Injuries
| 2025-07-10 |
 | Demarcus Robinson Status: Active San Francisco 49ers | Robinson, who pleaded no contest to a misdemeanor DUI charge stemming from his arrest last November, has been sentenced to three years' probation, the Orange County Register reports. |
| 2025-06-14 |
 | Brandon Aiyuk Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Thursday that Aiyuk (knee) has been "doing a tremendous job coming back," Kevin Patra of NFL.com reports. |
| 2025-06-13 |
 | Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey was one of a few 49ers veterans to participate in 11-on-11 work during mandatory minicamp, Matt Barrows of The Athletic reports. |
| 2025-06-12 |
 | Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings dealt with a minor calf injury during the offseason program, Matt Barrows of The Athletic reports. |
| 2025-06-11 |
 | Alfred Collins Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Collins (calf) will be back on the practice field during training camp, Vic Tafur of The Athletic reports. |
 | Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) isn't participating in San Francisco's minicamp, Matt Maiocco of NBC Sports Bay Area reports. |
| Brandon Aiyuk Status: Questionable San Francisco 49ers | Aiyuk (knee) is present at San Francisco's mandatory minicamp but is not practicing, though he contributed Tuesday by coaching up the team's younger receivers, Matt Barrows of The Athletic reports. |
| 2025-06-10 |
 | Ricky Pearsall Status: Questionable San Francisco 49ers | 49ers coach Kyle Shanahan said Tuesday that Pearsall (hamstring) is healthy enough to participate in mandatory minicamp but that the team plans to be careful, and to prioritize having the second-year wideout ready for training camp, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
| 2025-06-06 |
 | Isaac Guerendo Status: Active San Francisco 49ers | NA |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo (knee/ankle) was an active participant at voluntary OTAs, per the 49ers' official site. |
| 2025-06-03 |
 | Trent Williams Status: Active San Francisco 49ers | NA |
 | Trent Taylor Status: Injured Reserve San Francisco 49ers | ir |
| Trent Williams Status: Active San Francisco 49ers | Williams (ankle) has been an active participant at the 49ers' OTAs, Vic Tafur of The Athletic reports. |
 | Malik Knowles Status: Active San Francisco 49ers | Knowles signed a one-year contract with the 49ers on Tuesday. |
| Trent Taylor Status: Injured Reserve San Francisco 49ers | The 49ers placed Taylor (undisclosed) on injured reserve Tuesday. |
| 2025-06-02 |
 | Bryce Huff Status: Active San Francisco 49ers | Huff was traded from the Eagles to the 49ers on Monday in exchange for a mid-round pick in 2026, Adam Schefter of ESPN reports. |
| 2025-05-30 |
 | Spencer Burford Status: Active San Francisco 49ers | NA |
| Spencer Burford Status: Active San Francisco 49ers | Burford (calf) participated in Thursday's organized team activities, Matt Barrows of The Athletic reports. |
 | Renardo Green Status: Active San Francisco 49ers | Green (groin) participated in Thursday's organized team activities, Grant Cohn of Spots Illustrated reports. |
 | Tre Brown Status: Active San Francisco 49ers | NA |
| Tre Brown Status: Active San Francisco 49ers | Brown (knee) participated in Thursday's organized team activities, Matt Barrows of The Athletic reports. |
| 2025-05-29 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall is dealing with a hamstring injury, according to head coach Kyle Shanahan, Nick Wagoner of ESPN.com reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | questionable |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown will be out until training camp after undergoing a procedure on his ankle, Cam Inman of The San Jose Mercury News reports. |
| 2025-05-28 |
 | Mitch Wishnowsky Status: Active San Francisco 49ers | NA |
 | Thomas Morstead Status: Active San Francisco 49ers | Morstead signed with the 49ers on Wednesday. |
| 2025-05-19 |
 | Fred Warner Status: Active San Francisco 49ers | Warner signed a three-year, $63 million contract extension with the 49ers on Monday, Adam Schefter of ESPN reports. |
| 2025-05-16 |
 | Brock Purdy Status: Active San Francisco 49ers | Purdy and the 49ers agreed to terms Friday on a five-year, $265 million contract extension, Tom Pelissero of NFL Network reports. |
 | Greg Joseph Status: Active San Francisco 49ers | The 49ers are slated to sign Joseph, Matt Barrows of The Athletic reports. |
| 2025-05-13 |
 | Tre Tomlinson Status: Injured Reserve San Francisco 49ers | Tomlinson (undisclosed) reverted to the 49ers' injured reserve Tuesday, per the NFL's transaction log. |
| 2025-05-09 |
 | Kurtis Rourke Status: Questionable San Francisco 49ers | Rourke (knee) won't participate in the 49ers' rookie camp, Matt Maiocco of NBC Sports Bay Area reports. |
 | Andre Dillard Status: Active San Francisco 49ers | The 49ers signed Dillard (concussion) on Friday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2025-05-02 |
 | Ross Dwelley Status: Active San Francisco 49ers | Dwelley signed a one-year contract with the 49ers on Friday. |
| 2025-04-29 |
 | George Kittle Status: Active San Francisco 49ers | Kittle is signing a four-year, $76.4 million extension with the 49ers, ESPN's Nick Wagoner reports. |
| 2025-04-27 |
 | Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha may miss the beginning of the 2025 season due to a knee injury he suffered in Week 17 last year, Nick Wagoner of ESPN.com reports. |
| 2025-04-26 |
| Upton Stout Status: Active San Francisco 49ers | The 49ers selected Stout in the third round of the 2025 NFL Draft, 100th overall. | |
| CJ West Status: Active San Francisco 49ers | The 49ers selected West in the fourth round of the 2025 NFL Draft, 113th overall. | |
| Jordan Watkins Status: Active San Francisco 49ers | The 49ers selected Watkins in the fourth round of the 2025 NFL Draft, 138th overall. | |
| Marques Sigle Status: Active San Francisco 49ers | The 49ers selected Sigle in the fifth round of the 2025 NFL Draft, 160th overall. | |
| Jordan James Status: Active San Francisco 49ers | The 49ers selected James in the fifth round of the 2025 NFL Draft, 147th overall. | |
| Kurtis Rourke Status: Questionable San Francisco 49ers | The 49ers selected Rourke (knee) in the seventh round of the 2025 NFL Draft, 227th overall. | |
| Junior Bergen Status: Active San Francisco 49ers | The 49ers selected Bergen in the seventh round of the 2025 NFL Draft, 252nd overall. | |
| Connor Colby Status: Active San Francisco 49ers | The 49ers selected Colby in the seventh round of the 2025 NFL Draft, 249th overall. | |
| Alfred Collins Status: Active San Francisco 49ers | The 49ers selected Collins in the second round of the 2025 NFL Draft, 43rd overall. | |
| Nick Martin Status: Active San Francisco 49ers | The 49ers selected Martin in the third round of the 2025 NFL Draft, 75th overall. |
| 2025-04-25 |
| Mykel Williams Status: Active San Francisco 49ers | The 49ers selected Williams in the first round of the 2025 NFL Draft, 11th overall. |
| 2025-04-23 |
 | Brayden Willis Status: Active San Francisco 49ers | Willis signed his exclusive rights free-agent tender with the 49ers on Tuesday. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey is participating in the offseason program without any restrictions, ESPN.com's Nick Wagoner reports. |
| 2025-04-22 |
| Brock Purdy Status: Active San Francisco 49ers | Purdy is present Tuesday for the start of San Francisco's voluntary offseason program, Adam Schefter of ESPN reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle is not at team facilities for the start of San Francisco's voluntary offseason workout program, Adam Schefter of ESPN reports. |
| 2025-04-17 |
 | Jake Tonges Status: Active San Francisco 49ers | Tonges re-signed with the 49ers on a one-year, $1.03 million contract Thursday. |
| 2025-04-16 |
 | Isaac Alarcon Status: Suspension San Francisco 49ers | Alarcon was handed a six-game suspension Wednesday for violating the NFL's performance-enhancing substances policy, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-04-08 |
| Christian McCaffrey Status: Active San Francisco 49ers | San Francisco coach Kyle Shanahan said last week that McCaffrey (knee) is healthy and doing well, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-04-02 |
 | Jake Moody Status: Active San Francisco 49ers | Coach Kyle Shanahan said Tuesday that the 49ers intend to bring in a veteran kicker "who's capable of taking that job" to compete with Moody this offseason, Eric Branch of the San Francisco Chronicle reports. |
| 2025-03-31 |
| Brandon Aiyuk Status: Questionable San Francisco 49ers | GM John Lynch relayed Monday that Aiyuk, who tore the ACL and MCL in his right knee in October, met with Dr. Neal ElAttrache last week and got "good reviews" in terms of the progress he's made in his injury recovery, Nick Wagoner of ESPN reports. |
| 2025-03-27 |
 | Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu signed his one-year exclusive rights tendered contract with the 49ers on Wednesday. |
| 2025-03-18 |
 | Siran Neal Status: Active San Francisco 49ers | The 49ers are signing Neal to a two-year contract, Cameron Wolfe of NFL Network reports. |
| 2025-03-15 |
 | Kyle Juszczyk Status: Active San Francisco 49ers | Jusczyk and the 49ers have agreed on a two-year, $8 million contract, Adam Schefter of ESPN reports. |
| 2025-03-14 |
| Tre Brown Status: Questionable San Francisco 49ers | Brown (knee) signed with the 49ers on Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2025-03-13 |
 | Mac Jones Status: Active San Francisco 49ers | The 49ers signed Jones to a two-year, $7 million contract Wednesday, Ian Rapoport of NFL Network reports. |
 | Curtis Robinson Status: Active San Francisco 49ers | NA |
| Curtis Robinson Status: Active San Francisco 49ers | Robinson (knee) re-signed with the 49ers on Thursday via a one-year contract. |
| 2025-03-12 |
 | Jason Pinnock Status: Active San Francisco 49ers | Pinnock is slated to sign a one-year contract with the 49ers, Jordan Schultz of Fox Sports reports. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson is slated to sign a two-year contract with the 49ers, Ian Rapoport of NFL Network reports. |
| 2025-03-11 |
 | Luke Gifford Status: Active San Francisco 49ers | The 49ers are set to sign Gifford to a one-year contract when the new league year starts Wednesday, Tom Pelissero of NFL Network reports. |
 | Jordan Mason Status: Questionable San Francisco 49ers | The 49ers are giving Mason (ankle) a second-round restricted free agent tender, Adam Schefter of ESPN reports. |
 | Richie Grant Status: Active San Francisco 49ers | The 49ers will sign Grant to a one-year contract, Jeremy Fowler of ESPN.com reports. |
| 2025-03-10 |
 | Elijah Mitchell Status: Active San Francisco 49ers | NA |
 | Jaylon Moore Status: Active San Francisco 49ers | NA |
 | Talanoa Hufanga Status: Active San Francisco 49ers | NA |
 | Patrick Taylor Jr. Status: Active San Francisco 49ers | The 49ers re-signed Taylor to a one-year deal Monday, Tom Pelissero of NFL Network reports. |
 | Luke Farrell Status: Active San Francisco 49ers | Farrell is slated to sign a three-year, $20.25 million contract with the 49ers, Ian Rapoport of NFL Network reports. |
 | Kevin Givens Status: Questionable San Francisco 49ers | The 49ers re-signed Givens (pectoral) to a one-year contract Monday, Matt Barrows of The Athletic reports. |
| 2025-03-08 |
| Tre Tomlinson Status: Active San Francisco 49ers | The 49ers claimed Tomlinson off waivers Friday. |
| 2025-03-07 |
| Jordan Mason Status: Questionable San Francisco 49ers | Mason (ankle) is drawing trade interest, David Lombardi of The San Francisco Standard reports. |
| 2025-03-06 |
 | Javon Hargrave Status: Active San Francisco 49ers | San Francisco plans to release Hargrave on the first day of the new league year March 12, Adam Schefter of ESPN reports. |
| 2025-03-05 |
| Javon Hargrave Status: Active San Francisco 49ers | Hargrave has recovered from his triceps injury, Jeremy Fowler of ESPN.com reports. |
| 2025-02-28 |
 | Deebo Samuel Sr. Status: Active San Francisco 49ers | The Commanders and Texans are among the top teams that have expressed interest in acquiring Samuel, whose trade request San Francisco general manager John Lynch said the team plans to honor, Jordan Schultz of Fox Sports reports. |
| 2025-02-26 |
| Trent Williams Status: Questionable San Francisco 49ers | 49ers general manager John Lynch said Wednesday at the 2025 NFL Scouting Combine that Williams (ankle) is "motivated" and will return for a 16th season in the NFL as a member of the 49ers, Ian Rapoport of NFL Network reports. |
| Brock Purdy Status: Active San Francisco 49ers | NA |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | NA |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Speaking at the 2025 NFL Scouting Combine on Wednesday, 49ers GM John Lynch said the team plans to honor Samuel's wish for a trade, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | Speaking at the 2025 NFL Scouting Combine on Wednesday, 49ers GM John Lynch said the team and Purdy have already had conversations about a contract extension, Nick Wagoner of ESPN.com reports. |
| 2025-02-24 |
 | Ben Bartch Status: Active San Francisco 49ers | NA |
| Ben Bartch Status: Active San Francisco 49ers | The 49ers signed Bartch (ankle) to a one-year contract extension Monday. |
| 2025-02-21 |
| George Kittle Status: Active San Francisco 49ers | Kittle's agent has already discussed contract extension with the 49ers, Eric Branch of the San Francisco Chronicle reports. |
| 2025-02-13 |
| Mitch Wishnowsky Status: Questionable San Francisco 49ers | questionable |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Curtis Robinson Status: Questionable San Francisco 49ers | questionable |
 | George Odum Status: Questionable San Francisco 49ers | questionable |
| Jaylon Moore Status: Questionable San Francisco 49ers | questionable |
| Elijah Mitchell Status: Questionable San Francisco 49ers | questionable |
| Jordan Mason Status: Questionable San Francisco 49ers | questionable |
| Christian McCaffrey Status: Questionable San Francisco 49ers | questionable |
 | Darrell Luter Jr. Status: Questionable San Francisco 49ers | questionable |
 | Drake Jackson Status: Questionable San Francisco 49ers | questionable |
| 2025-02-11 |
 | De'Vondre Campbell Status: Active San Francisco 49ers | The 49ers lifted Campbell's suspension Monday, Aaron Wilson of KPRC 2 Houston reports. |
| 2025-02-09 |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | The 49ers have granted Samuel (ribs) and his agent permission to find a trade partner, Adam Schefter of ESPN reports. |
| 2025-01-17 |
 | Brandon Allen Status: Active San Francisco 49ers | Allen completed 17 of 30 pass attempts for 199 yards, one touchdown and two interceptions across three games with the 49ers in 2024. |
 | Chris Conley Status: Questionable San Francisco 49ers | Conley (elbow) appeared in 15 games for the 49ers this season, finishing with six receptions on 12 targets for 76 yards. |
 | Jacob Cowing Status: Active San Francisco 49ers | Cowing finished his rookie season with four receptions for 80 yards and one rushing attempt for seven yards across 15 active games. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk produced 26 rushing yards and a touchdown on five carries to go along with 19 receptions for 200 yards and a pair of scores while starting all 17 games for San Francisco this season. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown finished the regular season with 77 tackles (48 solo) and one interception across 17 starts for San Francisco. |
 | Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (shoulder) finished with 85 tackles (53 solo), two interceptions and one forced fumble across 15 starts in 2024. |
| Fred Warner Status: Active San Francisco 49ers | Warner finished the 2024 season with 131 tackles (76 solo), 1.0 sack, two interceptions, four forced fumbles and a defensive touchdown across 17 starts for San Francisco. |
 | Eric Saubert Status: Active San Francisco 49ers | Saubert recorded 11 receptions for 97 yards and a touchdown across 17 games this season. |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha (knee) finished his rookie season with 72 tackles (32 solo) and one interception across 16 games with the 49ers. |
| Talanoa Hufanga Status: Questionable San Francisco 49ers | Hufanga (concussion) finished with 38 tackles (20 solo) in seven active games in 2024. |
 | Nick Bosa Status: Active San Francisco 49ers | Bosa finished with 52 tackles (33 solo), 9.0 sacks, one interception and one fumble forced across 14 starts in 2024. |
| 2025-01-09 |
 | Isaac Yiadom Status: Active San Francisco 49ers | Yiadom accumulated 46 tackles (38 solo), six pass defenses (including one interception), two forced fumbles and one fumble recovery across 17 regular-season games in 2024. |
 | Charvarius Ward Status: Active San Francisco 49ers | Ward finished the 2024 season with 54 tackles (38 solo) and seven pass breakups across 12 games. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (groin) finished the 2024 regular season with 61 tackles (41 solo), 13 pass defenses (including one interception) and one forced fumble across 17 games. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu finished the 2024 regular season with 35 tackles (25 solo), including 3.0 sacks, one pass defense and one forced fumble across 16 games. |
 | Maliek Collins Status: Active San Francisco 49ers | Collins finished the 2024 season with 33 tackles (20 solo), including 5.0 sacks, and two fumble recoveries across 17 games. |
 | Leonard Floyd Status: Active San Francisco 49ers | Floyd totaled 42 tackles (25 solo), including 8.5 sacks, one pass defense and one forced fumble across 17 regular-season games. |
 | Dee Winters Status: Active San Francisco 49ers | Winters finished the 2024 season with 44 tackles (26 solo) and four pass breakups across 15 games. |
| George Odum Status: Injured Reserve San Francisco 49ers | Odum tallied 16 tackles (14 solo) and four pass defenses across 12 regular-season games in 2024. |
 | Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos finished the 2024 season with 19 tackles (14 solo), including 4.0 sacks, across 11 games. |
 | Jordan Elliott Status: Active San Francisco 49ers | Elliott finished the 2024 regular season with 19 tackles (12 solo) through 15 games. |
| 2025-01-08 |
 | Isaiah Hodgins Status: Active San Francisco 49ers | San Francisco signed Hodgins to a reserve/future contract Tuesday. |
 | Russell Gage Status: Active San Francisco 49ers | The 49ers signed Gage to a reserve/future deal Tuesday. |
| Javon Hargrave Status: Injured Reserve San Francisco 49ers | General manager John Lynch confirmed Wednesday that the 49ers plan to release Hargrave (triceps) after June 1, Nick Wagoner of ESPN.com reports. |
| 2025-01-07 |
 | Terique Owens Status: Active San Francisco 49ers | San Francisco signed Owens to a reserve/future contract Monday. |
 | Tanner Mordecai Status: Active San Francisco 49ers | The 49ers signed Mordecai to a reserve/future contract Monday. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The Athletic reports. |
| Trent Taylor Status: Active San Francisco 49ers | Taylor signed a reserve/future contract with San Francisco on Monday. |
 | Mason Pline Status: Active San Francisco 49ers | The 49ers signed Pline (undisclosed) to a reserve/future contract Monday. |
| 2025-01-06 |
 | Colton McKivitz Status: Questionable San Francisco 49ers | questionable |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallares of the 49ers' official site reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | questionable |
 | Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
 | Khalil Davis Status: Active San Francisco 49ers | NA |
 | Tre Avery Status: Active San Francisco 49ers | NA |
 | Joshua Dobbs Status: Active San Francisco 49ers | Dobbs completed 29 of 43 pass attempts for 326 yards, two touchdowns and two interceptions while rushing eight times for 17 yards and a third score while coughing up a fumble in Sunday's 47-24 loss to Arizona. |
| George Kittle Status: Active San Francisco 49ers | Kittle brought in two of three targets for 27 yards in Sunday's 47-24 loss to the Cardinals. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall corralled six of eight targets for 69 yards and a touchdown in Sunday's 47-24 loss to the Cardinals. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor rushed 17 times for 109 yards while catching one of four targets for 12 receiving yards in Sunday's 47-24 loss to Arizona. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings finished with seven receptions on 10 targets for 52 yards in Sunday's 47-24 loss to Arizona. |
| Jake Moody Status: Active San Francisco 49ers | Moody went 1-for-2 on field-goal attempts while converting all three of his extra-point attempts in Sunday's 47-24 loss to the Cardinals. |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | McCaffrey (knee) said Monday he's "definitely close" to 100 percent healthy and could have played had the 49ers qualified for the playoffs, Nick Wagoner of ESPN.com reports. |
| Mason Pline Status: Active San Francisco 49ers | NA |
| Isaac Guerendo Status: Questionable San Francisco 49ers | questionable |
| 2025-01-05 |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | The 49ers placed Burford (calf) on injured reserve Saturday. |
 | Demetrius Flannigan-Fowles Status: Injured Reserve San Francisco 49ers | Flannigan-Fowles (calf) was placed on the 49ers' injured reserve Saturday |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (ankle) is active for Sunday's matchup against the Cardinals, Lindsey Pallares of the 49ers' official site reports. |
 | Israel Abanikanda Status: Out San Francisco 49ers | Abanikanda (coach's decision) is inactive for Sunday's Week 18 matchup versus Arizona, Lindsey Pallares of the 49ers' official site reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle (ankle/hamstring) is listed as active Sunday in Arizona, Lindsey Pallares of the 49ers' official site reports. |
| Deebo Samuel Sr. Status: Out San Francisco 49ers | inactive |
| Brock Purdy Status: Out San Francisco 49ers | inactive |
| Deommodore Lenoir Status: Out San Francisco 49ers | inactive |
| Khalil Davis Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| Tre Avery Status: Out San Francisco 49ers | inactive |
| Colton McKivitz Status: Active San Francisco 49ers | NA |
| Isaac Yiadom Status: Active San Francisco 49ers | Yiadom (pelvis) is active for Sunday's contest against the Cardinals, Lindsey Pallares of the 49ers' official site reports. |
| Isaac Guerendo Status: Out San Francisco 49ers | Guerendo won't return to Sunday's game at Arizona due to knee and ankle injuries. |
| Talanoa Hufanga Status: Questionable San Francisco 49ers | Hufanga was diagnosed with a concussion during Sunday's game against the Cardinals and will not return, Nick Wagoner of ESPN.com reports. |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha (knee) has been ruled out for the rest of Sunday's contest versus the Cardinals, Matt Maiocco of NBC Sports Bay Area reports. |
| Chris Conley Status: Questionable San Francisco 49ers | Conley (elbow) is questionable to return to Sunday's contest against the Cardinals, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green has been deemed questionable to return to Sunday's Week 18 matchup against Arizona due to a groin injury, Lindsey Pallares of the 49ers' official site reports. |
| 2025-01-04 |
| Demetrius Flannigan-Fowles Status: Injured Reserve San Francisco 49ers | ir |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | ir |
| Trent Taylor Status: Active San Francisco 49ers | The 49ers elevated Taylor from the practice squad to the active roster Saturday. |
| Robert Beal Jr. Status: Out San Francisco 49ers | Beal (ankle) has been ruled out for Sunday's game against the Cardinals, Bo Brack of GoPHNX.com reports. |
| Isaac Yiadom Status: Questionable San Francisco 49ers | Yiadom (pelvis) is listed as questionable for Sunday's game against the Cardinals. |
| Spencer Burford Status: Out San Francisco 49ers | Burford (calf) has been ruled out for Sunday's game against Arizona, Bo Brack of GoPHNX.com reports. |
| 2025-01-03 |
| Deommodore Lenoir Status: Out San Francisco 49ers | out |
| Demetrius Flannigan-Fowles Status: Doubtful San Francisco 49ers | doubtful |
| Spencer Burford Status: Out San Francisco 49ers | out |
| Robert Beal Jr. Status: Out San Francisco 49ers | out |
| Leonard Floyd Status: Active San Francisco 49ers | NA |
| Nick Bosa Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (illness/chest) doesn't have an injury designation for Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle/hamstring) is listed as questionable for Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (elbow) has been ruled out for Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Deebo Samuel Sr. Status: Out San Francisco 49ers | Samuel (ribs/wrist) has been ruled out for Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Isaac Yiadom Status: Questionable San Francisco 49ers | Yiadom (pelvis) upgraded to a limited practice Thursday, Nick Wagoner of ESPN.com reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) was a non-participant in Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (knee) has no injury designation ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports. |
| Leonard Floyd Status: Active San Francisco 49ers | Floyd (shoulder) has no injury designation ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) is listed as questionable ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports. |
| Demetrius Flannigan-Fowles Status: Doubtful San Francisco 49ers | Flannigan-Fowles (calf) is listed as doubtful ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports. |
| Deommodore Lenoir Status: Out San Francisco 49ers | Lenoir (shoulder) has been ruled out ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports. |
| 2025-01-02 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (illness/chest) practiced in a limited capacity Thursday, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Doubtful San Francisco 49ers | Purdy (right elbow) didn't practice Thursday, Nick Wagoner of ESPN.com reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel (ribs/wrist) won't take part in Thursday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle/hamstring) was limited at practice Thursday, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall was limited at Wednesday's practice due to an illness and a chest injury, Matt Barrows of The Athletic reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | questionable |
| Isaac Yiadom Status: Questionable San Francisco 49ers | questionable |
| Colton McKivitz Status: Questionable San Francisco 49ers | questionable |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | questionable |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | questionable |
| Charvarius Ward Status: Active San Francisco 49ers | NA |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) was a limited participant at the 49ers' practice Wednesday. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (shoulder) did not practice Wednesday. |
| Isaac Yiadom Status: Questionable San Francisco 49ers | Yiadom (pelvis) did not participate at the 49ers practice Wednesday. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) did not practice Wednesday. |
| Leonard Floyd Status: Questionable San Francisco 49ers | Floyd (shoulder) did not participate at the 49ers' practice Wednesday. |
| 2025-01-01 |
| Brock Purdy Status: Doubtful San Francisco 49ers | The 49ers announced Wednesday that Joshua Dobbs will start in place of Purdy (elbow) in Sunday's Week 18 game against Arizona. |
| Joshua Dobbs Status: Active San Francisco 49ers | Coach Kyle Shanahan said Wednesday that Dobbs will start Sunday's game at Arizona, Nick Wagoner of ESPN.com reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel won't participate in Wednesday's practice due to rib and knee injuries, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Out San Francisco 49ers | out |
| George Kittle Status: Questionable San Francisco 49ers | Kittle won't practice Wednesday due to ankle and hamstring injuries, Nick Wagoner of ESPN.com reports. |
| 2024-12-31 |
| Brandon Allen Status: Out San Francisco 49ers | Allen (coach's decision) is inactive for Monday's game against the Lions, Nick Wagoner of ESPN.com reports. |
| Israel Abanikanda Status: Out San Francisco 49ers | Abanikanda (coach's decision) is inactive for Monday's game against the Lions, Lindsey Pallares of the 49ers' official site reports. |
| Joshua Dobbs Status: Active San Francisco 49ers | Dobbs is active and will operate as the 49ers' top backup quarterback in Monday night's matchup with the Lions, Eric Branch of the San Francisco Chronicle reports. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (ankle) is active for Monday night's game against the Lions, Lindsey Pallares of the 49ers' official site reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall finished with eight receptions on 10 targets for 141 yards and a touchdown while adding six rushing yards on two attempts in Monday's 40-34 loss to Detroit. |
| Brock Purdy Status: Questionable San Francisco 49ers | Speaking after Monday night's loss to the Lions, coach Kyle Shanahan said Purdy's elbow injury isn't believed to be serious, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle corralled all eight of his targets for 112 receiving yards in Monday's 40-34 loss to the Lions. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel brought in his only target for a five-yard touchdown while adding 16 rushing yards on three attempts in Monday's 40-34 loss to the Lions. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings finished with seven receptions (on 10 targets) for 67 yards in Monday's 40-34 loss to the Lions. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo took nine carries for 34 yards while bringing in all four targets for 65 yards in Monday's 40-34 loss to the Lions. |
| Charvarius Ward Status: Questionable San Francisco 49ers | questionable |
 | Dre Greenlaw Status: Out San Francisco 49ers | out |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
| Khalil Davis Status: Active San Francisco 49ers | NA |
| Israel Abanikanda Status: Active San Francisco 49ers | NA |
| Brandon Allen Status: Active San Francisco 49ers | NA |
| Jake Moody Status: Active San Francisco 49ers | Moody went 4-for-5 on extra-point attempts but missed both of his field-goal tries during the 49ers' 40-34 loss to the Lions on Monday. |
| Brock Purdy Status: Doubtful San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Purdy was diagnosed with a contusion and nerve inflammation in his right elbow and is unlikely to be available for Sunday's game against the Cardinals, Lindsey Pallares of the 49ers' official site reports. |
| Demetrius Flannigan-Fowles Status: Questionable San Francisco 49ers | Flannigan-Fowles is considered day-to-day due to a calf injury, Matt Barrows of The Athletic reports. |
| Leonard Floyd Status: Questionable San Francisco 49ers | Floyd is considered day-to-day due to the shoulder injury he suffered in Monday's Week 17 loss to Detroit, Matt Barrows of The Athletic reports. |
| Joshua Dobbs Status: Active San Francisco 49ers | Dobbs took the field for the 49ers' final five offensive snaps of Monday's 40-34 loss to the Lions and completed three of four pass attempts for 35 yards while rushing for a seven-yard touchdown. |
| Dre Greenlaw Status: Injured Reserve San Francisco 49ers | The 49ers moved Greenlaw (calf) to IR on Tuesday. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor did not record a carry or a target while playing 13 offensive snaps (20 percent) in Monday's 40-34 loss to the Lions. |
| Jake Moody Status: Active San Francisco 49ers | Moody missed both of his field-goal attempts while going 4-for-5 on point-after tries in Monday's 40-34 loss to the Lions. |
| 2024-12-30 |
 | Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (knee) was activated from the injured reserve list Monday. |
 | Aaron Banks Status: Injured Reserve San Francisco 49ers | The 49ers placed Banks on injured reserve Monday. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune (knee) is active ahead of Monday night's matchup against the Lions, Lindsey Pallares of the 49ers' official site reports. |
| Charvarius Ward Status: Out San Francisco 49ers | inactive |
| Dre Greenlaw Status: Out San Francisco 49ers | inactive |
| Khalil Davis Status: Out San Francisco 49ers | inactive |
| Spencer Burford Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| 2024-12-29 |
| Charvarius Ward Status: Out San Francisco 49ers | Ward (personal) has been ruled out for Monday's Week 17 game against Detroit, Matt Barrows of The Athletic reports. |
| 2024-12-28 |
| Charvarius Ward Status: Questionable San Francisco 49ers | questionable |
| Spencer Burford Status: Out San Francisco 49ers | out |
| Robert Beal Jr. Status: Out San Francisco 49ers | out |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo (foot/hamstring) doesn't have a designation for Monday's game versus the Lions, Cam Inman of The San Jose Mercury News reports. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (illness) is absent from the 49ers' injury report ahead of Monday's matchup with the Lions. |
| Spencer Burford Status: Out San Francisco 49ers | Burford (calf) won't play in Monday's Week 17 tilt against Detroit, David Lombardi of SFStandard.com reports. |
| Robert Beal Jr. Status: Out San Francisco 49ers | Beal (ankle) has been ruled out for Monday's matchup against Detroit, Cam Inman of The San Jose Mercury News reports. |
| Leonard Floyd Status: Active San Francisco 49ers | NA |
| Charvarius Ward Status: Questionable San Francisco 49ers | Ward (personal) is listed as questionable for Monday's game against Detroit, Cam Inman of The San Jose Mercury News reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) is listed as questionable for Monday night's game against the Lions, Cam Inman of The San Jose Mercury News reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo (foot/hamstring) is expected to play Monday against the Lions, Adam Schefter of ESPN reports. |
| 2024-12-27 |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (illness) didn't practice Friday, Nick Wagoner of ESPN.com reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo (foot/hamstring) practiced in a limited capacity Friday, Nick Wagoner of ESPN.com reports. |
| Tatum Bethune Status: Injured Reserve San Francisco 49ers | Bethune (knee) was designated to return from injured reserve Friday, Aaron Wilson of KPRC 2 Houston reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters (chest) was a full participant in Thursday's practice. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) logged a limited practice session Thursday. |
| Colton McKivitz Status: Questionable San Francisco 49ers | questionable |
| Leonard Floyd Status: Questionable San Francisco 49ers | questionable |
| 2024-12-26 |
| Trent Williams Status: Injured Reserve San Francisco 49ers | ir |
| Dre Greenlaw Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Thursday that Greenlaw (calf) will be shut down for the rest of the 2024 regular season, David Lombardi of SFStandard.com reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Guerendo (foot/hamstring) will be limited at Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Trent Williams Status: Injured Reserve San Francisco 49ers | The 49ers placed Williams (ankle) on injured reserve Thursday, Matt Barrows of The Athletic reports. |
| Jaylon Moore Status: Injured Reserve San Francisco 49ers | The 49ers placed Moore (quadriceps) on injured reserve Wednesday. |
| 2024-12-25 |
| Jaylon Moore Status: Injured Reserve San Francisco 49ers | ir |
| 2024-12-24 |
| Fred Warner Status: Active San Francisco 49ers | Warner totaled 11 tackles (six solo) during the 49ers' loss to the Dolphins on Sunday. |
| Aaron Banks Status: Out San Francisco 49ers | Banks (knee) suffered a season-ending MCL injury in Sunday's loss to the Dolphins, David Lombardi of SFStandard.com reports. |
| Jaylon Moore Status: Out San Francisco 49ers | Moore (quadriceps) is done for remainder of the 2024 regular season, David Lombardi of SFStandard.com reports. |
| Trent Williams Status: Out San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Williams (ankle) is out for the season, Lindsey Pallares of the 49ers' official site reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (chest) is considered to be day-to-day with a chest injury heading into Week 17, Matt Barrows of The Athletic reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (ankle) is day-to-day with an ankle injury ahead of Monday's matchup with the Lions, Matt Barrows of The Athletic reports. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw (calf) will likely be shut down for the remainder of the 2024 regular season, David Lombardi of SFStandard.com reports. |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Jaylon Moore Status: Out San Francisco 49ers | out |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | questionable |
| Aaron Banks Status: Out San Francisco 49ers | out |
| Isaac Guerendo Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that the 49ers expect Guerendo (foot/hamstring) to practice Thursday, Nick Wagoner of ESPN.com reports. |
| Spencer Burford Status: Questionable San Francisco 49ers | Burford (calf) is awaiting an MRI on a calf injury, Matt Barrows of The Athletic reports. |
| 2024-12-23 |
| Aaron Banks Status: Questionable San Francisco 49ers | Banks (knee) has been ruled out of Sunday's game against the Dolphins, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Out San Francisco 49ers | out |
| Isaac Guerendo Status: Out San Francisco 49ers | out |
| Joshua Dobbs Status: Active San Francisco 49ers | NA |
 | Rock Ya-Sin Status: Active San Francisco 49ers | NA |
| Jake Tonges Status: Active San Francisco 49ers | NA |
| Khalil Davis Status: Active San Francisco 49ers | NA |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel caught seven of nine targets for 96 yards and a touchdown while adding 25 rushing yards on five attempts in Sunday's 29-17 loss to Miami. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 26 of 40 pass attempts for 313 yards, two touchdowns and one interception while adding 26 rushing yards on four attempts in Sunday's 29-17 loss to the Dolphins. |
| George Kittle Status: Active San Francisco 49ers | Kittle corralled eight of nine targets for 106 yards in Sunday's 29-17 loss to the Dolphins. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor ran the ball eight times for 24 yards while catching just one of five targets for one yard in Sunday's 29-17 loss to Miami. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings caught four of six targets for 51 yards in Sunday's 29-17 loss to the Dolphins. |
| Renardo Green Status: Active San Francisco 49ers | Green finished with 10 tackles (seven solo) and one pass defended in Sunday's 29-17 loss to the Dolphins. |
| Fred Warner Status: Active San Francisco 49ers | Warner racked up 11 tackles (six solo) in Sunday's 29-17 loss to the Dolphins. |
| Jake Moody Status: Active San Francisco 49ers | Moody went 1-for-2 on field-goal attempts and 2-for-2 on point-after tries in Sunday's 29-17 loss to Miami. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall had four receptions on as many targets for 37 yards in Sunday's 29-17 loss to Miami. |
| 2024-12-22 |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (calf) is out for the rest of Sunday's outing against the Dolphins, Matt Barrows of The Athletic reports. |
| Leonard Floyd Status: Active San Francisco 49ers | Floyd (shoulder) is back on the field in Sunday's matchup against the Dolphins, Matt Barrows of The Athletic reports. |
| Jaylon Moore Status: Questionable San Francisco 49ers | Moore (quadriceps) is questionable to return to Sunday's game against the Dolphins, Matt Barrows of The Athletic reports. |
| Robert Beal Jr. Status: Out San Francisco 49ers | Beal (ankle) is inactive for Sunday's game against the Dolphins, Lindsey Pallares of the 49ers' official site reports. |
| Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw (Achilles/knee) is active for Sunday's game against Miami. |
 | Ke'Shawn Vaughn Status: Active San Francisco 49ers | The 49ers elevated Vaughn from the practice squad ahead of Sunday's game at Miami, Matt Barrows of The Athletic reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (hip/oblique) is active for Sunday's game against the Dolphins. |
| Rock Ya-Sin Status: Out San Francisco 49ers | inactive |
| Trent Williams Status: Out San Francisco 49ers | inactive |
| Jake Tonges Status: Out San Francisco 49ers | inactive |
| Isaac Guerendo Status: Out San Francisco 49ers | inactive |
| Khalil Davis Status: Out San Francisco 49ers | inactive |
| Joshua Dobbs Status: Out San Francisco 49ers | inactive |
| Leonard Floyd Status: Active San Francisco 49ers | Floyd (shoulder) is questionable to return to Sunday's matchup against the Dolphins, Nick Wagoner of ESPN.com reports. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | questionable |
| 2024-12-21 |
| Trent Williams Status: Out San Francisco 49ers | Williams (ankle) has been ruled out for Sunday's matchup against Miami, Matt Maiocco of NBC Sports Bay Area reports. |
| 2024-12-20 |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor is preparing for a larger role with fellow running back Isaac Guerendo (hamstring/foot) ruled out for Sunday's game at Miami, 95.7 The Game reports. |
| Trent Williams Status: Out San Francisco 49ers | out |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
| Malik Mustapha Status: Active San Francisco 49ers | NA |
 | Nick Zakelj Status: Active San Francisco 49ers | NA |
| Maliek Collins Status: Active San Francisco 49ers | NA |
| Jaylon Moore Status: Active San Francisco 49ers | NA |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip/oblique) is listed as questionable ahead of Sunday's matchup against the Dolphins, Matt Maiocco of NBC Sports Bay Area reports. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw (Achilles/knee) is listed as questionable ahead of Sunday's matchup against the Dolphins, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (oblique/hip) was a non-participant at the 49ers' practice Thursday, Matt Maiocco of NBC Sports Bay Area reports. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha (chest) has no injury designation ahead of Sunday's matchup against the Dolphins, Matt Maiocco of NBC Sports Bay Area reports. |
| Isaac Guerendo Status: Out San Francisco 49ers | Guerendo (foot, hamstring) has been ruled out for Sunday's game at Miami, Matt Maiocco of NBC Sports Bay Area reports. |
| 2024-12-19 |
| Khalil Davis Status: Active San Francisco 49ers | Davis (knee) was not listed on the 49ers' injury report Wednesday. |
| Dee Winters Status: Active San Francisco 49ers | Winters (neck) was a full participant in Wednesday's practice. |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha (chest) was a limited participant in Wednesday's practice. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (groin) was a full participant in Wednesday's practice. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw (Achilles/knee) was listed as a limited practice participant on Wednesday's injury report. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (oblique/hip) was a limited participant in Wednesday's practice. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | The 49ers are not expected to have Guerendo (hamstring) available for Sunday's game against the Dolphins, Adam Schefter of ESPN reports. |
| 2024-12-18 |
| Nick Zakelj Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Active San Francisco 49ers | NA |
| Ji'Ayir Brown Status: Active San Francisco 49ers | NA |
| Jaylon Moore Status: Questionable San Francisco 49ers | questionable |
| Maliek Collins Status: Questionable San Francisco 49ers | questionable |
| Nick Bosa Status: Questionable San Francisco 49ers | questionable |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo (hamstring) will not practice Wednesday, David Lombardi of SFStandard.com reports. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges played all 14 of his snaps on special teams in Thursday's 12-6 loss to the Rams. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk played 27 of the 49ers' 54 snaps on offense and went without a carry or target in Thursday's 12-6 loss to the Rams. |
| Chris Conley Status: Active San Francisco 49ers | Conley went without a target while playing three of the 49ers' 54 snaps on offense in Thursday's 12-6 loss to the Rams. |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing returned five punts for 51 yards and went without a target while playing four of the 49ers' 54 snaps on offense in Thursday's 12-6 loss to the Rams. |
| Brayden Willis Status: Active San Francisco 49ers | Willis played all 20 of his snaps on special teams in Thursday's 12-6 loss to the Rams. |
| Eric Saubert Status: Active San Francisco 49ers | Saubert played 17 of the 49ers' 54 snaps on offense and went without a target in Thursday's 12-6 loss to the Rams. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | questionable |
| 2024-12-17 |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Malik Mustapha Status: Questionable San Francisco 49ers | questionable |
| Khalil Davis Status: Questionable San Francisco 49ers | questionable |
 | Ambry Thomas Status: Out San Francisco 49ers | out |
| 2024-12-16 |
| Trent Williams Status: Out San Francisco 49ers | out |
| Malik Mustapha Status: Out San Francisco 49ers | out |
| Khalil Davis Status: Out San Francisco 49ers | out |
| Joshua Dobbs Status: Active San Francisco 49ers | NA |
| Israel Abanikanda Status: Active San Francisco 49ers | NA |
| Rock Ya-Sin Status: Active San Francisco 49ers | NA |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (groin) recorded six tackles (four solo) during Thursday's 12-6 loss versus the Rams. |
| Talanoa Hufanga Status: Active San Francisco 49ers | Hufanga recorded eight tackles (two solo) during Thursday's 12-6 loss versus the Rams. |
| De'Vondre Campbell Status: Suspension San Francisco 49ers | The 49ers are expected to suspend Campbell for the final three games of the regular season after the linebacker refused to enter Thursday's 12-6 loss to the Rams, Ian Rapoport of NFL Network reports. |
| 2024-12-14 |
| Dee Winters Status: Questionable San Francisco 49ers | Winters is day-to-day due to a neck issue, Lindsey Pallares of the 49ers' official site reports. |
| De'Vondre Campbell Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said Friday that Campbell, who refused to enter Thursday's loss to the Rams, isn't expected to play another snap with the 49ers, Nick Wagoner of ESPN.com reports. |
| 2024-12-13 |
| Jake Moody Status: Active San Francisco 49ers | Moody went 2-for-2 on field-goal attempts with no point-after tries in Thursday's 12-6 loss to the Rams. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall had one reception on four targets for 16 yards in Thursday's 12-6 loss to the Rams. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor was on the field for three offensive snaps (six percent) and did not record a touch in Thursday's 12-6 loss to the Rams. |
| Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw (Achilles) is active for Thursday Night Football against the Rams, Lindsey Pallares of the 49ers' official site reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (oblique/hip) is active for Thursday night's matchup with the Rams, Lindsey Pallares of the 49ers' official site reports. |
| Ben Bartch Status: Injured Reserve San Francisco 49ers | Bartch (ankle) was placed on injured reserve Thursday, Matt Barrows of The Athletic reports. |
| Joshua Dobbs Status: Out San Francisco 49ers | Dobbs (coach's decision) is inactive for Thursday night's game against the Rams, Nick Wagoner of ESPN.com reports. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor may not start Thursday versus the Rams with Isaac Guerendo (foot) active for the contest. |
| Khalil Davis Status: Out San Francisco 49ers | Davis (knee) is inactive for Thursday Night Football against the Rams, Lindsey Pallares of the 49ers' official site reports. |
| Israel Abanikanda Status: Out San Francisco 49ers | Abanikanda (coach's decision) is inactive for Thursday's matchup with the Rams, Lindsey Pallares of the 49ers' official site reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (groin) is questionable to return to Thursday's game against the Rams, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings secured two of nine targets for 31 yards in the 49ers' 12-6 loss to the Rams on Thursday night. |
| George Kittle Status: Active San Francisco 49ers | Kittle secured four of seven targets for 61 yards in the 49ers' 12-6 loss to the Rams on Thursday night. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo rushed 16 times for 57 yards and brought in all four targets for 18 yards in the 49ers' 12-6 loss to the Rams on Thursday night. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 14 of 31 passes for 142 yards with no touchdowns and one interception and rushed once for three yards in the 49ers' 12-6 loss to the Rams on Thursday night. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw did not play for most of the second half of Thursday's 12-6 loss to the Rams due to Achilles and knee tightness, Cam Inman of The San Jose Mercury News reports. |
| De'Vondre Campbell Status: Active San Francisco 49ers | Campbell refused to enter the game in Thursday's 12-6 loss to the Rams, Matt Barrows of The Athletic reports. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel brought in three of seven targets for 16 yards, rushed twice for three yards and returned two kickoffs for 72 yards in the 49ers' 12-6 loss to the Rams on Thursday night. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (groin) is considered day-to-day after being injured in Thursday night's loss to the Rams, Lindsey Pallares of the 49ers' official site reports. |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Trent Williams Status: Out San Francisco 49ers | Head coach Kyle Shanahan told reporters Friday that Williams (ankle) is "trying to get back" and his recovery has been "a lot slower than anticipated," Nick Wagoner of ESPN.com reports. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Friday that Greenlaw (Achilles/knee) "checked out good" after making his season debut during Thursday's 12-6 loss to the Rams, and that he's now dealing with soreness and is considered day-to-day, David Lombardi of SFStandard.com reports. |
| Fred Warner Status: Active San Francisco 49ers | Warner finished with 15 tackles (eight solo) with a pass defended in Thursday's 12-6 loss to the Rams. |
| 2024-12-12 |
| Ke'Shawn Vaughn Status: Active San Francisco 49ers | The 49ers elevated Vaughn from the practice squad to the active roster ahead of Thursday's game versus the Rams. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | The 49ers have activated Greenlaw (Achilles) from the reserve/PUP list, but he remains questionable for Thursday's game against the Rams. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (oblique/hip) is listed as questionable for Thursday's game against the Rams but is considered likely to play, Adam Schefter of ESPN reports. |
| Ben Bartch Status: Injured Reserve San Francisco 49ers | ir |
| Rock Ya-Sin Status: Out San Francisco 49ers | inactive |
| Trent Williams Status: Out San Francisco 49ers | inactive |
| Malik Mustapha Status: Out San Francisco 49ers | inactive |
| Khalil Davis Status: Out San Francisco 49ers | inactive |
| Israel Abanikanda Status: Out San Francisco 49ers | inactive |
| Demetrius Flannigan-Fowles Status: Active San Francisco 49ers | Flannigan-Fowles (knee) doesn't have an injury status for Thursday's Week 15 tilt against the Rams. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo (foot) remains listed as questionable for Thursday's game against the Rams but insists he "feels good" and plans to play, sources tell Adam Schefter of ESPN. |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (Achilles) is expected to be activated from the reserve/PUP list on Thursday and suit up for San Francisco's home matchup against the Rams, Jeremy Fowler of ESPN.com reports. |
| 2024-12-11 |
| Trent Williams Status: Out San Francisco 49ers | out |
| Malik Mustapha Status: Out San Francisco 49ers | out |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo (foot) is listed as questionable for Thursday's game versus the Rams, Eric Branch of the San Francisco Chronicle reports. |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (Achilles) is listed as questionable ahead of Thursday night's matchup against the Rams, Eric Branch of the San Francisco Chronicle reports. |
| Trent Williams Status: Out San Francisco 49ers | Williams (ankle) has been ruled out ahead of Thursday night's matchup against the Rams, Eric Branch of the San Francisco Chronicle reports. |
| Demetrius Flannigan-Fowles Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Dee Winters Status: Active San Francisco 49ers | NA |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (oblique) is listed as questionable ahead of Thursday night's matchup against the Rams, Eric Branch of the San Francisco Chronicle reports. |
| Malik Mustapha Status: Out San Francisco 49ers | Mustapha (chest) has been ruled out ahead of Thursday night's matchup against the Rams, Eric Branch of the San Francisco Chronicle reports. |
| Khalil Davis Status: Questionable San Francisco 49ers | questionable |
| 2024-12-10 |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo (foot) won't participate in Tuesday's walk-through practice, Nick Wagoner of ESPN.com reports. |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha (chest) was estimated as a limited practice participant on Monday's injury report, Nick Wagoner of ESPN.com reports. |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (Achilles) was listed as a limited participant on Monday's practice estimation, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Out San Francisco 49ers | Bosa (oblique) was estimated as a DNP on Monday's injury report, Nick Wagoner of ESPN.com reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo (foot) was listed as a non-participant on Monday's estimated injury report, Nick Wagoner of ESPN.com reports. |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Ke'Shawn Vaughn Status: Active San Francisco 49ers | Vaughn reverted to the 49ers' practice squad Monday, per the NFL's transaction log. |
| Charvarius Ward Status: Active San Francisco 49ers | Ward finished Sunday's 38-13 win over Chicago with five tackles (four solo). |
| Talanoa Hufanga Status: Active San Francisco 49ers | Hufanga logged five tackles (two solo) in Sunday's 38-13 win over the Bears. |
| Leonard Floyd Status: Active San Francisco 49ers | Floyd registered 2.0 sacks in Sunday's 38-13 win over the Bears. |
| De'Vondre Campbell Status: Active San Francisco 49ers | Campbell finished Sunday's 38-13 win over the Bears with seven tackles (six solo). |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Demetrius Flannigan-Fowles Status: Questionable San Francisco 49ers | questionable |
| 2024-12-09 |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 20 of 25 pass attempts for 325 yards and a pair of touchdowns while rushing five times for 11 yards in Sunday's 38-13 win over the Bears. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said after Sunday's 38-13 win over the Bears that Guerendo has a possible foot sprain, Eric Branch of the San Francisco Chronicle reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (knee) recorded four tackles (all solo) and three sacks in Sunday's 38-13 blowout win over the Bears. |
| Jake Moody Status: Active San Francisco 49ers | Moody nailed his only field-goal attempt from 23 yards out while going 5-for-5 on point-after tries in Sunday's 38-13 win over the Bears. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings finished with seven receptions (eight targets) for 90 yards and a pair of scores in Sunday's 38-13 rout over the Bears. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall had one reception (on two targets) for five yards in Sunday's 38-13 rout of the Bears. |
| George Kittle Status: Active San Francisco 49ers | Kittle had six receptions on as many targets for 151 yards in Sunday's 38-13 win over Chicago. |
| Aaron Banks Status: Active San Francisco 49ers | NA |
| Isaac Guerendo Status: Questionable San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Guerendo has been diagnosed with a foot sprain and will be considered day-to-day heading into Thursday's game against the Rams, Nick Wagoner of ESPN.com reports. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel secured two of three targets for 22 yards while adding 13 rushing yards on five attempts in Sunday's 38-13 rout of the Bears. |
| Aaron Banks Status: Active San Francisco 49ers | Banks cleared the league's concussion protocols Monday, Nick Wagoner of ESPN.com reports. |
| Ben Bartch Status: Out San Francisco 49ers | Bartch suffered a high-ankle sprain in Sunday's win over the Bears and is slated to go on injured reserve this week, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Out San Francisco 49ers | Bosa (oblique) still is considered day-to-day as the 49ers start Week 15 prep Monday, Nick Wagoner of ESPN.com reports. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor rushed seven times for 25 yards and a touchdown while failing to pull in his lone target in Sunday's 38-13 win over Chicago. |
| Trent Williams Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Out San Francisco 49ers | out |
| Aaron Banks Status: Out San Francisco 49ers | out |
| Israel Abanikanda Status: Active San Francisco 49ers | NA |
| Rock Ya-Sin Status: Active San Francisco 49ers | NA |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo (foot) is questionable to return to Sunday's game against the Bears. He rushed 15 times for 78 yards and two touchdowns while catching both of his targets for 50 yards prior to the injury. |
| 2024-12-08 |
| Joshua Dobbs Status: Out San Francisco 49ers | Dobbs (coach's decision) is inactive for Sunday's game against the Bears. |
| Talanoa Hufanga Status: Active San Francisco 49ers | Hufanga (wrist) will play Sunday versus the Bears. |
| Demetrius Flannigan-Fowles Status: Out San Francisco 49ers | Flannigan-Fowles (knee) is listed as inactive for Sunday's matchup with the Bears. |
| Rock Ya-Sin Status: Out San Francisco 49ers | inactive |
| Trent Williams Status: Out San Francisco 49ers | inactive |
| Nick Bosa Status: Out San Francisco 49ers | inactive |
| Aaron Banks Status: Out San Francisco 49ers | inactive |
| Israel Abanikanda Status: Out San Francisco 49ers | inactive |
| Ke'Shawn Vaughn Status: Active San Francisco 49ers | The 49ers elevated Vaughn from the practice squad to the active roster Saturday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| George Odum Status: Injured Reserve San Francisco 49ers | The 49ers placed Odum (knee) on injured reserve Saturday, Matt Barrows of The Athletic reports. |
| Talanoa Hufanga Status: Questionable San Francisco 49ers | The 49ers activated Hufanga (wrist) from injured reserve Saturday, Matt Barrows of The Athletic reports. |
| Nick Bosa Status: Out San Francisco 49ers | Bosa (oblique) has been ruled out for Sunday's game against the Bears, Matt Barrows of The Athletic reports. |
| Aaron Banks Status: Out San Francisco 49ers | Banks (concussion) was downgraded to out Saturday ahead of Sunday's battle against the Bears, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch (ankle) is questionable to return to Sunday's game against Chicago, Nick Wagoner of ESPN.com reports. |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch (ankle) has been ruled out for the rest of Sunday's game against Chicago, Eric Branch of the San Francisco Chronicle reports. |
| 2024-12-07 |
| Trent Williams Status: Out San Francisco 49ers | Williams (ankle) has been ruled out for Sunday's game versus Chicago. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (knee) doesn't carry an injury designation into Sunday's game against the Bears and is expected to play. |
| Jordan Mason Status: Out San Francisco 49ers | Mason (ankle) has been ruled out for Sunday's game against the Bears. |
| Jordan Mason Status: Injured Reserve San Francisco 49ers | Mason (ankle) was officially placed on injured reserve Saturday, Adam Schefter of ESPN reports. |
| Aaron Banks Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Out San Francisco 49ers | out |
| 2024-12-06 |
| Jordan Elliott Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Trent Williams Status: Out San Francisco 49ers | out |
| George Odum Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Doubtful San Francisco 49ers | doubtful |
| Jordan Elliott Status: Active San Francisco 49ers | Elliott (concussion) has no injury designation ahead of Sunday's matchup against the Bears, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Demetrius Flannigan-Fowles Status: Questionable San Francisco 49ers | Flannigan-Fowles (knee) is listed as questionable ahead of Sunday's matchup against the Bears, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Talanoa Hufanga Status: Injured Reserve San Francisco 49ers | Hufanga (wrist) is listed as questionable ahead of Sunday's matchup against the Bears, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (Achilles) has been ruled out ahead of Sunday's matchup against the Bears, Cam Inman of The San Jose Mercury News reports. |
| Nick Bosa Status: Doubtful San Francisco 49ers | Bosa (oblique) is listed as doubtful ahead of Sunday's matchup against the Bears, Cam Inman of The San Jose Mercury News reports. |
| George Odum Status: Out San Francisco 49ers | Odum (knee) has been ruled out ahead of Sunday's matchup against the Bears, Cam Inman of The San Jose Mercury News reports. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (knee) was a full participant at the 49ers' practice Thursday, Nick Wagoner of ESPN.com reports. |
| 2024-12-05 |
| George Odum Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (knee) was a limited participant at San Francisco's practice Wednesday. |
| Talanoa Hufanga Status: Injured Reserve San Francisco 49ers | Hufanga (wrist) was a limited participant at the 49ers' practice Wednesday. |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (Achilles) was a limited participant at the 49ers' practice Wednesday. |
| 2024-12-04 |
| Trent Williams Status: Questionable San Francisco 49ers | Willims (ankle) will not practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | The 49ers promoted Taylor on Wednesday from the practice squad to the active roster. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (oblique) will not practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | Givens (pectoral) was placed on injured reserve Wednesday. |
| Jordan Mason Status: Out San Francisco 49ers | Mason (ankle) did not practice Wednesday, Matt Barrows of The Athletic reports. |
| Talanoa Hufanga Status: Injured Reserve San Francisco 49ers | Hufanga (wrist) was designated to return from injured reserve Wednesday. |
| 2024-12-03 |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | questionable |
| Demetrius Flannigan-Fowles Status: Questionable San Francisco 49ers | questionable |
| Jordan Elliott Status: Questionable San Francisco 49ers | questionable |
| Nick Bosa Status: Questionable San Francisco 49ers | questionable |
| Aaron Banks Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Active San Francisco 49ers | Green recorded six tackles (five solo) and a pass defensed during Sunday's 35-10 loss at Buffalo. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown recorded eight tackles (five solo) during Sunday's 35-10 loss at Buffalo. |
| De'Vondre Campbell Status: Active San Francisco 49ers | Campbell recorded five tackles (three solo) during Sunday's 35-10 loss at Buffalo. |
| Charvarius Ward Status: Active San Francisco 49ers | Ward recorded five tackles (two solo) during Sunday's 35-10 loss at Buffalo. |
| Talanoa Hufanga Status: Injured Reserve San Francisco 49ers | Coach Kyle Shanahan said Monday that Hufanga (wrist) will be designated for return from injured reserve this week, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | The 49ers placed McCaffrey (knee) on injured reserve Tuesday. |
| Israel Abanikanda Status: Active San Francisco 49ers | San Francisco claimed Abanikanda off waivers Tuesday. |
| 2024-12-02 |
| Renardo Green Status: Active San Francisco 49ers | Green (neck) is active for Sunday night's contest against the Bills, Lindsey Pallares of the team's official website reports. |
| Chris Conley Status: Active San Francisco 49ers | Conley (knee) is active for Sunday night's contest against the Bills, Lindsey Pallares of the team's official website reports. |
| Trent Williams Status: Out San Francisco 49ers | inactive |
| Deommodore Lenoir Status: Out San Francisco 49ers | inactive |
| Demetrius Flannigan-Fowles Status: Out San Francisco 49ers | inactive |
| Jordan Elliott Status: Out San Francisco 49ers | inactive |
| Nick Bosa Status: Out San Francisco 49ers | inactive |
| Aaron Banks Status: Out San Francisco 49ers | inactive |
| Brandon Allen Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Active San Francisco 49ers | NA |
| Brandon Allen Status: Out San Francisco 49ers | Allen (coach's decision) is inactive for Sunday night's contest against Buffalo and will be the 49ers' emergency third quarterback, Matt Barrows of The Athletic reports. |
| Joshua Dobbs Status: Active San Francisco 49ers | Dobbs is active and will operate as the 49ers' top backup quarterback for Sunday night's matchup with the Bills, Matt Barrows of The Athletic reports. |
| Demetrius Flannigan-Fowles Status: Out San Francisco 49ers | Flannigan-Fowles (knee) is inactive for Sunday night's contest against the Bills, Lindsey Pallares of the 49ers' official website reports. |
| Kevin Givens Status: Active San Francisco 49ers | Givens (groin) is active for Sunday night's contest against Buffalo, Lindsey Pallares of the 49ers' official website reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (knee) is questionable to return to Sunday's game against the Bills. |
| Kevin Givens Status: Questionable San Francisco 49ers | Givens (chest) is questionable to return to Sunday night's contest versus Buffalo. |
| Kevin Givens Status: Questionable San Francisco 49ers | Givens (chest) has been ruled out for the rest of Sunday night's matchup with the Bills. |
| Christian McCaffrey Status: Out San Francisco 49ers | out |
| Christian McCaffrey Status: Out San Francisco 49ers | McCaffrey (knee) won't return to Sunday's game against the Bills. |
| George Kittle Status: Active San Francisco 49ers | Kittle had one reception (on two targets) for seven yards in Sunday's 35-10 loss to Buffalo. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings brought in three of five targets for 56 yards in Sunday's 35-10 loss to the Bills. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel pulled in four of his five targets for 20 yards with a lost fumble in Sunday's 35-10 defeat at the hands of the Bills. He did not record a rushing attempt in the blowout loss. Samuel also tallied 208 yards on six kick returns. |
| Jordan Mason Status: Active San Francisco 49ers | Mason took 13 carries for 78 yards and received no targets in Sunday's 35-10 loss to Buffalo. |
| Christian McCaffrey Status: Doubtful San Francisco 49ers | McCaffrey (knee) suffered a PCL injury in Sunday's 35-10 loss to the Bills that may be season-ending, coach Kyle Shanahan revealed after the game, Ian Rapoport of NFL Network reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 11 of 18 pass attempts for 94 yards while rushing twice for four yards with a lost fumble in Sunday's 35-10 loss to the Bills. |
| Jake Moody Status: Active San Francisco 49ers | Moody went 1-for-3 on field-goal attempts while hitting his only point-after try in Sunday's 35-10 loss to the Bills. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall failed to bring in his lone target in Sunday's 35-10 loss to Buffalo. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo took four carries for 19 yards and a touchdown while losing three yards on his only reception in Sunday's 35-10 loss to the Bills. |
| Kevin Givens Status: Out San Francisco 49ers | out |
| Isaac Guerendo Status: Active San Francisco 49ers | With Christian McCaffrey (knee) and Jordan Mason (ankle) in line to be placed on injured reserve, Guerendo is expected to take over as the 49ers' starting running back, Adam Schefter of ESPN reports. |
| Jordan Mason Status: Out San Francisco 49ers | The 49ers are slated to place Mason (ankle) on injured reserve, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Out San Francisco 49ers | The 49ers plan to place McCaffrey (knee) on injured reserve, Ian Rapoport of NFL Network reports. |
| Trent Williams Status: Out San Francisco 49ers | out |
| Deommodore Lenoir Status: Out San Francisco 49ers | out |
| Jordan Elliott Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Out San Francisco 49ers | out |
| Aaron Banks Status: Out San Francisco 49ers | out |
| 2024-12-01 |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (shoulder), who is listed as questionable for Sunday's Week 13 matchup against Buffalo, didn't have any setbacks Friday or Saturday and is expected to start against the Bills, Adam Schefter of ESPN reports. |
| 2024-11-30 |
| Jordan Elliott Status: Out San Francisco 49ers | Elliott (concussion) has been ruled out for Sunday's battle against Buffalo, Lindsey Pallares of the 49ers' official site reports. |
| Deommodore Lenoir Status: Out San Francisco 49ers | Lenoir (knee) has been ruled out of Sunday's Week 13 matchup against the Bills, Lindsey Pallares of the 49ers' official site reports. |
| Nick Bosa Status: Out San Francisco 49ers | Bosa (hip/oblique) has been ruled out for Sunday's game against Buffalo, Lindsey Pallares of the 49ers' official site reports. |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing (concussion) does not have an injury designation for Sunday's Week 13 battle versus the Bills, Matt Maiocco of NBC Sports reports. |
| Demetrius Flannigan-Fowles Status: Questionable San Francisco 49ers | Flannigan-Fowles is questionable to play Sunday against the Bills due to a knee injury, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) is listed as questionable for Sunday's matchup versus Buffalo, Nick Wagoner of ESPN.com reports. |
| Chris Conley Status: Questionable San Francisco 49ers | Conley (knee) is questionable to suit up Sunday against Buffalo, Nick Wagoner of ESPN.com reports. |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (Achilles) has been ruled out to face the Bills on Sunday, Lindsey Pallares of the 49ers' official site reports. |
 | Dominick Puni Status: Active San Francisco 49ers | Puni (shoulder) does not carry an injury designation into Sunday's game against the Bills. |
| Kevin Givens Status: Questionable San Francisco 49ers | Givens (groin) is listed as questionable for Sunday's game against Buffalo, Nick Wagoner of ESPN.com reports. |
| Aaron Banks Status: Out San Francisco 49ers | Banks (concussion) has been ruled out for Sunday's game against the Bills, Lindsey Pallares of the 49ers' official site reports. |
| Trent Williams Status: Out San Francisco 49ers | Williams (ankle) has been ruled out for Sunday's game against the Bills, Lindsey Pallares of the 49ers' official site reports. |
| 2024-11-29 |
| Trent Williams Status: Out San Francisco 49ers | out |
| Deommodore Lenoir Status: Out San Francisco 49ers | out |
| Jordan Elliott Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Out San Francisco 49ers | out |
| Aaron Banks Status: Out San Francisco 49ers | out |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (shoulder) is listed as questionable for Sunday's game at Buffalo, with 49ers coach Kyle Shanahan saying Friday that he expects the QB to play, Nick Wagoner of ESPN.com reports. |
| Dominick Puni Status: Active San Francisco 49ers | NA |
| Chris Conley Status: Questionable San Francisco 49ers | Conley (knee) was listed as a limited practice participant on Thursday's injury report, Matt Barrows of The Athletic reports. |
| Jacob Cowing Status: Active San Francisco 49ers | NA |
| 2024-11-28 |
| Chris Conley Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (shoulder) was listed as limited on Thursday's injury report, Matt Barrows of The Athletic reports. |
| 2024-11-27 |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (Achilles) was designated to return from injured reserve Wednesday, Lindsey Pallares of the 49ers' official site reports. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (knee) will not practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (ankle) will not practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip/oblique) will not practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (shoulder) will be limited at Wednesday's practice, Nick Wagoner of ESPN.com reports. |
| Fred Warner Status: Active San Francisco 49ers | Warner told reporters Wednesday that he fractured a bone in his ankle in the 49ers' Week 4 win over the Patriots and has been playing through the issue since, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) was a limited participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Charvarius Ward Status: Active San Francisco 49ers | Ward (personal) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing (concussion) was listed as a full practice participant on Wednesday's injury report, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (shoulder) officially was limited at Wednesday's practice, Cam Inman of The San Jose Mercury News reports. However, Purdy attempted just two passes during the session, per Inman |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall failed to record a target in Sunday's 39-10 loss to the Packers. |
| 2024-11-26 |
| De'Vondre Campbell Status: Active San Francisco 49ers | Campbell finished with eight tackles (four solo) in Sunday's 38-10 loss to the Packers. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha finished with nine tackles (three solo), including a tackle for a loss, in Sunday's 38-10 loss to the Packers. |
| Isaac Yiadom Status: Active San Francisco 49ers | Yiadom finished with nine tackles (six solo) and a pass defensed in Sunday's 38-10 loss to the Packers. |
| Leonard Floyd Status: Active San Francisco 49ers | Floyd finished with four solo tackles, including 2.0 sacks, in Sunday's 38-10 loss to the Packers. |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Charvarius Ward Status: Questionable San Francisco 49ers | questionable |
| Kevin Givens Status: Questionable San Francisco 49ers | questionable |
| Jacob Cowing Status: Questionable San Francisco 49ers | questionable |
| Nick Bosa Status: Questionable San Francisco 49ers | questionable |
| 2024-11-25 |
| Charvarius Ward Status: Out San Francisco 49ers | out |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Kevin Givens Status: Out San Francisco 49ers | out |
| Jacob Cowing Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Out San Francisco 49ers | out |
| Khalil Davis Status: Active San Francisco 49ers | NA |
| Demetrius Flannigan-Fowles Status: Questionable San Francisco 49ers | Flannigan-Fowles (knee) has been ruled out for the rest of Sunday's game against the Packers, Lindsey Pallares of the 49ers' official site reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) is questionable to return to Sunday's game against the Packers, Lindsey Pallares of the 49ers' official site reports. |
| Aaron Banks Status: Questionable San Francisco 49ers | Banks suffered a concussion in Sunday's loss to the Packers, Eric Branch of the San Francisco Chronicle reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle (hamstring) caught all six of his targets for 82 yards and a touchdown in Sunday's 38-10 loss to Green Bay. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 11 times for 31 yards (one fumble) while catching three of four targets for 37 yards in Sunday's 38-10 loss to Green Bay. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings caught five of seven targets for 40 yards in Sunday's 38-10 loss to the Packers. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel had just one reception for 21 yards off of four targets in Sunday's 38-10 loss to the Packers. |
| Brandon Allen Status: Active San Francisco 49ers | Allen completed 17 of 29 pass attempts for 199 yards, one touchdown and one interception while rushing twice for five yards and losing a fumble in Sunday's blowout loss to Green Bay. |
| Jake Moody Status: Active San Francisco 49ers | Moody went 1-for-1 on field-goal attempts and 1-for-1 on extra-point attempts in Sunday's 38-10 loss to Green Bay. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir underwent an MRI done on his knee Monday, Nick Wagoner of ESPN.com reports. |
 | Jon Feliciano Status: Injured Reserve San Francisco 49ers | Feliciano (knee) will remain on injured reserve for the remainder of the season, Matt Barrows of The Athletic reports. |
| Dominick Puni Status: Questionable San Francisco 49ers | Puni (shoulder) will undergo an MRI this week, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Coach Kyle Shanahan said Purdy (shoulder) did some light throwing Monday and didn't have any issues, Nick Wagoner of ESPN.com reports. |
| Jordan Mason Status: Active San Francisco 49ers | Mason rushed three times for eight yards with one reception (two targets) for five yards in Sunday's 38-10 loss to Green Bay. |
| 2024-11-24 |
| Tatum Bethune Status: Injured Reserve San Francisco 49ers | The 49ers placed Bethune (knee) on injured reserve Saturday, Cam Inman of The San Jose Mercury News reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (ankle) is listed as questionable for Sunday's game against the Packers, but the 49ers are optimistic that he'll be able to play, Adam Schefter of ESPN reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (shoulder) has been ruled out for Sunday's game against the Packers, but the 49ers believe that he'll be able to return to action in their Week 13 matchup with the Bills on Dec. 1, Adam Schefter of ESPN reports. |
| Demetrius Flannigan-Fowles Status: Questionable San Francisco 49ers | questionable |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliot (concussion) has been ruled out for the remaidner of Sunday's game versus Green Bay, Eric Branch of the San Francisco Chronicle reports. |
| Demetrius Flannigan-Fowles Status: Questionable San Francisco 49ers | Flannigan-Fowles (knee) is questionable to return to Sunday's matchup versus the Packers. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (ankle) is listed as questionable for Sunday's game against the Packers, but he's viewed as a true game-time decision and may be facing an "uphill battle" to play, Jay Glazer reported on "Fox NFL Sunday." |
| Trent Williams Status: Out San Francisco 49ers | Williams (ankle) is inactive for Sunday's game against the Packers, Eric Branch of the San Francisco Chronicle reports. |
| Charvarius Ward Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Khalil Davis Status: Out San Francisco 49ers | inactive |
| Jacob Cowing Status: Out San Francisco 49ers | inactive |
| Nick Bosa Status: Out San Francisco 49ers | inactive |
| 2024-11-23 |
| Kevin Givens Status: Out San Francisco 49ers | Givens (groin) has been ruled out for Sunday's game against Green Bay, Matt Barrows of The Athletic reports. |
| Tatum Bethune Status: Out San Francisco 49ers | Bethune (knee) has been ruled out for Sunday's game against the Packers, Matt Barrows of The Athletic reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (ankle) is listed as questionable for Sunday's game against the Packers, Matt Barrows of The Athletic reports. |
| Tatum Bethune Status: Injured Reserve San Francisco 49ers | ir |
| 2024-11-22 |
| Brock Purdy Status: Questionable San Francisco 49ers | GM John Lynch said Friday morning that the 49ers feel good about Purdy's right shoulder after seeing results from an MRI, but Lynch acknowledged the quarterback's status is "tenuous" for Sunday at Green Bay, Cam Inman of the San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (shoulder) isn't participating at the start of practice Friday afternoon, Cam Inman of The San Jose Mercury News reports. |
| Charvarius Ward Status: Out San Francisco 49ers | out |
| Kevin Givens Status: Out San Francisco 49ers | out |
| Jacob Cowing Status: Out San Francisco 49ers | out |
| Tatum Bethune Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Out San Francisco 49ers | out |
| George Kittle Status: Active San Francisco 49ers | Kittle (hamstring) doesn't have an injury designation for Sunday's game at Green Bay, Cam Inman of The San Jose Mercury News reports. |
| Brandon Allen Status: Active San Francisco 49ers | Allen will replace Brock Purdy (shoulder) as the starting quarterback Sunday at Green Bay, Adam Schefter of ESPN reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (shoulder) has been ruled out for Sunday's game at Green Bay, Eric Branch of the San Francisco Chronicle reports. |
| Charvarius Ward Status: Out San Francisco 49ers | Ward (personal) has been ruled out ahead of Sunday's matchup against the Packers, Cam Inman of The San Jose Mercury News reports. |
| Jacob Cowing Status: Out San Francisco 49ers | Cowing (concussion) has been ruled out ahead of Sunday's matchup against the Packers, Cam Inman of The San Jose Mercury News reports. |
| Nick Bosa Status: Out San Francisco 49ers | Bosa (hip/oblique) has been ruled out ahead of Sunday's matchup against the Packers, Cam Inman of The San Jose Mercury News reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (ankle) missed practice for the second day in a row Thursday, Eric Branch of the San Francisco Chronicle reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip) did not participate in Thursday's practice, Eric Branch of the San Francisco Chronicle reports. |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing (concussion) did not participate in practice Thursday. |
| 2024-11-21 |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan told KNBR that Purdy practiced "a little more" Thursday than he did Wednesday and that he is "hopeful" the quarterback will be available Sunday in Green Bay. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (hamstring) practiced in a limited fashion Thursday, Nick Wagoner of ESPN.com reports. |
| 2024-11-20 |
| George Kittle Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Kittle (hamstring) will be a limited participant at Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (shoulder) will be limited at Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (hamstring) relayed his intention to return to action Week 12, saying he'll "for sure" play Sunday at Green Bay, David Lombardi of SFStandard.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip) was listed as a DNP on Wednesday's practice report, Cam Inman of The San Jose Mercury News reports. |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing (concussion) was a limited participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| 2024-11-19 |
| Leonard Floyd Status: Active San Francisco 49ers | Floyd tallied three tackles, including 1.5 sacks, in a loss to Seattle on Sunday. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir recorded eight tackles (all solo) Sunday in a Week 11 loss to the Seahawks. |
| Renardo Green Status: Active San Francisco 49ers | Green tallied eight tackles (seven solo) and one defensed pass in Sunday's Week 11 loss to Seattle. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams is dealing with soreness related to his ongoing ankle issue, Cam Inman of The San Jose Mercury News reports. |
| Charvarius Ward Status: Active San Francisco 49ers | Ward (personal) returned to the 49ers on Monday, David Lombardi of The San Francisco Standard reports. |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (Achilles) could have his 21-day practice window to return to injured reserve open this week, David Lombardi of The Athletic reports. |
| Kevin Givens Status: Questionable San Francisco 49ers | questionable |
| Tatum Bethune Status: Doubtful San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Bethune sustained a sprained MCL during Sunday's game versus the Seahawks and will be out for a while, Eric Branch of the San Francisco Chronicle reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip) has about a 50-50 chance to suit up next week against the Packers, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Charvarius Ward Status: Active San Francisco 49ers | NA |
| George Kittle Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that the 49ers expect Kittle (hamstring) to practice Wednesday, Nick Wagoner of ESPN.com reports. |
| 2024-11-18 |
| Charvarius Ward Status: Out San Francisco 49ers | out |
| Kevin Givens Status: Out San Francisco 49ers | out |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| Khalil Davis Status: Active San Francisco 49ers | NA |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip) is concerned that he will have to miss time after leaving Sunday's 20-17 loss to the Seahawks and not returning, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 19 times for 79 yards and brought in four of five targets for 27 yards in Sunday's 20-17 loss to Seattle. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 21 of 28 pass attempts for 159 yards, one touchdown and one interception while rushing five times for 40 yards and another touchdown in Sunday's 20-17 loss to Seattle. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel had four receptions (seven targets) for 22 yards while losing one yard on his only rushing attempt in Sunday's 20-17 loss to Seattle. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings corralled 10 of 11 targets for 91 yards and a touchdown in Sunday's 20-17 loss to Seattle. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall failed to bring in either of his two targets in Sunday's 20-17 loss to Seattle. |
| Jordan Mason Status: Active San Francisco 49ers | Mason took two carries for 13 yards and was not targeted as a receiver in Sunday's 20-17 loss to the Seahawks. |
| Jake Moody Status: Active San Francisco 49ers | Moody nailed his only field-goal attempt from 33 yards out while converting both point-after tries in Sunday's 20-17 loss to Seattle. |
| Eric Saubert Status: Active San Francisco 49ers | Saubert (illness) recorded one reception for seven yards in Sunday's 20-17 loss to Seattle. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Monday that Purdy is day-to-day due to a sore right shoulder, Nick Wagoner of ESPN.com reports. |
| 2024-11-17 |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | The 49ers activated Gross-Matos (knee) from injured reserve Saturday, Matt Barrows of The Athletic reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (knee) is questionable to return to Sunday's game against the Seahawks. |
 | Pat O'Donnell Status: Active San Francisco 49ers | The 49ers elevated O'Donnell from the practice squad to the active roster Saturday, Matt Barrows of The Athletic reports. |
| Darrell Luter Jr. Status: Injured Reserve San Francisco 49ers | Luter (pelvis) was placed on the 49ers' injured reserve Saturday, Matt Barrows of The Athletic reports. |
| Mitch Wishnowsky Status: Injured Reserve San Francisco 49ers | The 49ers placed Wishnowsky (back) on injured reserve Saturday, Matt Barrows of The Athletic reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (hamstring), who is listed as questionable for Sunday's game against Seattle, is unlikely to play, Adam Schefter reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (ankle) remains listed as questionable for Sunday's game against the Seahawks, but the 49ers are optimistic that he'll be available to play, Adam Schefter of ESPN reports. |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing (concussion) has been ruled out for the rest of Sunday's game against Seattle, Nick Wagoner of ESPN.com reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (knee) has been ruled out for the rest of Sunday's game against the Seahawks, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip) is questionable to return to Sunday's contest against the Seahawks. |
| Trent Williams Status: Active San Francisco 49ers | Williams (ankle) is active for Sunday's game against the Seahawks, Lindsey Peters of the 49ers' official site reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (knee) is active for Sunday's game against the Seahawks, Lindsey Peters of the 49ers' official site reports. |
| Joshua Dobbs Status: Out San Francisco 49ers | Dobbs (coach's decision) is inactive for Sunday's game against Seattle and will be San Francisco's emergency third quarterback, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (hip) is active for Sunday's game against the Seahawks, Lindsey Peters of the 49ers' official site reports. |
 | Ronnie Bell Status: Out San Francisco 49ers | Bell (coach's decision) is inactive for Sunday's game against the Seahawks, Lindsey Peters of the 49ers' official site reports. |
| Charvarius Ward Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Khalil Davis Status: Out San Francisco 49ers | inactive |
| Ben Bartch Status: Out San Francisco 49ers | inactive |
| Aaron Banks Status: Active San Francisco 49ers | NA |
| 2024-11-16 |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Gross-Matos (knee) is listed as questionable for Sunday's game against the Seahawks, Lindsey Pallares of the 49ers' official site reports. |
| Darrell Luter Jr. Status: Doubtful San Francisco 49ers | doubtful |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (ankle) is listed as questionable for Sunday's game against the Seahawks, Cam Inman of The San Jose Mercury News reports. |
| Mitch Wishnowsky Status: Out San Francisco 49ers | Wishnowsky (back) has been ruled out for Sunday's game against the Seahawks, Cam Inman of The San Jose Mercury News reports. |
| Kevin Givens Status: Out San Francisco 49ers | Givens (groin) has been ruled out for Sunday's game against Seattle, Cam Inman of The San Jose Mercury News reports. |
| Mitch Wishnowsky Status: Injured Reserve San Francisco 49ers | ir |
| Darrell Luter Jr. Status: Injured Reserve San Francisco 49ers | ir |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| 2024-11-15 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle) is present for Friday's practice, Nick Wagoner of ESPN.com reports. |
| Mitch Wishnowsky Status: Out San Francisco 49ers | out |
| Charvarius Ward Status: Out San Francisco 49ers | out |
| Darrell Luter Jr. Status: Questionable San Francisco 49ers | questionable |
| Kevin Givens Status: Out San Francisco 49ers | out |
| Aaron Banks Status: Questionable San Francisco 49ers | questionable |
| Chris Conley Status: Active San Francisco 49ers | NA |
| Jauan Jennings Status: Active San Francisco 49ers | NA |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (Achilles) doesn't have an injury designation for Sunday's game against Seattle, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (hamstring) is listed as questionable for Sunday's game against Seattle, Cam Inman of The San Jose Mercury News reports. |
 | Matthew Wright Status: Questionable San Francisco 49ers | questionable |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip) was a limited practice participant Friday and is listed as questionable against the Seahawks on Sunday, Cam Inman of The San Jose Mercury News reports. |
| Charvarius Ward Status: Out San Francisco 49ers | Ward (personal) has been ruled out for Sunday's game against the Seahawks, Cam Inman of The San Jose Mercury News reports. |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Brandon Aiyuk Status: Injured Reserve San Francisco 49ers | Aiyuk had surgery to repair the ACL and other damage in is right knee earlier this week, David Lombardi of The San Francisco Standard reports. |
| Chris Conley Status: Active San Francisco 49ers | Conley (hamstring) was a full practice participant Friday and carries no injury designation into Sunday's game against the Seahawks, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings was limited at Thursday's practice due to an ankle injury, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (hamstring) was limited in practice Thursday, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (Achilles) practiced on a limited basis Thursday, Nick Wagoner of ESPN.com reports. |
| 2024-11-14 |
| Mitch Wishnowsky Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Gross-Matos (knee) was a full participant in Wednesday's practice. |
| Renardo Green Status: Active San Francisco 49ers | Green (toe) was a full participant in Wednesday's practice. |
| Charvarius Ward Status: Questionable San Francisco 49ers | Ward (personal) was listed as a DNP on Wednesday. |
| Chris Conley Status: Questionable San Francisco 49ers | Conley (hamstring) was a limited participant in Wednesday's practice. |
| 2024-11-13 |
| Christian McCaffrey Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said McCaffrey (Achilles) will be a limited practice participant Wednesday, Nick Wagoner of ESPN.com reports. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk went without a carry or target while playing 25 of the 49ers' 64 offensive snaps in Sunday's 23-20 win over the Buccaneers. |
| George Kittle Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said Kittle (hamstring) won't practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir and the 49ers agreed to a five-year, $92 million extension Tuesday, Jeremy Fowler of ESPN.com reports. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha finished Sunday's 23-20 win over the Buccaneers with seven tackles (two solo). |
| George Kittle Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said that there "isn't much concern" about Kittle's status for Sunday's game against the Seahawks, despite the tight end not practicing Wednesday, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip) will not practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| 2024-11-12 |
| Charvarius Ward Status: Questionable San Francisco 49ers | questionable |
| Kevin Givens Status: Questionable San Francisco 49ers | questionable |
| Chris Conley Status: Questionable San Francisco 49ers | questionable |
| Chris Conley Status: Out San Francisco 49ers | Conley (hamstring) is expected to practice this week after missing Sunday's win over the Buccaneers, David Lombardi of The San Francisco Standard reports. |
| Dre Greenlaw Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Monday that he "doesn't expect" to open the 21-day practice window for Greenlaw (Achilles) this week, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green is considered day-to-day due to a toe injury, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Monday that Kittle is dealing with "hamstring irritation" in the wake of Sunday's win at Tampa Bay, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa tallied four tackles (three solo), with 1.0 sack, in the 49ers' win versus Tampa Bay on Sunday. |
| Fred Warner Status: Active San Francisco 49ers | Warner recorded nine tackles (six solo) during San Francisco's win over the Buccaneers on Sunday. |
| De'Vondre Campbell Status: Active San Francisco 49ers | Campbell compiled seven tackles (four solo) in the 49er's win Sunday versus Tampa Bay. |
| 2024-11-11 |
| Charvarius Ward Status: Out San Francisco 49ers | out |
| Kevin Givens Status: Out San Francisco 49ers | out |
| Chris Conley Status: Out San Francisco 49ers | out |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo had one carry for zero yards in Sunday's 23-20 win over Tampa Bay. |
| Jordan Mason Status: Active San Francisco 49ers | Mason (shoulder) had one carry for five yards in Sunday's 23-20 win over the Buccaneers. |
| Jake Moody Status: Active San Francisco 49ers | Moody (ankle) went 3-for-6 on field-goal attempts while converting both of his point-after tries in Sunday's 23-20 win over the Buccaneers. |
| 2024-11-10 |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall had four receptions (six targets) for 74 yards and a touchdown in Sunday's 23-20 win over Tampa Bay. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha (calf) is not among San Francisco's inactives for Sunday's matchup against Tampa Bay, Lindsey Pallares of the 49ers' official site reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (hip) is active for Sunday's Week 10 battle against the Buccaneers, Lindsey Pallares of the 49ers' official site reports. |
| Joshua Dobbs Status: Out San Francisco 49ers | Dobbs (coach's decision) is inactive for Sunday's game against Tampa Bay, Nick Wagoner of ESPN.com reports. |
| Brayden Willis Status: Out San Francisco 49ers | inactive |
| Charvarius Ward Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Chris Conley Status: Out San Francisco 49ers | inactive |
| Ben Bartch Status: Out San Francisco 49ers | inactive |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel (rib/oblique) is active for Sunday's game at Tampa Bay, Lindsey Pallares of the 49ers' official site reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (Achilles) remains listed as questionable for Sunday's game against the Buccaneers, but he's on track to play and expressed confidence that he's take on his usual workload in his season debut, Mike Garafolo of NFL Network reports. |
| Brayden Willis Status: Out San Francisco 49ers | Willis (coach's decision) is inactive for Sunday's game against Tampa Bay. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (Achilles) is listed as active Sunday at Tampa Bay, Lindsey Pallares of the 49ers' official site reports. |
| Jon Feliciano Status: Injured Reserve San Francisco 49ers | Feliciano (knee) has been downgraded to out for Sunday's game against Tampa Bay, Eric Branch of the San Francisco Chronicle reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel, who is officially questionable for Sunday's Week 10 battle against the Buccaneers due to an oblique injury, is expected to play, Adam Schefter of ESPN reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (Achilles), who is officially questionable for Sunday's Week 10 game against Tampa Bay, is expected to play, Adam Schefter of ESPN reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle had three receptions on four targets for 57 yards and a touchdown in Sunday's 23-20 win over the Buccaneers. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel (hip/oblique) corralled five of six targets for 62 yards and added 14 rushing yards on three attempts in Sunday's 23-20 win over the Buccaneers. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (hip) finished with seven receptions (11 targets) for 93 yards in Sunday's 23-20 win over Tampa Bay. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 25 of 36 pass attempts for 353 yards and two touchdowns while adding four rushing attempts for 17 yards in Sunday's 23-20 win over the Buccaneers. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (Achilles) rushed 13 times for 39 yards and caught six of seven targets for 68 yards in Sunday's 23-20 win over Tampa Bay. |
| 2024-11-09 |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Gross-Matos (knee) has been ruled out for Sunday's game against Tampa Bay. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (Achilles) was activated off injured reserve Saturday, Adam Schefter of ESPN reports. |
| 2024-11-08 |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha (calf) is listed as questionable ahead of Sunday's matchup against the Buccaneers, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Kevin Givens Status: Out San Francisco 49ers | Givens (groin) has been ruled out ahead of Sunday's matchup against the Buccaneers, David Lombardi of The San Francisco Standard reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip) is listed as questionable for Sunday's game against the Buccaneers, Cam Inman of The San Jose Mercury News reports. |
| Jordan Mason Status: Active San Francisco 49ers | Mason (shoulder) doesn't have an injury designation for Sunday's game in Tampa Bay, Brianna Dix of the Buccaneers' official site reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (hip) doesn't have an injury designation for Sunday's game in Tampa Bay, Brianna Dix of the Buccaneers' official site reports. |
| Charvarius Ward Status: Out San Francisco 49ers | Ward (personal) has been ruled out ahead of Sunday's matchup against the Buccaneers, David Lombardi of The San Francisco Standard reports. |
| Mitch Wishnowsky Status: Active San Francisco 49ers | NA |
| Chris Conley Status: Out San Francisco 49ers | out |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel (oblique/rib) is questionable for Sunday's game at Tampa Bay, Lindsey Pallares of the 49ers' official site reports. |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | McCaffrey (Achilles) is listed as questionable for Sunday's game at Tampa Bay, with coach Kyle Shanahan saying Friday that the running back will play, Eric Branch of the San Francisco Chronicle reports. |
| Chris Conley Status: Out San Francisco 49ers | Conley (hamstring) has been ruled out for Sunday's contest at Tampa Bay, David Lombardi of The San Francisco Standard reports. |
| Jake Moody Status: Active San Francisco 49ers | Moody (ankle) doesn't have a designation for Sunday's game in Tampa Bay. |
| Malik Mustapha Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (hip) practiced on a limited basis Thursday. |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha was a limited participant in practice Thursday due to a calf injury. |
| Jake Moody Status: Questionable San Francisco 49ers | Moody (ankle) was a limited participant in practice Thursday. |
| 2024-11-07 |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | Coach Kyle Shanahan said Thursday that he expects McCaffrey (Achilles) to make his season debut Sunday at Tampa Bay, David Lombardi of The San Francisco Standard reports. |
| Jordan Mason Status: Questionable San Francisco 49ers | Mason (shoulder) was a limited practice participant Thursday, Nick Wagoner of ESPN.com reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel (rib/oblique) practiced in a limited fashion Thursday, Nick Wagoner of ESPN.com reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters (concussion) was a full participant in San Francisco's practice Wednesday, Nick Wagoner of ESPN reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (ankle) was a full participant in Wednesday's practice. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (hip) was listed as a limited practice participant on Wednesday's injury report. |
| Mitch Wishnowsky Status: Questionable San Francisco 49ers | questionable |
| Jordan Mason Status: Active San Francisco 49ers | Mason (shoulder) practiced in full Wednesday. |
| Charvarius Ward Status: Questionable San Francisco 49ers | questionable |
| Charvarius Ward Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Wednesday that a return date for Ward (personal) has not been discussed, Eric Branch of the San Francisco Chronicle reports. |
| 2024-11-06 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jennings (hip) will be a limited participant at Wednesday's practice, Matt Barrows of The Athletic reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Samuel (oblique/ribs) will be limited at Wednesday's practice, Matt Barrows of The Athletic reports. |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | Coach Kyle Shanahan said McCaffrey will be limited at Wednesday's practice, but the running back has exhibited "no pain" with his Achilles, Adam Schefter of ESPN reports. |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | The 49ers designated Gross-Matos (knee) to return from injured reserve Wednesday. |
| Jake Moody Status: Questionable San Francisco 49ers | Moody (ankle) was a limited participant during Wednesday's practice, Matt Barrows of The Athletic reports. |
| Chris Conley Status: Questionable San Francisco 49ers | Conley (hamstring) did not practice Wednesday, Nick Wagoner of ESPN.com reports. |
| 2024-11-05 |
| Jake Moody Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Kevin Givens Status: Questionable San Francisco 49ers | questionable |
| Khalil Davis Status: Active San Francisco 49ers | The Texans traded Davis to the 49ers on Tuesday in exchange for a 2026 seventh-round pick, Dianna Russini of The Athletic reports. |
| 2024-11-04 |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | The 49ers designated McCaffrey (Achilles) to return from injured reserve Monday. |
| Jon Feliciano Status: Injured Reserve San Francisco 49ers | The 49ers opened Feliciano's (knee) 21-day practice window Monday. |
| 2024-10-29 |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | ir |
| Fred Warner Status: Active San Francisco 49ers | Warner tallied eight tackles (four solo) and a pass deflection during San Francisco's win over the Cowboys on Sunday. |
 | Anders Carlson Status: Active San Francisco 49ers | Carlson reverted to the 49ers' practice squad Monday. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa recorded three tackles (two solo), with 1.0 sack, during San Francisco's win Sunday over the Cowboys. |
| De'Vondre Campbell Status: Active San Francisco 49ers | Campbell logged seven tackles (six solo) in San Francisco's win Sunday versus Dallas. |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | ir |
| 2024-10-28 |
| Renardo Green Status: Questionable San Francisco 49ers | Green (ankle) suffered an ankle injury in Sunday night's 30-24 win over the Cowboys, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall had four receptions on as many targets for 38 yards while adding a 39-yard rush in Sunday's 30-24 win over the Cowboys. |
| Anders Carlson Status: Active San Francisco 49ers | Carlson went 3-for-3 on field-goal attempts and 3-for-3 on extra-point tries in Sunday's 30-24 victory over Dallas. |
| Chris Conley Status: Active San Francisco 49ers | Conley failed to bring in his lone target in Sunday's 30-24 win over the Cowboys. |
| Renardo Green Status: Questionable San Francisco 49ers | Green is considered day-to-day after sustaining an ankle injury in Sunday night's win over the Cowboys, Nick Wagoner of ESPN.com reports. |
| Jauan Jennings Status: Out San Francisco 49ers | Speaking Monday, coach Kyle Shanahan said Jennings (hip) is expected to return following San Francisco's Week 9 bye, Nick Wagoner of ESPN.com reports. |
| Chris Conley Status: Questionable San Francisco 49ers | questionable |
| Jordan Mason Status: Questionable San Francisco 49ers | Speaking Monday, coach Kyle Shanahan said Mason aggravated his existing shoulder injury in Sunday night's win over the Cowboys and is viewed as day to day, Nick Wagoner of ESPN.com reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Speaking Monday, coach Kyle Shanahan said Samuel has been diagnosed with rib and oblique strains and is day to day, Nick Wagoner of ESPN.com reports. |
| Jake Moody Status: Out San Francisco 49ers | out |
| Jauan Jennings Status: Out San Francisco 49ers | out |
| Kevin Givens Status: Out San Francisco 49ers | out |
 | Jalen Graham Status: Active San Francisco 49ers | NA |
| Rock Ya-Sin Status: Active San Francisco 49ers | NA |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| Jordan Mason Status: Questionable San Francisco 49ers | Mason (shoulder) is questionable to return to Sunday's game against the Cowboys. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (concussion) has been ruled out for the remainder of Sunday night's contest with the Cowboys, Lindsey Pallares of the 49ers' official site reports. |
| Chris Conley Status: Questionable San Francisco 49ers | Conley suffered a hamstring injury in Sunday's 30-24 win over the Cowboys, David Lombardi of the San Francisco Standard reports. |
| Jordan Mason Status: Questionable San Francisco 49ers | Coach Kyle Shanahan indicated after Sunday's 30-24 win over the Cowboys that Mason (shoulder) could have come back into the game if necessary, Matt Maiocco of NBC Sports reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle secured six of seven targets for 128 yards and a touchdown in Sunday's 30-24 win over Dallas. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo rushed 14 times for 85 yards and a touchdown while securing three of four targets for 17 yards in Sunday's 30-24 win over Dallas. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 18 of 26 pass attempts for 260 yards and a touchdown while rushing eight times for 56 yards and another score in Sunday's 30-24 win over the Cowboys. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel (ribs) is questionable to return to Sunday's game against the Cowboys, 49ers team reporter Lindsey Pallares reports. |
| 2024-10-27 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (foot), who is listed as questionable for Sunday's game against the Cowboys, is expected to play, Adam Schefter of ESPN reports. |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | McCaffrey (Achilles) is on track to participate in a "bonus" practice that the 49ers have scheduled during their Week 9 bye, Ian Rapoport of NFL Network reports. |
| Joshua Dobbs Status: Out San Francisco 49ers | Dobbs (coach's decision) is inactive for Sunday night's game against the Cowboys, Nick Wagoner of ESPN.com reports. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (illness) is active for Sunday Night Football against the Cowboys, Lindsey Pallares of the 49ers' official site reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle (foot) is active for Sunday's game versus the Cowboys, Lindsey Pallares of the 49ers' official site reports. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel (illness) is listed as active Sunday against the Cowboys, Lindsey Pallares of the 49ers' official site reports. |
| Rock Ya-Sin Status: Out San Francisco 49ers | inactive |
| Jake Moody Status: Out San Francisco 49ers | inactive |
| Jauan Jennings Status: Out San Francisco 49ers | inactive |
| Jalen Graham Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Ben Bartch Status: Out San Francisco 49ers | inactive |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel (illness) is likely to suit up in Sunday's Week 8 contest against the Cowboys, Jordan Schultz of Fox Sports reports. |
| 2024-10-26 |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (illness) is listed as questionable for Sunday's game against the Cowboys. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (elbow) was a full participant during Friday's practice and does not carry an injury designation into Sunday's game against Dallas. |
| Talanoa Hufanga Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Friday that it's "not a sure thing" that Hufanga will return from a wrist injury during the 2024 season, Nick Wagoner of ESPN.com reports. |
| Kevin Givens Status: Out San Francisco 49ers | Givens (groin) has been ruled out ahead of Sunday's game against the Cowboys, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Anders Carlson Status: Active San Francisco 49ers | The 49ers elevated Carlson from the practice squad to the active roster Saturday, in preparation for him to start Sunday's game against the Cowboys, Matt Barrows of The Athletic reports. |
| 2024-10-25 |
| Kevin Givens Status: Out San Francisco 49ers | out |
| Jauan Jennings Status: Out San Francisco 49ers | Jennings (hip) has been ruled out for Sunday's game against the Cowboys, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (foot) is listed as questionable for Sunday's game against the Cowboys, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel (illness) is listed as questionable for Sunday's game against the Cowboys, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Chris Conley Status: Active San Francisco 49ers | Conley (ankle) was a full practice participant Friday and doesn't have an injury designation for Sunday's game against the Cowboys. |
| Jordan Mason Status: Active San Francisco 49ers | Mason (shoulder) was a full practice participant Friday and doesn't have a designation for Sunday's game against the Cowboys. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | questionable |
| Nick Bosa Status: Active San Francisco 49ers | NA |
| 2024-10-24 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (hip) was a non-participant at Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jordan Mason Status: Questionable San Francisco 49ers | Mason (shoulder) practiced in a limited fashion Thursday, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (foot) practiced on a limited basis Thursday, Cam Inman of The San Jose Mercury News reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (elbow) was a limited participant in San Francisco's practice Wednesday, Cam Inman of The San Jose Mercury Newsreports. |
| Chris Conley Status: Questionable San Francisco 49ers | Conley (ankle) was a limited participant in San Francisco's practice Wednesday, Cam Inman of The San Jose Mercury Newsreports. |
| Darrell Luter Jr. Status: Active San Francisco 49ers | Luter (pelvis) did not appear on the 49ers' injury report Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel (illness) was present at the open portion of Thursday's practice, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (foot) returned to practice Thursday, David Lombardi of The San Francisco Standard reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel (wrist/illness) was limited at Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| 2024-10-23 |
| Leonard Floyd Status: Active San Francisco 49ers | Floyd finished with five tackles (one solo), including a tackle for a loss and 1.0 sacks, in Sunday's 28-18 loss to the Chiefs. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir recorded eight tackles (six solo), an interception and a pass breakup in Sunday's 28-18 loss to the Chiefs. |
 | Malik Turner Status: Active San Francisco 49ers | NA |
| Darrell Luter Jr. Status: Active San Francisco 49ers | NA |
| George Odum Status: Questionable San Francisco 49ers | questionable |
| Kevin Givens Status: Questionable San Francisco 49ers | questionable |
| Jordan Mason Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Mason will be limited at Wednesday's practice due to an ankle injury, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Kittle (foot) won't practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Samuel (illness) won't practice Wednesday but has a chance to play Sunday against the Cowboys, Matt Barrows of The Athletic reports. |
| Brandon Aiyuk Status: Injured Reserve San Francisco 49ers | The 49ers placed Aiyuk (knee) on injured reserve Wednesday. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jennings (hip) won't practice Wednesday, Matt Barrows of The Athletic reports. |
| 2024-10-22 |
| Anders Carlson Status: Active San Francisco 49ers | Carlson reverted to the 49ers' practice squad Monday, per the NFL's transaction log. |
| Darrell Luter Jr. Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Ronnie Bell Status: Active San Francisco 49ers | Bell played 24 of the 49ers' 63 snaps on offense and finished with one reception for 10 yards on two targets in Sunday's 28-18 loss to the Chiefs. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel (illness) was discharged from a San Francisco-area hospital Tuesday, Matt Barrows of The Athletic reports. |
| 2024-10-21 |
| Dre Greenlaw Status: Out San Francisco 49ers | Greenlaw (Achilles) is not expected to be ready for his season debut until a few weeks after the 49ers' bye, Nick Wagoner of ESPN.com reports. |
| Chris Conley Status: Questionable San Francisco 49ers | Conley (ankle) suffered an ankle sprain in Sunday's 28-18 loss to Kansas City, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Out San Francisco 49ers | Coach Kyle Shanahan said after Sunday's 28-18 loss to the Chiefs that the 49ers hope to get Jennings (hip) back for Week 8 against the Cowboys, Matt Barrows of The Athletic reports. |
| Brandon Aiyuk Status: Doubtful San Francisco 49ers | Coach Kyle Shanahan said after Sunday's 28-18 loss to the Chiefs that the 49ers are worried that Aiyuk tore his ACL, Adam Schefter of ESPN reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 17 of 31 pass attempts for 212 yards, no touchdowns and three interceptions while adding eight carries for 27 yards and two rushing scores in Sunday's 28-18 loss to Kansas City. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha recorded 12 tackles (six solo) during Sunday's 28-18 loss versus the Chiefs. |
| George Kittle Status: Active San Francisco 49ers | Kittle corralled six of seven targets for 92 yards in Sunday's 28-18 loss to the Chiefs. |
| Jordan Mason Status: Active San Francisco 49ers | Mason rushed 14 times for 58 yards and caught both of his targets for 11 yards in Sunday's 28-18 loss to the Chiefs. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo rushed once for two yards and caught his only target for five yards in Sunday's 28-18 loss to Kansas City. |
| Brandon Aiyuk Status: Doubtful San Francisco 49ers | Aiyuk's tests on his injured knee Monday revealed a season-ending injury, Jordan Schultz of Fox Sports reports. |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing caught two of three targets for 50 yards in Sunday's 28-18 loss to the Chiefs. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (chest) made his pro debut in Sunday's 28-18 loss to the Chiefs, grabbing three receptions for 21 yards off of five targets in Sunday's 28-18 loss to the Chiefs, |
| Brandon Aiyuk Status: Doubtful San Francisco 49ers | Aiyuk reportedly suffered a torn ACL and MCL during Sunday's loss to the Chiefs, according to Ian Rapoport of NFL Network. |
| Jake Moody Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Moody (ankle) won't play in next Sunday's game against the Cowboys, Cam Inman of The San Jose Mercury News reports. |
| Chris Conley Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Kittle has a sprained foot and is day-to-day, Cam Inman of The San Jose Mercury News reports. |
| Christian McCaffrey Status: Injured Reserve San Francisco 49ers | Coach Kyle Shanahan said Monday that McCaffrey (Achilles) is unlikely to practice this week, but the 49ers are hopeful the running back will be able to return after their Week 9 bye on Sunday, Nov. 10 at Tampa Bay, Nick Wagoner of ESPN.com reports. |
| Anders Carlson Status: Active San Francisco 49ers | Carlson went 2-for-2 on field-goal attempts and missed his only point-after try in Sunday's 28-18 loss to the Chiefs. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Monday that Samuel has been diagnosed with pneumonia and doesn't have a timeline for when he'll be available again, Matt Barrows of The Athletic reports. |
| Jake Moody Status: Out San Francisco 49ers | out |
| Brandon Aiyuk Status: Out San Francisco 49ers | Coach Kyle Shanahan confirmed Monday that Aiyuk sustained tears to the ACL and MCL in his right knee during Sunday's loss to the Chiefs, Nick Wagoner of ESPN.com reports. |
| Brayden Willis Status: Active San Francisco 49ers | NA |
| Jalen Graham Status: Active San Francisco 49ers | NA |
| Ben Bartch Status: Active San Francisco 49ers | NA |
| 2024-10-20 |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel is tending to an illness but is expected to play Sunday against the Chiefs, Matt Maiocco of NBC Sports Bay Area reports. |
| Deebo Samuel Sr. Status: Out San Francisco 49ers | Samuel has been ruled out of Sunday's contest versus the Chiefs due to an illness, Nick Wagoner of ESPN.com reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | Aiyuk won't return to Sunday's contest against the Chiefs due to a knee injury, Cam Inman of The San Jose Mercury News reports. |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | questionable |
| Brandon Aiyuk Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (chest) remains listed as questionable but is on track to make his NFL debut in Sunday's game against the Chiefs, Jay Glazer on Fox Sports reports. |
| Darrell Luter Jr. Status: Out San Francisco 49ers | Luter (pelvis) is inactive for Sunday's game against Kansas City. |
| Joshua Dobbs Status: Out San Francisco 49ers | Dobbs (coach's decision) is inactive for Sunday's game against the Chiefs, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (chest) is listed as active Sunday against the Chiefs. |
| Brayden Willis Status: Out San Francisco 49ers | inactive |
| Jake Moody Status: Out San Francisco 49ers | inactive |
| Jauan Jennings Status: Out San Francisco 49ers | inactive |
| Jalen Graham Status: Out San Francisco 49ers | inactive |
| Ben Bartch Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Active San Francisco 49ers | NA |
| 2024-10-19 |