Injuries
| 2026-02-06 |
 | Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey was named the 2025 Comeback Player of the Year on Thursday, Matt Barrows of The Athletic reports. |
| 2026-01-23 |
 | Hayden Rucci Status: Active San Francisco 49ers | The 49ers signed Rucci to a reserve/future contract Thursday. |
| 2026-01-22 |
 | Adrian Martinez Status: Active San Francisco 49ers | San Francisco signed Martinez to a reserve/future contract Tuesday. |
| 2026-01-21 |
 | Malik Turner Status: Active San Francisco 49ers | The 49ers signed Turner to a reserve/future contract Tuesday. |
 | Junior Bergen Status: Active San Francisco 49ers | Bergen signed a reserve/future contract with the 49ers on Tuesday. |
 | Eli Apple Status: Active San Francisco 49ers | The 49ers signed Apple to a reserve/future contract Tuesday. |
 | Mac Jones Status: Active San Francisco 49ers | San Francisco coach Kyle Shanahan said Wednesday that he expects Jones to be with the 49ers for 2026, Cam Inman of The San Jose Mercury News reports. |
 | Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco GM John Lynch said Wednesday that Aiyuk (knee) won't play for the 49ers again, Nick Wagoner of ESPN.com reports. |
 | Jake Tonges Status: Questionable San Francisco 49ers | Tonges suffered a plantar fascia injury in his foot during this past Saturday's divisional-round loss at Seattle, Cam Inman of The San Jose Mercury News reports. |
 | Nick Bosa Status: Injured Reserve San Francisco 49ers | The 49ers are hopeful that Bosa (ACL) will be back in time for training camp ahead of the 2026 season, Cam Inman of The San Jose Mercury News reports. |
| 2026-01-20 |
 | George Kittle Status: Injured Reserve San Francisco 49ers | Kittle said Monday that the right Achilles surgery he underwent last week went as well as possible, and the tight end said he expects to return to action "well before November" during the 2026 season, Eric Branch of the San Francisco Chronicle reports. |
 | Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) said Tuesday that he's confident he would have been able to play in the NFC Championship Game this weekend had the 49ers beaten the Seahawks in the divisional round, Matt Barrows of The Athletic reports. |
 | Mykel Williams Status: Injured Reserve San Francisco 49ers | Williams (knee) told reporters Tuesday that he "should" be ready to return for the beginning of training camp, Matt Barrows of The Athletic reports. |
| 2026-01-19 |
 | Ji'Ayir Brown Status: Questionable San Francisco 49ers | questionable |
 | Brandon Parker Status: Active San Francisco 49ers | NA |
 | Sebastian Valdez Status: Active San Francisco 49ers | NA |
 | Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson had three carries for four yards and one reception for three yards in Saturday's 41-6 playoff loss to the Seahawks. |
 | Kendrick Bourne Status: Active San Francisco 49ers | Bourne finished the regular season with 37 receptions for 551 yards across 16 games played with the 49ers. |
 | Demarcus Robinson Status: Active San Francisco 49ers | Robinson brought in his only target for one yard in Saturday's 41-6 divisional round loss to the Seahawks. |
 | Brock Purdy Status: Active San Francisco 49ers | Purdy said Monday that he will not require any offseason procedures to address the turf toe injury that hampered him early during the 2025 campaign, Nick Wagoner of ESPN.com reports. |
| 2026-01-18 |
 | Luke Gifford Status: Active San Francisco 49ers | Gifford (quadriceps) will play in Saturday's NFC divisional-round game versus the Seahawks. |
| Jake Tonges Status: Questionable San Francisco 49ers | Tonges is questionable to return to Saturday's divisional-round game against the 49ers due to a foot injury, Eric Williams of NFL on FOX reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey is sidelined to begin the second half of Saturday's divisional-round matchup against the Seahawks, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (shoulder) returned to Saturday's divisional-round game against the Seahawks, Eric Branch of the San Francisco Chronicle reports. |
 | Jauan Jennings Status: Active San Francisco 49ers | Jennings recorded two receptions on five targets for 39 yards in Saturday's divisional-round loss to the Seahawks. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 15 of 27 passes for 140 yards, no touchdowns and one interception in Saturday's 41-6 divisional-round loss to the Seahawks. He added five rushes for 37 yards but lost a fumble. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed the ball 11 times for 35 yards in Saturday's 41-6 divisional-round loss to the Seahawks. He added five receptions on six targets for 39 yards. |
 | Ricky Pearsall Status: Active San Francisco 49ers | Pearsall did not record a catch on two targets in Saturday's 41-6 divisional-round loss to the Seahawks. |
| 2026-01-17 |
 | Jacob Cowing Status: Injured Reserve San Francisco 49ers | Cowing (hamstring) has been ruled out for San Francisco's divisional-round matchup versus the Seahawks on Saturday. |
| Luke Gifford Status: Questionable San Francisco 49ers | The 49ers expect Gifford (quadriceps) to play in Saturday's divisional-round matchup versus the Seahawks, Matt Barrows of The Athletic reports. |
 | Dee Winters Status: Active San Francisco 49ers | Winters (ankle) is active for Saturday's divisional-round matchup versus the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (knee) is listed as active Saturday in Seattle, Briana Jeannel of the 49ers' official site reports. |
 | Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Sebastian Valdez Status: Out San Francisco 49ers | inactive |
| Brandon Parker Status: Out San Francisco 49ers | inactive |
 | Isaac Guerendo Status: Out San Francisco 49ers | inactive |
 | Kevin Givens Status: Out San Francisco 49ers | inactive |
| Ji'Ayir Brown Status: Out San Francisco 49ers | inactive |
 | Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| 2026-01-16 |
| Ji'Ayir Brown Status: Out San Francisco 49ers | Brown (hamstring) has been ruled out for Saturday's NFC divisional-round clash against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) has been ruled out for Saturday's NFC divisional-round clash against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (quadriceps) is listed as questionable for Saturday's NFC divisional-round tilt against Seattle, John Boyle of the Seahawks' official site reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (ankle) is listed as questionable for Saturday's NFC divisional-round game against the Seahawks, John Boyle of the Seahawks' official site reports. |
 | Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (knee) does not carry an injury designation into Saturday's NFC divisional-round clash against Seattle. |
 | Dominick Puni Status: Active San Francisco 49ers | Puni (ankle) does not carry an injury designation into Saturday's NFC divisional-round game against the Seahawks. |
| 2026-01-15 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) will be listed as questionable for Saturday's divisional-round game against the Seahawks, Matt Barrows of The Athletic reports. |
| Ji'Ayir Brown Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) was a limited participant at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (hamstring) did not participate at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (ankle) was a limited participant at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) was a limited participant at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Dominick Puni Status: Questionable San Francisco 49ers | Puni (ankle) was a limited participant in San Francisco's practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
 | Trent Williams Status: Active San Francisco 49ers | Williams (hamstring) was a full participant in San Francisco's practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| 2026-01-14 |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (quadriceps) did not participate in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (hamstring) did not participate in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (ankle) was a limited participant in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) was a limited participant in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) was a limited participant in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | The 49ers placed Kittle (Achilles) on injured reserve Wednesday. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) practiced in a limited capacity Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
 | Brayden Willis Status: Active San Francisco 49ers | The 49ers elevated Willis from the practice squad to the active roster. |
| 2026-01-13 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) was officially estimated as limited in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
 | Keion White Status: Questionable San Francisco 49ers | questionable |
| Dominick Puni Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Luke Gifford Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan announced that Kittle (Achilles) will undergo season-ending surgery Wednesday. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Pearsall (knee/ankle) will be listed as a limited participant in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | San Francisco head coach Kyle Shanahan said Warner (ankle) will be designated to return to practice Tuesday in order to participate in walk-throughs, with the hope that he could return for the NFC Championship Game if the 49ers advance that far in the postseason, Matt Maiocco of NBC Sports Bay Area reports. |
| 2026-01-12 |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson corralled six of seven targets for 111 yards and a touchdown in Sunday's 23-19 wild-card round win over Philadelphia. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) is not expected to return to practice this week, Mike Garafolo of NFL Network reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings had one reception on three targets for 45 yards and completed his only pass attempt for a 29-yard touchdown in Sunday's 23-19 wild-card game win over the Eagles. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 18 of 31 pass attempts for 262 yards, two touchdowns and two interceptions while rushing nine times for 24 yards in Sunday's 23-19 wild-card round win over Philadelphia. |
| George Kittle Status: Out San Francisco 49ers | out |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 15 times for 48 yards and caught six of eight targets for 66 yards and two touchdowns in Sunday's 23-19 playoff win over the Eagles. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges caught one of three targets for 14 yards in Sunday's 23-19 wild-card round win over the Eagles. |
| George Kittle Status: Out San Francisco 49ers | Head coach Kyle Shanahan confirmed after Sunday's 23-19 wild-card win over the Eagles that Kittle tore his Achilles during the game, Mike Garafolo of NFL Network reports. |
| Dee Winters Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Luke Gifford Status: Out San Francisco 49ers | out |
| 2026-01-11 |
| Dee Winters Status: Out San Francisco 49ers | inactive |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
 | Chase Lucas Status: Out San Francisco 49ers | inactive |
| Isaac Guerendo Status: Out San Francisco 49ers | inactive |
| Luke Gifford Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Trent Williams Status: Active San Francisco 49ers | Williams (hamstring) is active for Sunday's wild-card game versus the Eagles. |
| Keion White Status: Active San Francisco 49ers | White (groin/hamstring) is active for Sunday's wild-card game versus Philadelphia. |
 | Renardo Green Status: Active San Francisco 49ers | Green (ankle) is active for Sunday's wild-card matchup versus the Eagles. |
| Dee Winters Status: Out San Francisco 49ers | Winters (ankle) is inactive for Sunday's wild-card contest versus the Eagles. |
| Luke Gifford Status: Out San Francisco 49ers | Gifford (quadriceps) is inactive for Sunday's wild-card game versus the Eagles. |
| George Kittle Status: Out San Francisco 49ers | Kittle won't return to Sunday's playoff game against the Eagles after sustaining an Achilles' injury. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (hamstring) is questionable to return to Sunday's contest against the Eagles, Eric Branch of the San Francisco Chronicle reports. |
| Ji'Ayir Brown Status: Questionable San Francisco 49ers | Brown (hamstring) has been ruled out for the remainder of Sunday's contest against Philadelphia, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee/ankle) is inactive for Sunday's playoff game against the Eagles. |
| 2026-01-10 |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) is trending toward returning for Sunday's wild-card matchup against the Eagles, Jeremy Fowler of ESPN.com reports. |
 | Bryce Huff Status: Active San Francisco 49ers | Huff appeared in 15 games for the 49ers in 2025 and finished the regular season with 30 tackles (14 solo), 4.0 sacks and two forced fumbles. |
| Malik Turner Status: Active San Francisco 49ers | The 49ers elevated Turner to the active roster from their practice squad Saturday ahead of Sunday's wild-card matchup versus the Eagles. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | Cowing (hamstring) has been ruled out for San Francisco's wild-card matchup versus the Eagles on Sunday. |
 | Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir finished the 2025 regular season with 61 tackles (39 solo) and two interceptions across 17 starts. |
 | Malik Mustapha Status: Active San Francisco 49ers | Mustapha wrapped up 76 combined tackles (44 solo) and defended three passes (one interception) across 12 regular-season starts in 2025. |
| 2026-01-09 |
| Keion White Status: Questionable San Francisco 49ers | White (groin/hamstring) is listed as questionable ahead of Sunday's wild-card round matchup with the Eagles, Noah Furtado of the San Francisco Chronicle reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (foot) is listed as questionable for Sunday's wild-card round road game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (quadriceps) is listed as questionable for Sunday's wild-card round game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (ankle) is listed as questionable for Sunday's wild-card round road game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | Cowing (hamstring) is listed as questionable for Sunday's wild-card round game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports, but the wide receiver remains on injured reserve. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) is listed as questionable for Sunday's wild-card round road game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) is listed as questionable for Sunday's game at Philadelphia despite not practicing at all this week, Noah Furtado of the San Francisco Chronicle reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle (ankle) doesn't have an injury designation for Sunday's wild-card game at Philadelphia, Cam Inman of The San Jose Mercury News reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (ankle) is listed as questionable for Sunday's wild-card round matchup with the Eagles. |
 | Skyy Moore Status: Active San Francisco 49ers | Moore finished the 2025 regular season with five receptions for 87 yards, two carries for 11 yards and 1,198 combined return yards in 17 appearances. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown had 76 tackles (44 solo), two interceptions and one forced fumble in 17 regular-season starts with the 49ers in 2025. |
 | Upton Stout Status: Active San Francisco 49ers | Stout finished with 82 tackles (43 solo), one sack and one forced fumble across 16 regular-season games in 2025. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins was active for four games in 2025 and finished the regular season with two receptions on three targets for 26 yards. |
| 2026-01-08 |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) was seen sprinting on the side during Thursday's practice, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) isn't participating in Thursday's practice, Matt Barrows of The Athletic reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) was a limited participant in Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) was a limited practice participant Thursday, Cam Inman of The San Jose Mercury News reports. |
 | Jordan James Status: Active San Francisco 49ers | James did not record a touch while appearing in three games for the 49ers in 2025. |
 | Luke Farrell Status: Active San Francisco 49ers | Farrell finished his first regular season with San Francisco grabbing 11 of 14 targets for 85 yards and two touchdowns across 17 games. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo was only utilized on special teams this season, finishing with 100 kick return yards across 14 active games. |
| Mac Jones Status: Active San Francisco 49ers | Jones finished the regular season completing 70 percent of his pass attempts for 2,151 yards, 13 touchdowns and six interceptions across 11 games. |
| 2026-01-07 |
 | Eric Kendricks Status: Active San Francisco 49ers | The 49ers signed Kendricks from the practice squad to the active roster Wednesday. |
 | Tatum Bethune Status: Injured Reserve San Francisco 49ers | ir |
| Keion White Status: Questionable San Francisco 49ers | White (hamstring) won't participate in practice Wednesday, Matt Barrows of The Athletic reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (ankle) did not practice in Wednesday's session, Matt Barrows of The Athletic reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) won't participate in practice Wednesday, Vic Tafur of The Athletic reports. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | The 49ers designated Cowing (hamstring) to return from injured reserve Wednesday. |
| Tatum Bethune Status: Injured Reserve San Francisco 49ers | The 49ers moved Bethune (groin) to injured reserve Wednesday. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Pearsall (knee) will not practice Wednesday, Vic Tafur of The Athletic reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
 | Jordan Elliott Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Questionable San Francisco 49ers | KIttle (ankle) practiced on a limited basis Wednesday, Matt Barrows of The Athletic reports. |
| 2026-01-05 |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Luke Gifford Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that he expects Purdy (shoulder) to be a full participant in practice throughout the week leading up to Sunday's wild-card game at Philadelphia, David Lombardi of SFStandard.com reports. |
| Tatum Bethune Status: Out San Francisco 49ers | out |
| Tatum Bethune Status: Out San Francisco 49ers | 49ers' head coach Kyle Shanahan has ruled out the possibility of Bethune (groin) returning for the playoffs, David Lombardi of SFStandard.com reports. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Warner (ankle - IR) can return in the playoffs, but only if the team makes a deep playoff run, Matt Barrows reports. |
| Eric Kendricks Status: Active San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Kendricks has moved into the starting role at linebacker with Tatum Bethune out for the remainder of the season, Matt Maiocco of NBC Sports Bay Area reports. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Cowing (hamstring) will have his practice window opened Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | 49ers head coach Kyle Shanahan said Monday that Gifford (quadriceps) will be evaluated throughout the week to determine his status for the wild-card round, Nick Wagoner of ESPN.com reports. |
| 2026-01-04 |
| Trent Williams Status: Out San Francisco 49ers | Williams (hamstring) is inactive for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Keion White Status: Active San Francisco 49ers | White (groin) is active for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Questionable San Francisco 49ers | Winters suffered an ankle injury in Saturday's game against the Seahawks and is questionable to return. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed the ball eight times for 23 yards in Saturday's 13-3 loss to the Seahawks. He added six receptions on seven targets for 34 yards. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune is questionable to return to Saturday's game against the Seahawks due to a groin injury, Nick Wagoner of ESPN.com reports. |
 | Eddy Pineiro Status: Active San Francisco 49ers | Pineiro converted his only field-goal attempt of 48 yards in Saturday's 13-3 loss to Seattle. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges logged 11 snaps on special teams and was not used on offense in Saturday's 13-3 loss to the Seahawks. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne failed to catch his only target in Saturday's 13-3 loss to the Seahawks. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings recorded four receptions on six targets for 35 yards in Saturday's 13-3 loss to the Seahawks. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed two times for nine yards and was not targeted as a receiver in Saturday's 13-3 loss to Seattle. |
| George Kittle Status: Active San Francisco 49ers | Kittle recorded five receptions on seven targets for 29 yards in Saturday's 13-3 loss to the Seahawks. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson had three receptions on four targets for 24 yards in Saturday's 13-3 loss to the Seahawks. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 19 of 27 passes for 127 yards, no touchdowns and one interception in Saturday's 13-3 loss to the Seahawks. |
| Brock Purdy Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan relayed that Purdy suffered a "stinger" after taking a hard hit to his left shoulder on the 49ers' final offensive play of Saturday's 13-3 loss to the Seahawks, Noah Furtado and Eric Branch of the San Francisco Chronicle report. "It's just I got hit, and the left shoulder sort of lit up," Purdy said after the contest. "I feel good right now. We'll see how I feel [Sunday]." |
| Dee Winters Status: Questionable San Francisco 49ers | Winters could miss the wild-card round of the NFC playoffs due to an ankle injury he sustained during the 49ers' 13-3 loss to the Seahawks on Saturday, Noah Furtado and Eric Branch of the San Francisco Chronicle report. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan told reporters after the 49ers' 13-3 loss to the Seahawks on Saturday that Bethune's groin injury could prevent him from playing in the wild-card round of the NFC playoffs, Noah Furtado and Eric Branch of the San Francisco Chronicle report. |
| 2026-01-03 |
 | Curtis Robinson Status: Out San Francisco 49ers | Robinson (coach's decision) is inactive for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne is in line for more work Saturday versus the Seahawks with Ricky Pearsall (knee/ankle) inactive, Brianna Jeannel of the 49ers' official site reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (concussion) is active for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee/ankle) is inactive for Saturday's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. |
| Chase Lucas Status: Out San Francisco 49ers | inactive |
| Isaac Guerendo Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| 2026-01-02 |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (concussion) is questionable to play against the Seahawks on Saturday. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (knee) will not carry an injury designation into Saturday's contest against the Seahawks. |
 | Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (hip) does not have an injury designation for Saturday's matchup versus Seattle. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) is questionable to play Saturday versus the Seahawks. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) is listed as questionable for Saturday's game against the Seahawks. |
| 2026-01-01 |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) is listed as questionable for Saturday's game versus the Seahawks, Nick Wagoner of ESPN.com reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (back) doesn't have a designation for Saturday's game against the Seahawks, Nick Wagoner of ESPN.com reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (hip) was a limited practice participant Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (ankle/knee) was limited at practice Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) was limited in practice Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (back) practiced in a limited capacity Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-12-31 |
| Keion White Status: Questionable San Francisco 49ers | White (groin) did not participate in Tuesday's practice, Nick Wagoner of ESPN.com reports. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | San Francisco head coach Kyle Shanahan said Friday that Cowing (hamstring) could have his 21-day practice window opened during Week 18 prep, Matt Barrows of The Athletic reports. |
| Jordan James Status: Active San Francisco 49ers | James played just two snaps -- both on special teams -- in Sunday's 42-38 win over the Bears. |
| Skyy Moore Status: Active San Francisco 49ers | Moore carried once for 10 yards and brought back two punts for 11 yards and four kickoffs for 92 yards in Sunday's 42-38 win over the Bears. |
| George Kittle Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Wednesday that Kittle (ankle) is trending in the right direction to suit up Saturday night versus the Seahawks, Cam Inman of The San Jose Mercury News reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Wednesday that McCaffrey (back) is trending in the right direction to play Saturday against the Seahawks, Cam Inman of The San Jose Mercury News reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (neck) is expected to be listed as a full participant at practice Tuesday, Nick Wagoner of ESPN.com reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (hip) did not participate in Tuesday's practice, Nick Wagoner of ESPN.com reports. |
| Keion White Status: Questionable San Francisco 49ers | questionable |
| 2025-12-30 |
| George Kittle Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) will be a limited participant in Tuesday's practice, David Lombardi of SFStandard.com reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (back) will not practice Tuesday, Matt Barrows of The Athletic reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) won't participate in practice Tuesday, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (hamstring) was a limited participant in Tuesday's practice, Matt Barrows of The Athletic reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (concussion) was a limited participant in Tuesday's practice, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) will be limited in Tuesday's practice, Matt Barrows of The Athletic reports. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha registered three tackles (two solo) and one pass defense during San Francisco's 42-38 win over Chicago on Sunday. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown registered four tackles (one solo) and one pass defense during the 49ers' 42-38 win over the Bears on Sunday. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune logged 11 tackles (seven solo), including one stop for a loss, and one pass defense during the 49ers' 42-38 win over the Bears on Sunday. |
| 2025-12-29 |
| Curtis Robinson Status: Out San Francisco 49ers | Robinson (coach's decision) is inactive for Sunday night's contest against the Bears. |
| Isaac Guerendo Status: Out San Francisco 49ers | Guerendo (coach's decision) is inactive for Sunday night's contest against Chicago. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges is poised for a bigger role in the 49ers offense Sunday versus the Bears with George Kittle (ankle) inactive, Briana Jeannel of the team's official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Sunday night's contest against the Bears. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) is questionable to return to Sunday night's contest against the Bears. |
| Renardo Green Status: Out San Francisco 49ers | out |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson caught both of his targets for 30 yards in Sunday's 42-38 win over the Bears. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson took four carries for 22 yards and grabbed his only target for six yards in Sunday's 42-38 win over Chicago. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (concussion) will not return to Sunday night's game against the Bears, Eric Branch of the San Francisco Chronicle reports. |
| Trent Williams Status: Questionable San Francisco 49ers | Williams (hamstring) has been ruled out for the rest of Sunday night's contest against the Bears. |
| Luke Farrell Status: Active San Francisco 49ers | Farrell logged 27 snaps on offense (38 percent) and was not targeted in Sunday's 42-38 win over the Bears. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne caught his only target for 25 yards in Sunday's 42-38 win over the Bears. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey took 23 carries for 140 yards and a touchdown while corralling four of six targets for 41 yards in Sunday's 42-38 win over the Bears. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 24 of 33 pass attempts for 303 yards, three touchdowns and one interception while taking six carries for 28 yards and two touchdowns in Sunday's 42-38 win over Chicago. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro didn't attempt a field goal in Sunday night's 42-38 win over the Bears but converted all six of his extra-point tries. |
 | Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) will remain on the 49ers' reserve/non-football injury list for the rest of the 2025 season, Matt Maiocco of NBC Sports Bay Area reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings had two receptions on four targets for 42 yards and a touchdown in Sunday's 42-38 victory over Chicago. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges corralled seven of nine targets for 60 yards and a touchdown in Sunday's 42-38 win over the Bears. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (ankle/knee) had five receptions on eight targets for 85 yards in Sunday's 42-38 win over the Bears. |
| 2025-12-28 |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (ankle/knee) is active for Sunday's game against the Bears, Briana Jeannel of the 49ers' official site reports. |
| Renardo Green Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| George Kittle Status: Out San Francisco 49ers | Kittle (ankle) is listed as inactive Sunday against the Bears, Briana Jeannel of the 49ers' official site reports. |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) plans to work out before Sunday night's game against the Bears to determine if he will be able to play versus Chicago, Ian Rapoport of NFL Network reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (ankle/knee) remains listed as questionable for Sunday's game against the Bears but is likely to play, Adam Schefter of ESPN reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) remains listed as questionable for Sunday's game against the Bears but is considered "highly unlikely" to play, Adam Schefter of ESPN reports. |
| 2025-12-27 |
| Fred Warner Status: Injured Reserve San Francisco 49ers | Warner (ankle) is ahead of schedule in his recovery and could be a candidate to return to action if the 49ers make a deep playoff run, Ian Rapoport and Mike Garafolo of NFL Network report. |
| Brayden Willis Status: Active San Francisco 49ers | The 49ers elevated Willis from the practice squad to the active roster ahead of Sunday's game against the Bears. |
| 2025-12-26 |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) was a limited participant at practice Thursday, Cam Inman of The San Jose Mercury News reports. |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) has been ruled out for Sunday's game against Chicago, Matt Maiocco of NBC Sports Bay Area reports. |
| Renardo Green Status: Out San Francisco 49ers | Green (neck) has been Matt Maiocco of NBC Sports Bay Area for Sunday's game against the Bears, Matt reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (ankle/knee) is listed as questionable for Sunday's game versus the Bears, Matt Maiocco of NBC Sports Bay Area reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) is listed as questionable for Sunday's game against the Bears, Matt Maiocco of NBC Sports Bay Area reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (knee) doesn't have an injury designation ahead of Sunday's game against the Bears, Matt Barrows of The Athletic reports. |
| George Kittle Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Friday that the status of Kittle (ankle) for Sunday night's game against the Bears will likely be a game-dime decision, Cam Inman of The San Jose Mercury News reports. |
| 2025-12-25 |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (knee) did not practice Wednesday, per the NFL's injury report. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) was a limited participant in Wednesday's practice, per the NFL's injury report. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune (ankle) was a full participant in Wednesday's practice, per the NFL's injury report. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) was listed as limited on Thursday's practice report, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle (ankle) was listed as a non-participant on Thursday's injury report, Cam Inman of The San Jose Mercury News reports. |
| 2025-12-24 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Pearsall (knee/ankle) will be limited at practice Wednesday, Matt Maiocco of NBC Sports Bay Area reports. |
| George Kittle Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Kittle (ankle) won't practice Wednesday but "has a chance" to play Sunday against the Bears, Nick Wagoner of ESPN.com reports. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown tallied nine tackles (five solo) and forced a fumble Sunday in a 48-27 win against the Colts. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha tallied eight tackles (three solo) in Monday's 48-27 victory against Indianapolis. |
| Dee Winters Status: Active San Francisco 49ers | Winters logged three tackles (one solo) and two defensed passes, including an interception that he returned for a touchdown, in Monday's 48-27 victory versus the Colts. |
| 2025-12-23 |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro converted two of three field-goal attempts and all six PATs in Monday night's 48-27 win over the Colts. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos (hamstring) is active for Monday night's game against the Colts. |
| Curtis Robinson Status: Out San Francisco 49ers | Robinson (coach's decision) is inactive for Monday night's game against the Colts. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins is active for Monday night's game against the Colts. |
| Jordan James Status: Active San Francisco 49ers | James is active for Monday night's game against the Colts. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges caught one of two targets for seven yards in Monday's 48-27 win over the Colts. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed five times for 20 yards while failing to catch his only target in Monday's 48-27 win over Indianapolis. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle was diagnosed with a low-to-mid-grade ankle sprain following an MRI on Tuesday, Jeremy Fowler of ESPN.com reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (ankle) is questionable to return to Monday's game against the Colts. |
| George Kittle Status: Questionable San Francisco 49ers | Kittle is dealing with an ankle injury and is questionable to return to Monday's Week 16 matchup against Indianapolis, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey handled 21 carries for 117 yards and caught six of eight targets for 29 yards and a pair of touchdowns in Monday's 48-27 win over Indianapolis. |
| George Kittle Status: Questionable San Francisco 49ers | San Francisco coach Kyle Shanahan said after Monday's 48-27 win against the Colts that it's too early to know the severity of Kittle's ankle injury, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 25 of 34 pass attempts for 295 yards, five touchdowns and one interception while taking two carries for 11 yards in Monday's 48-27 rout of the Colts. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson had two receptions on as many targets for 22 yards and a touchdown in Monday's 48-27 win over Indianapolis. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne had three receptions on five targets for 27 yards in Monday's 48-27 win over the Colts. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings corralled five of six targets for 71 yards and a touchdown in Monday's 48-27 win over the Colts. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| 2025-12-22 |
| Isaac Guerendo Status: Out San Francisco 49ers | Guerendo (coach's decision) is inactive for Monday night's game against the Colts. |
| Ricky Pearsall Status: Out San Francisco 49ers | inactive |
| Chase Lucas Status: Out San Francisco 49ers | inactive |
| Renardo Green Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| Eric Kendricks Status: Active San Francisco 49ers | Kendricks was elevated from the 49ers' practice squad to the active roster Monday. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos (hamstring) was activated off the 49ers' injured reserve list Monday, Adam Schefter of ESPN reports. |
| 2025-12-21 |
 | Spencer Burford Status: Active San Francisco 49ers | Burford (ankle) doesn't have an injury designation ahead of Monday night's game against the Colts. |
| 2025-12-20 |
| Jordan Elliott Status: Active San Francisco 49ers | Elliott (knee) does not carry an injury designation for Monday's game against the Colts. |
 | Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu (ankle) does not carry an injury designation for Monday's game against Indianapolis. |
| Spencer Burford Status: Active San Francisco 49ers | NA |
 | Nick Martin Status: Injured Reserve San Francisco 49ers | The 49ers placed Martin (concussion) on injured reserve Saturday. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune (ankle) is cleared for Monday's game against the Colts, Matt Barrows of The Athletic reports. |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Gross-Matos (hamstring/knee) is officially listed as questionable for Monday's game against the Colts, Matt Maiocco of NBC Sports Bay Area reports. |
| Renardo Green Status: Out San Francisco 49ers | Green (neck) has been ruled out for Monday's contest against the Colts, Matt Maiocco of NBC Sports Bay Area reports. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne is poised to take on a larger role against the Colts on Monday after Ricky Pearsall (knee/ankle) was officially ruled out, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee/ankle) has been ruled out for Monday's game against the Colts, Matt Maiocco of NBC Sports Bay Area reports. |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) is ruled out for Monday's game against the Colts, Briana Jeannel of the team's official site reports. |
| 2025-12-19 |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (ankle) was a limited participant in Friday's practice, Nick Wagoner of ESPN.com reports. |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (ankle) logged a limited practice Thursday, Cam Inman of The San Jose Mercury News reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) practiced in limited fashion Thursday, Cam Inman of The San Jose Mercury News reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee/ankle) isn't practicing Friday, Cam Inman of The San Jose Mercury News reports. |
| Spencer Burford Status: Questionable San Francisco 49ers | Burford (ankle) did not practice Thursday, Cam Inman of The San Jose Mercury News reports. |
| 2025-12-18 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Pearsall (knee/ankle) won't practice Thursday, but the wide receiver is feeling much better and has a chance to play Monday at Indianapolis, Nick Wagoner of ESPN.com reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (ankle) will be limited at practice Thursday, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
| 2025-12-17 |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha logged 10 tackles (six solo) during the 49ers' win over the Titans on Sunday. |
| 2025-12-16 |
| Tatum Bethune Status: Out San Francisco 49ers | Head coach Kyle Shanahan relayed Monday that he expects Bethune (ankle) to return to practice for Week 16 prep, Matt Barrows of The Athletic reports. |
| Jordan Elliott Status: Out San Francisco 49ers | Elliott (knee) is expected to practice this week, Matt Barrows of The Athletic reports. |
| Sam Okuayinonu Status: Out San Francisco 49ers | Okuayinonu (ankle) is expected to return to practice during Week 16 prep, Matt Barrows of The Athletic reports. |
| Spencer Burford Status: Active San Francisco 49ers | Burford avoided a high ankle sprain after exiting Sunday's win over the Titans, David Lombardi of SFStandard.com reports. |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Monday that Gross-Matos (hamstring) should return to practice ahead of the 49ers' Week 16 tilt against the Colts on Monday, Dec. 22, Matt Barrows of The Athletic reports. |
| Nick Martin Status: Out San Francisco 49ers | Martin remains in the league's concussion protocol Monday, Matt Barrows of The Athletic reports. |
| 2025-12-15 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (back) took 22 carries for 73 yards and a touchdown while grabbing his only target for 14 yards in Sunday's 37-24 win over Tennessee. |
| Sam Okuayinonu Status: Out San Francisco 49ers | out |
| Nick Martin Status: Out San Francisco 49ers | out |
| Jordan Elliott Status: Out San Francisco 49ers | out |
| Tatum Bethune Status: Out San Francisco 49ers | out |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro went 3-for-3 on field-goal attempts and made all four of his PATs in Sunday's 37-24 win over the Titans. |
| Sebastian Valdez Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that Pearsall played through ankle and knee injuries during Sunday's 37-24 win over Tennessee, Mike Masala of USA Today reports. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne had two receptions on three targets for 17 yards in Sunday's 37-24 win over the Titans. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson hauled in both of his targets for 36 yards in Sunday's 37-24 win over Tennessee. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo logged three snaps on special teams in Sunday's 37-24 win over the Titans. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed nine times for 21 yards and returned two kicks for 53 yards in Sunday's 37-24 win over the Titans. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 23 of 30 pass attempts for 295 yards and three touchdowns while adding seven carries for 44 yards and a lost fumble in Sunday's 37-24 win over the Titans. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Coach Kyle Shanahan acknowledged Monday that he's unsure whether Pearsall (knee/ankle) will practice this week, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall hauled in six of seven targets for 96 yards in Sunday's 37-24 win over Tennessee. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings finished with three receptions on five targets for 37 yards and two touchdowns in Sunday's 37-24 win over the Titans. |
| George Kittle Status: Active San Francisco 49ers | Kittle brought in eight of nine targets for 88 yards and a touchdown in Sunday's 37-24 win over the Titans. |
| 2025-12-14 |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's matchup against Tennessee. |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Sebastian Valdez Status: Out San Francisco 49ers | inactive |
| Sam Okuayinonu Status: Out San Francisco 49ers | inactive |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (back) is active for Sunday's game against the Titans. |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Tatum Bethune Status: Out San Francisco 49ers | inactive |
| Jordan Elliott Status: Out San Francisco 49ers | Elliot (knee) has been ruled out for Sunday's game against the Titans, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-12-13 |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) is out for Sunday's game versus the Titans, Cam Inman of The San Jose Mercury News reports. |
| Nick Martin Status: Out San Francisco 49ers | Martin (concussion) is out for Sunday's game versus Tennessee, Cam Inman of The San Jose Mercury News reports. |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Gross-Matos (hamstring) is out for Sunday's game versus Tennessee, Cam Inman of The San Jose Mercury News reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | Although he was added to the 49ers' injury report Saturday, McCaffrey (back) is expected to play against the Titans on Sunday, Adam Schefter of ESPN reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | The 49ers placed Aiyuk (knee) on the reserve/left squad list Saturday, Matt Barrows of The Athletic reports. |
| 2025-12-12 |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey (illness) is practicing Friday, Noah Furtado of the San Francisco Chronicle reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey (illness) doesn't have an injury designation for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (ankle) did not practice Thursday. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (ribs) logged a limited practice Thursday. |
| Tatum Bethune Status: Out San Francisco 49ers | Bethune (ankle) has been ruled out for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports. |
| Sam Okuayinonu Status: Out San Francisco 49ers | Okuayinonu (ankle) has been ruled out for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk (ribs) does not have an injury designation for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports. |
| Nick Martin Status: Out San Francisco 49ers | out |
| 2025-12-11 |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | San Francisco has designated Gross-Matos (knee) to return to practice from IR on Thursday, Matt Maiocco of NBC Sports Bay Area reports. |
| Christian McCaffrey Status: Questionable San Francisco 49ers | McCaffrey was limited at Thursday's practice due to an illness, David Lombardi of SFStandard.com reports. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro (right hamstring) practiced in full Wednesday. |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) practiced in full Wednesday. |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (ankle) did not practice Wednesday. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (ribs) logged a limited practice Wednesday. |
| 2025-12-10 |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (ankle) is not participating in Wednesday's practice, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2025-12-09 |
| Kurtis Rourke Status: Out San Francisco 49ers | Rourke (knee) had his 21-day practice window opened Monday by the 49ers. |
 | Garret Wallow Status: Active San Francisco 49ers | The 49ers claimed Wallow off waivers Monday. |
 | Ben Bartch Status: Injured Reserve San Francisco 49ers | The 49ers placed Bartch (foot) on injured reserve Monday. |
| Eddy Pineiro Status: Questionable San Francisco 49ers | questionable |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | questionable |
| Tatum Bethune Status: Questionable San Francisco 49ers | questionable |
| 2025-12-08 |
| Ben Bartch Status: Injured Reserve San Francisco 49ers | ir |
| 2025-12-03 |
 | Clelin Ferrell Status: Active San Francisco 49ers | Ferrell compiled nine tackles (six solo), including 2.0 sacks, during San Francisco's win over the Browns on Sunday. |
| 2025-12-02 |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco general manager John Lynch reiterated Tuesday that he's still "hopeful" Aiyuk (knee) will play at some point this season, though Lynch acknowledged that he wasn't sure how realistic the wideout's return might be, Cam Inman of The San Jose Mercury News reports. |
| Ben Bartch Status: Out San Francisco 49ers | Head coach Kyle Shanahan told reporters Monday that Bartch will be placed on injured deserve after spraining his foot during the 49ers' 26-8 win over the Browns on Sunday, David Lombardi of SFStandard.com reports. |
| Tatum Bethune Status: Out San Francisco 49ers | Bethune (ankle) is closing in on a return to action, Matt Barrows of The Athletic reports. |
| Eddy Pineiro Status: Out San Francisco 49ers | Pineiro (hamstring) is expected to return to action following the 49ers' bye week in Week 14, Matt Barrows of The Athletic reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk is dealing with a rib fracture ahead of the 49ers' bye week, David Lombardi of SFStandard.com reports. |
 | Matt Gay Status: Active San Francisco 49ers | The 49ers reverted Gay to their practice squad Monday, per the NFL's transaction log. |
| 2025-12-01 |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson turned eight carries into 26 yards in Sunday's 26-8 victory over Cleveland. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson failed to secure his only target while gaining six yards on his first carry of the season in Sunday's 26-8 win over Cleveland. |
| Eddy Pineiro Status: Out San Francisco 49ers | out |
| Sam Okuayinonu Status: Out San Francisco 49ers | out |
| Tatum Bethune Status: Out San Francisco 49ers | out |
| Kevin Givens Status: Active San Francisco 49ers | NA |
 | Connor Colby Status: Active San Francisco 49ers | NA |
| Jordan Watkins Status: Active San Francisco 49ers | NA |
| Jordan James Status: Active San Francisco 49ers | NA |
| Matt Gay Status: Active San Francisco 49ers | Gay converted both of his field-goal attempts and both extra-point tries in the 49ers' 26-8 win over the Browns on Sunday. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne was held without a catch (one target) in Sunday's 26-8 win over the Browns. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk will have further evaluation on his ribs injury once the team returns to Santa Clara, Nick Wagoner of ESPN.com reports. |
| Ben Bartch Status: Out San Francisco 49ers | out |
| 2025-11-30 |
| Nick Martin Status: Questionable San Francisco 49ers | Martin has entered the league's concussion protocol and has been ruled out for the rest of Sunday's game against the Browns, Cam Inman of The San Jose Mercury News reports. |
| Nick Martin Status: Questionable San Francisco 49ers | Martin has exited Sunday's game against the Browns and is being evaluated for a possible concussion, Nick Wagoner of ESPN.com reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | questionable |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch (foot) has been ruled out for the rest of Sunday's game against the Browns, Matt Maiocco of NBC Sports Bay Area reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (ribs) is questionable to return to Sunday's game against the Browns, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Active San Francisco 49ers | Kittle caught four of five targets for 67 yards in Sunday's 26-8 win over the Browns. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall caught two of three targets for 14 yards in Sunday's 26-8 win over the Browns. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings caught four of six targets for 39 yards and a touchdown in Sunday's 26-8 win over the Browns. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey carried the ball 20 times for 53 yards and a touchdown and caught all four of his targets for 21 yards in Sunday's 26-8 win over the Browns. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 16 of 29 passes for 168 yards and a touchdown in Sunday's 26-8 win over the Browns. He added four rushing yards and a TD on two carries. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Browns, Briana Jeannel of the 49ers' official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Sunday's matchup with the Browns, Briana Jeannel of the 49ers' official site reports. |
| Eddy Pineiro Status: Out San Francisco 49ers | inactive |
| Sam Okuayinonu Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Connor Colby Status: Out San Francisco 49ers | inactive |
| Tatum Bethune Status: Out San Francisco 49ers | inactive |
| 2025-11-29 |
| Matt Gay Status: Active San Francisco 49ers | The 49ers elevated Gay from the practice squad to the active roster Saturday, and he will serve as the 49ers' starting kicker against the Browns on Sunday. |
| Robert Beal Jr. Status: Active San Francisco 49ers | Beal (concussion) does not carry an injury designation ahead of Sunday's game at Cleveland, Noah Furtado of the San Francisco Chronicle reports. |
| 2025-11-28 |
| Luke Gifford Status: Active San Francisco 49ers | NA |
| Robert Beal Jr. Status: Active San Francisco 49ers | NA |
| Eddy Pineiro Status: Out San Francisco 49ers | Pineiro (hamstring) has been ruled out for Sunday's game at Cleveland, Nick Wagoner of ESPN.com reports. |
| Luke Gifford Status: Active San Francisco 49ers | Gifford (hip/neck) is good to go for San Francisco's matchup versus the Browns on Sunday, Noah Furtado of the San Francisco Chronicle reports. |
| Tatum Bethune Status: Out San Francisco 49ers | Bethune (ankle) has been ruled out for Sunday's game against the Browns, Nick Wagoner of ESPN.com reports. |
| 2025-11-27 |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan relayed Wednesday that the 49ers will not designate Gross-Matos (knee) to return from injured reserve, Matt Maiocco of NBC Sports Bay Area reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | The 49ers listed Bethune (ankle) as a DNP on Thursday's practice report, Cam Inman of The San Jose Mercury News reports. |
| Eddy Pineiro Status: Questionable San Francisco 49ers | Pineiro (hamstring) was listed as a DNP on Thursday's practice report, Cam Inman of The San Jose Mercury News reports. |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | Beal (concussion) logged a full practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (hip/neck) was a limited participant at practice Wednesday, Matt Barrows of The Athletic reports. |
| Sam Okuayinonu Status: Out San Francisco 49ers | Okuayinonu (ankle) is expected to miss multiple weeks, Matt Barrows of The Athletic reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (ankle) was absent from practice Wednesday, Matt Barrows of The Athletic reports. |
| 2025-11-26 |
| Brandon Aiyuk Status: Out San Francisco 49ers | Aiyuk (knee) won't return to practice this week, Matt Maiocco of NBC Sports Bay Area reports. |
| Eddy Pineiro Status: Questionable San Francisco 49ers | Pineiro (hamstring) will not participate in practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Sam Okuayinonu Status: Out San Francisco 49ers | out |
| Luke Gifford Status: Questionable San Francisco 49ers | questionable |
| Matt Gay Status: Active San Francisco 49ers | Gay reverted to the 49ers' practice squad Tuesday, per the NFL transaction log. |
| Upton Stout Status: Active San Francisco 49ers | Stout recorded six tackles (two solo) with one pass defensed in Monday's 20-9 win over the Panthers. |
| Dee Winters Status: Active San Francisco 49ers | Winters recorded one tackle (one solo) in Monday's 20-9 win over the Panthers. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha recorded seven tackles (seven solo) and one tackle for loss in Monday's 20-9 win over the Panthers. |
| 2025-11-25 |
| Eddy Pineiro Status: Questionable San Francisco 49ers | questionable |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
| Tatum Bethune Status: Questionable San Francisco 49ers | questionable |
| Connor Colby Status: Active San Francisco 49ers | NA |
| Kevin Givens Status: Active San Francisco 49ers | NA |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown recorded five tackles (four solo) and two interceptions in Monday night's win over the Panthers. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne was not targeted as a receiver in Monday's 20-9 win over the Panthers. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson brought in his only target for eight yards in Monday's 20-9 win over Carolina. |
| Robert Beal Jr. Status: Out San Francisco 49ers | Beal (concussion) is inactive for Monday's game against the Panthers, Briana Jeannel of the 49ers' official site reports. |
| Luke Gifford Status: Active San Francisco 49ers | Gifford (hip/neck) is active for Monday's game against the Panthers, Briana Jeannel of the 49ers' official site reports. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Monday's game against the Panthers, Briana Jeannel of the 49ers' official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Monday's game against the Panthers, Briana Jeannel of the 49ers' official site reports. |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (ankle) is questionable to return to Monday's game against Carolina, Matt Barrows of The Athletic reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 24 times for 89 yards and a touchdown while corralling all seven of his targets for 53 yards in Monday's 20-9 win over Carolina. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings had five receptions on seven targets for 41 yards and a touchdown in Monday's 20-9 win over Carolina. |
| George Kittle Status: Active San Francisco 49ers | Kittle finished with six receptions on 10 targets for 78 yards in Monday's 20-9 victory over the Panthers. |
| Matt Gay Status: Active San Francisco 49ers | Gay converted both of his field-goal tries and both of his point-after attempts in Monday's 20-9 Week 12 win over Carolina. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 23 of 32 pass attempts for 193 yards, one touchdown and three interceptions while rushing six times for 16 yards in Monday's 20-9 win over the Panthers. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed seven times for 40 yards while catching one of two targets for four yards in Monday's 20-9 win over Carolina. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall finished with two receptions on four targets for six yards while taking one carry for two yards in Monday's 20-9 win over the Panthers. |
| 2025-11-24 |
| Matt Gay Status: Active San Francisco 49ers | San Francisco has elevated Gay from the practice squad to the active roster to start versus the Panthers on Monday, |
| Eddy Pineiro Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Connor Colby Status: Out San Francisco 49ers | inactive |
| Tatum Bethune Status: Out San Francisco 49ers | inactive |
| 2025-11-23 |
| Robert Beal Jr. Status: Doubtful San Francisco 49ers | Beal (concussion) has been ruled out for Monday night's game against Carolina, Cam Inman of The San Jose Mercury Newsreports. |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (hip/neck) is questionable for Monday night's game against the Panthers, Cam Inman of The San Jose Mercury News reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | The 49ers remain committed to getting Aiyuk (knee) "healthy and back on the field" in 2025, even though the team had approximately $27 million in guarantees for the 2026 season voided in his contract, Mike Garafolo of NFL Network reports. |
| 2025-11-22 |
| Brandon Aiyuk Status: Out San Francisco 49ers | Aiyuk (knee) is considered unlikely to play for the 49ers again after the team voided guarantees in his contract for 2026, Diana Russini and Michael Silver of The Athletic reports. |
| Tatum Bethune Status: Out San Francisco 49ers | Bethune (ankle) has been ruled out for Monday's game against Carolina, Cam Inman of The San Jose Mercury News reports. |
| Eddy Pineiro Status: Out San Francisco 49ers | Pineiro (hamstring) has been ruled out for Monday's game against the Panthers, Cam Inman of The San Jose Mercury News reports. |
| Robert Beal Jr. Status: Doubtful San Francisco 49ers | doubtful |
| 2025-11-21 |
| Eddy Pineiro Status: Questionable San Francisco 49ers | Pineiro (hamstring) did not participate in practice Thursday, Matt Barrows of The Athletic reports. |
| Tatum Bethune Status: Doubtful San Francisco 49ers | Bethune (ankle) did not participate at practice Thursday, Matt Barrows of The Athletic reports. |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | Beal (concussion) was a non-participant at practice Thursday, Matt Barrows of The Athletic reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (hip/neck) was a limited participant at practice Thursday, Matt Barrows of The Athletic reports. |
| 2025-11-19 |
| Matt Gay Status: Active San Francisco 49ers | The 49ers signed Gay to the practice squad Wednesday. |
| Renardo Green Status: Active San Francisco 49ers | Green recorded six tackles (four solo) during San Francisco's win over the Cardinals on Sunday. |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown tallied seven tackles (three solo) in San Francisco's win over the Cardinals on Sunday. |
| Upton Stout Status: Active San Francisco 49ers | Stout tallied seven tackles (two solo) and forced a fumble in San Francisco's win versus the Cardinals on Sunday. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha logged four tackles (one solo) and an interception during San Francisco's win over the Cardinals on Sunday. |
| 2025-11-18 |
| Dee Winters Status: Active San Francisco 49ers | Winters posted 10 tackles (five solo) during the 49ers' 41-22 win over the Cardinals on Sunday. |
| Curtis Robinson Status: Active San Francisco 49ers | Robinson totaled 12 tackles (five solo) during the 49ers' 41-22 win over the Cardinals on Sunday. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir posted seven tackles (four solo) and two pass defenses (including an interception) during the 49ers' 41-22 win over the Cardinals on Sunday. |
| 2025-11-17 |
| George Kittle Status: Active San Francisco 49ers | Kittle hauled in all six of his targets for 67 yards and two touchdowns in Sunday's 41-22 rout of the Cardinals. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings had four receptions on six targets for 54 yards in Sunday's 41-22 win over the Cardinals. |
| Skyy Moore Status: Active San Francisco 49ers | Moore was not targeted as a receiver while returning two kicks for 107 combined yards in Sunday's 41-22 win over Arizona. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed eight times for 24 yards while failing to bring in his only target in Sunday's 41-22 win over Arizona. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson had one reception on two targets for 13 yards in Sunday's 41-22 victory over the Cardinals. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne was not targeted as a receiver in Sunday's 41-22 win over the Cardinals. |
| Eddy Pineiro Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Monday that Pineiro (hamstring) is considered week-to-week, David Lombardi of SFStandard.com reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Aiyuk's (knee) 21-day practice window will not be opened this week, and he remains week-to-week, Matt Barrows of The Athletic reports. |
| Luke Farrell Status: Active San Francisco 49ers | Farrell was not target as a receiver in Sunday's 41-22 victory over Arizona. |
| Tatum Bethune Status: Doubtful San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Bethune suffered a right high-ankle sprain in Sunday's 41-22 win over the Cardinals and is expected to miss multiple weeks, David Lombardi of SFStandard.com reports. |
| Tatum Bethune Status: Doubtful San Francisco 49ers | doubtful |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | Coach Kyle Shanahan said Monday that Cowing's (hamstring) 21-day practice window will likely be opened following the 49ers' Week 14 bye, Matt Maiocco of NBC Sports Bay Area reports. |
| Clelin Ferrell Status: Active San Francisco 49ers | NA |
| Eli Apple Status: Active San Francisco 49ers | NA |
| Kevin Givens Status: Active San Francisco 49ers | NA |
| Connor Colby Status: Active San Francisco 49ers | NA |
| Jordan James Status: Active San Francisco 49ers | NA |
| Jordan Watkins Status: Active San Francisco 49ers | NA |
| Brock Purdy Status: Active San Francisco 49ers | Purdy (toe) completed 19 of 26 pass attempts for 200 yards and three touchdowns while losing seven yards on his only carry in Sunday's 41-22 win over the Cardinals. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 13 times for 81 yards and two touchdowns while bringing in five of six targets for 40 yards and a third score in Sunday's 41-22 rout of the Cardinals. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (knee) had one reception on three targets for no gain in Sunday's 41-22 win over the Cardinals. |
| 2025-11-16 |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (calf) is active for Sunday's Week 11 matchup against Arizona, Eric Branch of the San Francisco Chronicle reports. |
| Kevin Givens Status: Out San Francisco 49ers | inactive |
| Clelin Ferrell Status: Out San Francisco 49ers | inactive |
| Connor Colby Status: Out San Francisco 49ers | inactive |
| Eli Apple Status: Out San Francisco 49ers | inactive |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | Beal suffered a concussion in the first half of Sunday's contest against Arizona, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (ankle) is questionable to return to Sunday's contest against the Cardinals, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Eddy Pineiro Status: Questionable San Francisco 49ers | Pineiro (hamstring) is questionable to return to Sunday's game against the Cardinals, Eric Branch of the San Francisco Chronicle reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy (toe) will be playing with no restrictions during Sunday's game against the Cardinals and will require no extra padding or a special shoe to protect his foot, Jay Glazer reported on "Fox NFL Sunday." |
| 2025-11-15 |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (calf) is listed as questionable for Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters (knee) does not carry an injury designation into Sunday's game against Arizona. |
 | Alfred Collins Status: Active San Francisco 49ers | Collins (hip) does not carry an injury designation into Sunday's game against the Cardinals. |
| 2025-11-14 |
| Dee Winters Status: Active San Francisco 49ers | NA |
| Alfred Collins Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (knee) doesn't have an injury designation for Sunday's game against the Cardinals, Matt Barrows of The Athletic reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones will return to a backup role with teammate Brock Purdy (toe) cleared to start Sunday's game against the Cardinals. |
| Brock Purdy Status: Active San Francisco 49ers | NA |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (calf) was a limited participant in practice Thursday, Eric Branch of the San Francisco Chronicle reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) practiced in a limited capacity Thursday, Eric Branch of the San Francisco Chronicle reports. |
| 2025-11-13 |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said on the 49ers Game Plan on Thursday that Purdy (toe) is slated to start Sunday's game at Arizona, Matt Maiocco of NBC Sports Bay Area reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins (hip) was a limited practice participant Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) was a limited practice participant Wednesday, Cam Inman of The San Jose Mercury News reports. |
| 2025-11-12 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) is returning to practice Wednesday, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) will be a limited but "aggressive" participant at Wednesday's practice with the intention to start Sunday's game at Arizona, Cam Inman of The San Jose Mercury News reports. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha notched eight tackles (four solo) in Sunday's loss to the Rams. |
| Upton Stout Status: Active San Francisco 49ers | Stout secured four tackles (one solo) against the Rams in Sunday's loss. |
| Dee Winters Status: Active San Francisco 49ers | Winters recorded eight tackles (five solo) in Sunday's Week 10 loss to the Rams. |
| 2025-11-11 |
| Ji'Ayir Brown Status: Active San Francisco 49ers | Brown recorded 10 tackles (three solo) and one pass defensed in Sunday's 42-26 loss to the Rams. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune recorded 10 tackles (two solo), including one tackle for loss in Sunday's 42-26 loss to the Rams. |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
| 2025-11-10 |
| Luke Farrell Status: Active San Francisco 49ers | Farrell had two receptions on as many targets for 15 yards and a touchdown in Sunday's 42-26 loss to the Rams. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins was limited to three snaps on offense (five percent) and did not garner a target in Sunday's 42-26 loss to the Rams. |
| Skyy Moore Status: Active San Francisco 49ers | Moore secured his only target for 18 yards in Sunday's 42-26 loss to the Rams. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson had three receptions on four targets for 34 yards in Sunday's 42-26 loss to the Rams. |
| Brandon Aiyuk Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that the 49ers don't intend to open Aiyuk's (knee) practice window this week, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Pearsall (knee) has a chance to practice Wednesday, Matt Barrows of The Athletic reports. |
| Brock Purdy Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Purdy (toe) will continue to increase his activity level this week, Nick Wagoner of ESPN.com reports. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson took eight carries for 41 yards and a touchdown while catching his only target for four yards in Sunday's 42-26 loss to the Rams. |
| George Kittle Status: Active San Francisco 49ers | Kittle secured all nine of his targets for 84 yards and a touchdown in Sunday's 42-26 loss to the Rams. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings corralled six of nine targets for 71 yards and a touchdown while losing a fumble in Sunday's 42-26 loss to the Rams. |
| Mac Jones Status: Active San Francisco 49ers | Jones completed 33 of 39 pass attempts for 319 yards, three touchdowns and one interception while gaining three yards on one rush attempt in Sunday's 42-26 loss to the Rams. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 12 times for 30 yards and brought in eight of 10 targets for 66 yards in Sunday's 42-26 loss to the Rams. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro did not attempt a field goal and went 2-for-3 on extra-point tries in Sunday's 42-26 loss to the Rams. |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Alfred Collins Status: Out San Francisco 49ers | out |
| Connor Colby Status: Active San Francisco 49ers | NA |
| Sebastian Valdez Status: Active San Francisco 49ers | NA | |
| Jordan James Status: Active San Francisco 49ers | NA |
 | Marques Sigle Status: Active San Francisco 49ers | NA |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne caught his only target for 19 yards in Sunday's 42-26 loss to the Rams. |
| 2025-11-09 |
| Keion White Status: Active San Francisco 49ers | White (groin) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports. |
| Alfred Collins Status: Out San Francisco 49ers | Collins (hip) is inactive for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports. |
| Ben Bartch Status: Active San Francisco 49ers | Bartch (ankle) is active for Sunday's battle against the Rams, Briana Jeannel of the 49ers' official site reports. |
 | Kalia Davis Status: Active San Francisco 49ers | Davis (ankle) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports. |
| Ben Bartch Status: Questionable San Francisco 49ers | The 49ers activated Bartch (ankle) from injured reserve Saturday. |
| Mykel Williams Status: Injured Reserve San Francisco 49ers | The 49ers placed Williams (knee) on injured reserve Saturday. |
| 2025-11-08 |
| Bryce Huff Status: Active San Francisco 49ers | Huff (hamstring) does not carry an injury designation into Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
| Keion White Status: Questionable San Francisco 49ers | White (groin) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
| Kalia Davis Status: Questionable San Francisco 49ers | Davis (ankle) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (thigh) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins (hip) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports. |
 | Jake Brendel Status: Active San Francisco 49ers | Brendel (hamstring) does not have an injury designation for Sunday's battle against the Rams, Nick Wagoner of ESPN.com reports. |
| Mykel Williams Status: Injured Reserve San Francisco 49ers | ir |
| Ben Bartch Status: Questionable San Francisco 49ers | questionable |
| 2025-11-07 |
| Keion White Status: Questionable San Francisco 49ers | questionable |
| Kalia Davis Status: Questionable San Francisco 49ers | questionable |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
| Keion White Status: Questionable San Francisco 49ers | White was a limited participant in practice Thursday due to a groin injury, Matt Barrows of The Athletic reports. |
| Kalia Davis Status: Questionable San Francisco 49ers | Davis (ankle) was a limited participant in practice Thursday, Matt Barrows of The Athletic reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins has a hip injury and did not participate in Thursday's practice, Matt Barrows of The Athletic reports. |
| Bryce Huff Status: Questionable San Francisco 49ers | Huff (hamstring) was a limited participant in practice for the second day in a row Thursday, Matt Barrows of The Athletic reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) was a limited participant in Thursday's practice, Matt Barrows of The Athletic reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune (thigh) was a limited participant in practice for the second day in a row Thursday, Matt Barrows of The Athletic reports. |
| Jake Brendel Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) has been ruled out for Sunday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones will start Sunday's game against the Rams even if Brock Purdy (toe) is active, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) is listed as questionable for Sunday's game against the Rams, but Mac Jones will start even if Purdy is active, Nick Wagoner of ESPN.com reports. |
| 2025-11-06 |
| Dee Winters Status: Questionable San Francisco 49ers | questionable |
| Tatum Bethune Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) didn't practice Thursday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) remained limited at Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Bryce Huff Status: Questionable San Francisco 49ers | Huff (hamstring) was a limited participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) was limited in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Tatum Bethune Status: Questionable San Francisco 49ers | Bethune was limited in Wednesday's practice due to a thigh injury, Cam Inman of The San Jose Mercury News reports. |
| 2025-11-05 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) isn't practicing Wednesday, Matt Barrows of The Athletic reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan said Wednesday that he's "pretty confident" Aiyuk (knee) will play at some point this season, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) will be limited at Wednesday's practice, Matt Barrows of The Athletic reports. |
| 2025-11-04 |
| Mykel Williams Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Monday that Williams tore his ACL during the fourth quarter of Sunday's 34-24 win over the Giants, Matt Barrows and Dianna Russini of The Athletic report. |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Bryce Huff Status: Questionable San Francisco 49ers | questionable |
| Jake Brendel Status: Questionable San Francisco 49ers | questionable |
| 2025-11-03 |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro made both of his field-goal attempts and connected on all four of his point-after tries during the 49ers' 34-24 win over the Giants on Sunday. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune recorded 16 total tackles (eight solo) and a pass defensed in Sunday's 34-24 win over the Giants. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins hauled in his only target for 19 yards in Sunday's 34-24 win over the Giants. |
| Skyy Moore Status: Active San Francisco 49ers | Moore had one reception for 21 yards while returning five combined kicks for 85 yards in Sunday's 34-24 win over the Giants. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson finished with no receptions on one target in Sunday's 34-24 win over the Giants. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson took five carries for 53 yards and a touchdown in Sunday's 34-24 win over the Giants. He also returned a kickoff for 41 yards. |
| Ricky Pearsall Status: Out San Francisco 49ers | Coach Kyle Shanahan noted Monday that Pearsall (knee) has a chance to play Sunday against the Rams, but will be evaluated mid-week, Matt Barrows of The Athletic reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Aiyuk (knee) won't have his 21-day practice window opened this week, David Lombardi of SFStandard.com reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Bryce Huff Status: Out San Francisco 49ers | out |
| Jake Brendel Status: Out San Francisco 49ers | out |
 | CJ West Status: Active San Francisco 49ers | NA |
| Jordan James Status: Active San Francisco 49ers | NA |
| 2025-11-02 |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne caught both of his targets for 34 yards in Sunday's 34-24 win over the Giants. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings caught four of five targets for 41 yards and a touchdown in Sunday's 34-24 win over the Giants. |
| George Kittle Status: Active San Francisco 49ers | Kittle caught all four of his targets for 32 yards in Sunday's 34-24 win over the Giants. |
| Marques Sigle Status: Out San Francisco 49ers | Sigle (coach's decision) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports. |
| Sam Okuayinonu Status: Active San Francisco 49ers | Okuayinonu (ankle) is active for Sunday's matchup with the Giants, Briana Jeannel of the 49ers' official site reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters (knee) is active for Sunday's contest against the Giants, Briana Jeannel of the 49ers' official site reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports. |
| CJ West Status: Out San Francisco 49ers | inactive |
| Ricky Pearsall Status: Out San Francisco 49ers | inactive |
| Jordan James Status: Out San Francisco 49ers | inactive |
| Bryce Huff Status: Out San Francisco 49ers | inactive |
| Jake Brendel Status: Out San Francisco 49ers | inactive |
| Jordan Elliott Status: Active San Francisco 49ers | Elliott (ankle) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports. |
| Spencer Burford Status: Active San Francisco 49ers | Burford (knee) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports. |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliott (ankle) is expected to play in Sunday's game against the Giants, Eric Branch of the San Francisco Chronicle reports. |
| Yetur Gross-Matos Status: Injured Reserve San Francisco 49ers | Gross-Matos (knee) was placed on injured reserve Saturday. |
| Ben Bartch Status: Injured Reserve San Francisco 49ers | Bartch (ankle) was ruled out ahead of Sunday's game against the Giants. |
| Spencer Burford Status: Questionable San Francisco 49ers | Burford (knee) was activated from injured reserve Saturday. |
| Upton Stout Status: Active San Francisco 49ers | NA |
| Mykel Williams Status: Questionable San Francisco 49ers | questionable |
| Mac Jones Status: Active San Francisco 49ers | Jones completed 19 of 24 passes for 235 yards and two touchdowns in Sunday's 34-24 win over the Giants. He added four rushing attempts for four yards. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 28 times for 106 yards and a touchdown while catching five of six targets for 67 yards and a touchdown in Sunday's 34-24 win over the Giants. |
| Mykel Williams Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said Mykel Williams might have injured his ACL in Sunday's win over the Giants, Vic Tafur of The Athletic reports. |
| 2025-11-01 |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliott (ankle), who is questionable for Sunday's matchup against the Giants, is not traveling with the 49ers to New York on Friday due to personal reasons, Vic Tafur of The Athletic reports. |
| Jake Brendel Status: Out San Francisco 49ers | Brendel (hamstring) was ruled out ahead of Sunday's matchup against the Giants,Jennifer Lee Chan of NBC Sports Bay Area reports. |
| 2025-10-31 |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (ankle) was a limited participant in Thursday's practice, Eric Branch of the San Francisco Chronicle reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) was a limited participant in Thursday's practice, Eric Branch of the San Francisco Chronicle reports. |
| Renardo Green Status: Active San Francisco 49ers | Green registered eight tackles (four solo) during the 49ers' 26-15 loss to the Texans on Sunday. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir registered three tackles (two solo) and one interception during the 49ers' 26-15 loss to the Texans on Sunday. |
| Bryce Huff Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Jake Brendel Status: Out San Francisco 49ers | out |
| Upton Stout Status: Active San Francisco 49ers | NA |
| Alfred Collins Status: Active San Francisco 49ers | NA |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) won't play Sunday against the Giants, Cam Inman of The San Jose Mercury News reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones will start Sunday's game at the Giants, Matt Maiocco of NBC Sports Bay Area reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) won't start Sunday's game against the Giants but is listed as questionable to be available in a backup capacity, Matt Maiocco of NBC Sports Bay Area reports. |
| Bryce Huff Status: Out San Francisco 49ers | Huff (hamstring) has been ruled out for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliott (ankle) is questionable for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) is listed as questionable for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | Gross-Matos (knee/hamstring) has been ruled out for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (shoulder) has no injury designation ahead of Sunday's game against the Giants. |
| 2025-10-30 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) didn't take part in Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) was limited at Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu (ankle) did not participate at practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Bryce Huff Status: Questionable San Francisco 49ers | Huff (hamstring) did not participate at practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (shoulder) was a limited participant at practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) did not participate at practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Ben Bartch Status: Injured Reserve San Francisco 49ers | Bartch (ankle) was a limited participant in San Francisco's practice Wednesday, David Lombardi of SFStandard.com reports. |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliott (ankle) was a limited participant in San Francisco's practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | Burford (knee) was a full participant in San Francisco's practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Jake Brendel Status: Questionable San Francisco 49ers | Brendel (hamstring) didn't participate in San Francisco's practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| 2025-10-29 |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha made 12 tackles (six solo) during Sunday's loss to the Texans. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune made 14 tackles (four solo) during Sunday's loss to the Texans. |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee/knee) practiced in full Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) officially was limited at Wednesday's practice, Eric Branch of the San Francisco Chronicle reports. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges recorded a two-yard touchdown reception on his lone target while playing five of the 49ers' 48 snaps on offense in Sunday's 26-15 loss to the Texans. |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins recorded a seven-yard reception on two targets in Sunday's 26-15 loss to the Texans. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo played all 10 of his snaps on special teams in Sunday's 26-15 loss to the Texans. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) is expected to be limited at Wednesday's practice, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) isn't practicing Wednesday, Vic Tafur of The Athletic reports. |
| Keion White Status: Active San Francisco 49ers | The 49ers acquired White and a 2026 seventh-round pick from the Patriots on Tuesday in exchange for a 2026 sixth-round pick, Tom Pelissero of NFL Network reports. |
| 2025-10-28 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Bryce Huff Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Jake Brendel Status: Questionable San Francisco 49ers | questionable |
| 2025-10-27 |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Bryce Huff Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Jake Brendel Status: Out San Francisco 49ers | out |
| CJ West Status: Active San Francisco 49ers | NA |
| Jordan James Status: Active San Francisco 49ers | NA |
| Mac Jones Status: Active San Francisco 49ers | Jones completed 19 of 32 passes for 193 yards with two touchdowns and one interception while adding two rushes for 23 yards in the 49ers' 26-15 loss to the Texans on Sunday. He also threw a two-point conversion pass. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson pulled in two of three targets for five yards while catching a successful two-point attempt in Sunday's 26-15 loss to Houston. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson did not record a touch on offense while returning three kicks for 99 yards in Sunday's 26-15 loss to the Texans. |
| George Kittle Status: Active San Francisco 49ers | Kittle brought in four of five targets for 43 yards and a touchdown in the 49ers' 26-15 loss to the Texans on Sunday. |
| Skyy Moore Status: Active San Francisco 49ers | Moore failed to collect his only target on offense while returning two kicks for 52 yards in Sunday's 26-15 loss to the Texans. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne brought in three of four targets for 44 yards in the 49ers' 26-15 loss to the Texans on Sunday. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings brought in four of seven targets for 45 yards in the 49ers' 26-15 loss to the Texans on Sunday. |
| Dee Winters Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said Monday that Winters is considered day-to-day due to a knee injury he sustained during Sunday's 26-15 loss to the Texans, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
| Brandon Aiyuk Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that the 49ers don't intend to designate Aiyuk (knee) to return from the reserve/PUP list Wednesday, Matt Barrows of The Athletic reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Monday that Jones suffered a bruised knee during Sunday's 26-15 loss at Houston and is "day-to-day," David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has a chance to return to action Sunday at the Giants, Nick Wagoner of ESPN.com reports. "It's too early to say," coach Kyle Shanahan said Monday. "I don't think it's a long shot. We'll see how he's doing on Wednesday." |
| 2025-10-26 |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed eight times for 25 yards and brought in three of six targets for 43 yards in the 49ers' 26-15 loss to the Texans on Sunday. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro made his lone extra-point try during the 49ers' 26-15 loss to the Texans on Sunday. |
| Luke Gifford Status: Active San Francisco 49ers | Gifford is active for Sunday's game against the Texans. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (quadriceps) is active for Sunday's game against the Texans. |
| CJ West Status: Out San Francisco 49ers | inactive |
| Brock Purdy Status: Out San Francisco 49ers | inactive |
| Ricky Pearsall Status: Out San Francisco 49ers | inactive |
| Jordan James Status: Out San Francisco 49ers | inactive |
| Bryce Huff Status: Out San Francisco 49ers | inactive |
| Yetur Gross-Matos Status: Out San Francisco 49ers | inactive |
| Jake Brendel Status: Out San Francisco 49ers | inactive |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliot (ankle) is questionable to return to Sunday's game against Houston, |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | Burford (knee) has been ruled out for Sunday's game against Houston. |
| Sam Okuayinonu Status: Questionable San Francisco 49ers | Okuayinonu is questionable to return to Sunday's matchup against Houston due to an ankle injury, Nick Wagoner of ESPN.com reports. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters (knee) has been ruled out for the rest of Sunday's game against the Texans. |
| Jordan Elliott Status: Questionable San Francisco 49ers | Elliott (ankle) has been ruled out for the rest of Sunday's game against the Texans, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-10-24 |
| Brandon Aiyuk Status: Out San Francisco 49ers | Coach Kyle Shanahan said Friday that the 49ers may designate Aiyuk (knee) to return from the reserve/PUP list next week, David Lombardi of SFStandard.com reports. |
| Bryce Huff Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Jake Brendel Status: Out San Francisco 49ers | out |
| Mac Jones Status: Active San Francisco 49ers | Jones will start Sunday's game at Houston after coach Kyle Shanahan ruled out Brock Purdy (toe), Adam Schefter of ESPN reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) has been ruled out for Sunday's game at Houston, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has been ruled out for Sunday's game at Houston, Nick Wagoner of ESPN.com reports. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (quadriceps) is listed as questionable for Sunday's game against the Texans, Nick Wagoner of ESPN.com reports. |
| Bryce Huff Status: Out San Francisco 49ers | Huff (hamstring) has been ruled out for Sunday's game against the Texans, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | Gross-Matos (knee/hamstring) has been ruled out for Sunday's game against the Texans, Nick Wagoner of ESPN.com reports. |
| Mac Jones Status: Active San Francisco 49ers | With Brock Purdy (toe) unlikely to be ready to play Sunday against the Texans, Jones is expected to make another start at quarterback, Ian Rapoport of NFL Network reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) is not expected to start Sunday against the Texans, Ian Rapoport of NFL Network reports. |
| Jake Brendel Status: Out San Francisco 49ers | Brendel (hamstring) is listed as out for Sunday's game at Houston, Nick Wagoner of ESPN.com reports. |
| Luke Gifford Status: Questionable San Francisco 49ers | Gifford (hamstring) is listed as questionable for Sunday's game at Houston, Nick Wagoner of ESPN.com reports. |
| 2025-10-23 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) didn't take part in Thursday's practice, Matt Barrows of The Athletic reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) was a limited practice participant Thursday, Matt Barrows of The Athletic reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (ankle) was a full practice participant Thursday, Matt Barrows of The Athletic reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (toe) was a full participant in Thursday's practice, Matt Barrows of The Athletic reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (toe) was a limited participant at practice Wednesday, Vic Tafur of The Athletic reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (ankle) was a limited participant at practice Wednesday, Vic Tafur of The Athletic reports. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (quadricep) did not participate at practice Wednesday, Vic Tafur of The Athletic reports. |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | The 49ers designated Burford (knee) to return to practice on Wednesday. |
| Brandon Aiyuk Status: Out San Francisco 49ers | San Francisco general manager John Lynch said Thursday that he has both hope and "evidence" that Aiyuk (knee) will soon be ready to make his 2025 debut, David Lombardi of SFStandard.com reports. |
| 2025-10-22 |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) will not participate in Wednesday's practice, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) will be limited in practice Wednesday, Vic Tafur of The Athletic reports. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha tallied six tackles (three solo) Sunday in a 20-10 win over the Falcons. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle recorded two tackles (one solo) while playing just 31 percent of San Francisco's defensive snaps in Sunday's 20-10 win over Atlanta. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | questionable |
| Luke Gifford Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Active San Francisco 49ers | Winters totaled three tackles (all solo) in Sunday's 20-10 win against Atlanta. |
| 2025-10-21 |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune recorded 10 tackles (four solo), including one tackle forloss, in Sunday's 20-10 win over the Falcons. |
| 2025-10-20 |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne pulled in both of his targets for 14 yards in Sunday's 20-10 win over the Falcons. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (ankle/ribs/shoulder) had four receptions on seven targets for 31 yards in Sunday's 20-10 win over Atlanta. |
| George Kittle Status: Active San Francisco 49ers | Kittle (hamstring) failed to bring in either of his targets in Sunday's 20-10 win over the Falcons. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee/oblique) completed 17 of 26 pass attempts for 152 yards and an interception while recording five rush attempts for 11 yards in Sunday's 20-10 win over the Falcons. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 24 times for 129 yards and two touchdowns while bringing in seven of eight targets for 72 yards in Sunday's 20-10 win over the Falcons. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges logged eight snaps on offense (12 percent) and was not targeted in Sunday's 20-10 win over the Falcons. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson carried the ball nine times for 36 yards and was not targeted as a receiver in Sunday's 20-10 win over Atlanta. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson failed to catch his only target in Sunday's 20-10 win over the Falcons. |
| Ricky Pearsall Status: Out San Francisco 49ers | Coach Kyle Shanahan noted Monday that the 49ers will continue monitoring Pearsall (knee) ahead of Sunday's game against the Texans, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Coach Kyle Shanahan noted Monday that the 49ers will continue monitoring Purdy (toe) ahead of this coming Sunday's game against the Texans, per Nick Wagoner of ESPN.com, while acknowledging at this stage that the QB playing this weekend is viewed as a stretch, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan relayed Monday that Green (toe) will be considered day-to-day heading into the 49ers' Week 8 clash against the Texans on Sunday, Nick Wagoner of ESPN.com reports. |
| Bryce Huff Status: Doubtful San Francisco 49ers | Huff is expected to miss a couple weeks due to a hamstring injury, Matt Maiocco of NBC Sports Bay Area reports. |
| Jake Brendel Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said Monday that Brendel is expected to be sidelined for a couple of weeks due to a hamstring injury, Matt Maiocco of NBC Sports Bay Area reports. |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
 | Drew Moss Status: Active San Francisco 49ers | NA |
| Jake Brendel Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | Green (toe) is questionable to return to Sunday night's contest against Atlanta, Matt Barrows of The Athletic reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (toe) has been ruled out for the rest of Sunday night's game against the Falcons, Nick Wagoner of ESPN.com reports. |
| Jake Brendel Status: Questionable San Francisco 49ers | Brendel has a hamstring injury and has been ruled out for the rest of Sunday night's matchup with the Falcons, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-10-19 |
| Malik Turner Status: Active San Francisco 49ers | The 49ers elevated Turner from the practice squad to the active roster Saturday. |
 | Marquez Valdes-Scantling Status: Questionable San Francisco 49ers | questionable |
| Fred Warner Status: Injured Reserve San Francisco 49ers | The 49ers placed Warner (ankle) on injured reserve Saturday. |
| Kevin Givens Status: Questionable San Francisco 49ers | The 49ers reinstated Givens (pectoral) from injured reserve Saturday. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) will be out for Sunday's game against the Falcons, but the 49ers are hopeful that the quarterback will return to the lineup for a Week 8 contest in Houston, Tom Pelissero of NFL Network reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (neck) is active for Sunday night's matchup with the Falcons. |
| Upton Stout Status: Out San Francisco 49ers | Stout (ankle) is inactive for Sunday night's clash with the Falcons. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday Night Football against the Falcons. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Sunday night's matchup with the Falcons. |
| Brock Purdy Status: Out San Francisco 49ers | inactive |
| Ricky Pearsall Status: Out San Francisco 49ers | inactive |
| Drew Moss Status: Out San Francisco 49ers | inactive |
| Yetur Gross-Matos Status: Out San Francisco 49ers | inactive |
| Kevin Givens Status: Active San Francisco 49ers | NA |
| Kevin Givens Status: Active San Francisco 49ers | Givens (pectoral) is active for Sunday night's game against the Falcons. |
| 2025-10-18 |
| Jordan Watkins Status: Active San Francisco 49ers | Watkins does not have an injury designation ahead of Sunday's game against the Falcons, Briana Jeannel of the 49ers' official site reports. |
| Skyy Moore Status: Active San Francisco 49ers | Moore does not have an injury designation ahead of Sunday's game against the Falcons, Briana Jeannael of the 49ers' official site reports. |
| George Kittle Status: Active San Francisco 49ers | The 49ers activated Kittle (hamstring) from injured reserve Saturday, and he has no designation for Sunday's game against the Falcons. |
| Fred Warner Status: Injured Reserve San Francisco 49ers | ir |
| 2025-10-17 |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Mac Jones Status: Active San Francisco 49ers | Coach Kyle Shanahan said Friday that Jones (knee/oblique) will start Sunday's game against the Falcons with Brock Purdy (toe) ruled out, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | San Francisco coach Kyle Shanahan confirmed Friday that the team plans to activate Kittle (hamstring) from injured reserve ahead of Sunday's game against Atlanta, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) has been ruled out for Sunday's game against the Falcons, Matt Barrows of The Athletic reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (ankle/rib/shoulder) doesn't have an injury designation for Sunday's game against the Falcons, Matt Barrows of The Athletic reports. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Dominick Puni Status: Active San Francisco 49ers | NA |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has been ruled out for Sunday's game against Atlanta, Matt Barrows of The Athletic reports. |
| Marquez Valdes-Scantling Status: Injured Reserve San Francisco 49ers | Valdes-Scantling (calf) was placed on injured reserve Friday. |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Friday that the 49ers will likely activate Givens (pectoral) from injured reserve ahead of Sunday's game against the Falcons, Matt Barrows of The Athletic reports. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | Gross-Matos (hamstring) is listed as out for Sunday's game versus Atlanta, Nick Wagoner of ESPN.com reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout injured his ankle during Thursday's practice and is questionable to play against the Falcons on Sunday, Noah Furtado of the San Francisco Chronicle reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) is listed as questionable for Sunday's game versus the Falcons, Nick Wagoner of ESPN.com reports. |
| Jacob Cowing Status: Injured Reserve San Francisco 49ers | Head coach Kyle Shanahan said Friday that Cowing (hamstring) is "getting close" to returning from injured reserve, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) isn't practicing Friday, Nick Wagoner of ESPN.com reports. |
| 2025-10-16 |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) was a limited participant in practice for the second day in a row Thursday, Cam Inman of The San Jose Mercury News reports. |
| Skyy Moore Status: Questionable San Francisco 49ers | Moore (ankle) was a limited participant in practice Thursday after missing Wednesday's session, Cam Inman of The San Jose Mercury News reports. |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | Givens (pectoral) was a full participant at practice Thursday, Cam Inman of The San Jose Mercury News reports. |
| Marquez Valdes-Scantling Status: Questionable San Francisco 49ers | Valdes-Scantling missed Thursday's practice due to a calf injury, Cam Inman of The San Jose Mercury News reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) was a non-participant at Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/rib/shoulder) was a limited practice participant Thursday, Cam Inman of The San Jose Mercury News reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee/oblique) practiced in full Thursday, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | Kittle (hamstring) practiced in a limited capacity Thursday, Cam Inman of The San Jose Mercury News reports. |
| CJ West Status: Questionable San Francisco 49ers | questionable |
| Dominick Puni Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | questionable |
| Kalia Davis Status: Questionable San Francisco 49ers | questionable |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) was a limited participant at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) was a limited participant at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Fred Warner Status: Out San Francisco 49ers | 49ers coach Kyle Shanahan said Tuesday that Warner (ankle) has undergone successful surgery to address the right dislocated and fractured ankle he suffered Week 6, Matt Barrows of The Athletic reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) was a limited practice participant Thursday, Cam Inman of The San Jose Mercury News reports. |
| Marquez Valdes-Scantling Status: Questionable San Francisco 49ers | questionable |
| Kalia Davis Status: Active San Francisco 49ers | NA |
| CJ West Status: Active San Francisco 49ers | NA |
| Mac Jones Status: Active San Francisco 49ers | NA |
| 2025-10-15 |
| Marques Sigle Status: Active San Francisco 49ers | Sigle registered four tackles (all solo) Sunday in a loss to the Buccaneers. |
| Mac Jones Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jones (knee/oblique) will be limited at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Skyy Moore Status: Questionable San Francisco 49ers | San Francisco coach Kyle Shanahan said Wednesday that Moore (ankle) is not practicing, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | Coach Kyle Shanahan said Kittle (hamstring) will be limited at Wednesday's practice, thereby designating the tight end to return from injured reserve, Cam Inman of The San Jose Mercury News reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco coach Kyle Shanahan said Pearsall (knee) will not practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) will be limited at Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Jennings (ribs) will be limited in practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| 2025-10-14 |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
 | Jason Pinnock Status: Active San Francisco 49ers | Pinnock played two snaps on special teams and none on defense in Sunday's 30-19 loss to the Buccaneers. |
| 2025-10-13 |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee/oblique) completed 27 of 39 pass attempts for 347 yards and two interceptions while rushing five times for 13 yards in Sunday's 30-19 loss to the Buccaneers. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro made all four of his field-goal attempts and his lone extra-point try during the 49ers' 30-19 loss to the Buccaneers on Sunday. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges corralled six of seven targets for 57 yards in Sunday's 30-19 loss to Tampa Bay. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne finished with five receptions on nine targets for 142 yards in Sunday's 30-19 loss to the Buccaneers. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson had two receptions on three targets for 44 yards in Sunday's 30-19 loss to the Buccaneers. |
| Tatum Bethune Status: Active San Francisco 49ers | Bethune recorded 10 total tackles (five solo) during Sunday's 30-19 loss to the Buccaneers. |
| Skyy Moore Status: Active San Francisco 49ers | Moore logged three snaps (four percent) on offense and did not record a touch while generating 134 return yards on six combined attempts in Sunday's 30-19 loss to Tampa Bay. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson did not record a carry and caught all three of his targets for eight yards in Sunday's 30-19 loss to the Buccaneers. |
| Marquez Valdes-Scantling Status: Active San Francisco 49ers | Valdes-Scantling had two receptions on three targets for 22 yards in Sunday's 30-19 loss to the Buccaneers. |
| Ricky Pearsall Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Pearsall (knee) will be evaluated Wednesday to see if he'll be able to practice this week, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Purdy (toe) will be evaluated Wednesday to see if the quarterback will be able to practice this week, Nick Wagoner of ESPN.com reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | Coach Kyle Shanahan said Monday that the 49ers expect Kittle (hamstring) to practice this week, Nick Wagoner of ESPN.com reports. |
| Fred Warner Status: Out San Francisco 49ers | Warner (ankle) will undergo season-ending surgery Tuesday, Nick Wagoner of ESPN.com reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Aiyuk (knee) is getting "closer and closer" to being able to practice, but the 49ers don't have a specific timeline for the wide receiver to do so, Nick Wagoner of ESPN.com reports. |
| Jordan Watkins Status: Out San Francisco 49ers | out |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Nick Martin Status: Active San Francisco 49ers | NA |
| 2025-10-12 |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey took 17 carries for 54 yards and a touchdown while hauling in seven of eight targets for 57 yards in Sunday's 30-19 loss to the Buccaneers. |
| Fred Warner Status: Out San Francisco 49ers | Head coach Kyle Shanahan told reporters after Sunday's 30-19 loss to the Buccaneers that Warner will undergo season-ending surgery on his right ankle, Nick Wagoner of ESPN.com reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings said after Sunday's loss to the Bucs that he played with five broken ribs against Tampa Bay, David Lombardi of SFStandard.com reports. |
| Upton Stout Status: Active San Francisco 49ers | Stout (ankle) is active for Sunday's game against the Buccaneers, Briana Jeannel of the 49ers' official site reports. |
| Alfred Collins Status: Active San Francisco 49ers | Collins (knee) will play in the 49ers' matchup versus the Buccaneers on Sunday, Briana Jeannel of the team's official site reports. |
| Malik Mustapha Status: Active San Francisco 49ers | Mustapha (knee) is active for Sunday's game against the Buccaneers, Briana Jeannel of the 49ers' official site reports. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Buccaneers, Briana Jeannel of the 49ers' official site reports. |
| Kalia Davis Status: Active San Francisco 49ers | Davis (hand) is active for San Francisco's matchup versus Tampa Bay on Sunday, Briana Jeannel of the team's official site reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (ankle/rib) is listed as active Sunday at Tampa Bay, Briana Jeannel of the 49ers' official site reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee/oblique) is active for Sunday's game in Tampa Bay, Briana Jeannel of the 49ers' official site reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) may be able to return to action in Week 7 against Atlanta, Adam Schefter of ESPN reports. |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings, who is questionable to play against Tampa Bay on Sunday due to an ankle injury, is expected to suit up, Adam Schefter of ESPN reports. |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Yetur Gross-Matos Status: Out San Francisco 49ers | inactive |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has "a chance" to play in next Sunday's Week 7 game against the Falcons, Adam Schefter of ESPN reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (oblique/knee), who is officially questionable to suit up Sunday against the Buccaneers, is expected to play and start, Adam Schefter of ESPN reports. |
| Fred Warner Status: Questionable San Francisco 49ers | Warner (ankle) will miss the remainder of San Francisco's matchup versus the Buccaneers on Sunday, Jennifer Lee Chan of NBC Sports reports. |
| 2025-10-11 |
| Robert Beal Jr. Status: Active San Francisco 49ers | Beal (groin) doesn't carry an injury designation into Sunday's game against Tampa Bay, Greg Auman of Fox Sports reports. |
| Malik Mustapha Status: Questionable San Francisco 49ers | The 49ers activated Mustapha (knee) off injured reserve Saturday. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (calf) has been ruled out for Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports. |
| Yetur Gross-Matos Status: Out San Francisco 49ers | Gross-Matos (hamstring) will not play in Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports. |
| Malik Mustapha Status: Out San Francisco 49ers | Mustapha (knee) is listed as questionable for Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports. |
| Kalia Davis Status: Questionable San Francisco 49ers | Davis (hand) is questionable to face the Buccaneers on Sunday, Greg Auman of Fox Sports reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins (knee) is questionable for Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle) is listed as questionable and may be a game-time decision Sunday at Tampa Bay, ESPN.com's Nick Wagoner reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee) is expected to start Sunday's game at Tampa Bay, ESPN.com's Nick Wagoner reports. |
| 2025-10-10 |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee/oblique) is practicing Friday and doing more throwing than the day before, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/rib) is practicing Friday, Cam Inman of The San Jose Mercury News reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) isn't practicing Friday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) is doing side work Friday but still isn't practicing, Cam Inman of The San Jose Mercury News reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins (knee) was a limited participant at practice Thursday, Vic Tafur of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) did not participate at practice Thursday, Vic Tafur of The Athletic reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/rib) is listed as questionable for Sunday's game at Tampa Bay, Matt Maiocco of NBC Sports Bay Area reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee/oblique) is listed as questionable for Sunday's game at Tampa Bay, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) has been ruled out for Sunday's game at Tampa Bay, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Yetur Gross-Matos Status: Out San Francisco 49ers | out |
| Kalia Davis Status: Questionable San Francisco 49ers | questionable |
| CJ West Status: Active San Francisco 49ers | NA |
| Robert Beal Jr. Status: Active San Francisco 49ers | NA |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | Givens (pectoral) is out for Sunday's game against Tampa Bay, Greg Auman of Fox Sports reports. |
| 2025-10-09 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/rib) returned to practice Thursday, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) didn't practice Thursday but was seen doing some conditioning work while wearing cleats, Cam Inman of The San Jose Mercury News reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee) was in uniform for Thursday's practice but didn't attempt many throws, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) was working on the side with a sleeve on his right leg during Thursday's practice, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/rib) practiced in a limited fashion Thursday, Vic Tafur of The Athletic reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee/oblique) officially was limited at Thursday's practice, Vic Tafur of The Athletic reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins (knee) did not practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Upton Stout Status: Questionable San Francisco 49ers | Stout (ankle) was a limited practice participant Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Malik Mustapha Status: Out San Francisco 49ers | Mustapha (knee) practiced fully Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) did not practice Wednesday, Eric Branch of the San Francisco Chronicle reports. |
| Kevin Givens Status: Injured Reserve San Francisco 49ers | The 49ers designated Givens (pectoral) to return from injured reserve Wednesday. |
| 2025-10-08 |
| Mac Jones Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jones (knee) will be limited in practice Wednesday, Matt Barrows of The Athletic reports. |
| CJ West Status: Questionable San Francisco 49ers | questionable |
| Mac Jones Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jennings (ankle/ribs) won't participate in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| George Kittle Status: Injured Reserve San Francisco 49ers | San Francisco head coach Kyle Shanahan said Wednesday that there's a chance Kittle (hamstring) could return from IR in time to play Week 7 against the Falcons, David Lombardi of SFStandard.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Pearsall (knee) won't take part in practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe) won't practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| 2025-10-07 |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
| 2025-10-06 |
| Jordan Watkins Status: Out San Francisco 49ers | out |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ricky Pearsall Status: Out San Francisco 49ers | out |
| Jauan Jennings Status: Out San Francisco 49ers | out |
| Robert Beal Jr. Status: Out San Francisco 49ers | out |
| Nick Martin Status: Active San Francisco 49ers | NA |
| Jordan James Status: Active San Francisco 49ers | NA |
| Malik Mustapha Status: Out San Francisco 49ers | The 49ers opened Mustapha's (knee) 21-day practice window to return from the reserve/PUP list. |
| 2025-10-04 |
| Yetur Gross-Matos Status: Doubtful San Francisco 49ers | Coach Kyle Shanahan said Friday that Gross-Matos will miss some time with a strained hamstring, Nick Wagoner of ESPN.com reports. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir registered six tackles (two solo) and one pass defense during the 49ers' 26-23 overtime win over the Rams. |
| Dee Winters Status: Active San Francisco 49ers | Winters registered four tackles (three solo) during Thursday's 26-23 overtime win over the Rams. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle registered 13 tackles (seven solo) and one pass defense during Thursday's 26-23 overtime win over the Rams. |
| Fred Warner Status: Active San Francisco 49ers | Warner logged 12 tackles (seven solo) during the 49ers' 26-23 overtime win over the Rams on Thursday. |
| 2025-10-03 |
| Kalia Davis Status: Questionable San Francisco 49ers | Davis (hand) is questionable to return to Thursday's game against the Rams, Eric Branch of the San Francisco Chronicle reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Kalia Davis Status: Questionable San Francisco 49ers | Davis (hand) has been ruled out for the rest of Thursday night's game against the Rams, Ian Rapoport of NFL Network reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters is back in the game Thursday night after briefly leaving with a shoulder issue, Matt Maiocco of NBC Sports Bay Area reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | Gross-Matos has a hamstring injury and has been ruled out for the rest of Thursday's game against the Rams, Eric Branch of the San Francisco Chronicle reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones completed 33 of 49 passes for 342 yards with two touchdowns and no interceptions while adding four rushes for five yards in the 49ers' 26-23 overtime win over the Rams on Thursday night. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 22 times for 57 yards and brought in eight of nine targets for 82 yards and a touchdown in the 49ers' 26-23 overtime win over the Rams on Thursday night. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro went 4-for-4 on field-goal tries and made both of his extra-point attempts in Thursday's 26-23 overtime win over the Rams. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson brought in three of seven targets for 39 yards in the 49ers' 26-23 overtime win over the Rams on Thursday night. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges secured seven of 11 targets for 41 yards and a touchdown in the 49ers' 26-23 overtime win over the Rams on Thursday night. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne brought in 10 of 11 targets for 142 yards in the 49ers' 26-23 overtime win over the Rams on Thursday night. |
| Brock Purdy Status: Out San Francisco 49ers | Head coach Kyle Shanahan confirmed after Thursday's 26-23 overtime victory over the Rams that Purdy is without a timeline for a return after a recent MRI revealed that he aggravated a turf toe injury in the Week 4 loss to the Jaguars, Ian Rapoport of NFL Network reports. "He's week-to-week," Shanahan said of Purdy. "Don't know how [the toe] will heal." |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed five times for 12 yards and was not targeted as a receiver in Thursday's 26-23 overtime win against the Rams. |
| Kalia Davis Status: Doubtful San Francisco 49ers | Davis (hand) is set to undergo surgery after breaking his hand in Thursday's 26-23 win over the Rams, Ian Rapoport of NFL Network reports. |
| Upton Stout Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Doubtful San Francisco 49ers | doubtful |
| Alfred Collins Status: Questionable San Francisco 49ers | questionable |
| George Kittle Status: Injured Reserve San Francisco 49ers | San Francisco head coach Kyle Shanahan said Friday that Kittle (hamstring) is considered a "long shot" to be available for the team's Week 6 game against the Buccaneers, but the tight end could be more likely to return from injured reserve for a Week 7 matchup with the Falcons on Oct. 19, Adam Schefter of ESPN reports. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk had one carry for a loss of one yard and three receptions on four targets for 21 yards in Thursday's 26-23 overtime win over the Rams. |
| Skyy Moore Status: Active San Francisco 49ers | Moore had one carry for one yard without being targeted as a receiver in Thursday's 26-23 win over the Rams. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo ran back one kickoff for 18 yards while receiving no carries or targets in Thursday's 26-23 overtime win over the Rams. |
| Upton Stout Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan relayed Friday that Stout is considered day-to-day due to an ankle sprain that he suffered during the 49ers' 23-20 overtime win over the Rams on Thursday, Nick Wagoner of ESPN.com reports. |
| Alfred Collins Status: Questionable San Francisco 49ers | Collins sprained his knee during the 49ers' 23-20 overtime win over the Rams on Thursday, Nick Wagoner of ESPN.com reports. |
| Malik Mustapha Status: Out San Francisco 49ers | Head coach Kyle Shanahan said Friday that the 49ers will aim to open Mustapha's (knee) 21-day practice window Monday, Matt Barrows of The Athletic reports. |
| 2025-10-02 |
| Robert Beal Jr. Status: Out San Francisco 49ers | inactive |
| George Kittle Status: Injured Reserve San Francisco 49ers | Kittle has had no setbacks while on injured reserve due to a hamstring injury and has a chance to return Week 6 at Tampa Bay, Ian Rapoport of NFL Network reports. |
| Robert Beal Jr. Status: Out San Francisco 49ers | Beal (groin) has been ruled out for Thursday night's contest against the Rams, Matt Barrows of The Athletic reports. |
| Malik Turner Status: Active San Francisco 49ers | The 49ers elevated Turner from the practice squad to the active roster ahead of Thursday night's game against the Rams. |
| Adrian Martinez Status: Active San Francisco 49ers | The 49ers signed Martinez from the practice squad to the active roster ahead of Thursday's game against the Rams. |
| CJ West Status: Active San Francisco 49ers | West (thumb) is active for Thursday's game against the Rams, Briana Jeannel of the 49ers' official site reports. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Thursday night's game against the Rams, Briana Jeannel of the 49ers' official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Brock Purdy Status: Out San Francisco 49ers | inactive |
| Ricky Pearsall Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Jauan Jennings Status: Out San Francisco 49ers | inactive |
| 2025-10-01 |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee) was listed as a full participant at the 49ers' walkthrough Tuesday, Vic Tafur of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) was a non-participant in Tuesday's walk-through practice. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee) will start Thursday at the Rams after Brock Purdy (toe) was ruled out for that contest, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Out San Francisco 49ers | Pearsall (knee) is ruled out for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Renardo Green Status: Active San Francisco 49ers | NA |
| Dee Winters Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Mykel Williams Status: Active San Francisco 49ers | NA |
| Robert Beal Jr. Status: Out San Francisco 49ers | out |
| Jauan Jennings Status: Out San Francisco 49ers | Jennings (ankle, ribs) is ruled out for Thursday's matchup against the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe) has been ruled out for Thursday's game at the Rams, Matt Maiocco of NBC Sports Bay Area reports. |
| Renardo Green Status: Active San Francisco 49ers | Green (neck) doesn't carry an injury designation into Thursday night's game against the Rams, Matt Barrows of The Athletic reports. |
| Dee Winters Status: Active San Francisco 49ers | Winters (knee) doesn't carry an injury designation into Thursday night's game against the Rams, Matt Barrows of The Athletic reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (calf) has been ruled out for Thursday night's game against the Rams, Matt Barrows of The Athletic reports. |
| 2025-09-30 |
| CJ West Status: Questionable San Francisco 49ers | questionable |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Tuesday that he expects Pearsall (knee) to be listed as questionable for Thursday's game against the Rams, The Athletic reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | San Francisco general manager John Lynch said Tuesday that he expects Purdy (toe) to be listed as questionable for Thursday's game against the Rams, The Athletic reports. "We will take every precaution to make sure Brock's all right, Lynch said. "I think he is. Now it's just a matter of, can he turn it around on a short week?" |
| Jauan Jennings Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said that Jennings (ankle/ribs) won't participate in Tuesday's walk-through practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan said that Pearsall (knee) won't participate in Tuesday's walk-through practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) will be a non-participant in Tuesday's walk-through practice, Matt Maiocco of NBC Sports Bay Area reports. |
| Marques Sigle Status: Active San Francisco 49ers | Sigle logged eight tackles (six solo) and one pass defense during the 49ers' 26-21 loss to the Jaguars on Sunday. |
| 2025-09-29 |
| Brock Purdy Status: Active San Francisco 49ers | Purdy completed 22 of 38 pass attempts for 309 yards, two touchdowns, two interceptions and one lost fumble while rushing twice for 13 yards in Sunday's 26-21 loss to the Jaguars. |
| CJ West Status: Out San Francisco 49ers | out |
| Jordan Watkins Status: Out San Francisco 49ers | out |
| Nick Martin Status: Active San Francisco 49ers | NA |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (ankle/shoulder) brought in two of four targets for 24 yards in Sunday's 26-21 loss to Jacksonville. |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Ricky Pearsall Status: Questionable San Francisco 49ers | San Francisco head coach Kyle Shanahan said Monday that the team's initial belief is that Pearsall (knee) is dealing with a "minor PCL" injury, Nick Wagoner of ESPN.com reports. |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson caught one of two targets for 20 yards in Sunday's 26-21 loss to Jacksonville. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne was held to one reception on four targets for 17 yards in Sunday's 26-21 loss to the Jaguars. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges had three receptions on five targets for 58 yards and a touchdown in Sunday's 26-21 loss to the Jaguars. |
| Malik Mustapha Status: Out San Francisco 49ers | Head coach Kyle Shanahan told reporters Monday that the 49ers are hopeful Mustapha (knee) can practice following the team's Week 6 matchup against the Buccaneers, David Lombardi of SFStandard.com reports. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo logged 14 snaps on special teams and was not used on offense in Sunday's 26-21 loss to the Jaguars. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed five times for 21 yards and was not targeted as a receiver in Sunday's 26-21 loss to Jacksonville. |
| Skyy Moore Status: Active San Francisco 49ers | Moore failed to bring in his only target on offense while returning four combined kicks for 96 yards in Sunday's 26-21 loss to the Jaguars. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) was listed as a non-participant on Monday's estimated practice report, Cam Inman of The San Jose Mercury News reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/ribs) was listed as a non-participant on Monday's practice estimate, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) was listed as a non-participant on Monday's estimated injury report, Cam Inman of The San Jose Mercury News reports. |
| Renardo Green Status: Out San Francisco 49ers | Green (neck) was listed as a limited participant on Monday's estimated practice report. |
| Dee Winters Status: Questionable San Francisco 49ers | Winters was listed as a limited participant in Monday's estimated practice report due to a knee injury. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee) was listed as full on Monday's practice estimate. |
| Mykel Williams Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Robert Beal Jr. Status: Questionable San Francisco 49ers | questionable |
| Fred Warner Status: Active San Francisco 49ers | Warner recorded eight tackles (six solo) with a forced fumble in Sunday's 26-21 loss to the Jaguars. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey took 17 carries for 49 yards while adding six receptions on 11 targets for 92 yards and a touchdown in Sunday's 26-21 loss to Jacksonville. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall said he felt some pain and instability after he fell hard on his knee in Sunday's loss to the Jaguars, David Lombardi of SFStandard.com reports. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro connected on both field-goal attempts and his only extra-point try in Sunday's 26-21 loss to the Jaguars. |
| 2025-09-28 |
| Renardo Green Status: Out San Francisco 49ers | Green (neck) is inactive for Sunday's game against Jacksonville, Briana Jeannel of the 49ers' official site reports. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Jaguars, Briana Jeannel of the 49ers' official site reports. |
| Marquez Valdes-Scantling Status: Out San Francisco 49ers | Valdes-Scantling (coach's decision) is inactive for Sunday's game against the Jaguars. |
| Mac Jones Status: Active San Francisco 49ers | Jones (knee) is active for Sunday's contest against the Jaguars, Briana Jeannel of the 49ers' official site reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (knee) is listed as active Sunday against the Jaguars, Briana Jeannel of the 49ers' official site reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings (ankle/shoulder) is active for Sunday's game versus the Jaguars, Briana Jeannel of the 49ers' official site reports. |
| CJ West Status: Out San Francisco 49ers | inactive |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Connor Colby Status: Active San Francisco 49ers | NA |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) is expected to suit up for Sunday's game versus the Jaguars, Adam Schefter of ESPN reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) is slated to play Sunday versus the Jaguars, Adam Schefter of ESPN reports. |
| Jake Tonges Status: Questionable San Francisco 49ers | Tonges suffered a shoulder injury during Sunday's contest against the Jaguars, Matt Maiocco of NBC Sports Bay Area reports. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges (shoulder) has returned for Sunday's game against the Jaguars, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall sustained a right knee injury during Sunday's contest against the Jaguars, Eric Branch of the San Francisco Chronicle reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall (knee) returned to Sunday's game against the Jaguars, Eric Branch of the San Francisco Chronicle reports. |
| 2025-09-26 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) is in uniform for practice Friday, Matt Barrows of The Athletic reports. |
| Deommodore Lenoir Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee) is listed as questionable for Sunday's contest versus the Jaguars, Nick Wagoner of ESPN.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) is listed as questionable for Sunday's contest against the Jaguars, Nick Wagoner of ESPN.com reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder/ankle) is listed as questionable for Sunday's game versus the Jaguars, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Active San Francisco 49ers | Purdy (left shoulder/knee) doesn't have a designation for and will start Sunday's game against the Jaguars, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) is questionable to play Sunday against the Jaguars. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (calf) has been ruled out for Sunday's contest against the Jaguars. |
| Deommodore Lenoir Status: Active San Francisco 49ers | Lenoir (illness) was a full participant at practice Friday. |
| Nick Bosa Status: Injured Reserve San Francisco 49ers | Bosa (knee) underwent surgery to address his torn ACL on Friday, Cam Inman of The San Jose Mercury News reports. |
| CJ West Status: Out San Francisco 49ers | out |
| CJ West Status: Out San Francisco 49ers | West (thumb) has been ruled out for Sunday's contest against Jacksonville. |
| 2025-09-25 |
| Nick Bosa Status: Injured Reserve San Francisco 49ers | The 49ers placed Bosa (knee) on injured reserve Thursday. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) isn't practicing Thursday, David Lombardi of SFStandard.com reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) participated in Thursday's practice, David Lombardi of SFStandard.com reports. |
| Kalia Davis Status: Active San Francisco 49ers | NA |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan told KNBR on Thursday that Purdy (left shoulder/knee) is progressing toward a return to action Sunday against the Jaguars, per Ian Rapoport of NFL Network. "I think (the toe) is feeling better each day, and if that continues he should be good on Sunday," Shanahan said. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall (knee) was limited at practice Thursday, Nick Wagoner of ESPN.com reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Jones (knee) practiced in a limited capacity Thursday, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green (neck) logged a limited practice Wednesday, Matt Barrows of The Athletic reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) did not practice Wednesday, Matt Barrows of The Athletic reports. |
| Mykel Williams Status: Active San Francisco 49ers | Williams logged a full practice session Wednesday, Matt Barrows of The Athletic reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (left shoulder/toe) was a limited practice participant Thursday, Nick Wagoner of ESPN.com reports. |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | Lenoir (illness) logged a limited practice Wednesday, Matt Barrows of The Athletic reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | 49ers GM John Lynch said Thursday that Aiyuk (knee, PUP) is "not close" to returning, David Lombardi of SFStandard.com reports. |
| 2025-09-24 |
| Mac Jones Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Jones (knee) will be a limited practice participant Wednesday, Matt Barrows of The Athletic reports. |
| Ricky Pearsall Status: Questionable San Francisco 49ers | Pearsall will miss Wednesday's practice due to a knee injury, David Lombardi of SFStandard.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (left shoulder/toe) will be limited at Wednesday's practice, Matt Barrows of The Athletic reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) is not participating in Wednesday's practice, Cam Inman of The San Jose Mercury News reports. |
| Mykel Williams Status: Active San Francisco 49ers | NA |
| Deommodore Lenoir Status: Questionable San Francisco 49ers | questionable |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Kalia Davis Status: Questionable San Francisco 49ers | questionable |
| Connor Colby Status: Questionable San Francisco 49ers | questionable |
| Dee Winters Status: Active San Francisco 49ers | Winters logged eight tackles (four solo) and a pass defense during the 49ers' 16-15 win over the Cardinals on Sunday. |
| 2025-09-23 |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | questionable |
| 2025-09-22 |
| Jordan Watkins Status: Out San Francisco 49ers | out |
 | Jordan Jefferson Status: Active San Francisco 49ers | NA |
| Nick Martin Status: Active San Francisco 49ers | NA |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne had four receptions on six targets for 38 yards in Sunday's 16-15 win over Arizona. |
| Fred Warner Status: Active San Francisco 49ers | Warner tallied 11 total tackles (five solo) and two passes defended during Sunday's 16-15 win over the Cardinals. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo did not receive a carry while gaining 19 yards on a kickoff return in Sunday's 16-15 win over the Cardinals. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson had two carries for 22 yards and was not targeted as a receiver in Sunday's 16-15 win over Arizona. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges brought in two of three targets for 21 yards in Sunday's 16-15 win over the Cardinals. |
| Skyy Moore Status: Active San Francisco 49ers | Moore brought in his only target for 10 yards in Sunday's 16-15 win over the Cardinals. |
| Marquez Valdes-Scantling Status: Active San Francisco 49ers | Valdes-Scantling had one reception for nine yards in Sunday's 16-15 win over Arizona. |
| Nick Bosa Status: Doubtful San Francisco 49ers | Bosa (knee) is feared to have suffered a season-ending ACL tear during Sunday's win over the Cardinals, Adam Schefter of ESPN reports. |
| CJ West Status: Questionable San Francisco 49ers | questionable |
| Demarcus Robinson Status: Active San Francisco 49ers | Robinson's suspension has been lifted by the NFL, which sets the stage for the wideout to be available for Sunday's game against the Jaguars, Aaron Wilson of KPRC 2 Houston reports. |
| CJ West Status: Questionable San Francisco 49ers | Head coach Kyle Shanahan relayed Monday that West will need to undergo surgery to repair a broken thumb, Eric Branch of the San Francisco Chronicle reports. |
| Mykel Williams Status: Questionable San Francisco 49ers | Williams is considered day-to-day due to a wrist injury, Nick Wagoner of ESPN.com reports. |
| Renardo Green Status: Questionable San Francisco 49ers | Green is managing a neck injury and is considered day-to-day, Nick Wagoner of ESPN.com reports. |
| Jauan Jennings Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Jennings (shoulder/ankle) is considered "day-to-day," Nick Wagoner of ESPN.com reports. |
| Mac Jones Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Monday that Jones is day-to-day after aggravating a PCL sprain in his left knee during Sunday's 18-16 win against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Out San Francisco 49ers | Coach Kyle Shanahan confirmed Monday that Bosa is out for the season with an ACL injury, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Out San Francisco 49ers | Coach Kyle Shanahan said Monday that Purdy (left shoulder/toe) will resume practicing Wednesday, at which point the 49ers will evaluate him to see if he'll be ready to return Sunday against the Jaguars, Nick Wagoner of ESPN.com reports. |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro hit all three field-goal tries, including a 35-yarder as time expired, and his only extra-point attempt in Sunday's 16-15 win over the Cardinals. |
| Mac Jones Status: Questionable San Francisco 49ers | questionable |
| Mac Jones Status: Questionable San Francisco 49ers | Jones said he aggravated a previous knee injury in Sunday's win over the Cardinals, Ian Rapoport of NFL Network reports. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall racked up eight receptions on 11 targets for 117 yards in Sunday's 16-15 victory over the Cardinals. |
| 2025-09-21 |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Jordan Jefferson Status: Out San Francisco 49ers | inactive |
| Connor Colby Status: Active San Francisco 49ers | NA |
| Spencer Burford Status: Injured Reserve San Francisco 49ers | Burford (knee) was placed on injured reserve Saturday. |
| Malik Turner Status: Active San Francisco 49ers | The 49ers elevated Turner from the practice squad to the active roster Saturday. |
| Adrian Martinez Status: Active San Francisco 49ers | The 49ers elevated Martinez from the practice squad to the active roster Saturday. |
| Brock Purdy Status: Questionable San Francisco 49ers | The 49ers are optimistic that Purdy (toe/shoulder) -- who is listed as questionable but not expected to play Sunday against the Cardinals -- could be ready to start the team's Week 4 game versus the Jaguars, aIan Rapoport of NFL Network reports. |
| Connor Colby Status: Active San Francisco 49ers | Colby (groin) is active for Sunday's Week 3 clash against the Cardinals, Briana Jeannel of the 49ers' official site reports. |
| Mykel Williams Status: Questionable San Francisco 49ers | Williams is questionable to return to Sunday's game against the Cardinals due to a wrist injury, Matt Barrows of The Athletic reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa is questionable to return to Sunday's game against the Cardinals due to a knee injury, Nick Wagoner of ESPN.com reports. |
| Mykel Williams Status: Active San Francisco 49ers | Williams (wrist) has returned to Sunday's contest against the Cardinals, Nick Wagoner of ESPN.com reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) has been ruled out for the rest of Sunday's game against the Cardinals, Matt Maiocco of NBC Sports Bay Area reports. |
| Nick Bosa Status: Questionable San Francisco 49ers | Bosa (knee) did not tear his ACL when he got injured during Sunday's 16-15 win over the Cardinals, Matt Barrows of The Athletic reports. |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey rushed 17 times for 52 yards while corralling 10 of 15 targets for 88 yards in Sunday's 16-15 victory over the Cardinals. |
| Kendrick Bourne Status: Active San Francisco 49ers | San Francisco head coach Kyle Shanahan said that Bourne is "probably" going to be a starting receiver for the team in Sunday's game against the Cardinals with Jauan Jennings (ankle) listed as questionable but set to be inactive for the Week 3 contest, Matt Maiocco of NBC Sports Bay Area reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) is not in line to play Sunday against the Cardinals, according to Adam Schefter of ESPN. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (left shoulder/toe) isn't in line to play Sunday against the Cardinals, Adam Schefter of ESPN reports. |
| Mac Jones Status: Active San Francisco 49ers | Jones will start Sunday's game against the Cardinals after the 49ers ruled out Brock Purdy (left shoulder/toe). |
| Brock Purdy Status: Out San Francisco 49ers | The 49ers downgraded Purdy (toe/shoulder) from questionable to out for Sunday's game against the Cardinals. |
| Jauan Jennings Status: Out San Francisco 49ers | The 49ers downgraded Jennings (ankle/shoulder) from questionable to out for Sunday's game against the Cardinals. |
| 2025-09-20 |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (calf) has been ruled out ahead of Sunday's game against the Jaguars, Matt Barrows of The Athleticreports. |
| Connor Colby Status: Questionable San Francisco 49ers | Colby (groin) is listed as questionable for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports. |
| Kyle Juszczyk Status: Active San Francisco 49ers | Juszczyk does not have an injury designation ahead of Sunday's matchup against the Cardinals, Tyler Drake of ArizonaSports.com reports. |
| Yetur Gross-Matos Status: Active San Francisco 49ers | Gross-Matos does not have an injury designation ahead of Sunday's game against the Cardinals, Tyler Drake of ArizonaSports.com reports. |
 | Siran Neal Status: Active San Francisco 49ers | Neal does not have an injury designation for Sunday's game against the Cardinals, Tyler Drake of ArizonaSports.com reports. |
| Spencer Burford Status: Out San Francisco 49ers | Burford (knee) has been ruled out ahead of Sunday's game against the Cardinals, Matt Barrows of The Athletic reports. |
| 2025-09-19 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/calf) doesn't appear to be practicing Friday, Matt Barrows of The Athletic reports. |
| Spencer Burford Status: Out San Francisco 49ers | out |
| Mac Jones Status: Active San Francisco 49ers | Jones is on track for another start, with 49ers coach Kyle Shanhan saying Friday that Brock Purdy (toe/shoulder) is "highly unlikely" to start Sunday's game against Arizona, Adam Schefter of ESPN reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) is listed as questionable for Sunday's game against the Cardinals, Matt Barrows of The Athletic reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (shoulder/toe) is listed as questionable for Sunday's game against the Cardinals, even though 49ers coach Kyle Shanahan considers the quarterback "highly unlikely" to play, Adam Schefter of ESPN reports. |
| Connor Colby Status: Questionable San Francisco 49ers | questionable |
| Trent Williams Status: Active San Francisco 49ers | NA |
| Siran Neal Status: Active San Francisco 49ers | NA |
| Yetur Gross-Matos Status: Active San Francisco 49ers | NA |
| 2025-09-18 |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe/left shoulder) participated in the media-access portion of Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Trent Williams Status: Questionable San Francisco 49ers | questionable |
| Jordan Watkins Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) didn't take part in Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (toe) officially was limited at Thursday's practice, Nick Wagoner of ESPN.com reports. |
| Jordan Watkins Status: Questionable San Francisco 49ers | Watkins (calf) was a limited participant at the 49ers' practice Thursday, Matt Barrows of The Athletic reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk (concussion) was a limited participant at practice Thursday, Matt Barrows of The Athletic reports. |
| 2025-09-17 |
| Brayden Willis Status: Active San Francisco 49ers | The 49ers signed Willis to the active roster from the practice squad Wednesday. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder/ankle) will be limited at practice Wednesday, Cam Inman of The San Jose Mercury News reports. |
| Brock Purdy Status: Questionable San Francisco 49ers | Coach Kyle Shanahan said Purdy (toe/shoulder) will be limited at Wednesday's practice, Eric Branch of the San Francisco Chronicle reports. |
| Brandon Aiyuk Status: Out San Francisco 49ers | Aiyuk (knee) did some running while his teammates were practicing Wednesday, Nick Wagoner of ESPN.com reports. |
| Yetur Gross-Matos Status: Questionable San Francisco 49ers | questionable |
| Ben Bartch Status: Injured Reserve San Francisco 49ers | ir |
| Brock Purdy Status: Questionable San Francisco 49ers | Purdy (left shoulder/toe) officially was a limited practice participant Wednesday, Matt Barrows of The Athletic reports. |
| Ben Bartch Status: Injured Reserve San Francisco 49ers | Bartch (ankle) was placed on injured reserve Wednesday, Noah Furtado of the San Francisco Chronicle reports. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (ankle/shoulder) officially didn't practice Wednesday, Matt Barrows of The Athletic reports. |
| 2025-09-16 |
| Brock Purdy Status: Questionable San Francisco 49ers | questionable |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Ben Bartch Status: Out San Francisco 49ers | Bartch will be sidelined for a few weeks after suffering a high-ankle sprain in Sunday's win over the Saints, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Siran Neal Status: Questionable San Francisco 49ers | Neal has entered the league's concussion protocol following the 49ers' Week 2 win over the Saints, Nick Wagoner of ESPN.com reports. |
| Ben Bartch Status: Doubtful San Francisco 49ers | Bartch suffered a high ankle sprain during the 49ers' win over New Orleans on Sunday, Nick Wagoner of ESPN reports. |
| Spencer Burford Status: Questionable San Francisco 49ers | Burford suffered a knee injury in Sunday's 26-21 win over the Saints, David Lombardi of SFStandard.com reports. |
| 2025-09-15 |
| Nick Bosa Status: Active San Francisco 49ers | Bosa recorded nine total tackles (three solo), including 1.0 sacks, during Sunday's 26-21 win over the Saints. |
| Brian Robinson Jr. Status: Active San Francisco 49ers | Robinson rushed six times for 20 yards and caught his only target for a loss of one yard in Sunday's 26-21 win over New Orleans. |
| Marquez Valdes-Scantling Status: Active San Francisco 49ers | Valdes-Scantling failed to bring in his only target in Sunday's 26-21 win over the Saints. |
| Jake Tonges Status: Active San Francisco 49ers | Tonges finished with four receptions on five targets for 31 yards in Sunday's 26-21 win over the Saints. |
| Luke Farrell Status: Active San Francisco 49ers | Farrell brought in two of three targets for 15 yards and a touchdown in Sunday's 26-21 win over the Saints. |
| Spencer Burford Status: Questionable San Francisco 49ers | questionable |
| Jauan Jennings Status: Questionable San Francisco 49ers | Coach Kyle Shanahan noted Monday that Jennings came out of Week 2 action with an ankle injury, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Ben Bartch Status: Doubtful San Francisco 49ers | doubtful |
| Eddy Pineiro Status: Active San Francisco 49ers | Pineiro went 2-for-3 on extra-point attempts and made both of his field-goal tries during the 49ers' 26-21 win over the Saints on Sunday. |
| Brock Purdy Status: Out San Francisco 49ers | out |
| Jordan Jefferson Status: Active San Francisco 49ers | NA |
| Nick Martin Status: Active San Francisco 49ers | NA |
 | Austen Pleasants Status: Active San Francisco 49ers | NA |
| Drew Moss Status: Active San Francisco 49ers | NA |
| Fred Warner Status: Active San Francisco 49ers | Warner recorded 11 total tackles (seven solo), one pass defended, one forced fumble and one fumble recovery in Sunday's 26-21 win over the Saints. |
| Isaac Guerendo Status: Active San Francisco 49ers | Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints. |
| 2025-09-14 |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings, who is questionable to play Sunday against New Orleans due to a shoulder injury, is considered a game-time decision, though there is "optimism he goes," Ian Rapoport of NFL Network reports. |
| Jauan Jennings Status: Active San Francisco 49ers | Jennings caught five of 10 targets for 89 yards and a touchdown in Sunday's 26-21 win over New Orleans. |
| Mac Jones Status: Active San Francisco 49ers | Jones completed 26 of 39 passes for 279 yards and three touchdowns in Sunday's 26-21 win over the Saints. He added six rushing yards on six carries. |
| Brock Purdy Status: Out San Francisco 49ers | Purdy (toe/shoulder), who has been ruled out for Sunday's game in New Orleans, is considered unlikely to be available for the 49ers' Week 3 game versus the Cardinals, though his condition his improved over the past week, Adam Schefter of ESPN reports. "We'll see for next week," one source told Schefter, regarding Purdy's status. "Next week will be tight, but he progressed a lot this week." |
| Christian McCaffrey Status: Active San Francisco 49ers | McCaffrey carried the ball 13 times for 55 yards and caught six of seven targets for 52 yards and a touchdown in Sunday's 26-21 win over the Saints. |
| Jauan Jennings Status: Questionable San Francisco 49ers | Jennings (shoulder) remains listed as questionable but is expected to play Sunday in New Orleans, Adam Schefter of ESPN reports. |
| Kendrick Bourne Status: Active San Francisco 49ers | Bourne caught all three of his targets for 32 yards in Sunday's 26-21 win over the Saints. |
| Ricky Pearsall Status: Active San Francisco 49ers | Pearsall caught four of six targets for 56 yards in Sunday's 26-21 win over the Saints. He also had minus-four yards on his only carry. |
| Jordan James Status: Out San Francisco 49ers | James (coach's decision) is inactive for Sunday's game against the Saints, Briana Jeannel of the 49ers' official site reports. |
| Trent Williams Status: Active San Francisco 49ers | Williams (knee) is active for Sunday's matchup with the Saints, Briana Jeannel of the 49ers' official site reports. |
| Jordan Watkins Status: Out San Francisco 49ers | Watkins (coach's decision) is inactive for Sunday's game at New Orleans, Briana Jeannel of the 49ers' official site reports. |
| Austen Pleasants Status: Out San Francisco 49ers | inactive |
| Drew Moss Status: Out San Francisco 49ers | inactive |
| Nick Martin Status: Out San Francisco 49ers | inactive |
| Jordan Jefferson Status: Out San Francisco 49ers | inactive |
| Siran Neal Status: Questionable San Francisco 49ers | Neal is being evaluated for a concussion and is questionable to return to Sunday's game against the Saints, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Kyle Juszczyk Status: Questionable San Francisco 49ers | Juszczyk has been ruled out for the rest of Sunday's game against the Saints due to a concussion, Jennifer Lee Chan of NBC Sports Bay Area reports. |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch has an ankle injury and is questionable to return to Sunday's matchup with the Saints. |
| Ben Bartch Status: Questionable San Francisco 49ers | Bartch (ankle) has been downgraded to out for the rest of Sunday's game against the Saints, Matt Maiocco of NBC Sports Bay Area reports. |
| 2025-09-13 |