Injuries
| 2026-10-18 |
 | Nick Bosa Status: Out San Francisco 49ers | Bosa (knee/calf) has been ruled out for Monday's Week 6 matchup against the Commanders, Cam Inman of The San Jose Mercury News reports. |
 | Marques Sigle Status: Out San Francisco 49ers | Sigle (ankle) won't play in Monday's Week 6 matchup against Washington, Cam Inman of The San Jose Mercury News reports. |
 | James Thompson Jr. Status: Active San Francisco 49ers | Thompson (ankle) doesn't carry an injury designation into Monday night's game against the Commanders. |
 | Mykel Williams Status: Questionable San Francisco 49ers | Williams (knee) is questionable for Monday night's game against the Commanders. |
 | Upton Stout Status: Questionable San Francisco 49ers | Stout (shoulder) is questionable for Monday night's game against the Commanders. |
| 2026-10-17 |
 | Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs/Achilles) was working off to the side during the opening portion of Saturday's practice, Nick Wagoner of ESPN.com reports. |
 | Romello Height Status: Questionable San Francisco 49ers | questionable |
| James Thompson Jr. Status: Active San Francisco 49ers | NA |
 | Colton McKivitz Status: Active San Francisco 49ers | NA |
 | Christian Kirk Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Saturday that the 49ers may activate Kirk (calf) from injured reserve ahead of Monday's game against the Commanders, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs) is listed as questionable for Monday's game against Washington, Vic Tafur of The Athletic reports. |
| Marques Sigle Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Out San Francisco 49ers | out |
 | Kaelon Black Status: Active San Francisco 49ers | Black was excused from Saturday's practice to address a personal matter but does not have an injury designation for Monday's Week 6 matchup against Washington, Nick Wagoner of ESPN.com reports. |
| Romello Height Status: Active San Francisco 49ers | NA |
| 2026-10-16 |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee/calf) was a non-participant at Thursday's practice, Matt Barrows of The Athletic reports. |
| Marques Sigle Status: Doubtful San Francisco 49ers | Sigle (ankle) didn't take part in Thursday's practice, Matt Barrows of The Athletic reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs/Achilles) was working on the side during the open portion of Friday's practice, Nick Wagoner of ESPN.com reports. |
 | Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (knee) was a full participant in Friday's practice, Harrison Rich of the San Francisco Chronicle reports. |
| Christian Kirk Status: Injured Reserve San Francisco 49ers | Kirk (calf) remained limited in Friday's practice, Harrison Rich of the San Francisco Chronicle reports. |
| Romello Height Status: Questionable San Francisco 49ers | questionable |
 | Carver Willis Status: Active San Francisco 49ers | NA |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs/Achilles) was a non-participant at Friday's practice, Harrison Rich of the San Francisco Chronicle reports. |
| 2026-10-15 |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (knee) will be limited at Thursday's practice, head coach Kyle Shanahan told reporters Thursday, Cam Inman of Bay Area News Group reports. |
 | Deebo Samuel Sr. Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Thursday that the 49ers will "hold off" on placing Samuel (hamstring) on IR due to the team's bye in Week 8, Vic Tafur of the Athletic reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said Evans won't practice Thursday due to rib and Achilles injuries, Cam Inman of The San Jose Mercury News reports. |
 | Demarcus Robinson Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Thursday that Robinson (ankle) has an "outside chance" to return from injured reserve for the 49ers' Week 7 game versus the Falcons but is more likely to be activated following the team's Week 8 bye, David Lombardi of SFStandard.com reports. |
| Christian Kirk Status: Injured Reserve San Francisco 49ers | Kirk (calf) had his 21-day practice window opened Thursday. |
| Mykel Williams Status: Questionable San Francisco 49ers | questionable |
| Carver Willis Status: Questionable San Francisco 49ers | questionable |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Colton McKivitz Status: Questionable San Francisco 49ers | questionable |
 | Siran Neal Status: Questionable San Francisco 49ers | questionable |
 | Gracen Halton Status: Questionable San Francisco 49ers | questionable |
| Christian Kirk Status: Injured Reserve San Francisco 49ers | Kirk (calf) was limited in his return to practice Thursday, Matt Barrows of The Athletic reports. |
| 2026-10-14 |
 | Dre Greenlaw Status: Suspension San Francisco 49ers | Greenlaw's appeal of a one-game suspension was denied by the NFL on Tuesday, Adam Schefter of ESPN reports. |
| 2026-10-13 |
| James Thompson Jr. Status: Questionable San Francisco 49ers | questionable |
| Marques Sigle Status: Doubtful San Francisco 49ers | doubtful |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | questionable |
| Nick Bosa Status: Questionable San Francisco 49ers | questionable |
 | Nick Martin Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Monday that Martin's (hamstring) status will be evaluated "in these next couple of days," Nick Wagoner of ESPN.com reports. |
| 2026-10-12 |
| Mike Evans Status: Active San Francisco 49ers | Evans caught seven of 10 targets for 113 yards and a touchdown in Sunday's 32-29 win over the Seahawks. He also caught a successful two-point conversion. |
 | Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 11 times for 68 yards and a touchdown while catching all three of his targets for 15 yards in Sunday's 32-29 win over the Seahawks. |
 | George Kittle Status: Active San Francisco 49ers | Kittle (illness) caught five of six targets for 24 yards in Sunday's 32-29 win over the Seahawks. |
 | Brock Purdy Status: Active San Francisco 49ers | Purdy completed 19 of 29 passes for 189 yards, two touchdowns and one interception in Sunday's 32-29 win over the Seahawks. He also rushed five times for six yards and threw a successful two-point conversion. |
| Deebo Samuel Sr. Status: Out San Francisco 49ers | Samuel is expected to miss at least a couple weeks due to a hamstring injury he sustained during the 49ers' 32-29 win over the Seahawks on Sunday, David Lombardi of the San Francisco Standard reports. |
| Marques Sigle Status: Out San Francisco 49ers | out |
 | Tatum Bethune Status: Active San Francisco 49ers | NA |
 | Enrique Cruz Jr. Status: Active San Francisco 49ers | NA |
 | Kurtis Rourke Status: Active San Francisco 49ers | NA |
| James Thompson Jr. Status: Out San Francisco 49ers | out |
| Kyle Juszczyk Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Out San Francisco 49ers | out |
 | Garret Wallow Status: Out San Francisco 49ers | out |
| Deebo Samuel Sr. Status: Questionable San Francisco 49ers | Samuel is scheduled to undergo an MRI after exiting Sunday's 32-29 win over the Seahawks due to a hamstring injury, Ian Rapoport of NFL Network reports. |
| Garret Wallow Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that Wallow will miss "at least a couple of weeks" due to a hamstring strain, Nick Wagoner of ESPN.com reports. |
| Kyle Juszczyk Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Monday that Juszczyk (knee) could return for Week 6 against the Commanders on Sunday, Matt Barrows of The Athletic reports. |
| Nick Bosa Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Monday that Bosa (calf) "has a chance" to play against the Commanders on Sunday, David Lombardi of SFStandard.com reports. |
| Christian Kirk Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Monday that Kirk (calf) is "unlikely" to return to practice this week, Nick Wagoner of ESPN.com reports. |
 | Eddy Pineiro Status: Active San Francisco 49ers | Pineiro went 1-for-2 on field-goal attempts and made all three of his extra-point tries during the 49ers' 32-29 win over the Seahawks on Sunday. |
 | Renardo Green Status: Active San Francisco 49ers | Green logged one solo tackle and three pass defenses (including two interceptions) during the 49ers' 32-29 win over the Seahawks on Sunday. |
| James Thompson Jr. Status: Out San Francisco 49ers | Thompson (ankle) could return to action in Week 6 against Washington, Matt Barrows of The Athletic reports. |
| Dre Greenlaw Status: Suspension San Francisco 49ers | Greenlaw was handed a one-game suspension without pay Monday for an act of unsportsmanlike conduct during Sunday's win over the Seahawks, Tom Pelissero of Netflix reports. |
| 2026-10-11 |
| Deebo Samuel Sr. Status: Out San Francisco 49ers | Samuel (hamstring) has been ruled out for the remainder of Sunday's game against the Seahawks, Ian Rapoport of NFL Network reports. |
| George Kittle Status: Active San Francisco 49ers | The 49ers announced that Kittle is dealing with an illness but will play in Sunday's game against the Seahawks, Nick Wagoner of ESPN.com reports. |
 | Jack Stoll Status: Active San Francisco 49ers | The 49ers elevated Stoll from the practice squad to the active roster Saturday. |
| Mykel Williams Status: Active San Francisco 49ers | The 49ers activated Williams (knee) from the reserve/PUP list Saturday, and he no longer carries an injury designation into Sunday's NFC West tilt against the Seahawks. |
| Upton Stout Status: Active San Francisco 49ers | Stout (shoulder) is active for Sunday's game against the Seahawks, Brooke Evans of the 49ers' official site reports. |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (coach's decision) is inactive for Sunday's game against the Seahawks. |
| Marques Sigle Status: Out San Francisco 49ers | inactive |
| James Thompson Jr. Status: Out San Francisco 49ers | inactive |
| Kyle Juszczyk Status: Out San Francisco 49ers | inactive |
| Enrique Cruz Jr. Status: Out San Francisco 49ers | inactive |
| Tatum Bethune Status: Out San Francisco 49ers | inactive |
| Nick Bosa Status: Out San Francisco 49ers | inactive |
| 2026-10-10 |
| James Thompson Jr. Status: Out San Francisco 49ers | Thompson (ankle) has been ruled out for Sunday's game against the Seahawks. |
| Mykel Williams Status: Out San Francisco 49ers | Williams (knee) is listed as questionable ahead of Sunday's game against the Seahawks. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (shoulder) is listed as questionable ahead of Sunday's game against the Seahawks. |
| Nick Bosa Status: Out San Francisco 49ers | Bosa (calf) has been ruled out ahead of Sunday's game against the Seahawks. |
| 2026-10-09 |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs) was suited up and preparing to take part at the beginning of Friday's practice, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Active San Francisco 49ers | Evans (ribs) does not have an injury designation for Sunday's game against the Seahawks, Nick Wagoner of ESPN.com reports. |
| James Thompson Jr. Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Out San Francisco 49ers | out |
| 2026-10-08 |
| Kaelon Black Status: Active San Francisco 49ers | Black (illness) upgraded to a full practice Thursday, Harrison Rich of the San Francisco Chronicle reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs) didn't practice Thursday, but he was able to run on a side field during the open portion of the session, Cam Inman of The San Jose Mercury News reports. |
| 2026-10-07 |
| Mike Evans Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Evans (ribs) is expected to be limited at Wednesday's practice, Nick Wagoner of ESPN.com reports. |
| Kaelon Black Status: Questionable San Francisco 49ers | questionable |
| Kaelon Black Status: Questionable San Francisco 49ers | Black (illness) was limited in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs) was listed as a limited participant for Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
 | Fred Warner Status: Active San Francisco 49ers | Warner recorded seven tackles (three solo) and two passes defensed during Sunday's 24-14 win versus the Broncos. |
| Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw recorded 12 tackles (seven solo) and forced a fumble during Sunday's 24-14 win versus the Broncos. |
 | Dante Pettis Status: Out San Francisco 49ers | out |
| Marques Sigle Status: Out San Francisco 49ers | out |
| Upton Stout Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that Stout is day-to-day with an AC joint sprain in his shoulder, David Lombardi of SFStandard.com reports. |
| Kyle Juszczyk Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that Juszczyk will miss multiple weeks after hyperextending and sustaining a bone bruise to his right knee in Sunday's 24-14 win over the Broncos, Matt Barrows of The Athletic reports. |
| 2026-10-06 |
| James Thompson Jr. Status: Doubtful San Francisco 49ers | doubtful |
| Nick Bosa Status: Doubtful San Francisco 49ers | doubtful |
| James Thompson Jr. Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Thompson (ankle) is not expected back for Week 5, Cam Inman of The San Jose Mercury News reports. |
| Kaelon Black Status: Active San Francisco 49ers | Black turned six carries into 13 yards during the 49ers' 24-14 win over the Broncos on Sunday. |
| 2026-10-05 |
| George Kittle Status: Active San Francisco 49ers | Kittle secured four of six targets for 70 yards and a touchdown in the 49ers' 24-14 win over the Broncos on Sunday. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro went 1-for-2 on field-goal attempts and made all three of his PATs during Sunday's 24-14 win over Denver. |
| Kyle Juszczyk Status: Doubtful San Francisco 49ers | Juszczyk is believed to have sustained a sprained right knee in Sunday's 24-14 win over the Broncos and is likely to miss "several weeks," Ian Rapoport of NFL Network reports. |
| Nick Bosa Status: Out San Francisco 49ers | Bosa (calf) is unlikely to be ready for the 49ers' Week 5 matchup against the Seahawks, Cam Inman of The San Jose Mercury News reports. |
| Marques Sigle Status: Doubtful San Francisco 49ers | Sigle is expected to miss multiple weeks due to a high-ankle injury that he sustained during the 49ers' 24-14 win over the Broncos on Sunday, Matt Barrows of The Athletic reports. |
| Marques Sigle Status: Questionable San Francisco 49ers | Sigle suffered an ankle injury during Sunday's 24-14 win over the Broncos. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel caught five of six targets for 26 yards and a touchdown while also adding 44 yards on three carries and 49 kickoff-return yards during Sunday's 24-14 win over the Broncos. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 19 of 30 passes for 218 yards with two touchdowns and no interceptions while adding 10 carries for 29 yards in the 49ers' 24-14 win over the Broncos on Sunday. |
| Mike Evans Status: Active San Francisco 49ers | Evans brought in five of eight targets for 76 yards in the 49ers' 24-14 win over the Broncos on Sunday. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 15 times for 52 yards and a touchdown and brought in three of five targets for 18 yards in the 49ers' 24-14 win over the Broncos on Sunday. |
| James Thompson Jr. Status: Out San Francisco 49ers | out |
| Tatum Bethune Status: Active San Francisco 49ers | NA |
| Nick Bosa Status: Out San Francisco 49ers | out |
| Enrique Cruz Jr. Status: Active San Francisco 49ers | NA |
 | Ephesians Prysock Status: Active San Francisco 49ers | NA |
| Kurtis Rourke Status: Active San Francisco 49ers | NA |
| 2026-10-04 |
| Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw (quadriceps) is active for Sunday's game against the Broncos. |
 | Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive against Denver on Sunday. |
| Mike Evans Status: Active San Francisco 49ers | Evans (ribs) is active for Sunday's game against the Broncos. |
| James Thompson Jr. Status: Out San Francisco 49ers | inactive |
| Ephesians Prysock Status: Out San Francisco 49ers | inactive |
| Kurtis Rourke Status: Out San Francisco 49ers | inactive |
| Enrique Cruz Jr. Status: Out San Francisco 49ers | inactive |
 | Keion White Status: Active San Francisco 49ers | NA |
 | Jaden Dugger Status: Active San Francisco 49ers | NA |
| Tatum Bethune Status: Out San Francisco 49ers | inactive |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw (quadriceps) is expected to play against the Broncos on Sunday, Jeremy Fowler of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans remains listed as questionable for Sunday's game against Denver but is slated to play with a protective covering over his fractured ribs, Jay Glazer of Fox Sports reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (shoulder) is questionable to return to Sunday's game against the Broncos, Nick Wagoner of ESPN.com reports. |
| Kyle Juszczyk Status: Out San Francisco 49ers | Juszczyk (knee) has been ruled out for the remainder of Sunday's game against the Broncos, Eric Branch of the San Francisco Chronicle reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (shoulder) returned to Sunday's game against the Broncos, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs) has said "he'll do his best to be out there" Sunday against the Broncos, Ian Rapoport of NFL Network reports. |
| 2026-10-03 |
| Romello Height Status: Active San Francisco 49ers | Height (hand) does not carry an injury designation for Sunday's game against Denver. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw (quadriceps) is listed as questionable for Sunday's game against Denver. |
 | Trent Williams Status: Active San Francisco 49ers | Williams (neck) does not have any injury designation ahead of Sunday's game against the Broncos. |
 | Malik Turner Status: Active San Francisco 49ers | The 49ers elevated Turner from their practice squad to their active roster Saturday. |
| 2026-10-02 |
| Christian Kirk Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Friday that the 49ers could open Kirk's (calf) practice window to return from injured reserve in two weeks, Matt Barrows of The Athletic reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Friday that Evans (ribs) will be a game-time decision for Sunday's contest against the Broncos, Vic Tafur of The Athletic reports. |
| Trent Williams Status: Active San Francisco 49ers | NA |
| Jaden Dugger Status: Questionable San Francisco 49ers | questionable |
| Romello Height Status: Active San Francisco 49ers | NA |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw (quadriceps) did not practice Thursday, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs) was in uniform and running on the side during the media-access portion of Friday's practice, Nick Wagoner of ESPN.com reports. |
| 2026-10-01 |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs) was a non-participant at Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Gracen Halton Status: Active San Francisco 49ers | Halton (ankle) was not listed on Wednesday's practice report, Vic Tafur of The Athletic reports. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw (quadriceps) didn't practice Wednesday, Vic Tafur of The Athletic reports. |
 | KhaDarel Hodge Status: Questionable San Francisco 49ers | Hodge (knee) did not practice Wednesday, Vic Tafur of The Athletic reports. |
 | Brandin Cooks Status: Active San Francisco 49ers | The 49ers signed Cooks from the practice squad to the active roster Thursday, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (ribs) was working on the side during Thursday's practice, Nick Wagoner of ESPN.com reports. |
| 2026-09-30 |
| Mykel Williams Status: Out San Francisco 49ers | The 49ers opened Williams' (knee) 21-day practice window Wednesday to return from the reserve/PUP list, Matt Maiocco of NBC Sports Bay Area reports. |
| Keion White Status: Questionable San Francisco 49ers | questionable |
| Gracen Halton Status: Active San Francisco 49ers | NA |
| Renardo Green Status: Active San Francisco 49ers | Green recorded 13 tackles (seven solo) and one pass breakup in Sunday's 36-30 win over the Cardinals. |
| Fred Warner Status: Active San Francisco 49ers | Warner recorded 17 tackles (eight solo) in Sunday's win over Arizona. |
| KhaDarel Hodge Status: Questionable San Francisco 49ers | questionable |
| Mike Evans Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Evans (ribs) won't practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| 2026-09-29 |
| Kaelon Black Status: Active San Francisco 49ers | Black turned four carries into 17 yards and failed to haul in his lone target during the 49ers' 36-30 win over the Cardinals on Sunday. |
| James Thompson Jr. Status: Out San Francisco 49ers | Thompson (ankle) won't play in San Francisco's Week 4 matchup versus the Broncos, Jennifer Lee Chan of NBC Sports Bay Area reports. |
 | Jordan Watkins Status: Active San Francisco 49ers | Watkins recorded two receptions for 60 yards on two targets in Sunday's 36-30 win over the Cardinals. |
| Romello Height Status: Questionable San Francisco 49ers | questionable |
| KhaDarel Hodge Status: Active San Francisco 49ers | Hodge went without a target while logging 30 of the 49ers' 54 offensive snaps in Sunday's 36-30 win over the Cardinals. |
 | Jacob Cowing Status: Active San Francisco 49ers | Cowing failed to corral either of his two targets while playing 17 of the 49ers' 54 snaps on offense in Sunday's 36-30 win over the Cardinals. |
| 2026-09-28 |
| James Thompson Jr. Status: Out San Francisco 49ers | out |
| Romello Height Status: Out San Francisco 49ers | out |
| Tatum Bethune Status: Active San Francisco 49ers | NA |
| Nick Bosa Status: Out San Francisco 49ers | out |
| Enrique Cruz Jr. Status: Active San Francisco 49ers | NA |
| Ephesians Prysock Status: Active San Francisco 49ers | NA |
| Kurtis Rourke Status: Active San Francisco 49ers | NA |
| George Kittle Status: Active San Francisco 49ers | Kittle brought in six of seven targets for 82 yards and two touchdowns in the 49ers' 36-30 win over the Cardinals on Sunday. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 15 of 27 passes for 297 yards with four touchdowns and no interceptions and rushed twice for 34 yards in the 49ers' 36-30 win over the Cardinals on Sunday. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel turned two carries into 14 yards and scored an 80-yard touchdown during Sunday's 36-30 win over Arizona. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans is considered day-to-day after sustaining a rib strain during Sunday's 36-30 win over the Cardinals, Ian Rapoport of NFL Network reports. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro connected on a 57-yard field-goal try but only went three of five on extra-point attempts in Sunday's 36-30 win over the Cardinals. |
| Nick Bosa Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Bosa (calf) won't play this coming Sunday against the Broncos, Cam Inman of The San Jose Mercury News reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 15 times for 75 yards and a touchdown while bringing in four of five targets for 41 yards in the 49ers' 36-30 win over the Cardinals on Sunday. |
| 2026-09-27 |
 | Jack Jones Status: Active San Francisco 49ers | Jones (foot) is active for Sunday's game against the Cardinals, Brooke Evans of the 49ers' official site reports. |
| Ephesians Prysock Status: Out San Francisco 49ers | inactive |
| Kurtis Rourke Status: Out San Francisco 49ers | inactive |
| James Thompson Jr. Status: Out San Francisco 49ers | inactive |
| Romello Height Status: Out San Francisco 49ers | inactive |
| Tatum Bethune Status: Out San Francisco 49ers | inactive |
| Nick Bosa Status: Out San Francisco 49ers | inactive |
| Enrique Cruz Jr. Status: Out San Francisco 49ers | inactive |
| Mike Evans Status: Active San Francisco 49ers | Evans (hip) is listed as active Sunday against the Cardinals, Brooke Evans of the 49ers' official site reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (hip) intends to play Sunday versus the Cardinals, Jeremy Fowler of ESPN reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans suffered an apparent undisclosed injury during Sunday's game against the Cardinals, Matt Barrows of The Athletic reports. |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Mike Evans Status: Out San Francisco 49ers | Evans left Sunday's contest against the Cardinals due to a rib injury and won't return, Nick Wagoner of ESPN.com reports. |
| Gracen Halton Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (neck) is questionable to return to Sunday's game against the Cardinals, Adam Schefter of ESPN reports. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw (quadriceps) is questionable to return to Sunday's game against the Cardinals, Eric Branch of the San Francisco Chronicle reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (head) has returned to Sunday's game against the 49ers, Eric Branch of the San Francisco Chronicle reports. |
| Gracen Halton Status: Questionable San Francisco 49ers | Halton (ankle) is questionable to return to Sunday's game against Arizona, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (rib) is dealing with a rib strain after exiting Sunday's game against the Cardinals, Ian Rapoport of NFL Network reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans has a rib/oblique injury, head coach Kyle Shanahan revealed after Sunday's 36-30 win over the Cardinals, Matt Barrows of The Athletic reports. |
| 2026-09-26 |
| Demarcus Robinson Status: Injured Reserve San Francisco 49ers | The 49ers placed Robinson (ankle) on injured reserve Saturday. |
| James Thompson Jr. Status: Out San Francisco 49ers | Thompson (ankle) is listed as out for Sunday's game against Arizona. |
| 2026-09-25 |
| Nick Bosa Status: Doubtful San Francisco 49ers | Bosa injured his calf during Thursday's practice and is expected to miss "a few weeks," according to Adam Schefter of ESPN. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (hip) is taking part in Friday's practice, David Lombardi of the San Francisco Standard reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (hip) is listed as questionable for Sunday's game versus the Cardinals, Cam Inman of The San Jose Mercury News reports. |
| James Thompson Jr. Status: Out San Francisco 49ers | out |
| Romello Height Status: Out San Francisco 49ers | out |
| Nick Bosa Status: Out San Francisco 49ers | out |
| Romello Height Status: Out San Francisco 49ers | Height (hand) has been ruled out ahead of Sunday's game against the Cardinals. |
| Nick Bosa Status: Out San Francisco 49ers | Bosa (calf) has been ruled out ahead of Sunday's game against the Cardinals. |
| Romello Height Status: Questionable San Francisco 49ers | Height (hand) did not participate in Thursday's practice, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (calf/knee) did not participate in Thursday's practice, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2026-09-24 |
| Mike Evans Status: Questionable San Francisco 49ers | The hip injury Evans sustained in Sunday's win over the Dolphins "does not seem to be major," and the wideout has a "good chance" of practicing Thursday or Friday and playing this weekend against the Cardinals, Ian Rapoport of NFL Network reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (hip) was seen running on a side field at Thursday's practice, Matt Barrows of The Athletic reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | questionable |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (hip) didn't participate in Thursday's practice, Harrison Rich of the San Francisco Chronicle reports. |
 | Naquan Jones Status: Active San Francisco 49ers | The 49ers signed Jones to the active roster Wednesday from the Vikings' practice squad. |
| 2026-09-23 |
 | C.J. West Status: Injured Reserve San Francisco 49ers | ir |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (hip) won't practice Wednesday, Vic Tafur of The Athletic reports. |
 | Ji'Ayir Brown Status: Active San Francisco 49ers | Brown recorded 13 tackles (four solo) during Sunday's 35-13 win versus the Dolphins. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle recorded seven tackles (three solo) including 1.0 sacks during Sunday's 35-13 win versus the Dolphins. |
| Fred Warner Status: Active San Francisco 49ers | Warner recorded five tackles (one solo) including 0.5 sacks and a forced fumble during Sunday's 35-13 win versus the Dolphins. |
| C.J. West Status: Injured Reserve San Francisco 49ers | The 49ers placed West (undisclosed) on injured reserve Wednesday. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk recorded two catches on two targets for 27 yards and a touchdown in Sunday's win over the Dolphins. |
 | Mac Jones Status: Active San Francisco 49ers | Jones was 0-for-0 passing for zero yards during Sunday's 35-13 victory over the Dolphins. |
| 2026-09-22 |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro did not have any field-goal tries but converted on all five of his extra-point attempts during Sunday's 35-13 win versus the Dolphins. |
| Romello Height Status: Questionable San Francisco 49ers | Height will undergo hand surgery Tuesday, David Lombardi of SFStandard.com reported Monday. |
| Jordan James Status: Active San Francisco 49ers | James saw four carries for 15 yards in Sunday's 35-13 win over the Dolphins. |
| 2026-09-21 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 10 times for 23 yards and two touchdowns while catching both of his targets for 43 yards in Sunday's 35-13 win over the Dolphins. |
| Tatum Bethune Status: Active San Francisco 49ers | NA |
| Enrique Cruz Jr. Status: Active San Francisco 49ers | NA |
| Ephesians Prysock Status: Active San Francisco 49ers | NA |
| Kaelon Black Status: Active San Francisco 49ers | Black (groin) rushed seven times for 25 yards and wasn't targeted in Sunday's 35-13 win over the Dolphins. |
| George Kittle Status: Active San Francisco 49ers | Kittle caught all four of his targets for 80 yards and a touchdown in Sunday's 35-13 win over the Dolphins. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 20 of 22 passes for 287 yards and two touchdowns in Sunday's 35-13 win over the Dolphins. He also rushed three times for 30 yards and a touchdown. |
| Demarcus Robinson Status: Out San Francisco 49ers | out |
| Mike Evans Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Evans (hip) will "have to be managed this week" leading up to Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Demarcus Robinson Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Robinson is facing a recovery timeline of 3-to-6 weeks after sustaining a high-ankle sprain in Sunday's 35-13 win over the Dolphins, Nick Wagoner of ESPN.com reports. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel caught three of four targets for 31 yards in the 49ers' 35-13 win over the Dolphins on Sunday. He rushed one time for four yards. |
| James Thompson Jr. Status: Doubtful San Francisco 49ers | doubtful |
 | Brandon Aiyuk Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Sunday that he's not viewing Aiyuk as an option for the 49ers while the club contends with multiple injuries at receiver, Matt Barrows of The Athletic reports. |
| James Thompson Jr. Status: Doubtful San Francisco 49ers | Thompson suffered a high-ankle sprain during Sunday's 35-13 win over Miami, David Lombardi of SFStandard.com reports. |
| 2026-09-20 |
| Mike Evans Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said after Sunday's 35-13 win over the Dolphins that Evans (hip) is fine, Vic Tafur of The Athletic reports. |
| Demarcus Robinson Status: Doubtful San Francisco 49ers | Coach Kyle Shanahan said Robinson is believed to have suffered a high-ankle sprain in Sunday's win over the Dolphins, Vic Tafur of The Athletic reports. |
| Romello Height Status: Active San Francisco 49ers | Height (hand) is questionable to return to Sunday's game against the Dolphins, Nick Wagoner of ESPN.com reports. |
| Kaelon Black Status: Active San Francisco 49ers | Black (groin) is active for Sunday's Week 2 matchup against the Dolphins, Nick Wagoner of ESPN.com reports. |
| Kurtis Rourke Status: Out San Francisco 49ers | inactive |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Ephesians Prysock Status: Out San Francisco 49ers | inactive |
| Enrique Cruz Jr. Status: Out San Francisco 49ers | inactive |
| Tatum Bethune Status: Out San Francisco 49ers | inactive |
| Kaelon Black Status: Questionable San Francisco 49ers | Black (groin) is on track to play Sunday against the Dolphins, Adam Schefter of ESPN reports. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro (illness) is active for Sunday's game against the Dolphins. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Sunday's game against the Dolphins. |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (coach's decision) is inactive for Sunday's game against the Dolphins but will serve as the emergency third quarterback. |
| Demarcus Robinson Status: Questionable San Francisco 49ers | Robinson (ankle) is questionable to return to Sunday's game against the Dolphins. |
| James Thompson Jr. Status: Questionable San Francisco 49ers | questionable |
| Romello Height Status: Active San Francisco 49ers | Height (hand) has returned to Sunday's contest against the Dolphins, Eric Branch of the San Francisco Chronicle reports. |
| Jack Jones Status: Questionable San Francisco 49ers | Jones (foot) is questionable to return to Sunday's game against the Dolphins, Nick Wagoner of ESPN.com reports. |
| Demarcus Robinson Status: Questionable San Francisco 49ers | Robinson (ankle) has been ruled out for the rest of Sunday's game against the Dolphins, Matt Barrows of The Athletic reports. |
| James Thompson Jr. Status: Questionable San Francisco 49ers | Thompson (ankle) is questionable to return to Sunday's contest against Miami, Eric Branch of the San Francisco Chronicle reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans sustained a hip injury during Sunday's contest against the Dolphins, Matt Barrows of The Athletic reports. |
| 2026-09-19 |
| Eddy Pineiro Status: Questionable San Francisco 49ers | Pineiro (illness) is expected to be active Sunday against the Dolphins, Matt Maiocco of NBC Sports Bay Area reports. |
 | De'Zhaun Stribling Status: Injured Reserve San Francisco 49ers | The 49ers placed Stribling (ankle) on injured reserve Saturday. |
| 2026-09-18 |
| Eddy Pineiro Status: Questionable San Francisco 49ers | Pineiro (illness) was a non-participant at the 49ers' practice Thursday, Matt Maiocco of NBC Sports Bay Area reports. |
| Eddy Pineiro Status: Questionable San Francisco 49ers | Pineiro (illness) is listed as questionable for Sunday's game against the Dolphins, Cam Inman of The San Jose Mercury News reports. |
| Kaelon Black Status: Questionable San Francisco 49ers | Black (groin) is listed as questionable for Sunday's game against the Dolphins, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle (Achilles) practiced fully Friday and does not have an injury designation for Week 2, according to David Furones of the South Florida Sun Sentinel. |
| Keion White Status: Active San Francisco 49ers | NA |
| Kyle Juszczyk Status: Active San Francisco 49ers | NA |
| 2026-09-17 |
| Kaelon Black Status: Questionable San Francisco 49ers | Black was limited at Thursday's practice due to a groin injury, Matt Maiocco of NBC Sports Bay Area reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) practiced in a limited capacity Thursday, Matt Maiocco of NBC Sports Bay Area reports. |
 | Khalid Kareem Status: Active San Francisco 49ers | NA |
| 2026-09-16 |
| KhaDarel Hodge Status: Active San Francisco 49ers | The 49ers promoted Hodge to the active roster Wednesday, Jeremy Fowler of ESPN.com reports. |
| George Kittle Status: Questionable San Francisco 49ers | questionable |
| Keion White Status: Questionable San Francisco 49ers | questionable |
| Khalid Kareem Status: Questionable San Francisco 49ers | questionable |
| Eddy Pineiro Status: Questionable San Francisco 49ers | questionable |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) was limited in practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Eddy Pineiro Status: Questionable San Francisco 49ers | Pineiro (illness) did not participate at practice Wednesday, Nick Wagoner of ESPN.com reports. |
| De'Zhaun Stribling Status: Doubtful San Francisco 49ers | The 49ers are expected to place Stribling (ankle) on injured reserve, Adam Schefter of ESPN.com reports. |
 | Jake Tonges Status: Injured Reserve San Francisco 49ers | ir |
| Jake Tonges Status: Injured Reserve San Francisco 49ers | Tonges (knee) was placed on injured reserve Wednesday. |
| Jake Tonges Status: Injured Reserve San Francisco 49ers | Tonges (knee) required surgery for an MCL tear and is done for the season, Cam Inman reports. |
| De'Zhaun Stribling Status: Out San Francisco 49ers | Stribling underwent ankle surgery Wednesday and is expected to miss 10 weeks, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-09-15 |
 | Brayden Willis Status: Active San Francisco 49ers | The 49ers signed Willis from the practice squad to the active roster Tuesday, Nick Wagoner of ESPN.com reports. |
| 2026-09-14 |
| Tatum Bethune Status: Active San Francisco 49ers | NA |
| Enrique Cruz Jr. Status: Active San Francisco 49ers | NA |
| Jordan James Status: Active San Francisco 49ers | NA |
| Ephesians Prysock Status: Active San Francisco 49ers | NA |
| Kurtis Rourke Status: Active San Francisco 49ers | NA |
| Jordan Watkins Status: Active San Francisco 49ers | NA |
| 2026-09-13 |
| De'Zhaun Stribling Status: Doubtful San Francisco 49ers | Stribling (ankle) is expected to miss at least one month after he was diagnosed Sunday with a deltoid sprain of his left ankle, Ian Rapoport of NFL Network reports. |
| 2026-09-12 |
 | Luke Farrell Status: Active San Francisco 49ers | Farrell secured both of his targets for 19 yards in the 49ers' 27-7 win over the Rams in Week 1. |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing returned two punts for 17 yards in the 49ers' 27-7 win over the Rams in Week 1. |
| Renardo Green Status: Active San Francisco 49ers | Green logged three tackles (two solo) and one pass defensed for an interception in the 49ers' 27-7 Week 1 victory over the Rams. |
 | Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir logged six tackles (three solo) in the 49ers' 27-7 Week 1 victory over the Rams. |
| Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw logged six tackles (one solo) during the 49ers' 27-7 win over the Rams in Week 1. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa made four tackles (three solo) in the 49ers' 27-7 Week 1 victory over the Rams. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle recorded nine tackles (four solo) during the 49ers' 27-7 win against the Rams in Week 1. |
| 2026-09-11 |
| De'Zhaun Stribling Status: Active San Francisco 49ers | Stribling (ankle) returned to Thursday's game against the Rams, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Jake Tonges Status: Questionable San Francisco 49ers | Tonges (knee) is questionable to return to Thursday's game against the Rams, Nick Wagoner of ESPN.com reports. |
| De'Zhaun Stribling Status: Out San Francisco 49ers | Stribling (ankle) has been ruled out for the remainder of Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Jake Tonges Status: Questionable San Francisco 49ers | Tonges (knee) will not return to Thursday's game against the Rams, Brooke Evans of the 49ers' official website reports. |
| Mike Evans Status: Active San Francisco 49ers | Evans secured six of seven targets for 49 yards and a touchdown during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro converted two of his three field-goal attempts and all three of his extra-point tries Thursday in a season-opening 27-7 win against the Rams. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 25 of 34 passes for 205 yards with three touchdowns and one interception while adding five rushes for 29 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia. |
| Jake Tonges Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said after Thursday night's win over the Rams that Tonges' knee injury "does not look good," Vic Tafur of The Athletic reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 10 times for 68 yards and brought in five of eight targets for 20 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia. |
| George Kittle Status: Active San Francisco 49ers | Kittle brought in two of five targets for 12 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia. |
| Kaelon Black Status: Active San Francisco 49ers | Black rushed 14 times for 65 yards and brought in his only target for five yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia. |
| Fred Warner Status: Active San Francisco 49ers | Warner finished Thursday's 27-7 win against the Rams with 11 tackles (five solo) and a defensed pass. |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel brought in six of seven targets for 48 yards and a touchdown, rushed once for 12 yards and returned two kickoffs for 74 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson caught two passes on three targets for 50 yards and a touchdown during the 49ers' 27-7 win over the Rams in Week 1. |
| 2026-09-10 |
| Ephesians Prysock Status: Out San Francisco 49ers | Prysock (coach's decision) is officially inactive for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Tatum Bethune Status: Out San Francisco 49ers | Bethune (coach's decision) is officially inactive for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is officially inactive for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
 | Luke Gifford Status: Active San Francisco 49ers | Gifford (hamstring) does not have an injury designation ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Gracen Halton Status: Active San Francisco 49ers | Halton (ankle) does not have an injury designation ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Romello Height Status: Active San Francisco 49ers | Height (ankle) does not have an injury designation ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (hamstring) does not have an injury designation ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw (Achilles) does not have an injury designation ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (finger) does not have an injury designation for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Bosa Status: Active San Francisco 49ers | Bosa (knee) does not have an injury designation for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle (Achilles) isn't listed on the 49ers' injury report ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| KhaDarel Hodge Status: Active San Francisco 49ers | The 49ers elevated Hodge from the practice squad to the active roster for the team's Week 1 game against the Rams in Melbourne, Australia. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is officially inactive for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
 | Alfred Collins Status: Injured Reserve San Francisco 49ers | San Francisco placed Collins (knee) on injured reserve Thursday. |
| Ephesians Prysock Status: Out San Francisco 49ers | inactive |
| Kurtis Rourke Status: Out San Francisco 49ers | inactive |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Tatum Bethune Status: Out San Francisco 49ers | inactive |
| Enrique Cruz Jr. Status: Out San Francisco 49ers | inactive |
| James Thompson Jr. Status: Active San Francisco 49ers | NA |
| 2026-09-09 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) remained limited in Wednesday's practice, Nick Wagoner of ESPN.com reports. |
| Jack Jones Status: Active San Francisco 49ers | Jones (hand) was a full participant in Wednesday's practice. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | questionable |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
 | Dominick Puni Status: Active San Francisco 49ers | NA |
 | Vederian Lowe Status: Active San Francisco 49ers | NA |
| Keion White Status: Active San Francisco 49ers | NA |
| Ephesians Prysock Status: Active San Francisco 49ers | NA |
 | Malik Mustapha Status: Active San Francisco 49ers | Mustapha (hamstring) did not appear on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (ribs) did not appear on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area repors. |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing (groin) did not appear on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (hip) was a full participant at the 49ers' practice Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) was limited in Tuesday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins (knee) was a limited participant at the 49ers' practice Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Ephesians Prysock Status: Active San Francisco 49ers | Prysock (shoulder) was a full participant at the 49ers' practice Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (hamstring) was a limited participant at the 49ers' practice Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Romello Height Status: Questionable San Francisco 49ers | Height was a limited participant in practice Tuesday due to an ankle injury, Matt Maiocco of NBC Sports Bay Area reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (finger) was a limited participant at the 49ers' practice Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Dominick Puni Status: Active San Francisco 49ers | Puni (concussion) was not listed on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Keion White Status: Active San Francisco 49ers | White (groin) was not listed on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Dre Greenlaw Status: Questionable San Francisco 49ers | Greenlaw (Achilles) was a limited participant at the 49ers' practice Tuesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Alfred Collins Status: Out San Francisco 49ers | out |
| George Kittle Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Kittle (Achilles) could have his workload monitored against the Rams on Thursday, Matt Maiocco of NBC Sports Bay Area reports. |
| Vederian Lowe Status: Active San Francisco 49ers | Lowe (ankle) did not appear on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area |
| Alfred Collins Status: Out San Francisco 49ers | Collins will miss the entire 2026 season after suffering a torn patellar tendon during Tuesday's practice, Nick Wagoner of ESPN.com reports. |
| 2026-09-08 |
| Mykel Williams Status: Out San Francisco 49ers | out |
| Kurtis Rourke Status: Questionable San Francisco 49ers | questionable |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Ephesians Prysock Status: Questionable San Francisco 49ers | questionable |
| Mike Evans Status: Questionable San Francisco 49ers | questionable |
| Gracen Halton Status: Questionable San Francisco 49ers | questionable |
 | Nate Hobbs Status: Injured Reserve San Francisco 49ers | ir |
| Mike Evans Status: Active San Francisco 49ers | NA |
| De'Zhaun Stribling Status: Active San Francisco 49ers | Stribling (shoulder) was not listed on the injury report the 49ers released Tuesday, according to Matt Maiocco of NBC Sports Bay Area. |
| Mike Evans Status: Active San Francisco 49ers | Evans (adductor) was not listed on the injury report the 49ers released Tuesday, according to Matt Maiocco of NBC Sports Bay Area. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) was listed as a limited participant on Tuesday's injury report, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (undisclosed) was not listed on the injury report the 49ers released Tuesday, according to Matt Maiocco of NBC Sports Bay Area. |
| Malik Mustapha Status: Active San Francisco 49ers | NA |
| Jacob Cowing Status: Active San Francisco 49ers | NA |
| Kurtis Rourke Status: Active San Francisco 49ers | NA |
| Upton Stout Status: Active San Francisco 49ers | NA |
| Nick Bosa Status: Questionable San Francisco 49ers | San Francisco defensive coordinator Raheem Morris said Monday that Bosa (knee) will play in Thursday's Week 1 matchup against the Rams, Harrison Rich of the San Francisco Chronicle reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) is in full uniform for the 49ers' practice session in Melbourne, Australia on Tuesday (local time), Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) is in full uniform for the 49ers' practice session taking place Tuesday afternoon local time in Melbourne, Australia, Nick Wagoner of ESPN.com reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (shoulder) is in full uniform for Monday's practice in Melbourne, Australia, Nick Wagoner of ESPN.com reports. |
| 2026-09-07 |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) was not participating in drills in the early portion of Monday's practice that was open to the media, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) was not participating in drills in the early portion of the 49ers' practice Monday morning in Australia, Matt Maiocco of NBC Sports Bay Area reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (adductor) was spotted on the field in full uniform during the open portion of Monday's practice in Melbourne, Australia, Nick Wagoner of ESPN.com reports. |
 | Sam Okuayinonu Status: Injured Reserve San Francisco 49ers | Okuayinonu broke his foot and is set to have surgery to repair the issue, Matt Barrows of The Athletic reports. |
| 2026-09-06 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) is slated to practice Monday in Melbourne, Australia, Matt Barrows of The Athletic reports. |
| 2026-09-05 |
| Sam Okuayinonu Status: Injured Reserve San Francisco 49ers | ir |
| Sam Okuayinonu Status: Injured Reserve San Francisco 49ers | The 49ers placed Okuayinonu (foot) on injured reserve Friday. |
| 2026-09-04 |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | questionable |
| 2026-09-03 |
 | Victor Dimukeje Status: Questionable San Francisco 49ers | questionable |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (foot) will not travel with the team to Melbourne, Australia ahead of the Week 1 game versus the Rams, Nick Wagoner of ESPN.com reports. |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | questionable |
| 2026-09-02 |
| Nick Martin Status: Injured Reserve San Francisco 49ers | The 49ers placed Martin (hamstring) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) will travel to Australia with the 49ers and "is trending in the right direction to play" in the season opener Sept. 10 versus the Rams, Ian Rapoport of NFL Network reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (groin) returned to Wednesday, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) is making the trip to Australia and still could have a chance to play in the 49ers' Week 1 matchup against the Rams in Melbourne, Ian Rapoport of ESPN and NFL Network reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (finger) was a full participant in Wednesday's practice, Nick Wagoner of ESPN.com reports. |
| 2026-09-01 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) participated in practice Monday and plans to do so again Tuesday, David Lombardi of the San Francisco Standard reports. |
| Mike Evans Status: Questionable San Francisco 49ers | 49ers general manager John Lynch said Tuesday the team hopes to have Evans (groin) back at practice next week, David Lombardi of the San Francisco Standard reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) worked to the side on the practice field Monday and is expected to do the same Tuesday, with a return to practice planned for Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (finger) is not practicing Tuesday, Matt Barrows of The Athletic reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) suited up and went through drills at Tuesday's practice, according to Matt Lively of CBS Sports Bay Area. |
| Nick Martin Status: Injured Reserve San Francisco 49ers | ir |
| Nate Hobbs Status: Injured Reserve San Francisco 49ers | ir |
| Brayden Willis Status: Questionable San Francisco 49ers | Willis (concussion) participated in Tuesday's practice, Nick Wagoner of ESPN.com reports. |
| Nate Hobbs Status: Injured Reserve San Francisco 49ers | The 49ers placed Hobbs (groin) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports. |
 | Nick Zakelj Status: Injured Reserve San Francisco 49ers | Zakelj (undisclosed) was placed on the 49ers' injured reserve Sunday. |
 | Brett Toth Status: Injured Reserve San Francisco 49ers | The 49ers placed Toth (concussion) on injured reserve Sunday. |
 | Austen Pleasants Status: Injured Reserve San Francisco 49ers | The 49ers placed Pleasants (knee) on injured reserve with a designation to return Sunday. |
| 2026-08-31 |
| Christian Kirk Status: Injured Reserve San Francisco 49ers | ir |
| Christian Kirk Status: Injured Reserve San Francisco 49ers | Kirk (calf) was placed on injured reserve by the 49ers on Sunday with a designation to return. |
| Nick Zakelj Status: Injured Reserve San Francisco 49ers | ir |
| Brett Toth Status: Injured Reserve San Francisco 49ers | ir |
| Austen Pleasants Status: Injured Reserve San Francisco 49ers | ir |
| Mykel Williams Status: Out San Francisco 49ers | Williams (knee) was moved to the reserve/PUP list by the 49ers on Sunday. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) will be eased back into practice this week, Matt Barrows of The Athletic reports. |
| 2026-08-30 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) is expected to practice this week as he continues his push to play in the 49ers' season opener against the Rams in Australia, Adam Schefter of ESPN reports. |
 | Isaac Guerendo Status: Out San Francisco 49ers | Guerendo (pectoral) was placed on the reserve/PUP list, Jeremy Fowler of ESPN reports. |
 | Jarrett Patterson Status: Active San Francisco 49ers | Patterson was traded to the 49ers on Sunday, Tom Pelissero of Netflix reports. |
| 2026-08-29 |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel didn't play in Thursday's preseason victory against Las Vegas. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy sat out Thursday's exhibition win over the Raiders. |
| 2026-08-28 |
| Ephesians Prysock Status: Questionable San Francisco 49ers | Prysock suffered a shoulder injury and will not return to Thursday's preseason matchup with the Raiders, Noah Furtado of the San Francisco Chronicle reports. |
| Victor Dimukeje Status: Injured Reserve San Francisco 49ers | Dimukeje (undisclosed) was placed on injured reserve by the 49ers on Thursday. |
 | Jah Joyner Status: Active San Francisco 49ers | Joyner signed with the 49ers on Thursday. |
| Brayden Willis Status: Questionable San Francisco 49ers | Willis (concussion) has been ruled out for the remainder of Thursday's preseason matchup with the Raiders, Noah Furtado of the San Francisco Chronicle reports. |
| Jordan James Status: Active San Francisco 49ers | NA |
| Jordan James Status: Active San Francisco 49ers | James (ribs) rushed eight times for 35 yards and brought in one of two targets for 20 yards in the 49ers' 18-12 preseason win over the Raiders on Thursday. |
| Kaelon Black Status: Active San Francisco 49ers | Black rushed four times for 28 yards and failed to bring in his only target in the 49ers' 18-12 preseason win over the Raiders on Thursday. |
 | Patrick Taylor Jr. Status: Questionable San Francisco 49ers | questionable |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro made all six of his field-goal attempts in Thursday night's 18-12 preseason win over the Raiders. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins caught four of eight targets for 64 yards in Thursday night's 18-12 preseason win over the Raiders. |
| Mac Jones Status: Active San Francisco 49ers | Jones completed one of his five pass attempts for seven yards in Thursday night's preseason finale against the Raiders. |
| 2026-08-27 |
| Victor Dimukeje Status: Injured Reserve San Francisco 49ers | ir |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (shoulder) won't suit up for Thursday's preseason contest at Las Vegas, David Lombardi of SFStandard.com reports. |
| 2026-08-26 |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (hip) did not participate at the 49ers' training camp practice Tuesday, Nick Wagoner of ESPN.com reports. |
 | Robert Jones Status: Questionable San Francisco 49ers | Jones (calf) did not participate at the 49ers' training camp practice Tuesday, Nick Wagoner of ESPN.com reports. |
| Kurtis Rourke Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Rourke (ribs) has a chance to return to the field next week, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans' groin injury is considered minor, and he plans to be ready for the 49ers' Week 1 regular-season opener against the Rams on Thursday, Sept. 10, Jeremy Fowler of ESPN reports. |
| 2026-08-25 |
 | Josiah Deguara Status: Active San Francisco 49ers | Deguara was released by the 49ers on Monday. |
 | Xavier Thomas Status: Injured Reserve San Francisco 49ers | Thomas (undisclosed) reverted to injured reserve with the 49ers on Monday, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans is not practicing Tuesday due to a groin injury, Matt Maiocco of NBC Sports Bay Area reports. |
| Kurtis Rourke Status: Questionable San Francisco 49ers | questionable |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Robert Jones Status: Questionable San Francisco 49ers | questionable |
| Jacob Cowing Status: Questionable San Francisco 49ers | questionable |
| Jacob Cowing Status: Questionable San Francisco 49ers | Cowing (groin) did not participate at the 49ers' training camp practice Tuesday, Nick Wagoner of ESPN.com reports. |
| 2026-08-24 |
| Xavier Thomas Status: Injured Reserve San Francisco 49ers | ir |
 | Tanner McLachlan Status: Questionable San Francisco 49ers | questionable |
 | Titus Leo Status: Questionable San Francisco 49ers | questionable |
 | Deion Jones Status: Active San Francisco 49ers | Jones was traded from the Saints to the 49ers in exchange for running back Zamir White on Sunday, Adam Schefter of ESPN reports. |
| 2026-08-23 |
| Xavier Thomas Status: Questionable San Francisco 49ers | questionable |
| Khalil Dinkins Status: Active San Francisco 49ers | The 49ers signed Dinkins to a three-year contract Saturday. | |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) was activated from the active/PUP list Sunday. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) is in uniform for Sunday's training camp practice, Matt Barrows of The Athletic reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (shoulder) returned to practice Sunday, Nick Wagoner of ESPN.com reports. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (shoulder) participated in Sunday's training camp practice, Noah Furtado of the San Francisco Chronicle reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) was in uniform for Sunday's practice but did not participate in team drills, Vic Tafur of The Athletic reports. |
| Romello Height Status: Questionable San Francisco 49ers | Height (undisclosed) did not participate in Sunday's practice, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) said Sunday that he always planned to take a break during training camp and then "ramp back up," Vic Tafur of The Athletic reports. |
| 2026-08-22 |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir is day-to-day with a shoulder injury, Nick Wagoner of ESPN.com reports. |
| Nick Martin Status: Questionable San Francisco 49ers | questionable |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) is suited up for Saturday's practice, Nick Wagoner of ESPN.com reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling is considered day-to-day due to a shoulder injury, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Martin Status: Questionable San Francisco 49ers | Martin (hamstring) didn't participate in San Francisco's practice Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| Jordan James Status: Questionable San Francisco 49ers | James (ribs) returned to practice Saturday, Nick Wagoner of ESPN.com reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk (calf) continued to work on a side field at Saturday's practice, Vic Tafur of The Athletic reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) took part in 11-on-11 work at Saturday's practice, Noah Furtado of the San Francisco Chronicle reports. |
| Romello Height Status: Active San Francisco 49ers | Height (elbow) recorded one tackle for a loss in Thursday's 41-17 preseason win over the Chargers. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu recorded two solo tackles in Thursday night's 41-17 preseason win over the Chargers. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges did not record any stats in Thursday's 41-17 preseason win against the Chargers. |
| 2026-08-21 |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (undisclosed) will not play in Thursday night's preseason game against the Chargers, David Lombardi of SFStandard.com reports. |
 | Khalil Herbert Status: Active San Francisco 49ers | The 49ers signed Herbert on Thursday. |
| Patrick Taylor Jr. Status: Injured Reserve San Francisco 49ers | The 49ers placed Taylor (undisclosed) on injured reserve Thursday, David Lombardi of SFStandard.com reports. |
| George Kittle Status: Out San Francisco 49ers | Kittle (Achilles) visited with Dr. Neal ElAttrache on Wednesday and remains ahead of schedule in his recovery with a chance to play Week 1 against the Rams, Adam Schefter of ESPN reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green has a hamstring injury and is questionable to return to Thursday's matchup with the Chargers. |
| Austen Pleasants Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed four of six passes for 29 yards with no touchdowns or interceptions and rushed once for three yards in the 49ers' 41-17 preseason win over the Chargers on Thursday night. |
| Austen Pleasants Status: Questionable San Francisco 49ers | Pleasants won't return to Thursday's preseason game at the Chargers due to a knee injury, Jennifer Lee Chan of NBC Sports Bay Area reports |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel brought in one of two targets for four yards in the 49ers' 41-17 preseason win over the Chargers on Thursday night. |
| Kaelon Black Status: Active San Francisco 49ers | Black rushed eight times for 33 yards and wasn't targeted in the 49ers' 41-17 preseason win over the Chargers on Thursday night. |
| De'Zhaun Stribling Status: Active San Francisco 49ers | Stribling secured four of five targets for 46 yards in the 49ers' 41-17 preseason win over the Chargers on Thursday. |
| Sam Okuayinonu Status: Active San Francisco 49ers | NA |
| Romello Height Status: Active San Francisco 49ers | NA |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson did not receive any targets in Thursday night's 41-17 preseason win over the Chargers. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro converted five PAT's and two field goal attempts in Thursday night's 41-17 preseason win over the Chargers. |
 | Sincere McCormick Status: Active San Francisco 49ers | McCormick rushed six times for 53 yards and a touchdown in Thursday night's 41-17 preseason win over the Chargers. |
| 2026-08-20 |
| Titus Leo Status: Injured Reserve San Francisco 49ers | Leo (undisclosed) reverted from waivers to San Francisco's injured reserve list Wednesday, Nick Wagoner of ESPN.com reports. |
| Patrick Taylor Jr. Status: Injured Reserve San Francisco 49ers | ir |
| 2026-08-19 |
| Brett Toth Status: Questionable San Francisco 49ers | questionable |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | questionable |
| Dominick Puni Status: Questionable San Francisco 49ers | questionable |
| Gracen Halton Status: Questionable San Francisco 49ers | questionable |
 | KJ Henry Status: Questionable San Francisco 49ers | questionable |
| Nate Hobbs Status: Questionable San Francisco 49ers | questionable |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | questionable |
| Titus Leo Status: Questionable San Francisco 49ers | questionable |
| Christian McCaffrey Status: Questionable San Francisco 49ers | questionable |
| Mike Evans Status: Questionable San Francisco 49ers | questionable |
| Mykel Williams Status: Out San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Williams (knee) is considered a "long shot" to play in Week 1 against the Rams, Dylan Grausz of NBC Sports reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | questionable |
| Kaelon Black Status: Active San Francisco 49ers | NA |
 | Jakob Robinson Status: Active San Francisco 49ers | NA |
| De'Zhaun Stribling Status: Active San Francisco 49ers | NA |
| 2026-08-18 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey is dealing with "tightness," but it doesn't seem to be an issue to worry about, Ian Rapoport of NFL Network reports. |
| Victor Dimukeje Status: Active San Francisco 49ers | Dimukeje signed with the 49ers on Monday. |
| Kaelon Black Status: Questionable San Francisco 49ers | Black (thigh) is back in uniform for Tuesday's practice session, Matt Barrows of The Athletic |
| Christian McCaffrey Status: Active San Francisco 49ers | Coach Kyle Shanahan said McCaffrey (undisclosed) would've practiced Tuesday if the 49ers hadn't been in a joint session with the Chargers, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Active San Francisco 49ers | Coach Kyle Shanahan said after Tuesday's joint practice with the Chargers that Evans (quadriceps) experienced some tightness and doesn't believe the issue to be a serious one, Matt Maiocco of NBC Sports Bay Area reports. |
| Kaelon Black Status: Questionable San Francisco 49ers | Black (thigh) looked like himself at Tuesday's practice, Grant Cohn of SI.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | San Francisco coach Kyle Shanahan said Tuesday that Purdy has a "good chance" to play in Thursday's preseason matchup with the Chargers, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa's (knee) tendinitis symptoms have been subsiding recently, David Lombardi of SFStandard.com reports. |
| 2026-08-17 |
| Gracen Halton Status: Active San Francisco 49ers | Halton (ankle) was unavailable for practice Sunday, Matt Maiocco of NBC Sports Bay Area reports. |
| Dominick Puni Status: Active San Francisco 49ers | Puni (concussion) was unavailable for the 49ers' preseason practice Sunday, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-08-16 |
| George Kittle Status: Out San Francisco 49ers | Kittle (Achilles) said Sunday that he's "very confident" he won't start the season on PUP and that he's still got a chance to play Week 1 versus the Rams, Nick Wagoner of ESPN.com reports. |
| 2026-08-15 |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing (hip) was a full participant in Saturday's practice, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Mike Evans Status: Active San Francisco 49ers | Evans (quadriceps) participated in team drills during Saturday's training camp practice, Noah Furtado of the San Francisco Chronicle reports. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle (oblique) was a full participant in Saturday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Martin Status: Active San Francisco 49ers | Martin (stinger) was a full participant in Saturday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (ribs) was a full participant in Saturday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (undisclosed) remained sidelined during practice Saturday, Nick Wagoner of ESPN.com reports. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune logged six tackles (two solo), including 1.0 sacks, during Thursday night's preseason opener against the Titans. |
| Jakob Robinson Status: Questionable San Francisco 49ers | Robinson logged two solo tackles in Thursday night's preseason opener against the Titans. |
| 2026-08-14 |
| Kaelon Black Status: Questionable San Francisco 49ers | Black (thigh) will not play in Thursday's preseason opener against the Titans, Nick Wagoner of ESPN.com reports. |
| Jordan James Status: Questionable San Francisco 49ers | James (ribs) will not play in Thursday's preseason opener against the Titans, Nick Wagoner of ESPN.com reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk (calf) is not suited up for Thursday's preseason opener against the Titans, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) is not dressed in uniform for Thursday night's preseason opener against the Titans, Nick Wagoner of ESPN.com reports. |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (ribs) is questionable to return to Thursday night's contest against the Titans, Nick Wagoner of ESPN.com reports. |
| Jack Jones Status: Active San Francisco 49ers | Jones (hand) is questionable to return to Thursday's preseason opener against the Titans, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (ribs) will not return to Thursday night's preseason opener against the Titans, Matt Maiocco of NBC Sports Bay Area reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling brought in seven of eight targets for 63 yards in the 49ers' 19-13 preseason loss to the Titans on Thursday. |
| Tatum Bethune Status: Active San Francisco 49ers | NA |
| Deebo Samuel Sr. Status: Active San Francisco 49ers | Samuel did not play in Thursday night's preseason opener against the Titans. |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (ribs) was discharged from the hospital Thursday night, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Nate Hobbs Status: Active San Francisco 49ers | Hobbs (groin) is projected to miss a few weeks due to injury, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-08-13 |
 | Ricky Pearsall Status: Injured Reserve San Francisco 49ers | Pearsall announced Thursday in a post on his personal Instagram account that he underwent season-ending surgery to repair the PCL in his right knee, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy isn't in line to play in Thursday's preseason opener against the Titans, Vic Tafur and Matt Barrows report. |
| KJ Henry Status: Active San Francisco 49ers | Henry (undisclosed) reverted to the 49ers' injured reserve list Thursday, per the NFL's transaction log. |
| 2026-08-12 |
 | Zamir White Status: Active San Francisco 49ers | The 49ers signed White on Wednesday. |
| 2026-08-11 |
| Brock Purdy Status: Active San Francisco 49ers | Purdy and rookie wide receiver De'Zhaun Stribling have been starting to connect more frequently at training camp, Marc Adams of 49ers Webzone reports. |
| Carver Willis Status: Active San Francisco 49ers | Willis has cleared concussion protocol and was a full participant in Monday's practice, David Lombardi of SFStandard.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) is in pads and taking part in warmups ahead of Tuesday's joint practice with the Titans, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (undisclosed) isn't participating in Tuesday's joint practice with the Titans, Cam Inman of The San Jose Mercury News reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Tuesday that Bosa has missed recent practices due to soreness/tendinitis in his right knee, and the pass rusher is considered week-to-week, Noah Furtado of the San Francisco Chronicle reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) took part primarily in individual drills at Tuesday's joint practice with the Titans, Nick Wagoner of ESPN.com reports. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson has been working with the first-team offense in training camp due to multiple injuries to the 49ers' wide receiver corps, Dan Graziano of ESPN.com reports. |
| 2026-08-10 |
| Christian McCaffrey Status: Active San Francisco 49ers | Offensive coordinator Klay Kubiak said the 49ers are "just managing" McCaffrey (undisclosed), who missed Monday's practice due to "tightness," Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Out San Francisco 49ers | Kittle (Achilles) was seen running routes, catching passes and doing conditioning work prior to Monday's practice, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (ACL) did not participate during the 49ers' training camp practice Monday, Eric Branch of the San Francisco Chronicle reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey won't practice Monday due to "tightness," Nick Wagoner of ESPN.com reports. |
| 2026-08-08 |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (hamstring) participated in 11-on-11 team drills during Saturday's training camp practice, Noah Furtado of the San Francisco Chronicle reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said the 49ers continue to "be smart with" Evans (quadriceps), who didn't practice Saturday, Nick Wagoner of ESPN.com reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk (calf) remained sidelined at Saturday's practice, Nick Wagoner of ESPN.com reports. |
| Luke Gifford Status: Active San Francisco 49ers | Gifford did not practice Saturday due to a hamstring injury, Matt Barrows of The Athletic reports. |
| 2026-08-07 |
| Gracen Halton Status: Active San Francisco 49ers | Halton (knee) participated during the 49ers' training camp practice Thursday, Chris Biderman of The Sacramento Bee reports. |
| Brett Toth Status: Active San Francisco 49ers | Toth (concussion) was absent from Thursday's training camp session, Cam Inman of The San Jose Mercury News reports. |
 | Kion Smith Status: Active San Francisco 49ers | Smith and the 49ers agreed on a one-year contract Thursday. |
| 2026-08-06 |
| Nick Zakelj Status: Active San Francisco 49ers | Zakelj (upper body) exited San Francisco's practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Carver Willis Status: Active San Francisco 49ers | Willis (concussion) didn't participate in San Francisco's training camp Wednesday, Cam Inman of The San Jose Mercury News reports. |
 | Ogbo Okoronkwo Status: Active San Francisco 49ers | The 49ers signed Okoronko on Wednesday, Jeremy Fowler of ESPN reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (hamstring) is in uniform for Thursday's practice, Matt Barrows of The Athletic reports. |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | In his return to practice Thursday, Stribling (hamstring) didn't take part in team drills, Matt Barrows of The Athletic reports. |
| Gracen Halton Status: Active San Francisco 49ers | NA |
| Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw (undisclosed) was a participant in Thursday's training camp session, Cam Inman of The San Jose Mercury News reports. |
 | Osa Odighizuwa Status: Questionable San Francisco 49ers | Odighizuwa (undisclosed) was a participant in Thursday's training camp session, Cam Inman of The San Jose Mercury News reports. |
| 2026-08-05 |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) didn't practice Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing (hip) did not participate in Wednesday's training camp session, Cam Inman of The San Jose Mercury News reports. |
| Osa Odighizuwa Status: Questionable San Francisco 49ers | Odighizuwa (undisclosed) did not participate at the 49ers' training camp practice Wednesday, Nick Wagoner of ESPN.com reports. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (finger) did not participate in Wednesday's training camp session, Cam Inman of The San Jose Mercury News reports. |
| Dre Greenlaw Status: Active San Francisco 49ers | Greenlaw (undisclosed) did not participate in Wednesday's training camp session, Cam Inman of The San Jose Mercury News reports. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu suffered an apparent ankle injury during the 49ers' training camp practice Wednesday, Matt Barrows of The Athletic reports. |
| KhaDarel Hodge Status: Active San Francisco 49ers | The 49ers signed Hodge to a contract Wednesday, Jeremy Fowler of ESPN.com reports. |
| 2026-08-04 |
| Ricky Pearsall Status: Injured Reserve San Francisco 49ers | Pearsall (knee) is one of the few prominent athletes to have surgery on an isolated PCL injury, making it difficult to set expectations for rehab length or a potential return to pre-injury form, Eric Branch of the San Francisco Chronicle reports. |
| 2026-08-03 |
| Mikail Kamara Status: Injured Reserve San Francisco 49ers | Kamara (knee) reverted to the 49ers' injured reserve Monday, per the NFL's transaction log. | |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling (hamstring) remains day-to-day and won't practice Monday, Nick Wagoner of ESPN.com reports. |
| Kaelon Black Status: Questionable San Francisco 49ers | Black is missing Monday's practice due to an adductor injury, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Active San Francisco 49ers | Evans (quad) won't practice Monday, Nick Wagoner of ESPN.com reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans (quadriceps) didn't don a uniform at Monday's practice, but he did make some stationary over-the-shoulder catches during special-teams drills, Matt Barrows of The Athletic reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk (calf) worked out on the side at Monday's practice, Matt Barrows of The Athletic reports. |
| Mike Evans Status: Questionable San Francisco 49ers | Evans, who didn't practice Monday, is tending to a minor quad strain, Ian Rapoport of NFL Network reports. |
| 2026-08-02 |
| Khalil Herbert Status: Active San Francisco 49ers | The 49ers signed Herbert to a one-year deal Sunday. |
| 2026-08-01 |
 | Trenton Irwin Status: Active San Francisco 49ers | The 49ers signed Irwin to a one-year contract Friday. |
| Josiah Deguara Status: Active San Francisco 49ers | Deguara signed a one-year contract with the 49ers on Friday. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown (hamstring) is participating at the 49ers' training camp, Ines Diaz of the team's official site reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (ACL) is doing individual work on the side at the 49ers' training camp, Nick Wagoner of ESPN reports. |
| Alfred Collins Status: Active San Francisco 49ers | The 49ers activated Collins (shoulder) from the active/PUP list Friday after passing a physical, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| De'Zhaun Stribling Status: Active San Francisco 49ers | Stribling will have the opportunity to earn an expanded role in the 49ers' offense after Ricky Pearsall (knee) was placed on injured reserve Saturday. |
| Ricky Pearsall Status: Injured Reserve San Francisco 49ers | Pearsall was placed on injured reserve Saturday and will undergo season-ending PCL surgery on his right knee, Cam Inman of The San Jose Mercury News reports. |
| Mikail Kamara Status: Questionable San Francisco 49ers | questionable | |
| De'Zhaun Stribling Status: Questionable San Francisco 49ers | Stribling will not participate in Saturday's training camp practice due to hamstring tightness, David Lombardi of SFStandard.com reports. |
 | Cameron Sample Status: Questionable San Francisco 49ers | questionable |
| Keion White Status: Questionable San Francisco 49ers | White (groin) left Saturday's practice early, Nick Wagoner of ESPN.com reports. |
| Romello Height Status: Questionable San Francisco 49ers | Height (elbow) did not participate in Saturday's practice session, Nick Wagoner of ESPN.com reports. |
| Cameron Sample Status: Questionable San Francisco 49ers | Sample (knee) missed Saturday's practice session, David Lombardi of SFStandard.com reports. |
| Mikail Kamara Status: Questionable San Francisco 49ers | Kamara (knee) was unable to finish Saturday's practice due to injury, Nick Wagoner of ESPN.com reports. | |
| Deebo Samuel Status: Active San Francisco 49ers | Samuel was a full participant in Saturday's training camp practice, his first since signing with the 49ers on Thursday, Matt Barrows of The Athletic reports. |
| Tanner McLachlan Status: Questionable San Francisco 49ers | McLachlan (undisclosed) reverted to the 49ers' injured reserve Saturday, per the NFL's transaction log. |
| 2026-07-31 |
| Tanner McLachlan Status: Questionable San Francisco 49ers | questionable |
| Alfred Collins Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco assistant head coach Chris Foerster said Friday that the team is "continuing to evaluate" Pearsall (knee) after the wide receiver aggravated the PCL issue in his right knee during early training camp practices, Matt Barrows of The Athletic reports. |
 | Andrew Farmer II Status: Injured Reserve San Francisco 49ers | San Francisco placed Farmer (back) on its injured reserve list Thursday, Aaron Wilson of KPRC 2 Houston reports. |
 | William Bradley-King Status: Injured Reserve San Francisco 49ers | San Francisco placed Bradley-King (undisclosed) on its injured reserve list Thursday, Aaron Wilson of KPRC 2 Houston reports. |
| Deebo Samuel Status: Active San Francisco 49ers | Samuel and the 49ers agreed on a one-year, $7 million contract Thursday, Ian Rapoport of NFL Network reports. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | NA |
| 2026-07-30 |
| Mac Jones Status: Active San Francisco 49ers | NA |
| Mac Jones Status: Active San Francisco 49ers | Jones (undisclosed) passed his conditioning test and is good to go for training camp, Vic Tafur and Matt Barrows of The Athletic report. |
| 2026-07-29 |
| Jordan James Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Malik Mustapha Status: Questionable San Francisco 49ers | questionable |
| William Bradley-King Status: Questionable San Francisco 49ers | questionable |
| Kaelon Black Status: Active San Francisco 49ers | Black faces an opportunity to handle the bulk of No. 2 running back role behind Christian McCaffrey early in training camp after Jordan James suffered a fractured rib on Tuesday, David Lombardi of SFStandard.com reports. |
| Jordan James Status: Questionable San Francisco 49ers | James fractured a rib during Tuesday's practice, Vic Tafur of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) is dealing with knee swelling in the early stages of training camp, Vic Tafur of The Athletic reports. |
| Malik Mustapha Status: Questionable San Francisco 49ers | Mustapha (hamstring) was ruled out of Wednesday's practice, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | The 49ers have some "concern" about Pearsall's latest knee issue and are "exploring all options" when it comes to what the next step will be in addressing it, Nick Wagoner of ESPN reports. |
| 2026-07-28 |
| Andrew Farmer II Status: Questionable San Francisco 49ers | Farmer (back) did not participate during the 49ers' training camp practice Monday, Nick Wagoner of ESPN.com reports. |
| Vederian Lowe Status: Questionable San Francisco 49ers | Lowe suffered a high ankle sprain during the 49ers' practice Sunday, Nick Wagoner of ESPN.com reports. |
| Gracen Halton Status: Questionable San Francisco 49ers | Halton is missing practice during the 49ers' training camp due to a bone bruise on his knee, Nick Wagoner of ESPN.com reports. |
| 2026-07-27 |
| Jordan James Status: Active San Francisco 49ers | James appears to be operating as the No. 2 running back behind Christian McCaffrey to begin training camp, Nick Wagoner of ESPN.com reports. |
| Jake Tonges Status: Active San Francisco 49ers | NA |
| Jake Tonges Status: Active San Francisco 49ers | Tonges (foot) is participating in practice to begin training camp, Brooke Evans of the 49ers' official site reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk sustained a calf injury during Sunday's practice and is not practicing Monday, Nick Wagoner of ESPN.com reports. |
| Gracen Halton Status: Questionable San Francisco 49ers | questionable |
| Andrew Farmer II Status: Questionable San Francisco 49ers | questionable |
| Nate Hobbs Status: Active San Francisco 49ers | NA |
| Romello Height Status: Active San Francisco 49ers | Height (lower body) was carted off the field at Monday's practice due to cramps, rather than any sort of severe injury, Nick Wagoner of ESPN.com reports. |
| Nate Hobbs Status: Active San Francisco 49ers | Hobbs (knee) is participating at the 49ers' training camp, Vic Tafur of The Athletic reports. |
| Romello Height Status: Active San Francisco 49ers | Height (lower body) was carted off the field at Monday's practice, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-07-26 |
 | Kevin Givens Status: Active San Francisco 49ers | The 49ers signed Givens to a one-year deal Sunday. |
| Vederian Lowe Status: Questionable San Francisco 49ers | Lowe exited San Francisco's practice Sunday with an ankle injury, David Lombardi of SFStandard.com reports. |
| Christian Kirk Status: Questionable San Francisco 49ers | Kirk walked off with an apparent injury during the 49ers' practice Sunday, Matt Barrows of The Athletic reports. |
| Vederian Lowe Status: Questionable San Francisco 49ers | questionable |
| 2026-07-25 |
| Mykel Williams Status: Out San Francisco 49ers | out |
| Isaac Guerendo Status: Out San Francisco 49ers | out |
| George Kittle Status: Out San Francisco 49ers | out |
| Khalil Dinkins Status: Questionable San Francisco 49ers | questionable | |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco general manager John Lynch told reporters Saturday that Aiyuk (knee) will remain on the 49ers' reserve/left squad list, Adam Schefter of ESPN reports. |
| Alfred Collins Status: Out San Francisco 49ers | out |
| George Kittle Status: Out San Francisco 49ers | The 49ers placed Kittle (Achilles) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| Alfred Collins Status: Out San Francisco 49ers | The 49ers Matt Maiocco of NBC Sports Bay Area Collins (shoulder) on the active/PUP list Saturday, Matt reports. |
| Isaac Guerendo Status: Out San Francisco 49ers | The 49ers placed Guerendo (pectoral) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| Mykel Williams Status: Out San Francisco 49ers | The 49ers placed Williams (knee) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) wasn't placed on the PUP list ahead of the start of San Francisco's training camp, Matt Barrows of The Athletic reports. |
| Tanner McLachlan Status: Active San Francisco 49ers | The 49ers signed McLachlan on Saturday, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-07-18 |
| Khalil Dinkins Status: Out San Francisco 49ers | The 49ers placed Dinkins (undisclosed) on the active/non-football injury list Saturday. |
| 2026-07-16 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey has been named the Best Comeback Athlete the 2026 ESPYS, Briana Jeannel of the 49ers' official site reports. |
| 2026-06-27 |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall is expected to enter training camp as San Francisco's starting wide receiver opposite Mike Evans, Kyle Madson of USA Today reports. |
| 2026-06-25 |
| Mac Jones Status: Questionable San Francisco 49ers | Jones, who dealt with a sore shoulder during the 49ers' spring program, threw passes this week at Tight End University, an event hosted by teammate George Kittle (Achilles), David Lombardi of the San Francisco Standard reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy, who has been participating in this week's Tight End University, an event hosted by teammate George Kittle (Achilles), said that he plans to gather with other 49ers for throwing sessions over the next month prior to training camp, David Lombardi of the San Francisco Standard reports. |
| 2026-06-24 |
| Brandon Aiyuk Status: Out San Francisco 49ers | In a video posted to Instagram Wednesday, Aiyuk (knee) said that if the 49ers released him, he'd sign with the Commanders "tomorrow," ESPN.com reports. |
| 2026-06-23 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) said Tuesday that he feels "definitely on track" for Week 1 though "nothing is 100 percent certain," David Lombardi of SFStandard.com reports. |
| 2026-06-10 |
| Sincere McCormick Status: Active San Francisco 49ers | McCormick signed a one-year deal with the 49ers on Wednesday. |
| 2026-06-04 |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (undisclosed) did not throw during practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) said Wednesday that he's "doing great" and is "ahead of schedule" in his rehab, ESPN.com's Nick Wagoner reports. |
| Mike Evans Status: Active San Francisco 49ers | Evans is making a strong impression at voluntary OTAs and feels rejuvenated after an injury-plagued 2025, Matt Barrows of The Athletic reports. |
| 2026-06-03 |
 | Ashtyn Davis Status: Active San Francisco 49ers | The Lions signed Davis on Tuesday. |
| Brandon Aiyuk Status: Out San Francisco 49ers | Aiyuk (knee) has been issued an arrest warrant on a misdemeanor charge of exhibition of speed by the Santa Clara County District Attorney's Office, David Lombardi of SFStandard.com reports. |
| Mac Jones Status: Questionable San Francisco 49ers | questionable |
| 2026-05-29 |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) told reporters Thursday that he expects to be ready for training camp and the regular season, Matt Maiocco of NBC Sports Bay Area reports. |
| Isaac Guerendo Status: Questionable San Francisco 49ers | Guerendo is not participating in OTAs due to a torn pectoral, Cam Inman of The San Jose Mercury News reports. |
 | Darrick Forrest Status: Injured Reserve San Francisco 49ers | San Francisco placed Forrest (undisclosed) on its injured reserve list Thursday. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey said after Thursday's OTAs that he's looking forward to sustaining another heavy workload in 2026 and that any reductions in touches should come in practice rather than games, Nick Wagoner of ESPN.com reports. |
| 2026-05-28 |
| Jacob Cowing Status: Active San Francisco 49ers | NA |
| Darrick Forrest Status: Injured Reserve San Francisco 49ers | ir |
| Isaac Guerendo Status: Questionable San Francisco 49ers | questionable |
| Jacob Cowing Status: Active San Francisco 49ers | Cowing (hamstring) is participating in OTAs, Matt Maiocco of NBC Sports Bay Area reports. |
 | Jermar Jefferson Status: Active San Francisco 49ers | Jefferson signed with the 49ers on Thursday. |
 | Jordan Mims Status: Active San Francisco 49ers | San Francisco signed Mims to a one-year contract Thursday. |
| 2026-05-27 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (Achilles) said Wednesday that he is still targeting the 49ers' regular-season opener against the Rams in Week 1 as his return date, Cameron DaSilva of USA Today reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones agreed to terms Wednesday on a contract restructure with the 49ers that adds a $300,000 roster bonus for 2026, Tom Pelissero of NFL Network reports. |
| 2026-05-22 |
| Jordan James Status: Active San Francisco 49ers | James "seems the most likely" of San Francisco's running backs behind Christian McCaffrey to earn the No. 2 running-back role for the upcoming campaign, Nick Wagoner of ESPN.com reports. |
| 2026-05-07 |
| De'Zhaun Stribling Status: Active San Francisco 49ers | The 49ers' selection of Stribling at No. 33 overall in the 2026 NFL Draft was partially motivated by the organization's strong belief in his personality, leadership and work ethic, according to Matt Barrow of The Athletic. |
| Kurtis Rourke Status: Active San Francisco 49ers | NA |
| Kurtis Rourke Status: Active San Francisco 49ers | Rourke (knee) will participate in rookie minicamp starting Friday, David Lombardi of SFStandard.com reports. |
| 2026-05-04 |
| Kaelon Black Status: Active San Francisco 49ers | Black is set to compete with recent draft picks Jordan James and Isaac Guerendo for backup touches behind Christian McCaffrey, Grant Gordon of NFL.com reports. |
| 2026-04-30 |
| George Kittle Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Thursday that Kittle (Achilles) is aiming to be ready for the 49ers' Week 1 game against the Rams, David Lombardi of SFStandard.com reports. |
 | Tre Tomlinson Status: Active San Francisco 49ers | NA |
| 2026-04-29 |
 | Patrick McMorris Status: Active San Francisco 49ers | The 49ers signed McMorris to a one-year deal Tuesday, Adam Schefter of ESPN reports. |
| 2026-04-27 |
| Sincere McCormick Status: Active San Francisco 49ers | McCormick signed with the 49ers on Monday, David Lombardi of SFStandard.com reports. |
| 2026-04-26 |
| Khalil Dinkins Status: Active San Francisco 49ers | The 49ers signed Dinkins as an undrafted free agent Sunday. | |
| Will Pauling Status: Active San Francisco 49ers | The 49ers signed Pauling as an undrafted free agent Sunday. | |
| Wesley Grimes Status: Active San Francisco 49ers | The 49ers signed Grimes as an undrafted free agent Sunday. |
| 2026-04-25 |
| Gracen Halton Status: Active San Francisco 49ers | The 49ers selected Halton in the fourth round of the 2026 NFL Draft, 107th overall. | |
| Ephesians Prysock Status: Active San Francisco 49ers | The 49ers selected Prysock in the fourth round of the 2026 NFL Draft, 139th overall. | |
| Carver Willis Status: Active San Francisco 49ers | The 49ers selected Willis in the fourth round of the 2026 NFL Draft, 127th overall. | |
| Jaden Dugger Status: Active San Francisco 49ers | The 49ers selected Dugger in the fifth round of the 2026 NFL Draft, 154th overall. | |
| Enrique Cruz Jr. Status: Active San Francisco 49ers | The 49ers selected Cruz in the fifth round of the 2026 NFL Draft, 179th overall. | |
| Romello Height Status: Active San Francisco 49ers | The 49ers selected Height in the third round of the 2026 NFL Draft, 70th overall. | |
| Kaelon Black Status: Active San Francisco 49ers | The 49ers selected Black in the third round of the 2026 NFL Draft, 90th overall. |
| 2026-04-24 |
| De'Zhaun Stribling Status: Active San Francisco 49ers | The 49ers selected Stribling in the second round of the 2026 NFL Draft, 33rd overall. |
| 2026-04-20 |
| Trent Williams Status: Active San Francisco 49ers | Williams and San Francisco agreed to terms Monday on a two-year, $50 million contract extension, Adam Schefter of ESPN reports. |
| Fred Warner Status: Active San Francisco 49ers | NA |
| Fred Warner Status: Active San Francisco 49ers | Warner (ankle) said at the start of San Francisco's voluntary workout program Monday that he no longer has any limitations relating to the ankle injury he suffered Week 6 of the 2025 season, Noah Furtado of the San Francisco Chronicle reports. |
| 2026-04-10 |
| Jack Jones Status: Active San Francisco 49ers | Jones signed a one-year contract with San Francisco on Friday, Ian Rapoport of NFL Network reports. |
| 2026-04-09 |
| Cam Sample Status: Active San Francisco 49ers | Sample has agreed to a one-year deal with the 49ers, Tom Pelissero of NFL Network reports. |
| 2026-03-30 |
| Christian McCaffrey Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that "in order to have [McCaffrey] be as good as he can be throughout the whole year, we've got to get someone to help him," Matt Barrows of The Athletic reports. |
| 2026-03-29 |
| George Kittle Status: Questionable San Francisco 49ers | 49ers general manager John Lynch told reporters Sunday that he is "hopeful" that Kittle (Achilles) will be available for Week 1 of the 2026 season, Nick Wagoner of ESPN.com reports. |
| Mykel Williams Status: Questionable San Francisco 49ers | 49ers GM John Lynch said Sunday that Williams (knee) is expected to be back for training camp, David Lombardi of SFStandard.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | 49ers GM said Sunday at the NFL's league meetings that he expects Bosa (knee) to be ready for training camp, David Lombardi of SFStandard.com reports |
| Nick Martin Status: Active San Francisco 49ers | San Francisco GM John Lynch said Sunday that Martin has been cleared from the concussion that ended his 2026 season, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Active San Francisco 49ers | 49ers GM John Lynch said Sunday that talks with Williams regarding a reworked contract have "intensified" over the last week, Eric Branch of the San Francisco Chronicle reports. |
| 2026-03-25 |
 | Ben Bartch Status: Active San Francisco 49ers | NA |
| 2026-03-24 |
| Rob Jones Status: Active San Francisco 49ers | The 49ers are set to sign Jones to a contract, Tom Pelissero of NFL Network reports. |
| 2026-03-21 |
| Trent Williams Status: Active San Francisco 49ers | The 49ers declined Williams' $10 million option bonus Friday, instead adding it to his base salary for the 2026 season, David Lombardi of SFStandard.com reports. |
| 2026-03-19 |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu signed his restricted free-agent tender with the 49ers on Wednesday. |
| 2026-03-16 |
| Christian Kirk Status: Active San Francisco 49ers | Kirk is slated to sign a one-year, $6 million contract with San Francisco, NFL reporter Jordan Schultz reports. |
| 2026-03-15 |
 | Corliss Waitman Status: Active San Francisco 49ers | The 49ers are set to sign Waitman, Tom Pelissero of NFL Network reports. |
| 2026-03-13 |
| Nate Hobbs Status: Questionable San Francisco 49ers | The 49ers agreed to terms with Hobbs (knee) on a one-year, $4 million contract Thursday, Aaron Wilson of KPRC 2 Houston reports. |
| Luke Gifford Status: Active San Francisco 49ers | The 49ers and Gifford agreed to terms on a two-year, $5.3 million extension Friday, Tom Pelissero of NFL Network reports. |
| 2026-03-12 |
| Dre Greenlaw Status: Active San Francisco 49ers | The 49ers signed Greenlaw to a one-year, $7.5 million contract Thursday, Ian Rapoport of NFL Network reports. |
| 2026-03-11 |
| Garret Wallow Status: Active San Francisco 49ers | Wallow is in line to sign a one-year contract with the 49ers on Tuesday, Matt Barrows of The Athletic reports. |
| Brett Toth Status: Active San Francisco 49ers | Toth (concussion) agreed to terms Tuesday on a one-year contract with the 49ers, Dave Zangaro of NBC Sports Philadelphia reports. |
| Patrick Taylor Jr. Status: Active San Francisco 49ers | Taylor (shoulder) is slated to re-sign with the 49ers, per his representation at Equity Sports. |
| Jake Tonges Status: Questionable San Francisco 49ers | Tonges (foot) is signing a two-year, $8 million contract to stay with the 49ers, Ian Rapoport of NFL Network reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | The 49ers are still expected to move on from Aiyuk (knee) but won't necessarily release him Wednesday, Nick Wagoner of ESPN.com reports. |
| Osa Odighizuwa Status: Questionable San Francisco 49ers | The 49ers acquired Odighizuwa (elbow) from the Cowboys in exchange for a 2026 third-round pick Wednesday, Adam Schefter of ESPN reports. |
| 2026-03-09 |
| Vederian Lowe Status: Active San Francisco 49ers | Lowe and the 49ers agreed to a two-year, $12 million contract Monday that includes $5.75 million guaranteed, Ian Rapoport of NFL Network reports. |
| 2026-03-07 |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro and the 49ers agreed to a four-year, $17 million contract Saturday, Adam Schefter of ESPN reports. |
| 2026-02-25 |
| Trent Williams Status: Active San Francisco 49ers | San Francisco general manager John Lynch said Tuesday at the NFL Scouting Combine that Williams and the team have "had really good, productive and substantive meetings" regarding a contract restructure, Nick Wagoner of ESPN reports. |
| 2026-02-19 |
 | Curtis Robinson Status: Active San Francisco 49ers | Robinson recorded 42 tackles (19 solo) with one pass defended across 14 active games with the 49ers in 2025. |
 | Clelin Ferrell Status: Active San Francisco 49ers | Ferrell finished the 2025 regular season with 24 tackles (13 solo) and 4.0 sacks in eight games played for the 49ers. |
 | Kalia Davis Status: Active San Francisco 49ers | Davis finished the regular season with 28 tackles (10 solo), three passes defended and 0.5 sacks across 17 games played. |
 | Jordan Elliott Status: Active San Francisco 49ers | Elliott appeared in 16 games for the 49ers in 2025, finishing the regular season with 31 tackles (eight solo) and one pass batted down. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu finished the 2025 regular season with 39 tackles (23 solo), 3.0 sacks and a forced fumble across 15 active games. |
| Alfred Collins Status: Active San Francisco 49ers | Collins recorded 17 tackles (four solo), two forced fumbles and one sack across 16 regular season games in 2025. |
| C.J. West Status: Active San Francisco 49ers | West appeared in 14 games for the 49ers in 2025, finishing the regular season with 21 tackles (12 solo) and one sack. |
| 2026-02-17 |