Injuries
| 2025-09-16 |
 | Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Out San Francisco 49ers | out |
 | Ben Bartch Status: Out San Francisco 49ers | Bartch will be sidelined for a few weeks after suffering a high-ankle sprain in Sunday's win over the Saints, Jennifer Lee Chan of NBC Sports Bay Area reports. |
 | Siran Neal Status: Questionable San Francisco 49ers | Neal has entered the league's concussion protocol following the 49ers' Week 2 win over the Saints, Nick Wagoner of ESPN.com reports. |
| Ben Bartch Status: Doubtful San Francisco 49ers | Bartch suffered a high ankle sprain during the 49ers' win over New Orleans on Sunday, Nick Wagoner of ESPN reports. |
 | Spencer Burford Status: Questionable San Francisco 49ers | Burford suffered a knee injury in Sunday's 26-21 win over the Saints, David Lombardi of SFStandard.com reports. |
| 2025-09-15 |
 | Nick Bosa Status: Active San Francisco 49ers | Bosa recorded nine total tackles (three solo), including 1.0 sacks, during Sunday's 26-21 win over the Saints. |
 | Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed six times for 20 yards and caught his only target for a loss of one yard in Sunday's 26-21 win over New Orleans. |
 | Marquez Valdes-Scantling Status: Active San Francisco 49ers | Valdes-Scantling failed to bring in his only target in Sunday's 26-21 win over the Saints. |
 | Jake Tonges Status: Active San Francisco 49ers | Tonges finished with four receptions on five targets for 31 yards in Sunday's 26-21 win over the Saints. |
 | Luke Farrell Status: Active San Francisco 49ers | Farrell brought in two of three targets for 15 yards and a touchdown in Sunday's 26-21 win over the Saints. |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
 | Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan noted Monday that Jennings came out of Week 2 action with an ankle injury, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Ben Bartch Status: Doubtful San Francisco 49ers | doubtful |
 | Eddy Pineiro Status: Active San Francisco 49ers | Pineiro went 2-for-3 on extra-point attempts and made both of his field-goal tries during the 49ers' 26-21 win over the Saints on Sunday. |
| Brock Purdy Status: Out San Francisco 49ers | out |
 | Jordan Jefferson Status: Active San Francisco 49ers | NA |
 | Nick Martin Status: Active San Francisco 49ers | NA |
 | Austen Pleasants Status: Active San Francisco 49ers | NA |
 | Drew Moss Status: Active San Francisco 49ers | NA |
 | Fred Warner Status: Active San Francisco 49ers | Warner recorded 11 total tackles (seven solo), one pass defended, one forced fumble and one fumble recovery in Sunday's 26-21 win over the Saints. |
 | Isaac Guerendo Status: Active San Francisco 49ers | Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints. |
| 2025-09-14 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings, who is questionable to play Sunday against New Orleans due to a shoulder injury, is considered a game-time decision, though there is "optimism he goes," Ian Rapoport of NFL Network reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings caught five of 10 targets for 89 yards and a touchdown in Sunday's 26-21 win over New Orleans. |
 | Mac Jones Status: Active San Francisco 49ers | Jones completed 26 of 39 passes for 279 yards and three touchdowns in Sunday's 26-21 win over the Saints. He added six rushing yards on six carries. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe/shoulder), who has been ruled out for Sunday's game in New Orleans, is considered unlikely to be available for the 49ers' Week 3 game versus the Cardinals, though his condition his improved over the past week, Adam Schefter of ESPN reports. "We'll see for next week," one source told Schefter, regarding Purdy's status. "Next week will be tight, but he progressed a lot this week." |
 | Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey carried the ball 13 times for 55 yards and caught six of seven targets for 52 yards and a touchdown in Sunday's 26-21 win over the Saints. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) remains listed as questionable but is expected to play Sunday in New Orleans, Adam Schefter of ESPN reports. |
 | Kendrick Bourne Status: Active San Francisco 49ers | Bourne caught all three of his targets for 32 yards in Sunday's 26-21 win over the Saints. |
 | Ricky Pearsall Status: Active San Francisco 49ers | Pearsall caught four of six targets for 56 yards in Sunday's 26-21 win over the Saints. He also had minus-four yards on his only carry. |
 | Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Saints, Briana Jeannel of the 49ers' official site reports. |
 | Trent Williams Status: Active San Francisco 49ers | Williams (knee) is active for Sunday's matchup with the Saints, Briana Jeannel of the 49ers' official site reports. |
 | Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Sunday's game at New Orleans, Briana Jeannel of the 49ers' official site reports. |
| Austen Pleasants Status: Out San Francisco 49ers | inactive |
| Drew Moss Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Jordan Jefferson Status: Out San Francisco 49ers | inactive |
| Siran Neal Status: Questionable San Francisco 49ers | Neal is being evaluated for a concussion and is questionable to return to Sunday's game against the Saints, Jennifer Lee Chan of NBC Sports Bay Area reports. |
 | Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk has been ruled out for the rest of Sunday's game against the Saints due to a concussion, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch has an ankle injury and is questionable to return to Sunday's matchup with the Saints. |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch (ankle) has been downgraded to out for the rest of Sunday's game against the Saints, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-09-13 |
| Jordan James Status: Active San Francisco 49ers | James (finger) doesn't have an injury designation heading into Sunday's Week 2 contest against the Saints, Noah Furtado of the San Francisco Chronicle reports. |
 | Brayden Willis Status: Active San Francisco 49ers | Willis was elevated from the 49ers' practice squad to the active roster Saturday. |
 | Adrian Martinez Status: Active San Francisco 49ers | Martinez was elevated from the 49ers' practice squad to the active roster Saturday. |
| 2025-09-12 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) returned to practice Friday, Noah Furtado of the San Francisco Chronicle reports. |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has been ruled out for Sunday's game at New Orleans, Matt Maiocco of NBC Sports Bay Area reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) is listed as questionable for Sunday's game at New Orleans, Matt Maiocco of NBC Sports Bay Area reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones will start Sunday's game at New Orleans in place of Brock Purdy (toe), Adam Schefter of ESPN reports. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins (ankle) doesn't have a designation for Sunday's game in New Orleans, Noah Furtado of the San Francisco Chronicle reports. |
 | Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) was a limited participant in Thursday's practice, Vic Tafur of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (ankle) was a limited participant in Thursday's practice, Vic Tafur of The Athletic reports. |
| Jordan James Status: Questionable San Francisco 49ers | James (finger) was a limited participant in Thursday's practice, Vic Tafur of The Athletic reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (knee) is questionable for Sunday's Week 2 game against New Orleans, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-09-11 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) was spotted working off to the side with a trainer during Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) officially didn't practice Thursday, Nick Wagoner of ESPN.com reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (ankle) was a limited participant at practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Jordan James Status: Questionable San Francisco 49ers | James (finger) was a limited participant at practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) did not participate at practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Brock Purdy Status: Doubtful San Francisco 49ers | Purdy, who coach Kyle Shanahan has called a "long shot" to play Sunday against the Saints, per Briana Jeannel of the 49ers' official site, could miss two-to-five weeks with a turf toe variant, according to Ian Rapoport of NFL Network. |
| 2025-09-10 |
| Mac Jones Status: Active San Francisco 49ers | San Francisco coach Kyle Shanahan suggested Jones is likely to start Sunday's game at New Orleans in place of Brock Purdy (toe, shoulder), Nick Wagoner of ESPN.com reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) won't take part in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe/left shoulder) won't practice Wednesday, Vic Tafur of The Athletic. Shanahan added that Purdy is "a long shot" to play Sunday at New Orleans, per David Lombardi of SFStandard.com. |
| Ben Bartch Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Luke Farrell Status: Active San Francisco 49ers | Farrell and Jake Tonges are in line for increased snaps, beginning Sunday versus the Saints, with starting tight end George Kittle (hamstring) having been placed on IR and out a minimum of four games, Dianna Russini, Vic Tafur and Matt Barrows of The Athletic report. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges and Luke Farrell are in line for more snaps at tight end, beginning Sunday versus the Saints, with George Kittle (hamstring) on IR and set to miss at least four games, Dianna Russini, Vic Tafur and Matt Barrows of The Athletic report. |
| 2025-09-09 |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Jordan James Status: Questionable San Francisco 49ers | questionable |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro agreed to a one-year contract with the 49ers on Tuesday, Adam Schefter of ESPN reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings appears to have avoided a serious injury to his left shoulder after he underwent an MRI on Monday, Ian Rapoport of NFL Network reports. |
 | George Kittle Status: Out San Francisco 49ers | The 49ers are expected to place Kittle (hamstring) on injured reserve within the next few days, Adam Schefter of ESPN reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | The 49ers placed Kittle (hamstring) on injured reserve Tuesday. |
 | Russell Gage Jr. Status: Active San Francisco 49ers | Gage reverted to San Francisco's practice squad Monday, per the NFL's transaction log. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa recorded six solo tackles, including 1.0 sacks, while also adding a forced fumble and a fumble recovery in Sunday's 17-13 win over the Seahawks. |
| 2025-09-08 |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne has agreed to terms Monday on a one-year contract worth up to $5 million with San Francisco, Adam Schefter of ESPN reports. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges hauled in all three of his targets for 15 yards and a touchdown in Sunday's 17-13 win over Seattle. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo played 15 snaps on special teams and did not receive a carry in Sunday's 17-13 win over the Seahawks. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed nine times for 33 yards with one reception for four yards on two targets in Sunday's 17-13 win over Seattle. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk had two receptions on as many targets for 32 yards in Sunday's 17-13 win over Seattle. |
| Luke Farrell Status: Active San Francisco 49ers | Farrell brought in his only target for four yards in Sunday's 17-13 win over the Seahawks. |
| Marquez Valdes-Scantling Status: Active San Francisco 49ers | Valdes-Scantling logged 27 snaps on offense and did not receive a target in Sunday's 17-13 win over the Seahawks. |
 | Skyy Moore Status: Active San Francisco 49ers | Moore did not receive a target and returned five combined kicks for 63 yards in Sunday's 17-13 win over Seattle. |
| Jordan Jefferson Status: Active San Francisco 49ers | NA |
| Nick Martin Status: Active San Francisco 49ers | NA |
 | Robert Beal Jr. Status: Active San Francisco 49ers | NA |
| Austen Pleasants Status: Active San Francisco 49ers | NA |
| Drew Moss Status: Active San Francisco 49ers | NA |
| Brock Purdy Status: Questionable San Francisco 49ers | The 49ers are expected to give Purdy (toe/shoulder) the entire week ahead of this coming Sunday's game at New Orleans to see if he'll be healthy enough to play, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| George Kittle Status: Out San Francisco 49ers | Kittle likely will miss 3-to-5 weeks due to the hamstring injury he sustained during Sunday's victory at Seattle, Ian Rapoport of NFL Network reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | The 49ers are awaiting the results of imaging done on Jennings' shoulder, Nick Wagoner of ESPN.com reports. |
 | Jake Moody Status: Active San Francisco 49ers | Moody went 1-for-3 on field-goal tries and 2-for-2 on PATs in Sunday's 17-13 win over the Seahawks. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 26 of 35 pass attempts for 277 yards, two touchdowns and two interceptions while taking five carries for 17 yards in Sunday's 17-13 win over the Seahawks. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall brought in four of seven targets for 108 yards in Sunday's 17-13 win over Seattle. |
| Fred Warner Status: Active San Francisco 49ers | Warner tallied eight total tackles (four solo), including one tackle for loss, in Sunday's 17-13 win over the Seahawks. |
 | Colton McKivitz Status: Active San Francisco 49ers | McKivitz signed a three-year, $45 million extension with the 49ers on Monday, Adam Schefter of ESPN reports. |
| 2025-09-07 |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (calf) remains listed as questionable for Sunday's game in Seattle, though he's still "trending" toward playing after he was a "big participant" in the 49ers' team walk-through Saturday, Ian Rapoport of NFL Network reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (calf) remains listed as questionable but is expected to play in Sunday's season opener against the Seahawks, Adam Schefter of ESPN reports. "He's good to go," one source told Schefter. |
| George Kittle Status: Out San Francisco 49ers | Kittle won't return to Sunday's game at Seattle due to a hamstring injury, Adam Schefter of ESPN reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings exited Sunday's game in Seattle due to a left shoulder injury, Adam Schefter of ESPN reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) will have an MRI within the next 24 hours to determine the severity of his injury, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (hamstring) will have an MRI within the next 24 hours to determine the severity of his injury, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (calf) handled 22 carries for 69 yards and nine receptions for 73 yards on 10 targets in Sunday's 17-13 win over the Seahawks. |
 | Marques Sigle Status: Active San Francisco 49ers | Sigle will be the 49ers' starting safety against the Seahawks on Sunday, Matt Maiocco of NBC Sports Bay Area reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (ankle) has been ruled out for Sunday's game against the Seahawks. |
| Jordan James Status: Out San Francisco 49ers | James (finger) is inactive for Sunday's game against the Seahawks. |
| Austen Pleasants Status: Out San Francisco 49ers | inactive |
| Drew Moss Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Jordan Jefferson Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (calf) is active for Sunday's game against the Seahawks. |
| 2025-09-06 |
| Russell Gage Jr. Status: Active San Francisco 49ers | The 49ers elevated Gage (knee) from the practice squad to the active roster ahead of Sunday's game at Seattle. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (calf), who is officially listed as questionable for Sunday's road game against the Seahawks, is expected to suit up unless he suffers any setbacks, Ian Rapoport of NFL Network reports. |
| 2025-09-05 |
 | Dominick Puni Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Jordan James Status: Doubtful San Francisco 49ers | James (finger) is listed as doubtful for Sunday's contest in Seattle, Matt Maiocco of NBC Sports Bay Area reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Coach Kyle Shanahan said Friday that Jennings (calf) is "good to go" for Sunday's contest at Seattle, Cam Inman of The San Jose Mercury News reports. "He's had a real good week," Shanahan added. "[He's] gotten better and better throughout the week, and I'm excited to see him out there Sunday." |
| Christian McCaffrey Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Friday that McCaffrey (calf) is listed as questionable for Sunday's game in Seattle, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (calf), who is listed as questionable for Sunday's game at Seattle, said Friday that he "feels great" and is preparing to suit up Week 1, David Lombardi of SFStandard.com reports. |
| Jordan Watkins Status: Doubtful San Francisco 49ers | Watkins (ankle) is listed as doubtful for Sunday's game at Seattle, Matt Maiocco of NBC Sports Bay Area reports. |
| Dominick Puni Status: Active San Francisco 49ers | Puni (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athletic reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (calf) practiced on a limited basis Thursday, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athleticreports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) was a limited participant in Thursday's practice. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (ankle) was a limited participant in Thursday's practice. |
| Jordan James Status: Questionable San Francisco 49ers | James (finger) was a limited participant in Thursday's practice. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (calf) is warming up in uniform at the start of Friday's practice, Nick Wagoner of ESPN.com reports. |
| 2025-09-04 |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey was limited at Thursday's practice due to a calf injury, Cam Inman of The San Jose Mercury News reports. |
 | Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu (shoulder) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) did not participate in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
 | CJ West Status: Active San Francisco 49ers | West (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
 | Upton Stout Status: Active San Francisco 49ers | Stout (calf) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
 | Mykel Williams Status: Active San Francisco 49ers | Williams (knee) practiced in full Wednesday, Cam Inman of The San Jose Mercury News reports. |
 | Jason Pinnock Status: Active San Francisco 49ers | Pinnock (heel) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
 | Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (hip) was not listed on the 49er's injury report Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (neck) was not listed on Wednesday's injury report, Cam Inman of The San Jose Mercury News reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | The 49ers and Jennings (calf) agreed to add $3 million in play-time incentives to his contract for the 2025 season, Adam Schefter of ESPN reports. |
| Dominick Puni Status: Questionable San Francisco 49ers | Puni (knee) was a limited participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Ben Bartch Status: Active San Francisco 49ers | Bartch (elbow) was a full participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| 2025-09-03 |
 | Tanner Mordecai Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Deommodore Lenoir Status: Active San Francisco 49ers | NA |
| Nick Bosa Status: Active San Francisco 49ers | NA |
| CJ West Status: Active San Francisco 49ers | NA |
| Jason Pinnock Status: Active San Francisco 49ers | NA |
| Mykel Williams Status: Active San Francisco 49ers | NA |
| Upton Stout Status: Active San Francisco 49ers | NA |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| Mac Jones Status: Active San Francisco 49ers | NA |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (ankle) was a non-participant at Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jennings (calf) will be a limited participant at Wednesday's practice, Nick Wagoner of ESPN.com reports. |
| 2025-09-02 |
| Marquez Valdes-Scantling Status: Active San Francisco 49ers | The 49ers signed Valdes-Scantling to the active roster from the practice squad Tuesday, Aaron Wilson of KPRC 2 Houston reports. |
 | Evan Anderson Status: Active San Francisco 49ers | The 49ers signed Anderson to their practice squad on Friday. |
| 2025-09-01 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (calf) is participating in practice Monday, Nick Wagoner of ESPN.com reports. |
 | Isaiah Prince Status: Questionable San Francisco 49ers | questionable |
| 2025-08-28 |
| Russell Gage Jr. Status: Questionable San Francisco 49ers | Gage (knee) is re-signing with the 49ers on Thursday, Adam Schefter of ESPN reports. |
| Russell Gage Jr. Status: Questionable San Francisco 49ers | Gage (knee) didn't practice Thursday, Matt Barrows of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (ankle) didn't practice Thursday, Matt Barrows of The Athletic reports. |
| Tanner Mordecai Status: Injured Reserve San Francisco 49ers | Modecai (undisclosed) cleared waivers and reverted to injured reserve Wednesday. |
 | Carter Bradley Status: Injured Reserve San Francisco 49ers | Bradley (undisclosed) cleared waivers and reverted to injured reserve Wednesday. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (calf) returned to practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
 | Jakob Robinson Status: Injured Reserve San Francisco 49ers | Robinson (forearm) was placed on injured reserve Tuesday. |
| 2025-08-27 |
 | Jacob Cowing Status: Injured Reserve San Francisco 49ers | ir |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | The 49ers placed Cowing (hamstring) on injured reserve Wednesday. |
| Jauan Jennings Status: Questionable San Francisco 49ers | The 49ers are unsure if Jennings (calf/contract) will play Week 1 at Seattle, but GM John Lynch said Wednesday that he won't trade the wide receiver, ESPN.com's Nick Wagoner reports. |
 | Kevin Givens Status: Injured Reserve San Francisco 49ers | Givens (pectoral) was placed on injured reserve Tuesday. |
| Jordan James Status: Questionable San Francisco 49ers | James (finger) returned to practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (undisclosed) was activated from the active/PUP list Tuesday. |
| Tanner Mordecai Status: Injured Reserve San Francisco 49ers | ir |
 | Malik Mustapha Status: Out San Francisco 49ers | Mustapha (knee) was placed on the reserve/PUP list Tuesday. |
| Carter Bradley Status: Injured Reserve San Francisco 49ers | ir |
 | Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) was placed on the reserve/non-football injury list Tuesday. |
| 2025-08-26 |
 | Brandon Aiyuk Status: Out San Francisco 49ers | The 49ers moved Aiyuk (knee) to the reserve/PUP list Tuesday. |
| Jakob Robinson Status: Injured Reserve San Francisco 49ers | ir |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | ir |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Isaiah Prince Status: Injured Reserve San Francisco 49ers | San Francisco placed Prince (knee) on its injured reserve list Monday. |
| 2025-08-25 |
| Isaiah Prince Status: Injured Reserve San Francisco 49ers | ir |
 | Stone Blanton Status: Active San Francisco 49ers | NA |
| 2025-08-24 |
 | Robbie Chosen Status: Active San Francisco 49ers | Chosen brought in all three of his targets for 24 receiving yards in Saturday's 30-23 preseason win over the Chargers. |
| George Kittle Status: Active San Francisco 49ers | Kittle isn't involved in warmups ahead of Saturday's preseason game against the Chargers, Matt Barrows of The Athletic reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey isn't warming up ahead of Saturday's preseason contest versus the Chargers, Matt Barrows of The Athletic reports. |
| Jacob Cowing Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Cowing (hamstring) could be sidelined for six weeks, Matt Maiocco of NBC Sports Bay Area reports. |
| Jakob Robinson Status: Questionable San Francisco 49ers | questionable |
| Isaiah Prince Status: Questionable San Francisco 49ers | Prince exited Saturday's preseason game against the Chargers with an apparent left knee injury and will not return, Matt Barrows of The Athletic reports. |
| Jakob Robinson Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Robinson is believed to have suffered a broken forearm in Saturday's preseason game against the Chargers, Matt Maiocco of NBC Sports Bay Area reports. |
| Skyy Moore Status: Active San Francisco 49ers | Moore recorded three receptions on six targets for 19 yards in Saturday's 30-23 preseason win over the Chargers. |
 | Demarcus Robinson Status: Suspension San Francisco 49ers | Robinson recorded two receptions on two targets for 30 yards and a touchdown in Saturday's 30-23 preseason win over the Chargers. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo (shoulder) rushed the ball eight times for 13 yards in Saturday's 30-23 preseason win over the Chargers. He added one reception on one target for one yard. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan relayed after Saturday's preseason contest against the Chargers that Jennings (calf) has a chance to be available for a Week 1 road matchup with the Seahawks, Matt Barrows of The Athletic reports. "I expect him to be back, he should be back from it," Shanahan said. "But you never know with a calf." |
| 2025-08-22 |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo may open the season as San Francisco's No. 2 running back even though the team is trading for Brian Robinson, Cam Inman of The San Jose Mercury News reports. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | The Commanders are trading Robinson to the 49ers, Tom Pelissero of NFL Network reports. |
 | Tre Brown Status: Injured Reserve San Francisco 49ers | Brown (heel) was placed on injured reserve Thursday. |
 | Corey Kiner Status: Injured Reserve San Francisco 49ers | Kiner (ankle) reverted to injured reserve with the 49ers on Thursday, Nick Wagoner of ESPN.com reports. |
| 2025-08-21 |
| Russell Gage Jr. Status: Questionable San Francisco 49ers | Gage (knee) is expected to miss 7-to-10 days due to a sprained MCL, Adam Schefter of ESPN reports. |
| Skyy Moore Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said Thursday that Moore is expected to suit up for Saturday's preseason finale against the Chargers, David Lombardi of SFStandard.com reports. |
| Robert Beal Jr. Status: Active San Francisco 49ers | NA |
| Robert Beal Jr. Status: Active San Francisco 49ers | Beal (groin) returned to practice Thursday, Nick Wagoner of ESPN.com reports. |
| Corey Kiner Status: Injured Reserve San Francisco 49ers | ir |
| Tre Brown Status: Injured Reserve San Francisco 49ers | ir |
| Tanner Mordecai Status: Active San Francisco 49ers | Mordecai signed with the 49ers on Thursday. |
 | Malik Knowles Status: Active San Francisco 49ers | The 49ers signed Knowles on Wednesday. |
| Skyy Moore Status: Active San Francisco 49ers | Moore was traded from the Chiefs to the 49ers on Wednesday for a swap of late-round picks, NFL reporter Jordan Schultz reports. |
| Russell Gage Jr. Status: Questionable San Francisco 49ers | questionable |
| 2025-08-20 |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing isn't practicing Wednesday after suffering a lower-body injury Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Demarcus Robinson Status: Suspension San Francisco 49ers | San Francisco head coach Kyle Shanahan said Wednesday that Robinson has been suspended the first three games of the regular season for violating the NFL's substance abuse policy, Adam Schefter of ESPN reports. |
 | Patrick Taylor Jr. Status: Injured Reserve San Francisco 49ers | Taylor will undergo season-ending surgery to repair a fracture in his shoulder, Nick Wagoner of ESPN.com reports. |
| 2025-08-19 |
| Patrick Taylor Jr. Status: Injured Reserve San Francisco 49ers | ir |
| Mac Jones Status: Questionable San Francisco 49ers | Jones is not practicing Tuesday due to an apparent knee injury suffered during Saturday's 22-19 preseason win over the Raiders, Matt Maiocco of NBC Sports Bay Area reports. |
 | Equanimeous St. Brown Status: Questionable San Francisco 49ers | questionable |
 | Ameer Abdullah Status: Questionable San Francisco 49ers | questionable |
| Corey Kiner Status: Doubtful San Francisco 49ers | doubtful |
| Mac Jones Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Tuesday that Jones will miss Saturday's preseason finale against the Chargers due to a knee sprain, Adam Schefter of ESPN reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Tuesday that the 49ers aren't worried about Stout's (calf) availability for Week 1 against the Seahawks on Sept. 7, David Lombardi of SFStandard.com reports. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo (shoulder) participated in Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| Patrick Taylor Jr. Status: Injured Reserve San Francisco 49ers | The 49ers placed Taylor (shoulder) on injured reserve Tuesday, Adam Schefter of ESPN reports. |
 | Nate Sudfeld Status: Active San Francisco 49ers | The 49ers signed Sudfeld on Tuesday, Adam Schefter of ESPN reports. |
| Corey Kiner Status: Questionable San Francisco 49ers | questionable |
| Stone Blanton Status: Questionable San Francisco 49ers | questionable |
 | Jordan Elliott Status: Active San Francisco 49ers | NA |
 | Renardo Green Status: Active San Francisco 49ers | NA |
| Sam Okuayinonu Status: Active San Francisco 49ers | NA |
| Jordan Elliott Status: Active San Francisco 49ers | Elliott (back) participated during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu (groin) participated during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (neck) was limited to individual drills during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| Jason Pinnock Status: Questionable San Francisco 49ers | Pinnock (heel) was limited to individual drills during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (hamstring) participated during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports. |
| 2025-08-18 |
 | Bradlee Anae Status: Questionable San Francisco 49ers | questionable |
| 2025-08-17 |
 | Chazz Surratt Status: Active San Francisco 49ers | NA |
| Kyle Juszczyk Status: Active San Francisco 49ers | NA |
| Marques Sigle Status: Active San Francisco 49ers | NA |
 | Ji'Ayir Brown Status: Active San Francisco 49ers | NA |
| Evan Anderson Status: Active San Francisco 49ers | NA |
 | Tatum Bethune Status: Active San Francisco 49ers | Bethune (ankle) logged two tackles (one solo) during Saturday's 22-19 preseason win over the Raiders. |
| Evan Anderson Status: Active San Francisco 49ers | Anderson (knee) played 27 snaps (25 on offense, two on special teams) but did not otherwise appear in the box score in the 49ers' 22-19 preseason win over the Raiders on Saturday. |
| Chazz Surratt Status: Active San Francisco 49ers | Surratt (undisclosed) tallied six tackles (six solo) during San Francisco's preseason win over the Raiders on Saturday. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle (knee) logged three tackles (three solo) in San Francisco's preseason win over the Raiders on Saturday. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (Achilles) played six snaps on offense without otherwise showing up on the box score during the 49ers' 22-19 preseason win over the Raiders on Saturday. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (ankle) logged four tackles (three solo) during the 49ers' 22-19 preseason win over the Raiders on Saturday. |
| Dominick Puni Status: Questionable San Francisco 49ers | Puni suffered a possible PCL injury in Saturday's preseason game against the Raiders and is expected to miss a few weeks, Eric Branch of the San Francisco Chronicle reports. |
| Jake Moody Status: Active San Francisco 49ers | Moody went 5-for-6 on field-goal attempts and 1-for-1 in extra-point tries during a 22-19 preseason win against the Raiders on Saturday. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall caught three of four targets for 42 yards in a 22-19 exhibition win against Las Vegas on Saturday. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed five of seven pass attempts for 66 yards with no touchdowns or interceptions in a 22-19 exhibition win over the Raiders on Saturday. |
| 2025-08-16 |
| George Kittle Status: Active San Francisco 49ers | Kittle will suit up alongside Brock Purdy and the majority of the 49ers' starters during Saturday's preseason game against the Raiders, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey will not join Brock Purdy and the majority of San Francisco's starters in suiting up for Saturday's preseason game against the Raiders, David Lombardi of SFStandard.com reports. |
| CJ West Status: Questionable San Francisco 49ers | West (knee) has been ruled out for Saturday's preseason game against the Raiders, Eric Branch of the San Francisco Chronicle reports. |
| Mykel Williams Status: Questionable San Francisco 49ers | Williams (knee) has been ruled out for Saturday's preseason game against Las Vegas, Eric Branch of the San Francisco Chronicle reports. |
 | Richie Grant Status: Questionable San Francisco 49ers | Grant (knee) will not play in Saturday's preseason game against the Raiders, Cam Inman of The San Jose Mercury News reports. |
| Jason Pinnock Status: Questionable San Francisco 49ers | Pinnock (heel) will not play against Las Vegas on Saturday, Cam Inman of The San Jose Mercury News reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (calf) will not play in Saturday's preseason game against the Raiders on Saturday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy is scheduled to play a series or two during Saturday's preseason matchup against the Raiders, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Dominick Puni Status: Questionable San Francisco 49ers | Puni has been ruled out for the rest of Saturday's preseason game against the Raiders due to a knee injury, Cam Inman of The San Jose Mercury News reports. |
| Corey Kiner Status: Questionable San Francisco 49ers | Kiner was carted off the field during the second quarter of Saturday's preseason game against the Raiders due to a left leg injury, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Patrick Taylor Jr. Status: Questionable San Francisco 49ers | Taylor is questionable to return to Saturday's preseason game against the Raiders due to a shoulder injury, Cam Inman of The San Jose Mercury News reports. |
| Patrick Taylor Jr. Status: Questionable San Francisco 49ers | Taylor (shoulder) has been ruled out for the rest of Saturday's preseason game against the Raiders, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Patrick Taylor Jr. Status: Questionable San Francisco 49ers | Taylor suffered a dislocated shoulder in Saturday's preseason game against the Raiders, Nick Wagoner of ESPN.com reports. |
| Corey Kiner Status: Questionable San Francisco 49ers | Kiner suffered a left high-ankle sprain in Saturday's preseason game versus Las Vegas, Eric Branch of the San Francisco Chronicle reports. |
| 2025-08-14 |
| Tre Brown Status: Questionable San Francisco 49ers | questionable |
| Jason Pinnock Status: Questionable San Francisco 49ers | questionable |
| Nick Bosa Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said Thursday that Bosa is dealing with neck soreness and could be back at practice next week, Nick Wagoner of ESPN.com reports. |
 | Andre Dillard Status: Injured Reserve San Francisco 49ers | Dillard (ankle) was placed on injured reserve Thursday. |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch (elbow) won't be available for Saturday's preseason game against Las Vegas, Nick Wagoner of ESPN.com reports. |
 | Demone Harris Status: Active San Francisco 49ers | Harris (head) signed with the 49ers on Thursday. |
| Tre Brown Status: Questionable San Francisco 49ers | Brown is dealing with a heel injury that puts him in jeopardy of missing Saturday's preseason game against the Raiders, Nick Wagoner of ESPN.com reports. |
| Jason Pinnock Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan told reporters Thursday that Pinnock is working through a heel injury, Nick Wagoner of ESPN.com reports. |
| Bradlee Anae Status: Injured Reserve San Francisco 49ers | Anae (undisclosed) was placed on injured reserve by the 49ers on Wednesday. |
| Andre Dillard Status: Injured Reserve San Francisco 49ers | ir |
| Demone Harris Status: Active San Francisco 49ers | NA |
| CJ West Status: Questionable San Francisco 49ers | questionable |
| CJ West Status: Questionable San Francisco 49ers | West has a hyperextended knee, David Lombardi of the San Francisco Standard reports. |
| Brock Purdy Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said Thursday that Purdy and "some" starters will suit up for Saturday's preseason game against the Raiders, Vic Tafur of The Athletic reports. |
| 2025-08-13 |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch suffered an undisclosed injury during San Francisco's practice Tuesday, Nick Wagoner of ESPN.com reports. |
| Bradlee Anae Status: Injured Reserve San Francisco 49ers | ir |
 | Malik Turner Status: Active San Francisco 49ers | The 49ers signed Turner to a contract Wednesday. |
| 2025-08-12 |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (calf) did not participate at Monday's training camp practice, David Lombardi of SFStandard.com reports. |
| Andre Dillard Status: Active San Francisco 49ers | The 49ers activated Dillard (undisclosed) off the active/PUP list Monday. |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing (hamstring) returned to a limited practice Tuesday, Nick Wagoner of ESPN.com reports. |
| Ben Bartch Status: Questionable San Francisco 49ers | questionable |
| 2025-08-11 |
| Andre Dillard Status: Active San Francisco 49ers | NA |
| Ameer Abdullah Status: Injured Reserve San Francisco 49ers | ir |
| Jordan Watkins Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that Watkins is nursing a high-ankle sprain and will be out roughly one month, Vic Tafur of The Athletic reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that Week 6 could be a realistic target for Aiyuk (ACL) to take the field, Vic Tafur of The Athletic reports. |
| Ameer Abdullah Status: Injured Reserve San Francisco 49ers | The 49ers placed Abdullah (ribs) on the injured reserve list Monday. |
 | Fabian Moreau Status: Questionable San Francisco 49ers | Moreau (undisclosed) did not play in Saturday's 30-9 loss to Denver, Matt Barrows of The Athletic reports. |
| Chazz Surratt Status: Questionable San Francisco 49ers | Surratt (undisclosed) did not play in Saturday's 30-9 loss to the Broncos, Matt Barrows of The Athletic reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune suffered an ankle injury in Saturday's 30-9 loss to the Broncos, Matt Barrows of The Athletic reports. |
| 2025-08-10 |
| Chazz Surratt Status: Questionable San Francisco 49ers | questionable |
| Fabian Moreau Status: Questionable San Francisco 49ers | questionable |
| Jordan Elliott Status: Questionable San Francisco 49ers | questionable |
 | Jeff Wilson Jr. Status: Active San Francisco 49ers | The 49ers signed Wilson to a contract Sunday, Adam Schefter of ESPN reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle isn't warming up ahead of Saturday's preseason game against the Broncos and isn't slated to play, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy didn't warm up and isn't likely to play in Saturday's preseason game against Denver, Nick Wagoner of ESPN.com reports. |
| Jordan Elliott Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Sunday that Elliott (back) is dealing with injury, Matt Barrows of The Athletic reports. |
| Jake Moody Status: Active San Francisco 49ers | Moody did not attempt a field goal while converting his lone extra-point attempt in Saturday's 30-9 preseason loss to Denver. |
| Mac Jones Status: Active San Francisco 49ers | Jones completed four of seven pass attempts for 74 yards and an interception while rushing once for two yards in Saturday's 30-9 preseason loss the Broncos. |
| Ameer Abdullah Status: Questionable San Francisco 49ers | questionable |
| Marques Sigle Status: Questionable San Francisco 49ers | questionable |
| Richie Grant Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Saturday that Grant (knee) did not suit up for the team's 30-9 preseason loss to Denver due to an injury and is expected to miss roughly one week, Nick Wagoner of ESPN.com reports. |
| Upton Stout Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Stout (calf) did not suit up for Saturday's 30-9 preseason loss to the Broncos due to calf tightness, Rich Cimini of ESPN.com reports. |
| Ameer Abdullah Status: Questionable San Francisco 49ers | Abdullah was forced out of Saturday's 30-9 preseason loss to the Broncos due to a ribs injury. |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Saturday that Beal (groin) suffered an injury late during the team's 30-9 preseason loss to Denver, David Lombardi of SFStandard.com reports. |
| Marques Sigle Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Saturday that Sigle (knee) will still undergo testing but that initial indications are that he's avoided a serious knee injury, Nick Wagoner of ESPN.com reports. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson brought in all two targets for 20 yards in the 49ers' 30-9 preseason loss to the Broncos on Saturday night. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins brought in three of six targets for 56 yards in the 49ers' 30-9 preseason loss to the Broncos on Saturday night. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor rushed five times for seven yards and a touchdown and secured his only target for four yards in the 49ers' 30-9 preseason loss to the Broncos on Saturday night. |
| 2025-08-09 |
 | Ke'Shawn Vaughn Status: Active San Francisco 49ers | The 49ers signed Vaughn to a contract Saturday. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. |
| 2025-08-08 |
| Equanimeous St. Brown Status: Injured Reserve San Francisco 49ers | The 49ers placed St. Brown on injured reserve Friday due to a foot injury, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy is a candidate to sit out Saturday's preseason opener against the Broncos, Cam Inman of The San Jose Mercury News reports. |
| Tanner Mordecai Status: Active San Francisco 49ers | The 49ers signed Mordecai to a contract Friday, Cam Inman of The San Jose Mercury News reports. |
| 2025-08-07 |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco GM John Lynch said Thursday he "doesn't think" Aiyuk (ACL), who remains on the active/PUP list, will be cleared to play Week 1, Cam Inman of The San Jose Mercury News reports. |
| Mykel Williams Status: Questionable San Francisco 49ers | Williams is unlikely to suit up for Saturday's preseason game against Denver after exiting Thursday's practice due to a knee injury, Matt Barrows of The Athletic reports. |
| Jordan James Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Thursday that James will miss a couple weeks due to a broken finger, Cam Inman of The San Jose Mercury News reports. |
| 2025-08-06 |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall has impressed in recent practices and was a clear standout on offense Tuesday, with quarterback Brock Purdy on five targets, Nick Wagoner of ESPN reports. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor should get an extended look this preseason after primary backup Isaac Guerendo (shoulder) suffered a multi-week injury in training camp. |
| 2025-08-05 |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (groin) sat out of practice Monday, Eric Branch of The San Francisco Chronicle reports. |
| Evan Anderson Status: Questionable San Francisco 49ers | questionable |
 | Andy Isabella Status: Questionable San Francisco 49ers | Isabella had to leave practice Monday with an undisclosed injury, Nick Wagoner of ESPN.com reports. |
| Evan Anderson Status: Questionable San Francisco 49ers | Anderson (knee) did not practice Monday, Nick Wagoner of ESPN.com reports. |
| Equanimeous St. Brown Status: Active San Francisco 49ers | The 49ers signed St. Brown on Tuesday, Matt Barrows of The Athletic reports. |
| 2025-08-04 |
| Ben Bartch Status: Active San Francisco 49ers | Offensive line coach Chris Foerster declared Sunday that the starting left guard spot is "Bartch's job to lose," Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Jordan James Status: Active San Francisco 49ers | James (knee) returned to practice Monday, Matt Barrows of The Athletic reports. |
| Jake Moody Status: Active San Francisco 49ers | Moody is the only kicker on San Francisco's roster after the team released Greg Joseph on Monday, Matt Maiocco of NBC Sports Bay Area reports. |
 | Mason Pline Status: Active San Francisco 49ers | Pline was waived by the 49ers on Monday, Matt Barrows of The Athletic reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | 49ers coach Kyle Shanahan said Monday that Guerendo (shoulder) is expected to miss a couple weeks, Matt Maiocco of NBC Sports Bay Area reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (calf) isn't practicing Monday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Andy Isabella Status: Questionable San Francisco 49ers | questionable |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | questionable |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | questionable |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) did not participate in practice Monday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (Achilles) did not participate in practice Monday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Kevin Givens Status: Questionable San Francisco 49ers | Givens is expected to miss the start of the 2025 regular season due to a pectoral injury, David Lombardi of SFStandard.com reports. |
| 2025-08-03 |
| Robbie Chosen Status: Active San Francisco 49ers | Chosen and the 49ers agreed on a one-year contract Sunday. |
| 2025-08-02 |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (undisclosed) is expected to return to practice Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| Jordan Watkins Status: Active San Francisco 49ers | NA |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo had an early departure from practice Saturday due to an apparent shoulder injury, Jennifer Lee Chan of NBC Sports Bay Area reports. |
 | Curtis Robinson Status: Active San Francisco 49ers | The 49ers activated Robinson (undisclosed) off the active/PUP list Saturday, Vic Tafur of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| 2025-08-01 |
| Ben Bartch Status: Active San Francisco 49ers | Bartch (quadriceps) was activated from the active/non-football injury list by the 49ers on Thursday. |
| Curtis Robinson Status: Active San Francisco 49ers | NA |
| Jordan James Status: Questionable San Francisco 49ers | questionable |
| 2025-07-31 |
 | Darrell Luter Jr. Status: Active San Francisco 49ers | Luter (pelvis) was cleared to start practicing Wednesday, Grant Cohn of Sports Illustrated reports. |
| Robert Beal Jr. Status: Active San Francisco 49ers | Beal (ankle) was a full participant in practice Tuesday, Grant Cohn reports. |
| Colton McKivitz Status: Active San Francisco 49ers | McKivitz (undisclosed) is fully healthy and participated in training camp Wednesday, Mike Maynard reports. |
| Jordan James Status: Active San Francisco 49ers | 49ers coach Kyle Shanahan said Thursday that James (knee) is not practicing due to "knee issues," Eric Branch of the San Francisco Chronicle reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | 49ers coach Kyle Shanahan said Thursday that Jennings (calf) is dealing with a reaggravation of the injury he dealt with during spring activities, Clayton Holloway of NFL Network reports. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (shoulder) was spotted taking reps during this week's training camp practice sessions, Matt Barrows of The Athletic reports. |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir is expected to miss the next few practices with a hip injury, David Lombardi of SFStandard.com reports. |
| Andy Isabella Status: Active San Francisco 49ers | The 49ers signed Isabella to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
 | Marquez Callaway Status: Active San Francisco 49ers | The 49ers signed Callaway to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Carter Bradley Status: Active San Francisco 49ers | The 49ers signed Bradley to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Ameer Abdullah Status: Active San Francisco 49ers | The 49ers signed Abdullah to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
 | Alfred Collins Status: Active San Francisco 49ers | Collins (calf) has fully participated in practices during the 49ers' first week of training camp, Mike Maynard of The Sporting News reports. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (ankle) has participated in practices during the 49ers' first week of training camp, Jerry McDonald of The Mercury News reports. |
| 2025-07-30 |
| Russell Gage Status: Active San Francisco 49ers | Gage put his improved health on display when he made an athletic grab during Tuesday's padded practice session, Matt Barrows of The Athletic reports. |
| Jordan James Status: Active San Francisco 49ers | James made a strong first impression on the 49ers' coaching staff during team practices this training camp, according to Matt Barrows of The Athletic. |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco offensive coordinator Klay Kubiak said Tuesday that Aiyuk (knee), who remains on the active/PUP, has been "kind of a coach on the side" throughout the early stages of training camp, Nick Wagoner of ESPN reports. |
| Colton McKivitz Status: Active San Francisco 49ers | NA |
| Darrell Luter Jr. Status: Active San Francisco 49ers | NA |
| Ji'Ayir Brown Status: Active San Francisco 49ers | NA |
| Alfred Collins Status: Active San Francisco 49ers | NA |
| Robert Beal Jr. Status: Active San Francisco 49ers | NA |
| 2025-07-29 |
| Mykel Williams Status: Questionable San Francisco 49ers | questionable |
| Mykel Williams Status: Questionable San Francisco 49ers | Williams (ankle) did not participate in Tuesday's practice, Nick Wagoner of ESPN.com reports. |
 | Tarron Jackson Status: Injured Reserve San Francisco 49ers | The 49ers placed Jackson (undisclosed) on injured reserve Tuesday. |
| Tarron Jackson Status: Questionable San Francisco 49ers | Jackson (undisclosed) was discharged from the hospital and returned to the 49ers on Monday, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-07-28 |
 | Dee Winters Status: Active San Francisco 49ers | Winters drew praise from a star teammate at the start of training camp as the linebacker prepares to compete for a starting role in 2025, Vic Tafur of The Athletic reports. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins is in the mix to be third or fourth on San Francisco's WR depth chart to start the season, according to Matt Barrows of The Athletic. |
 | Eli Apple Status: Active San Francisco 49ers | Apple and the 49ers agreed on a one-year contract Sunday, Adam Schefter of ESPN reports. |
| 2025-07-27 |
| Ricky Pearsall Status: Active San Francisco 49ers | The 49ers activated Pearsall (hamstring) from the active/PUP list Sunday. |
| Tarron Jackson Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings left practice Sunday due to a calf injury, Nick Wagoner of ESPN.com reports. |
| Jacob Cowing Status: Questionable San Francisco 49ers | San Francisco coach Kyle Shanahan said Sunday that he's hopeful Cowing (hamstring) will be back by the week of Aug. 11 for joint practices with the Raiders, David Lombardi of SFStandard.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (hamstring) is expected to be sidelined for the next several weeks, David Lombardi of SFStandard.com reports. |
| Tarron Jackson Status: Questionable San Francisco 49ers | Jackson (undisclosed) was taken to the hospital after suffering an injury during San Francisco's practice Sunday, Eric Branch of the San Francisco Chronicle reports. |
| 2025-07-26 |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | Green left Friday's practice due to a hamstring injury, Eric Branch of the San Francisco Chronicle reports. |
| 2025-07-25 |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (hamstring) is considered healthy and just needs to build endurance before getting clearance for training camp, Ralph Vacchiano of Fox Sports reports. |
| 2025-07-24 |
 | Quintez Cephus Status: Active San Francisco 49ers | The 49ers signed Cephus to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2025-07-23 |
| Ben Bartch Status: Out San Francisco 49ers | Bartch is dealing with a quadriceps injury, Eric Branch of the San Francisco Chronicle reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings participated in individual drills at the start of Wednesday's practice, David Lombardi of SFStandard.com reports. |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing pulled his hamstring Wednesday, Nick Wagoner of ESPN.com reports. |
| Jake Moody Status: Active San Francisco 49ers | Moody is competing with Greg Joseph for San Francisco's placekicker job, David Lombardi of SFStandard.com reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (hamstring) trained on a side field Wednesday and is expected to practice Sunday, Matt Barrows of The Athletic reports. |
| 2025-07-22 |
| Jauan Jennings Status: Active San Francisco 49ers | GM John Lynch said Tuesday that Jennings (calf) reported to 49ers training camp and passed a physical Monday, Eric Branch of the San Francisco Chronicle reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (hamstring) is expected to be cleared early in training camp after the 49ers placed him on the active/PUP list last Friday, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | Coach Kyle Shanahan said Tuesday that McCaffrey is "here and healthy" for the start of 49ers training camp, but the running back's workload will be managed in advance of the regular season, Nick Wagoner of ESPN.com reports. |
| Equanimeous St. Brown Status: Active San Francisco 49ers | The 49ers signed St. Brown on Tuesday, Eric Branch of the San Francisco Chronicle reports. |
| 2025-07-19 |
| Malik Mustapha Status: Out San Francisco 49ers | Mustapha (knee) was placed on the active/PUP list by the 49ers on Friday. |
| Ben Bartch Status: Out San Francisco 49ers | Bartch (undisclosed) was placed on the active/non-football injury list Friday. |
| Curtis Robinson Status: Out San Francisco 49ers | Robinson (undisclosed) was placed on the active/PUP list Friday. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | Gross-Matos (undisclosed) was placed on the active/PUP list Friday. |
| Andre Dillard Status: Out San Francisco 49ers | Dillard (undisclosed) was placed on the active/PUP list Friday. |
 | George Odum Status: Out San Francisco 49ers | Odum (knee) was placed on the active/non-football injury list Friday. |
| 2025-07-18 |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (hamstring) was placed on the active/PUP list by the 49ers on Friday. |
| George Odum Status: Out San Francisco 49ers | nfi-a |
| Ben Bartch Status: Out San Francisco 49ers | nfi-a |
| Brandon Aiyuk Status: Out San Francisco 49ers | Aiyuk (knee) was placed on the active/PUP list by the 49ers on Friday. |
| Curtis Robinson Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Andre Dillard Status: Out San Francisco 49ers | out |
| Malik Mustapha Status: Out San Francisco 49ers | out |
| 2025-07-16 |
| Kurtis Rourke Status: Out San Francisco 49ers | The 49ers placed Rourke (knee) on the active/non-football injury list Wednesday, Matt Barrows of The Athletic reports. |
| 2025-07-14 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (calf) is unhappy with his contract and wants a new deal or a trade, Adam Schefter of ESPN reports. |
| 2025-07-10 |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson, who pleaded no contest to a misdemeanor DUI charge stemming from his arrest last November, has been sentenced to three years' probation, the Orange County Register reports. |
| 2025-06-14 |
| Brandon Aiyuk Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Thursday that Aiyuk (knee) has been "doing a tremendous job coming back," Kevin Patra of NFL.com reports. |
| 2025-06-13 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey was one of a few 49ers veterans to participate in 11-on-11 work during mandatory minicamp, Matt Barrows of The Athletic reports. |
| 2025-06-12 |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings dealt with a minor calf injury during the offseason program, Matt Barrows of The Athletic reports. |
| 2025-06-11 |
| Alfred Collins Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Collins (calf) will be back on the practice field during training camp, Vic Tafur of The Athletic reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) isn't participating in San Francisco's minicamp, Matt Maiocco of NBC Sports Bay Area reports. |
| Brandon Aiyuk Status: Questionable San Francisco 49ers | Aiyuk (knee) is present at San Francisco's mandatory minicamp but is not practicing, though he contributed Tuesday by coaching up the team's younger receivers, Matt Barrows of The Athletic reports. |
| 2025-06-10 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | 49ers coach Kyle Shanahan said Tuesday that Pearsall (hamstring) is healthy enough to participate in mandatory minicamp but that the team plans to be careful, and to prioritize having the second-year wideout ready for training camp, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
| 2025-06-06 |
| Isaac Guerendo Status: Active San Francisco 49ers | NA |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo (knee/ankle) was an active participant at voluntary OTAs, per the 49ers' official site. |
| 2025-06-03 |
| Trent Williams Status: Active San Francisco 49ers | NA |
 | Trent Taylor Status: Injured Reserve San Francisco 49ers | ir |
| Trent Williams Status: Active San Francisco 49ers | Williams (ankle) has been an active participant at the 49ers' OTAs, Vic Tafur of The Athletic reports. |
| Malik Knowles Status: Active San Francisco 49ers | Knowles signed a one-year contract with the 49ers on Tuesday. |
| Trent Taylor Status: Injured Reserve San Francisco 49ers | The 49ers placed Taylor (undisclosed) on injured reserve Tuesday. |
| 2025-06-02 |
 | Bryce Huff Status: Active San Francisco 49ers | Huff was traded from the Eagles to the 49ers on Monday in exchange for a mid-round pick in 2026, Adam Schefter of ESPN reports. |
| 2025-05-30 |
| Spencer Burford Status: Active San Francisco 49ers | NA |
| Spencer Burford Status: Active San Francisco 49ers | Burford (calf) participated in Thursday's organized team activities, Matt Barrows of The Athletic reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (groin) participated in Thursday's organized team activities, Grant Cohn of Spots Illustrated reports. |
| Tre Brown Status: Active San Francisco 49ers | NA |
| Tre Brown Status: Active San Francisco 49ers | Brown (knee) participated in Thursday's organized team activities, Matt Barrows of The Athletic reports. |
| 2025-05-29 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall is dealing with a hamstring injury, according to head coach Kyle Shanahan, Nick Wagoner of ESPN.com reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | questionable |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown will be out until training camp after undergoing a procedure on his ankle, Cam Inman of The San Jose Mercury News reports. |
| 2025-05-28 |
 | Mitch Wishnowsky Status: Active San Francisco 49ers | NA |
 | Thomas Morstead Status: Active San Francisco 49ers | Morstead signed with the 49ers on Wednesday. |
| 2025-05-19 |
| Fred Warner Status: Active San Francisco 49ers | Warner signed a three-year, $63 million contract extension with the 49ers on Monday, Adam Schefter of ESPN reports. |
| 2025-05-16 |
| Brock Purdy Status: Active San Francisco 49ers | Purdy and the 49ers agreed to terms Friday on a five-year, $265 million contract extension, Tom Pelissero of NFL Network reports. |
 | Greg Joseph Status: Active San Francisco 49ers | The 49ers are slated to sign Joseph, Matt Barrows of The Athletic reports. |
| 2025-05-13 |
 | Tre Tomlinson Status: Injured Reserve San Francisco 49ers | Tomlinson (undisclosed) reverted to the 49ers' injured reserve Tuesday, per the NFL's transaction log. |
| 2025-05-09 |
| Kurtis Rourke Status: Questionable San Francisco 49ers | Rourke (knee) won't participate in the 49ers' rookie camp, Matt Maiocco of NBC Sports Bay Area reports. |
| Andre Dillard Status: Active San Francisco 49ers | The 49ers signed Dillard (concussion) on Friday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2025-05-02 |
 | Ross Dwelley Status: Active San Francisco 49ers | Dwelley signed a one-year contract with the 49ers on Friday. |
| 2025-04-29 |
| George Kittle Status: Active San Francisco 49ers | Kittle is signing a four-year, $76.4 million extension with the 49ers, ESPN's Nick Wagoner reports. |
| 2025-04-27 |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha may miss the beginning of the 2025 season due to a knee injury he suffered in Week 17 last year, Nick Wagoner of ESPN.com reports. |
| 2025-04-26 |
| Upton Stout Status: Active San Francisco 49ers | The 49ers selected Stout in the third round of the 2025 NFL Draft, 100th overall. | |
| CJ West Status: Active San Francisco 49ers | The 49ers selected West in the fourth round of the 2025 NFL Draft, 113th overall. | |
| Jordan Watkins Status: Active San Francisco 49ers | The 49ers selected Watkins in the fourth round of the 2025 NFL Draft, 138th overall. | |
| Marques Sigle Status: Active San Francisco 49ers | The 49ers selected Sigle in the fifth round of the 2025 NFL Draft, 160th overall. | |
| Jordan James Status: Active San Francisco 49ers | The 49ers selected James in the fifth round of the 2025 NFL Draft, 147th overall. | |
| Kurtis Rourke Status: Questionable San Francisco 49ers | The 49ers selected Rourke (knee) in the seventh round of the 2025 NFL Draft, 227th overall. | |
| Junior Bergen Status: Active San Francisco 49ers | The 49ers selected Bergen in the seventh round of the 2025 NFL Draft, 252nd overall. | |
| Connor Colby Status: Active San Francisco 49ers | The 49ers selected Colby in the seventh round of the 2025 NFL Draft, 249th overall. | |
| Alfred Collins Status: Active San Francisco 49ers | The 49ers selected Collins in the second round of the 2025 NFL Draft, 43rd overall. | |
| Nick Martin Status: Active San Francisco 49ers | The 49ers selected Martin in the third round of the 2025 NFL Draft, 75th overall. |
| 2025-04-25 |
| Mykel Williams Status: Active San Francisco 49ers | The 49ers selected Williams in the first round of the 2025 NFL Draft, 11th overall. |
| 2025-04-23 |
| Brayden Willis Status: Active San Francisco 49ers | Willis signed his exclusive rights free-agent tender with the 49ers on Tuesday. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey is participating in the offseason program without any restrictions, ESPN.com's Nick Wagoner reports. |
| 2025-04-22 |
| Brock Purdy Status: Active San Francisco 49ers | Purdy is present Tuesday for the start of San Francisco's voluntary offseason program, Adam Schefter of ESPN reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle is not at team facilities for the start of San Francisco's voluntary offseason workout program, Adam Schefter of ESPN reports. |
| 2025-04-17 |
| Jake Tonges Status: Active San Francisco 49ers | Tonges re-signed with the 49ers on a one-year, $1.03 million contract Thursday. |
| 2025-04-16 |
 | Isaac Alarcon Status: Suspension San Francisco 49ers | Alarcon was handed a six-game suspension Wednesday for violating the NFL's performance-enhancing substances policy, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-04-08 |
| Christian McCaffrey Status: Active San Francisco 49ers | San Francisco coach Kyle Shanahan said last week that McCaffrey (knee) is healthy and doing well, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-04-02 |
| Jake Moody Status: Active San Francisco 49ers | Coach Kyle Shanahan said Tuesday that the 49ers intend to bring in a veteran kicker "who's capable of taking that job" to compete with Moody this offseason, Eric Branch of the San Francisco Chronicle reports. |
| 2025-03-31 |
| Brandon Aiyuk Status: Questionable San Francisco 49ers | GM John Lynch relayed Monday that Aiyuk, who tore the ACL and MCL in his right knee in October, met with Dr. Neal ElAttrache last week and got "good reviews" in terms of the progress he's made in his injury recovery, Nick Wagoner of ESPN reports. |
| 2025-03-27 |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu signed his one-year exclusive rights tendered contract with the 49ers on Wednesday. |
| 2025-03-18 |
| Siran Neal Status: Active San Francisco 49ers | The 49ers are signing Neal to a two-year contract, Cameron Wolfe of NFL Network reports. |
| 2025-03-15 |
| Kyle Juszczyk Status: Active San Francisco 49ers | Jusczyk and the 49ers have agreed on a two-year, $8 million contract, Adam Schefter of ESPN reports. |
| 2025-03-14 |
| Tre Brown Status: Questionable San Francisco 49ers | Brown (knee) signed with the 49ers on Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2025-03-13 |
| Mac Jones Status: Active San Francisco 49ers | The 49ers signed Jones to a two-year, $7 million contract Wednesday, Ian Rapoport of NFL Network reports. |
| Curtis Robinson Status: Active San Francisco 49ers | NA |
| Curtis Robinson Status: Active San Francisco 49ers | Robinson (knee) re-signed with the 49ers on Thursday via a one-year contract. |
| 2025-03-12 |
| Jason Pinnock Status: Active San Francisco 49ers | Pinnock is slated to sign a one-year contract with the 49ers, Jordan Schultz of Fox Sports reports. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson is slated to sign a two-year contract with the 49ers, Ian Rapoport of NFL Network reports. |
| 2025-03-11 |
 | Luke Gifford Status: Active San Francisco 49ers | The 49ers are set to sign Gifford to a one-year contract when the new league year starts Wednesday, Tom Pelissero of NFL Network reports. |
 | Jordan Mason Status: Questionable San Francisco 49ers | The 49ers are giving Mason (ankle) a second-round restricted free agent tender, Adam Schefter of ESPN reports. |
| Richie Grant Status: Active San Francisco 49ers | The 49ers will sign Grant to a one-year contract, Jeremy Fowler of ESPN.com reports. |
| 2025-03-10 |
 | Elijah Mitchell Status: Active San Francisco 49ers | NA |
 | Jaylon Moore Status: Active San Francisco 49ers | NA |
 | Talanoa Hufanga Status: Active San Francisco 49ers | NA |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | The 49ers re-signed Taylor to a one-year deal Monday, Tom Pelissero of NFL Network reports. |
| Luke Farrell Status: Active San Francisco 49ers | Farrell is slated to sign a three-year, $20.25 million contract with the 49ers, Ian Rapoport of NFL Network reports. |
| Kevin Givens Status: Questionable San Francisco 49ers | The 49ers re-signed Givens (pectoral) to a one-year contract Monday, Matt Barrows of The Athletic reports. |
| 2025-03-08 |
| Tre Tomlinson Status: Active San Francisco 49ers | The 49ers claimed Tomlinson off waivers Friday. |
| 2025-03-07 |
| Jordan Mason Status: Questionable San Francisco 49ers | Mason (ankle) is drawing trade interest, David Lombardi of The San Francisco Standard reports. |
| 2025-03-06 |
 | Javon Hargrave Status: Active San Francisco 49ers | San Francisco plans to release Hargrave on the first day of the new league year March 12, Adam Schefter of ESPN reports. |
| 2025-03-05 |
| Javon Hargrave Status: Active San Francisco 49ers | Hargrave has recovered from his triceps injury, Jeremy Fowler of ESPN.com reports. |
| 2025-02-28 |
 | Deebo Samuel Sr. Status: Active San Francisco 49ers | The Commanders and Texans are among the top teams that have expressed interest in acquiring Samuel, whose trade request San Francisco general manager John Lynch said the team plans to honor, Jordan Schultz of Fox Sports reports. |
| 2025-02-26 |
| Trent Williams Status: Questionable San Francisco 49ers | 49ers general manager John Lynch said Wednesday at the 2025 NFL Scouting Combine that Williams (ankle) is "motivated" and will return for a 16th season in the NFL as a member of the 49ers, Ian Rapoport of NFL Network reports. |
| Brock Purdy Status: Active San Francisco 49ers | NA |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | NA |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Speaking at the 2025 NFL Scouting Combine on Wednesday, 49ers GM John Lynch said the team plans to honor Samuel's wish for a trade, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | Speaking at the 2025 NFL Scouting Combine on Wednesday, 49ers GM John Lynch said the team and Purdy have already had conversations about a contract extension, Nick Wagoner of ESPN.com reports. |
| 2025-02-24 |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| Ben Bartch Status: Active San Francisco 49ers | The 49ers signed Bartch (ankle) to a one-year contract extension Monday. |
| 2025-02-21 |
| George Kittle Status: Active San Francisco 49ers | Kittle's agent has already discussed contract extension with the 49ers, Eric Branch of the San Francisco Chronicle reports. |
| 2025-02-13 |
| Mitch Wishnowsky Status: Questionable San Francisco 49ers | questionable |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Curtis Robinson Status: Questionable San Francisco 49ers | questionable |
| George Odum Status: Questionable San Francisco 49ers | questionable |
| Jaylon Moore Status: Questionable San Francisco 49ers | questionable |
| Elijah Mitchell Status: Questionable San Francisco 49ers | questionable |
| Jordan Mason Status: Questionable San Francisco 49ers | questionable |
| Christian McCaffrey Status: Questionable San Francisco 49ers | questionable |
| Darrell Luter Jr. Status: Questionable San Francisco 49ers | questionable |
 | Drake Jackson Status: Questionable San Francisco 49ers | questionable |
| 2025-02-11 |
 | De'Vondre Campbell Status: Active San Francisco 49ers | The 49ers lifted Campbell's suspension Monday, Aaron Wilson of KPRC 2 Houston reports. |
| 2025-02-09 |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | The 49ers have granted Samuel (ribs) and his agent permission to find a trade partner, Adam Schefter of ESPN reports. |
| 2025-01-17 |
 | Brandon Allen Status: Active San Francisco 49ers | Allen completed 17 of 30 pass attempts for 199 yards, one touchdown and two interceptions across three games with the 49ers in 2024. |
 | Chris Conley Status: Questionable San Francisco 49ers | Conley (elbow) appeared in 15 games for the 49ers this season, finishing with six receptions on 12 targets for 76 yards. |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing finished his rookie season with four receptions for 80 yards and one rushing attempt for seven yards across 15 active games. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk produced 26 rushing yards and a touchdown on five carries to go along with 19 receptions for 200 yards and a pair of scores while starting all 17 games for San Francisco this season. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown finished the regular season with 77 tackles (48 solo) and one interception across 17 starts for San Francisco. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (shoulder) finished with 85 tackles (53 solo), two interceptions and one forced fumble across 15 starts in 2024. |
| Fred Warner Status: Active San Francisco 49ers | Warner finished the 2024 season with 131 tackles (76 solo), 1.0 sack, two interceptions, four forced fumbles and a defensive touchdown across 17 starts for San Francisco. |
 | Eric Saubert Status: Active San Francisco 49ers | Saubert recorded 11 receptions for 97 yards and a touchdown across 17 games this season. |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha (knee) finished his rookie season with 72 tackles (32 solo) and one interception across 16 games with the 49ers. |
| Talanoa Hufanga Status: Questionable San Francisco 49ers | Hufanga (concussion) finished with 38 tackles (20 solo) in seven active games in 2024. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa finished with 52 tackles (33 solo), 9.0 sacks, one interception and one fumble forced across 14 starts in 2024. |
| 2025-01-09 |
 | Isaac Yiadom Status: Active San Francisco 49ers | Yiadom accumulated 46 tackles (38 solo), six pass defenses (including one interception), two forced fumbles and one fumble recovery across 17 regular-season games in 2024. |
 | Charvarius Ward Status: Active San Francisco 49ers | Ward finished the 2024 season with 54 tackles (38 solo) and seven pass breakups across 12 games. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (groin) finished the 2024 regular season with 61 tackles (41 solo), 13 pass defenses (including one interception) and one forced fumble across 17 games. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu finished the 2024 regular season with 35 tackles (25 solo), including 3.0 sacks, one pass defense and one forced fumble across 16 games. |
 | Maliek Collins Status: Active San Francisco 49ers | Collins finished the 2024 season with 33 tackles (20 solo), including 5.0 sacks, and two fumble recoveries across 17 games. |
 | Leonard Floyd Status: Active San Francisco 49ers | Floyd totaled 42 tackles (25 solo), including 8.5 sacks, one pass defense and one forced fumble across 17 regular-season games. |
| Dee Winters Status: Active San Francisco 49ers | Winters finished the 2024 season with 44 tackles (26 solo) and four pass breakups across 15 games. |
| George Odum Status: Injured Reserve San Francisco 49ers | Odum tallied 16 tackles (14 solo) and four pass defenses across 12 regular-season games in 2024. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos finished the 2024 season with 19 tackles (14 solo), including 4.0 sacks, across 11 games. |
| Jordan Elliott Status: Active San Francisco 49ers | Elliott finished the 2024 regular season with 19 tackles (12 solo) through 15 games. |
| 2025-01-08 |
 | Isaiah Hodgins Status: Active San Francisco 49ers | San Francisco signed Hodgins to a reserve/future contract Tuesday. |
| Russell Gage Status: Active San Francisco 49ers | The 49ers signed Gage to a reserve/future deal Tuesday. |
| Javon Hargrave Status: Injured Reserve San Francisco 49ers | General manager John Lynch confirmed Wednesday that the 49ers plan to release Hargrave (triceps) after June 1, Nick Wagoner of ESPN.com reports. |
| 2025-01-07 |
 | Terique Owens Status: Active San Francisco 49ers | San Francisco signed Owens to a reserve/future contract Monday. |
| Tanner Mordecai Status: Active San Francisco 49ers | The 49ers signed Mordecai to a reserve/future contract Monday. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The Athletic reports. |
| Trent Taylor Status: Active San Francisco 49ers | Taylor signed a reserve/future contract with San Francisco on Monday. |
| Mason Pline Status: Active San Francisco 49ers | The 49ers signed Pline (undisclosed) to a reserve/future contract Monday. |
| 2025-01-06 |
| Colton McKivitz Status: Questionable San Francisco 49ers | questionable |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallares of the 49ers' official site reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | questionable |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
 | Khalil Davis Status: Active San Francisco 49ers | NA |
 | Tre Avery Status: Active San Francisco 49ers | NA |
 | Joshua Dobbs Status: Active San Francisco 49ers | Dobbs completed 29 of 43 pass attempts for 326 yards, two touchdowns and two interceptions while rushing eight times for 17 yards and a third score while coughing up a fumble in Sunday's 47-24 loss to Arizona. |
| George Kittle Status: Active San Francisco 49ers | Kittle brought in two of three targets for 27 yards in Sunday's 47-24 loss to the Cardinals. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall corralled six of eight targets for 69 yards and a touchdown in Sunday's 47-24 loss to the Cardinals. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor rushed 17 times for 109 yards while catching one of four targets for 12 receiving yards in Sunday's 47-24 loss to Arizona. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings finished with seven receptions on 10 targets for 52 yards in Sunday's 47-24 loss to Arizona. |
| Jake Moody Status: Active San Francisco 49ers | Moody went 1-for-2 on field-goal attempts while converting all three of his extra-point attempts in Sunday's 47-24 loss to the Cardinals. |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | McCaffrey (knee) said Monday he's "definitely close" to 100 percent healthy and could have played had the 49ers qualified for the playoffs, Nick Wagoner of ESPN.com reports. |
| Mason Pline Status: Active San Francisco 49ers | NA |
| Isaac Guerendo Status: Questionable San Francisco 49ers | questionable |
| 2025-01-05 |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | The 49ers placed Burford (calf) on injured reserve Saturday. |
 | Demetrius Flannigan-Fowles Status: Injured Reserve San Francisco 49ers | Flannigan-Fowles (calf) was placed on the 49ers' injured reserve Saturday |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (ankle) is active for Sunday's matchup against the Cardinals, Lindsey Pallares of the 49ers' official site reports. |
 | Israel Abanikanda Status: Out San Francisco 49ers | Abanikanda (coach's decision) is inactive for Sunday's Week 18 matchup versus Arizona, Lindsey Pallares of the 49ers' official site reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle (ankle/hamstring) is listed as active Sunday in Arizona, Lindsey Pallares of the 49ers' official site reports. |
| Deebo Samuel Sr. Status: Out San Francisco 49ers | inactive |
| Brock Purdy Status: Out San Francisco 49ers | inactive |
| Deommodore Lenoir Status: Out San Francisco 49ers | inactive |
| Khalil Davis Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| Tre Avery Status: Out San Francisco 49ers | inactive |
| Colton McKivitz Status: Active San Francisco 49ers | NA |
| Isaac Yiadom Status: Active San Francisco 49ers | Yiadom (pelvis) is active for Sunday's contest against the Cardinals, Lindsey Pallares of the 49ers' official site reports. |
| Isaac Guerendo Status: Out San Francisco 49ers | Guerendo won't return to Sunday's game at Arizona due to knee and ankle injuries. |
| Talanoa Hufanga Status: Questionable San Francisco 49ers | Hufanga was diagnosed with a concussion during Sunday's game against the Cardinals and will not return, Nick Wagoner of ESPN.com reports. |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha (knee) has been ruled out for the rest of Sunday's contest versus the Cardinals, Matt Maiocco of NBC Sports Bay Area reports. |
| Chris Conley Status: Questionable San Francisco 49ers | Conley (elbow) is questionable to return to Sunday's contest against the Cardinals, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green has been deemed questionable to return to Sunday's Week 18 matchup against Arizona due to a groin injury, Lindsey Pallares of the 49ers' official site reports. |
| 2025-01-04 |
| Demetrius Flannigan-Fowles Status: Injured Reserve San Francisco 49ers | ir |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | ir |
| Trent Taylor Status: Active San Francisco 49ers | The 49ers elevated Taylor from the practice squad to the active roster Saturday. |
| Robert Beal Jr. Status: Out San Francisco 49ers | Beal (ankle) has been ruled out for Sunday's game against the Cardinals, Bo Brack of GoPHNX.com reports. |
| Isaac Yiadom Status: Questionable San Francisco 49ers | Yiadom (pelvis) is listed as questionable for Sunday's game against the Cardinals. |
| Spencer Burford Status: Out San Francisco 49ers | Burford (calf) has been ruled out for Sunday's game against Arizona, Bo Brack of GoPHNX.com reports. |
| 2025-01-03 |
| Deommodore Lenoir Status: Out San Francisco 49ers | out |
| Demetrius Flannigan-Fowles Status: Doubtful San Francisco 49ers | doubtful |
| Spencer Burford Status: Out San Francisco 49ers | out |
| Robert Beal Jr. Status: Out San Francisco 49ers | out |
| Leonard Floyd Status: Active San Francisco 49ers | NA |
| Nick Bosa Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (illness/chest) doesn't have an injury designation for Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle/hamstring) is listed as questionable for Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (elbow) has been ruled out for Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Deebo Samuel Sr. Status: Out San Francisco 49ers | Samuel (ribs/wrist) has been ruled out for Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Isaac Yiadom Status: Questionable San Francisco 49ers | Yiadom (pelvis) upgraded to a limited practice Thursday, Nick Wagoner of ESPN.com reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) was a non-participant in Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (knee) has no injury designation ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports. |
| Leonard Floyd Status: Active San Francisco 49ers | Floyd (shoulder) has no injury designation ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) is listed as questionable ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports. |
| Demetrius Flannigan-Fowles Status: Doubtful San Francisco 49ers | Flannigan-Fowles (calf) is listed as doubtful ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports. |
| Deommodore Lenoir Status: Out San Francisco 49ers | Lenoir (shoulder) has been ruled out ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports. |
| 2025-01-02 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (illness/chest) practiced in a limited capacity Thursday, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Doubtful San Francisco 49ers | Purdy (right elbow) didn't practice Thursday, Nick Wagoner of ESPN.com reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel (ribs/wrist) won't take part in Thursday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle/hamstring) was limited at practice Thursday, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall was limited at Wednesday's practice due to an illness and a chest injury, Matt Barrows of The Athletic reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | questionable |
| Isaac Yiadom Status: Questionable San Francisco 49ers | questionable |
| Colton McKivitz Status: Questionable San Francisco 49ers | questionable |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | questionable |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | questionable |
| Charvarius Ward Status: Active San Francisco 49ers | NA |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) was a limited participant at the 49ers' practice Wednesday. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (shoulder) did not practice Wednesday. |
| Isaac Yiadom Status: Questionable San Francisco 49ers | Yiadom (pelvis) did not participate at the 49ers practice Wednesday. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) did not practice Wednesday. |
| Leonard Floyd Status: Questionable San Francisco 49ers | Floyd (shoulder) did not participate at the 49ers' practice Wednesday. |
| 2025-01-01 |
| Brock Purdy Status: Doubtful San Francisco 49ers | The 49ers announced Wednesday that Joshua Dobbs will start in place of Purdy (elbow) in Sunday's Week 18 game against Arizona. |
| Joshua Dobbs Status: Active San Francisco 49ers | Coach Kyle Shanahan said Wednesday that Dobbs will start Sunday's game at Arizona, Nick Wagoner of ESPN.com reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel won't participate in Wednesday's practice due to rib and knee injuries, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Out San Francisco 49ers | out |
| George Kittle Status: Questionable San Francisco 49ers | Kittle won't practice Wednesday due to ankle and hamstring injuries, Nick Wagoner of ESPN.com reports. |
| 2024-12-31 |
| Brandon Allen Status: Out San Francisco 49ers | Allen (coach's decision) is inactive for Monday's game against the Lions, Nick Wagoner of ESPN.com reports. |
| Israel Abanikanda Status: Out San Francisco 49ers | Abanikanda (coach's decision) is inactive for Monday's game against the Lions, Lindsey Pallares of the 49ers' official site reports. |
| Joshua Dobbs Status: Active San Francisco 49ers | Dobbs is active and will operate as the 49ers' top backup quarterback in Monday night's matchup with the Lions, Eric Branch of the San Francisco Chronicle reports. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (ankle) is active for Monday night's game against the Lions, Lindsey Pallares of the 49ers' official site reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall finished with eight receptions on 10 targets for 141 yards and a touchdown while adding six rushing yards on two attempts in Monday's 40-34 loss to Detroit. |
| Brock Purdy Status: Questionable San Francisco 49ers | Speaking after Monday night's loss to the Lions, coach Kyle Shanahan said Purdy's elbow injury isn't believed to be serious, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle corralled all eight of his targets for 112 receiving yards in Monday's 40-34 loss to the Lions. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel brought in his only target for a five-yard touchdown while adding 16 rushing yards on three attempts in Monday's 40-34 loss to the Lions. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings finished with seven receptions (on 10 targets) for 67 yards in Monday's 40-34 loss to the Lions. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo took nine carries for 34 yards while bringing in all four targets for 65 yards in Monday's 40-34 loss to the Lions. |
| Charvarius Ward Status: Questionable San Francisco 49ers | questionable |
 | Dre Greenlaw Status: Out San Francisco 49ers | out |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
| Khalil Davis Status: Active San Francisco 49ers | NA |
| Israel Abanikanda Status: Active San Francisco 49ers | NA |
| Brandon Allen Status: Active San Francisco 49ers | NA |
| Jake Moody Status: Active San Francisco 49ers | Moody went 4-for-5 on extra-point attempts but missed both of his field-goal tries during the 49ers' 40-34 loss to the Lions on Monday. |
| Brock Purdy Status: Doubtful San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Purdy was diagnosed with a contusion and nerve inflammation in his right elbow and is unlikely to be available for Sunday's game against the Cardinals, Lindsey Pallares of the 49ers' official site reports. |
| Demetrius Flannigan-Fowles Status: Questionable San Francisco 49ers | Flannigan-Fowles is considered day-to-day due to a calf injury, Matt Barrows of The Athletic reports. |
| Leonard Floyd Status: Questionable San Francisco 49ers | Floyd is considered day-to-day due to the shoulder injury he suffered in Monday's Week 17 loss to Detroit, Matt Barrows of The Athletic reports. |
| Joshua Dobbs Status: Active San Francisco 49ers | Dobbs took the field for the 49ers' final five offensive snaps of Monday's 40-34 loss to the Lions and completed three of four pass attempts for 35 yards while rushing for a seven-yard touchdown. |
| Dre Greenlaw Status: Injured Reserve San Francisco 49ers | The 49ers moved Greenlaw (calf) to IR on Tuesday. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor did not record a carry or a target while playing 13 offensive snaps (20 percent) in Monday's 40-34 loss to the Lions. |
| Jake Moody Status: Active San Francisco 49ers | Moody missed both of his field-goal attempts while going 4-for-5 on point-after tries in Monday's 40-34 loss to the Lions. |
| 2024-12-30 |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (knee) was activated from the injured reserve list Monday. |
 | Aaron Banks Status: Injured Reserve San Francisco 49ers | The 49ers placed Banks on injured reserve Monday. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune (knee) is active ahead of Monday night's matchup against the Lions, Lindsey Pallares of the 49ers' official site reports. |
| Charvarius Ward Status: Out San Francisco 49ers | inactive |
| Dre Greenlaw Status: Out San Francisco 49ers | inactive |
| Khalil Davis Status: Out San Francisco 49ers | inactive |
| Spencer Burford Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| 2024-12-29 |
| Charvarius Ward Status: Out San Francisco 49ers | Ward (personal) has been ruled out for Monday's Week 17 game against Detroit, Matt Barrows of The Athletic reports. |
| 2024-12-28 |
| Charvarius Ward Status: Questionable San Francisco 49ers | questionable |
| Spencer Burford Status: Out San Francisco 49ers | out |
| Robert Beal Jr. Status: Out San Francisco 49ers | out |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo (foot/hamstring) doesn't have a designation for Monday's game versus the Lions, Cam Inman of The San Jose Mercury News reports. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (illness) is absent from the 49ers' injury report ahead of Monday's matchup with the Lions. |
| Spencer Burford Status: Out San Francisco 49ers | Burford (calf) won't play in Monday's Week 17 tilt against Detroit, David Lombardi of SFStandard.com reports. |
| Robert Beal Jr. Status: Out San Francisco 49ers | Beal (ankle) has been ruled out for Monday's matchup against Detroit, Cam Inman of The San Jose Mercury News reports. |
| Leonard Floyd Status: Active San Francisco 49ers | NA |
| Charvarius Ward Status: Questionable San Francisco 49ers | Ward (personal) is listed as questionable for Monday's game against Detroit, Cam Inman of The San Jose Mercury News reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) is listed as questionable for Monday night's game against the Lions, Cam Inman of The San Jose Mercury News reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo (foot/hamstring) is expected to play Monday against the Lions, Adam Schefter of ESPN reports. |
| 2024-12-27 |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (illness) didn't practice Friday, Nick Wagoner of ESPN.com reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo (foot/hamstring) practiced in a limited capacity Friday, Nick Wagoner of ESPN.com reports. |
| Tatum Bethune Status: Injured Reserve San Francisco 49ers | Bethune (knee) was designated to return from injured reserve Friday, Aaron Wilson of KPRC 2 Houston reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters (chest) was a full participant in Thursday's practice. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) logged a limited practice session Thursday. |
| Colton McKivitz Status: Questionable San Francisco 49ers | questionable |
| Leonard Floyd Status: Questionable San Francisco 49ers | questionable |
| 2024-12-26 |
| Trent Williams Status: Injured Reserve San Francisco 49ers | ir |
| Dre Greenlaw Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Thursday that Greenlaw (calf) will be shut down for the rest of the 2024 regular season, David Lombardi of SFStandard.com reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Guerendo (foot/hamstring) will be limited at Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Trent Williams Status: Injured Reserve San Francisco 49ers | The 49ers placed Williams (ankle) on injured reserve Thursday, Matt Barrows of The Athletic reports. |
| Jaylon Moore Status: Injured Reserve San Francisco 49ers | The 49ers placed Moore (quadriceps) on injured reserve Wednesday. |
| 2024-12-25 |
| Jaylon Moore Status: Injured Reserve San Francisco 49ers | ir |
| 2024-12-24 |
| Fred Warner Status: Active San Francisco 49ers | Warner totaled 11 tackles (six solo) during the 49ers' loss to the Dolphins on Sunday. |
| Aaron Banks Status: Out San Francisco 49ers | Banks (knee) suffered a season-ending MCL injury in Sunday's loss to the Dolphins, David Lombardi of SFStandard.com reports. |
| Jaylon Moore Status: Out San Francisco 49ers | Moore (quadriceps) is done for remainder of the 2024 regular season, David Lombardi of SFStandard.com reports. |
| Trent Williams Status: Out San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Williams (ankle) is out for the season, Lindsey Pallares of the 49ers' official site reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (chest) is considered to be day-to-day with a chest injury heading into Week 17, Matt Barrows of The Athletic reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) is day-to-day with an ankle injury ahead of Monday's matchup with the Lions, Matt Barrows of The Athletic reports. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw (calf) will likely be shut down for the remainder of the 2024 regular season, David Lombardi of SFStandard.com reports. |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Jaylon Moore Status: Out San Francisco 49ers | out |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | questionable |
| Aaron Banks Status: Out San Francisco 49ers | out |
| Isaac Guerendo Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that the 49ers expect Guerendo (foot/hamstring) to practice Thursday, Nick Wagoner of ESPN.com reports. |
| Spencer Burford Status: Questionable San Francisco 49ers | Burford (calf) is awaiting an MRI on a calf injury, Matt Barrows of The Athletic reports. |
| 2024-12-23 |
| Aaron Banks Status: Questionable San Francisco 49ers | Banks (knee) has been ruled out of Sunday's game against the Dolphins, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Out San Francisco 49ers | out |
| Isaac Guerendo Status: Out San Francisco 49ers | out |
| Joshua Dobbs Status: Active San Francisco 49ers | NA |
 | Rock Ya-Sin Status: Active San Francisco 49ers | NA |
| Jake Tonges Status: Active San Francisco 49ers | NA |
| Khalil Davis Status: Active San Francisco 49ers | NA |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel caught seven of nine targets for 96 yards and a touchdown while adding 25 rushing yards on five attempts in Sunday's 29-17 loss to Miami. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 26 of 40 pass attempts for 313 yards, two touchdowns and one interception while adding 26 rushing yards on four attempts in Sunday's 29-17 loss to the Dolphins. |
| George Kittle Status: Active San Francisco 49ers | Kittle corralled eight of nine targets for 106 yards in Sunday's 29-17 loss to the Dolphins. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor ran the ball eight times for 24 yards while catching just one of five targets for one yard in Sunday's 29-17 loss to Miami. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings caught four of six targets for 51 yards in Sunday's 29-17 loss to the Dolphins. |
| Renardo Green Status: Active San Francisco 49ers | Green finished with 10 tackles (seven solo) and one pass defended in Sunday's 29-17 loss to the Dolphins. |
| Fred Warner Status: Active San Francisco 49ers | Warner racked up 11 tackles (six solo) in Sunday's 29-17 loss to the Dolphins. |
| Jake Moody Status: Active San Francisco 49ers | Moody went 1-for-2 on field-goal attempts and 2-for-2 on point-after tries in Sunday's 29-17 loss to Miami. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall had four receptions on as many targets for 37 yards in Sunday's 29-17 loss to Miami. |
| 2024-12-22 |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (calf) is out for the rest of Sunday's outing against the Dolphins, Matt Barrows of The Athletic reports. |
| Leonard Floyd Status: Active San Francisco 49ers | Floyd (shoulder) is back on the field in Sunday's matchup against the Dolphins, Matt Barrows of The Athletic reports. |
| Jaylon Moore Status: Questionable San Francisco 49ers | Moore (quadriceps) is questionable to return to Sunday's game against the Dolphins, Matt Barrows of The Athletic reports. |
| Robert Beal Jr. Status: Out San Francisco 49ers | Beal (ankle) is inactive for Sunday's game against the Dolphins, Lindsey Pallares of the 49ers' official site reports. |
| Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw (Achilles/knee) is active for Sunday's game against Miami. |
| Ke'Shawn Vaughn Status: Active San Francisco 49ers | The 49ers elevated Vaughn from the practice squad ahead of Sunday's game at Miami, Matt Barrows of The Athletic reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (hip/oblique) is active for Sunday's game against the Dolphins. |
| Rock Ya-Sin Status: Out San Francisco 49ers | inactive |
| Trent Williams Status: Out San Francisco 49ers | inactive |
| Jake Tonges Status: Out San Francisco 49ers | inactive |
| Isaac Guerendo Status: Out San Francisco 49ers | inactive |
| Khalil Davis Status: Out San Francisco 49ers | inactive |
| Joshua Dobbs Status: Out San Francisco 49ers | inactive |
| Leonard Floyd Status: Active San Francisco 49ers | Floyd (shoulder) is questionable to return to Sunday's matchup against the Dolphins, Nick Wagoner of ESPN.com reports. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | questionable |
| 2024-12-21 |
| Trent Williams Status: Out San Francisco 49ers | Williams (ankle) has been ruled out for Sunday's matchup against Miami, Matt Maiocco of NBC Sports Bay Area reports. |
| 2024-12-20 |