49ers
| 12/31/69 | 7:00 PM EST | |
| | ||
Injuries
| Date | Player | Status |
|---|---|---|
| 2025-10-21 | Yetur Gross-Matos | Questionable |
| 2025-10-20 | Yetur Gross-Matos | Out |
| 2025-10-20 | Bryce Huff | Doubtful |
| 2025-10-20 | Ricky Pearsall | Out |
| 2025-10-19 | Kevin Givens | Questionable |
| 2025-10-19 | Yetur Gross-Matos | Out |
| 2025-10-19 | Marquez Valdes-Scantling | Questionable |
| 2025-10-19 | Fred Warner | Injured Reserve |
| 2025-10-19 | Jordan Watkins | Out |
| 2025-10-18 | Fred Warner | Injured Reserve |
| 2025-10-17 | Renardo Green | Questionable |
| 2025-10-17 | Yetur Gross-Matos | Out |
| 2025-10-17 | George Kittle | Injured Reserve |
| 2025-10-17 | Ricky Pearsall | Out |
| 2025-10-17 | Brock Purdy | Out |
| 2025-10-17 | Upton Stout | Questionable |
| 2025-10-17 | Marquez Valdes-Scantling | Injured Reserve |
| 2025-10-16 | Kalia Davis | Questionable |
| 2025-10-16 | Kevin Givens | Injured Reserve |
| 2025-10-16 | Renardo Green | Questionable |
| 2025-10-16 | George Kittle | Injured Reserve |
| 2025-10-16 | Skyy Moore | Questionable |
| 2025-10-16 | Fred Warner | Out |
| 2025-10-16 | Jordan Watkins | Questionable |
Transactions
| Date | Transaction |
|---|---|
| 2025-10-21 | Released TE Messiah Swinson. Signed TE Brayden Willis to a contract. |
| 2025-10-18 | Activated TE George Kittle and DT Kevin Givens off injured reserve. Signed DE Trevis Gipson to the active roster. Placed LB Fred Warner on injured reserve. Waived TE Brayden Willis. |
| 2025-10-17 | Placed WR Marquez Valdes-Scantling on injured reserve. |
| 2025-10-16 | Designated TE George Kittle to return from injured reserve. |
