appearing in three games for the 49ers in 2025. |
 | Luke Farrell Status: Active San Francisco 49ers | Farrell finished his first regular season with San Francisco grabbing 11 of 14 targets for 85 yards and two touchdowns across 17 games. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo was only utilized on special teams this season, finishing with 100 kick return yards across 14 active games. |
| Mac Jones Status: Active San Francisco 49ers | Jones finished the regular season completing 70 percent of his pass attempts for 2,151 yards, 13 touchdowns and six interceptions across 11 games. |
| 2026-01-07 |
 | Eric Kendricks Status: Active San Francisco 49ers | The 49ers signed Kendricks from the practice squad to the active roster Wednesday. |
| Tatum Bethune Status: Injured Reserve San Francisco 49ers | ir |
| Keion White Status: Questionable San Francisco 49ers | White (hamstring) won't participate in practice Wednesday, Matt Barrows of The Athletic reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (ankle) did not practice in Wednesday's session, Matt Barrows of The Athletic reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) won't participate in practice Wednesday, Vic Tafur of The Athletic reports. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | The 49ers designated Cowing (hamstring) to return from injured reserve Wednesday. |
| Tatum Bethune Status: Injured Reserve San Francisco 49ers | The 49ers moved Bethune (groin) to injured reserve Wednesday. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Pearsall (knee) will not practice Wednesday, Vic Tafur of The Athletic reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Jordan Elliott Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Questionable San Francisco 49ers | KIttle (ankle) practiced on a limited basis Wednesday, Matt Barrows of The Athletic reports. |
| 2026-01-05 |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Luke Gifford Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that he expects Purdy (shoulder) to be a full participant in practice throughout the week leading up to Sunday's wild-card game at Philadelphia, David Lombardi of SFStandard.com reports. |
| Tatum Bethune Status: Out San Francisco 49ers | out |
| Tatum Bethune Status: Out San Francisco 49ers | 49ers' head coach Kyle Shanahan has ruled out the possibility of Bethune (groin) returning for the playoffs, David Lombardi of SFStandard.com reports. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Warner (ankle - IR) can return in the playoffs, but only if the team makes a deep playoff run, Matt Barrows reports. |
| Eric Kendricks Status: Active San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Kendricks has moved into the starting role at linebacker with Tatum Bethune out for the remainder of the season, Matt Maiocco of NBC Sports Bay Area reports. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Cowing (hamstring) will have his practice window opened Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Gifford (quadriceps) will be evaluated throughout the week to determine his status for the wild-card round, Nick Wagoner of ESPN.com reports. |
| 2026-01-04 |
| Trent Williams Status: Out San Francisco 49ers | Williams (hamstring) is inactive for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Keion White Status: Active San Francisco 49ers | White (groin) is active for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Questionable San Francisco 49ers | Winters suffered an ankle injury in Saturday's game against the Seahawks and is questionable to return. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed the ball eight times for 23 yards in Saturday's 13-3 loss to the Seahawks. He added six receptions on seven targets for 34 yards. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune is questionable to return to Saturday's game against the Seahawks due to a groin injury, Nick Wagoner of ESPN.com reports. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro converted his only field-goal attempt of 48 yards in Saturday's 13-3 loss to Seattle. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges logged 11 snaps on special teams and was not used on offense in Saturday's 13-3 loss to the Seahawks. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne failed to catch his only target in Saturday's 13-3 loss to the Seahawks. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings recorded four receptions on six targets for 35 yards in Saturday's 13-3 loss to the Seahawks. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed two times for nine yards and was not targeted as a receiver in Saturday's 13-3 loss to Seattle. |
| George Kittle Status: Active San Francisco 49ers | Kittle recorded five receptions on seven targets for 29 yards in Saturday's 13-3 loss to the Seahawks. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson had three receptions on four targets for 24 yards in Saturday's 13-3 loss to the Seahawks. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 19 of 27 passes for 127 yards, no touchdowns and one interception in Saturday's 13-3 loss to the Seahawks. |
| Brock Purdy Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan relayed that Purdy suffered a "stinger" after taking a hard hit to his left shoulder on the 49ers' final offensive play of Saturday's 13-3 loss to the Seahawks, Noah Furtado and Eric Branch of the San Francisco Chronicle report. "It's just I got hit, and the left shoulder sort of lit up," Purdy said after the contest. "I feel good right now. We'll see how I feel [Sunday]." |
| Dee Winters Status: Questionable San Francisco 49ers | Winters could miss the wild-card round of the NFC playoffs due to an ankle injury he sustained during the 49ers' 13-3 loss to the Seahawks on Saturday, Noah Furtado and Eric Branch of the San Francisco Chronicle report. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan told reporters after the 49ers' 13-3 loss to the Seahawks on Saturday that Bethune's groin injury could prevent him from playing in the wild-card round of the NFC playoffs, Noah Furtado and Eric Branch of the San Francisco Chronicle report. |
| 2026-01-03 |
| Curtis Robinson Status: Out San Francisco 49ers | Robinson (coach's decision) is inactive for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne is in line for more work Saturday versus the Seahawks with Ricky Pearsall (knee/ankle) inactive, Brianna Jeannel of the 49ers' official site reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (concussion) is active for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee/ankle) is inactive for Saturday's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Chase Lucas Status: Out San Francisco 49ers | inactive |
| Isaac Guerendo Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| 2026-01-02 |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (concussion) is questionable to play against the Seahawks on Saturday. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (knee) will not carry an injury designation into Saturday's contest against the Seahawks. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (hip) does not have an injury designation for Saturday's matchup versus Seattle. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) is questionable to play Saturday versus the Seahawks. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) is listed as questionable for Saturday's game against the Seahawks. |
| 2026-01-01 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) is listed as questionable for Saturday's game versus the Seahawks, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (back) doesn't have a designation for Saturday's game against the Seahawks, Nick Wagoner of ESPN.com reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (hip) was a limited practice participant Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (ankle/knee) was limited at practice Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) was limited in practice Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (back) practiced in a limited capacity Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-12-31 |
| Keion White Status: Questionable San Francisco 49ers | White (groin) did not participate in Tuesday's practice, Nick Wagoner of ESPN.com reports. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | San Francisco head coach Kyle Shanahan said Friday that Cowing (hamstring) could have his 21-day practice window opened during Week 18 prep, Matt Barrows of The Athletic reports. |
| Jordan James Status: Active San Francisco 49ers | James played just two snaps -- both on special teams -- in Sunday's 42-38 win over the Bears. |
| Skyy Moore Status: Active San Francisco 49ers | Moore carried once for 10 yards and brought back two punts for 11 yards and four kickoffs for 92 yards in Sunday's 42-38 win over the Bears. |
| George Kittle Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Wednesday that Kittle (ankle) is trending in the right direction to suit up Saturday night versus the Seahawks, Cam Inman of The San Jose Mercury News reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Wednesday that McCaffrey (back) is trending in the right direction to play Saturday against the Seahawks, Cam Inman of The San Jose Mercury News reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (neck) is expected to be listed as a full participant at practice Tuesday, Nick Wagoner of ESPN.com reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (hip) did not participate in Tuesday's practice, Nick Wagoner of ESPN.com reports. |
| Keion White Status: Questionable San Francisco 49ers | questionable |
| 2025-12-30 |
| George Kittle Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) will be a limited participant in Tuesday's practice, David Lombardi of SFStandard.com reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (back) will not practice Tuesday, Matt Barrows of The Athletic reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) won't participate in practice Tuesday, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (hamstring) was a limited participant in Tuesday's practice, Matt Barrows of The Athletic reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (concussion) was a limited participant in Tuesday's practice, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) will be limited in Tuesday's practice, Matt Barrows of The Athletic reports. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha registered three tackles (two solo) and one pass defense during San Francisco's 42-38 win over Chicago on Sunday. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown registered four tackles (one solo) and one pass defense during the 49ers' 42-38 win over the Bears on Sunday. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune logged 11 tackles (seven solo), including one stop for a loss, and one pass defense during the 49ers' 42-38 win over the Bears on Sunday. |
| 2025-12-29 |
| Curtis Robinson Status: Out San Francisco 49ers | Robinson (coach's decision) is inactive for Sunday night's contest against the Bears. |
| Isaac Guerendo Status: Out San Francisco 49ers | Guerendo (coach's decision) is inactive for Sunday night's contest against Chicago. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges is poised for a bigger role in the 49ers offense Sunday versus the Bears with George Kittle (ankle) inactive, Briana Jeannel of the team's official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Sunday night's contest against the Bears. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) is questionable to return to Sunday night's contest against the Bears. |
| Renardo Green Status: Out San Francisco 49ers | out |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson caught both of his targets for 30 yards in Sunday's 42-38 win over the Bears. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson took four carries for 22 yards and grabbed his only target for six yards in Sunday's 42-38 win over Chicago. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (concussion) will not return to Sunday night's game against the Bears, Eric Branch of the San Francisco Chronicle reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) has been ruled out for the rest of Sunday night's contest against the Bears. |
| Luke Farrell Status: Active San Francisco 49ers | Farrell logged 27 snaps on offense (38 percent) and was not targeted in Sunday's 42-38 win over the Bears. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne caught his only target for 25 yards in Sunday's 42-38 win over the Bears. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey took 23 carries for 140 yards and a touchdown while corralling four of six targets for 41 yards in Sunday's 42-38 win over the Bears. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 24 of 33 pass attempts for 303 yards, three touchdowns and one interception while taking six carries for 28 yards and two touchdowns in Sunday's 42-38 win over Chicago. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro didn't attempt a field goal in Sunday night's 42-38 win over the Bears but converted all six of his extra-point tries. |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) will remain on the 49ers' reserve/non-football injury list for the rest of the 2025 season, Matt Maiocco of NBC Sports Bay Area reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings had two receptions on four targets for 42 yards and a touchdown in Sunday's 42-38 victory over Chicago. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges corralled seven of nine targets for 60 yards and a touchdown in Sunday's 42-38 win over the Bears. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (ankle/knee) had five receptions on eight targets for 85 yards in Sunday's 42-38 win over the Bears. |
| 2025-12-28 |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (ankle/knee) is active for Sunday's game against the Bears, Briana Jeannel of the 49ers' official site reports. |
| Renardo Green Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| George Kittle Status: Out San Francisco 49ers | Kittle (ankle) is listed as inactive Sunday against the Bears, Briana Jeannel of the 49ers' official site reports. |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) plans to work out before Sunday night's game against the Bears to determine if he will be able to play versus Chicago, Ian Rapoport of NFL Network reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (ankle/knee) remains listed as questionable for Sunday's game against the Bears but is likely to play, Adam Schefter of ESPN reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) remains listed as questionable for Sunday's game against the Bears but is considered "highly unlikely" to play, Adam Schefter of ESPN reports. |
| 2025-12-27 |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) is ahead of schedule in his recovery and could be a candidate to return to action if the 49ers make a deep playoff run, Ian Rapoport and Mike Garafolo of NFL Network report. |
| Brayden Willis Status: Active San Francisco 49ers | The 49ers elevated Willis from the practice squad to the active roster ahead of Sunday's game against the Bears. |
| 2025-12-26 |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) was a limited participant at practice Thursday, Cam Inman of The San Jose Mercury News reports. |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) has been ruled out for Sunday's game against Chicago, Matt Maiocco of NBC Sports Bay Area reports. |
| Renardo Green Status: Out San Francisco 49ers | Green (neck) has been Matt Maiocco of NBC Sports Bay Area for Sunday's game against the Bears, Matt reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (ankle/knee) is listed as questionable for Sunday's game versus the Bears, Matt Maiocco of NBC Sports Bay Area reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) is listed as questionable for Sunday's game against the Bears, Matt Maiocco of NBC Sports Bay Area reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (knee) doesn't have an injury designation ahead of Sunday's game against the Bears, Matt Barrows of The Athletic reports. |
| George Kittle Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Friday that the status of Kittle (ankle) for Sunday night's game against the Bears will likely be a game-dime decision, Cam Inman of The San Jose Mercury News reports. |
| 2025-12-25 |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) did not practice Wednesday, per the NFL's injury report. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) was a limited participant in Wednesday's practice, per the NFL's injury report. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune (ankle) was a full participant in Wednesday's practice, per the NFL's injury report. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) was listed as limited on Thursday's practice report, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) was listed as a non-participant on Thursday's injury report, Cam Inman of The San Jose Mercury News reports. |
| 2025-12-24 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Pearsall (knee/ankle) will be limited at practice Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| George Kittle Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Kittle (ankle) won't practice Wednesday but "has a chance" to play Sunday against the Bears, Nick Wagoner of ESPN.com reports. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown tallied nine tackles (five solo) and forced a fumble Sunday in a 48-27 win against the Colts. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha tallied eight tackles (three solo) in Monday's 48-27 victory against Indianapolis. |
| Dee Winters Status: Active San Francisco 49ers | Winters logged three tackles (one solo) and two defensed passes, including an interception that he returned for a touchdown, in Monday's 48-27 victory versus the Colts. |
| 2025-12-23 |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro converted two of three field-goal attempts and all six PATs in Monday night's 48-27 win over the Colts. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (hamstring) is active for Monday night's game against the Colts. |
| Curtis Robinson Status: Out San Francisco 49ers | Robinson (coach's decision) is inactive for Monday night's game against the Colts. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins is active for Monday night's game against the Colts. |
| Jordan James Status: Active San Francisco 49ers | James is active for Monday night's game against the Colts. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges caught one of two targets for seven yards in Monday's 48-27 win over the Colts. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed five times for 20 yards while failing to catch his only target in Monday's 48-27 win over Indianapolis. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle was diagnosed with a low-to-mid-grade ankle sprain following an MRI on Tuesday, Jeremy Fowler of ESPN.com reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (ankle) is questionable to return to Monday's game against the Colts. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle is dealing with an ankle injury and is questionable to return to Monday's Week 16 matchup against Indianapolis, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey handled 21 carries for 117 yards and caught six of eight targets for 29 yards and a pair of touchdowns in Monday's 48-27 win over Indianapolis. |
| George Kittle Status: Questionable San Francisco 49ers | San Francisco coach Kyle Shanahan said after Monday's 48-27 win against the Colts that it's too early to know the severity of Kittle's ankle injury, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 25 of 34 pass attempts for 295 yards, five touchdowns and one interception while taking two carries for 11 yards in Monday's 48-27 rout of the Colts. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson had two receptions on as many targets for 22 yards and a touchdown in Monday's 48-27 win over Indianapolis. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne had three receptions on five targets for 27 yards in Monday's 48-27 win over the Colts. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings corralled five of six targets for 71 yards and a touchdown in Monday's 48-27 win over the Colts. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| 2025-12-22 |
| Isaac Guerendo Status: Out San Francisco 49ers | Guerendo (coach's decision) is inactive for Monday night's game against the Colts. |
| Ricky Pearsall Status: Out San Francisco 49ers | inactive |
| Chase Lucas Status: Out San Francisco 49ers | inactive |
| Renardo Green Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| Eric Kendricks Status: Active San Francisco 49ers | Kendricks was elevated from the 49ers' practice squad to the active roster Monday. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (hamstring) was activated off the 49ers' injured reserve list Monday, Adam Schefter of ESPN reports. |
| 2025-12-21 |
 | Spencer Burford Status: Active San Francisco 49ers | Burford (ankle) doesn't have an injury designation ahead of Monday night's game against the Colts. |
| 2025-12-20 |
| Jordan Elliott Status: Active San Francisco 49ers | Elliott (knee) does not carry an injury designation for Monday's game against the Colts. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu (ankle) does not carry an injury designation for Monday's game against Indianapolis. |
| Spencer Burford Status: Active San Francisco 49ers | NA |
| Nick Martin Status: Injured Reserve San Francisco 49ers | The 49ers placed Martin (concussion) on injured reserve Saturday. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune (ankle) is cleared for Monday's game against the Colts, Matt Barrows of The Athletic reports. |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Gross-Matos (hamstring/knee) is officially listed as questionable for Monday's game against the Colts, Matt Maiocco of NBC Sports Bay Area reports. |
| Renardo Green Status: Out San Francisco 49ers | Green (neck) has been ruled out for Monday's contest against the Colts, Matt Maiocco of NBC Sports Bay Area reports. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne is poised to take on a larger role against the Colts on Monday after Ricky Pearsall (knee/ankle) was officially ruled out, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee/ankle) has been ruled out for Monday's game against the Colts, Matt Maiocco of NBC Sports Bay Area reports. |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) is ruled out for Monday's game against the Colts, Briana Jeannel of the team's official site reports. |
| 2025-12-19 |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (ankle) was a limited participant in Friday's practice, Nick Wagoner of ESPN.com reports. |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (ankle) logged a limited practice Thursday, Cam Inman of The San Jose Mercury News reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) practiced in limited fashion Thursday, Cam Inman of The San Jose Mercury News reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) isn't practicing Friday, Cam Inman of The San Jose Mercury News reports. |
| Spencer Burford Status: Questionable San Francisco 49ers | Burford (ankle) did not practice Thursday, Cam Inman of The San Jose Mercury News reports. |
| 2025-12-18 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Pearsall (knee/ankle) won't practice Thursday, but the wide receiver is feeling much better and has a chance to play Monday at Indianapolis, Nick Wagoner of ESPN.com reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (ankle) will be limited at practice Thursday, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
| 2025-12-17 |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha logged 10 tackles (six solo) during the 49ers' win over the Titans on Sunday. |
| 2025-12-16 |
| Tatum Bethune Status: Out San Francisco 49ers | Head coach Kyle Shanahan relayed Monday that he expects Bethune (ankle) to return to practice for Week 16 prep, Matt Barrows of The Athletic reports. |
| Jordan Elliott Status: Out San Francisco 49ers | Elliott (knee) is expected to practice this week, Matt Barrows of The Athletic reports. |
| Sam Okuayinonu Status: Out San Francisco 49ers | Okuayinonu (ankle) is expected to return to practice during Week 16 prep, Matt Barrows of The Athletic reports. |
| Spencer Burford Status: Active San Francisco 49ers | Burford avoided a high ankle sprain after exiting Sunday's win over the Titans, David Lombardi of SFStandard.com reports. |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Monday that Gross-Matos (hamstring) should return to practice ahead of the 49ers' Week 16 tilt against the Colts on Monday, Dec. 22, Matt Barrows of The Athletic reports. |
| Nick Martin Status: Out San Francisco 49ers | Martin remains in the league's concussion protocol Monday, Matt Barrows of The Athletic reports. |
| 2025-12-15 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (back) took 22 carries for 73 yards and a touchdown while grabbing his only target for 14 yards in Sunday's 37-24 win over Tennessee. |
| Sam Okuayinonu Status: Out San Francisco 49ers | out |
| Nick Martin Status: Out San Francisco 49ers | out |
| Jordan Elliott Status: Out San Francisco 49ers | out |
| Tatum Bethune Status: Out San Francisco 49ers | out |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro went 3-for-3 on field-goal attempts and made all four of his PATs in Sunday's 37-24 win over the Titans. |
| Sebastian Valdez Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that Pearsall played through ankle and knee injuries during Sunday's 37-24 win over Tennessee, Mike Masala of USA Today reports. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne had two receptions on three targets for 17 yards in Sunday's 37-24 win over the Titans. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson hauled in both of his targets for 36 yards in Sunday's 37-24 win over Tennessee. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo logged three snaps on special teams in Sunday's 37-24 win over the Titans. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed nine times for 21 yards and returned two kicks for 53 yards in Sunday's 37-24 win over the Titans. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 23 of 30 pass attempts for 295 yards and three touchdowns while adding seven carries for 44 yards and a lost fumble in Sunday's 37-24 win over the Titans. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Coach Kyle Shanahan acknowledged Monday that he's unsure whether Pearsall (knee/ankle) will practice this week, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall hauled in six of seven targets for 96 yards in Sunday's 37-24 win over Tennessee. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings finished with three receptions on five targets for 37 yards and two touchdowns in Sunday's 37-24 win over the Titans. |
| George Kittle Status: Active San Francisco 49ers | Kittle brought in eight of nine targets for 88 yards and a touchdown in Sunday's 37-24 win over the Titans. |
| 2025-12-14 |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's matchup against Tennessee. |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Sebastian Valdez Status: Out San Francisco 49ers | inactive |
| Sam Okuayinonu Status: Out San Francisco 49ers | inactive |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (back) is active for Sunday's game against the Titans. |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Tatum Bethune Status: Out San Francisco 49ers | inactive |
| Jordan Elliott Status: Out San Francisco 49ers | Elliot (knee) has been ruled out for Sunday's game against the Titans, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-12-13 |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) is out for Sunday's game versus the Titans, Cam Inman of The San Jose Mercury News reports. |
| Nick Martin Status: Out San Francisco 49ers | Martin (concussion) is out for Sunday's game versus Tennessee, Cam Inman of The San Jose Mercury News reports. |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Gross-Matos (hamstring) is out for Sunday's game versus Tennessee, Cam Inman of The San Jose Mercury News reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | Although he was added to the 49ers' injury report Saturday, McCaffrey (back) is expected to play against the Titans on Sunday, Adam Schefter of ESPN reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | The 49ers placed Aiyuk (knee) on the reserve/left squad list Saturday, Matt Barrows of The Athletic reports. |
| 2025-12-12 |